Ph 2 paulozzi paone_kelly

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Pharmacy Track Panel Discussion: Trends in Prescribing Prac7ces Presenters: Len Paulozzi, MD, MPH Denise Paone, EdD Tom Kelly, R.Ph., B.Sc Moderator: Andrew Kolodny, MD

Transcript of Ph 2 paulozzi paone_kelly

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Pharmacy  Track  Panel  Discussion:  

Trends  in  Prescribing  Prac7ces    

Presenters:  Len  Paulozzi,  MD,  MPH  Denise  Paone,  EdD  Tom  Kelly,  R.Ph.,  B.Sc  

Moderator:  Andrew  Kolodny,  MD  

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Disclosures  

•  Len  Paulozzi  •  Denise  Paone  has  no  financial  rela7onships  with  proprietary  en77es  that  produce  health  care  goods  and  services  

•  Thomas  Kelly  has  financial  rela7onships  with  proprietary  en77es  that  produce  health  care  products  and  services.  These  financial  rela7onships  are:    –  President/C.E.O.  Medicine  To  Go  Pharmacies  

•  Retail  pharmacies    –  President/C.E.O./Partner,  PPTP.net,  LLC  

•  Online  due  diligence  tool  for  preven7on  of  misuse,  abuse,  and  diversion  

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Learning  Objec7ves  

1.  Describe  current  trends  in  effec7ve  prescribing  habits.    

2.  Outline  best  prac7ces  for  u7lizing  data  and  PDMPs  as  effec7ve  tools  in  dispensing  controlled  substances.    

3.  Evaluate  opportuni7es  for  pharmacists  to  collaborate  with  prescribers  to  create  an  effec7ve  treatment  plan  for  their  pa7ents.  

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TM

Centers for Disease Control and Prevention National Center for Injury Prevention and Control

Trends  in  Prescribing  of    Controlled  Substances,    United  States,  2007-­‐2012  

Len  Paulozzi,  MD,  MPH  

Centers  for  Disease  Control  and  Preven7on  

Na7onal  Prescrip7on  Drug  Summit  

Atlanta,  GA          April  22,  2014  

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Overview  

Trends  in  mortality  

Trends  in  prescribing  of  controlled  substances  Conclusions  

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Motor  vehicle  traffic,  poisoning,  and    drug  poisoning  death  rates,  United  States,    

1980-­‐-­‐2010  

0  

5  

10  

15  

20  

25  

1980   1985   1990   1995   2000   2005   2010  

Deaths  pe

r  100,000  po

pula?on

  Motor  vehicle  traffic  

Poisoning  

Drug  poisoning  

CDC/NCHS  Na7onal  Vital  Sta7s7cs  System  accessed  through  CDC  WONDER.  

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Drug  overdose  deaths  by  major  drug  type,  United  States,  1999-­‐2010  

CDC/NCHS  Na7onal  Vital  Sta7s7cs  System,  CDC  WONDER    

0  

2,000  

4,000  

6,000  

8,000  

10,000  

12,000  

14,000  

16,000  

18,000  

1999   2000   2001   2002   2003   2004   2005   2006   2007   2008   2009   2010  

Num

ber  of  Deaths  

Year  

Opioids   Heroin   Cocaine   Benzodiazepines  16,651  

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Rates  of  opioid  overdose  deaths,  sales  and  treatment  admissions,    U.S.,  1999-­‐2010  

National Vital Statistics System, DEA’s Automation of Reports and Consolidated Orders System, SAMHSA’s TEDS

0  

1  

2  

3  

4  

5  

6  

7  

8  

1999   2000   2001   2002   2003   2004   2005   2006   2007   2008   2009   2010  

Rate  

Opioid  Sales  KG/10,000    Opioid  Deaths/100,000  Opioid  Treatment  Admissions/10,000  

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Prescrip7on  Data  Source  

  Purchase  from  IMS  

•  Na7onal  Prescrip7on  Audit  (NPA)  2007-­‐2012  •  Data  from  38,000/57,000  pharmacies  

•  Includes  retail,  mail-­‐order,  and  long-­‐term  care  •  Na7onal-­‐level  counts  for  prescrip7ons  and  units  (e.g.,  pills)  

es7mated  using  a  proprietary  method  

•  CDC  converted  to  popula7on-­‐based  rates  •  Non-­‐Butrans  buprenorphine  excluded  from  opioid  rates  

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Total  prescrip7on  rate,    United  States,  2007-­‐2012  

128,000  

129,000  

130,000  

131,000  

132,000  

133,000  

134,000  

135,000  

136,000  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

Increase  from  13.1  to  13.5  prescrip7ons  per  person  from  2007  to  2012.  

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Opioid  analgesic  prescrip7on  and  unit  rates,    United  States,  2007-­‐2012  

7,500  

8,000  

8,500  

9,000  

9,500  

10,000  

0  

100,000  

200,000  

300,000  

400,000  

500,000  

600,000  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Units  per  10,000  

Unit  rate   Prescrip7on  rate  

1%  drop  from  2010  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013.  Excludes  buprenorphine  other  than  BuTrans  products.    Units  limited  to  solid  dosage  forms.  

1%  increase  from  2010  

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Percent  change  in  prescrip7on  rates,  all  drugs  versus  opioid  analgesics,  U.S.,  2007-­‐2012  

-­‐1  -­‐0.5  

0  0.5  1  

1.5  2  

2.5  3  

3.5  

2008   2009   2010   2011   2012  

Percen

t  chan

ge  

All  rx   Opioids  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

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Hydrocodone  and  oxycodone  prescrip7on  rate,    United  States,  2007-­‐2012  

0  500  

1,000  1,500  2,000  2,500  3,000  3,500  4,000  4,500  5,000  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Hydrocodone   Oxycodone  

OxyCon7n®  reformulated  ,  September,  2010  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

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Other  major  opioids  prescrip7on  rate,    United  States,  2007-­‐2012  

0  

100  

200  

300  

400  

500  

600  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Morphine   Fentanyl   Methadone   Codeine   Oxymorphone  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

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Other  major  opioids  prescrip7on  rate,    United  States,  2007-­‐2012  

0  

100  

200  

300  

400  

500  

600  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Morphine   Fentanyl   Methadone   Codeine   Oxymorphone  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

Methadone  increased  sharply  to  2008,  when  DEA  compelled  restricted  use  of  the  largest  formula7on.    Rate  in  2012  same  as  rate  in  2007.  

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Oxymorphone  prescrip7on  rate,    United  States,  2007-­‐2012  

0  

10  

20  

30  

40  

50  

60  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Source:  IMS  Vector  One® Na7onal  (VONA)  Extracted  July,  2013  

Abuse-­‐resistant  extended-­‐release  formula7on  (Opana  ER)  came  on  market  February,  2012.    

Rate  dropped  19%  from  2011  to  2012.  

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Opioid  analgesic  prescrip7on  rate  by  payment,    United  States,  2007-­‐2012  

0  1,000  2,000  3,000  4,000  5,000  6,000  7,000  8,000  9,000  

10,000  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Total   Cash  

Cash  17%  of  all    opioid  rx  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  Excludes  buprenorphine  other  than  BuTrans  products  

Cash  9%  of  all  opioid  rx  

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Hydrocodone  and  oxycodone  prescrip7on  rate  paid  with  cash,  United  States,  2007-­‐2012  

0  100  200  300  400  500  600  700  800  900  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Hydrocodone   Oxycodone  

48%  drop  from  20077  

39%  drop  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

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Benzodiazepine  prescrip7on  and  unit  rates,    United  States,  2007-­‐2012  

200,000  

205,000  

210,000  

215,000  

220,000  

225,000  

230,000  

235,000  

240,000  

2,500  2,700  2,900  3,100  3,300  3,500  3,700  3,900  4,100  4,300  

2007   2008   2009   2010   2011   2012  

Units  per  10,000  

Prescrip?on

s  pe

r  10

,000

 

Prescrip7on  rate   Unit  rate  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

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Major  benzodiazepine  prescrip7on  rate,    United  States,  2007-­‐2012  

0  

200  

400  

600  

800  

1,000  

1,200  

1,400  

1,600  

1,800  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

  Alprazolam  

Clonazepam  

Lorazepam  

Diazepam  

Temazepam  

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

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Carisoprodol  prescrip7on  rate,    United  States,  2007-­‐2012  

290  

300  

310  

320  

330  

340  

350  

360  

370  

2007   2008   2009   2010   2011   2012  

Prescrip?on

s  pe

r  10

,000

 

Source:  IMS  Na7onal  Prescrip7on  Audit  (NPA)®  Extracted  July,  2013  

DEA  places  carisoprodol  in  Schedule  IV,  Jan  2012;  11%  drop  

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Conclusions  

 Drug  overdose  epidemic  driven  by  overdoses  of  prescrip?on  opioids,  oPen  combined  with  benzodiazepines  and/or  muscle  relaxants   Opioid  overdose  rates  parallel  prescrip?on  rates  

 Steady  increase  in  opioid  prescribing  rate  since  1999  has  finally  leveled  off   Abuse-­‐resistant  formula?on,  scheduling  change  appear  to  be  associated  with  largest  declines  in  certain  drugs  

 Overall  declines  alone  likely  too  small  to  reduce  prescrip?on  overdose  mortality  aPer  2010  

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Comments or questions: Len Paulozzi, MD, MPH

[email protected]

The  findings  and  conclusions  in  this  report  are  those  of  the  author  and  do  not  necessarily  represent  the  official  posi6on  of  the  Centers  for  Disease  Control  and  Preven6on/the  Agency  for  Toxic  Substances  and  Disease  Registry.  The  presenter  has  no  conflicts  of  interest  to  report.

Acknowledgements: Jinnan Liu, PhD Karin Mack, PhD

Chris Jones, PharmD, MPH

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Prescrip?on  Monitoring  Program  (PMP)  in  New  York  City  

Denise  Paone,  EdD  Director  of  Research  and  Surveillance    

Bureau  of  Alcohol  and  Drug  Use    Preven7on,  Care,  and  Treatment  

New  York  City  Department  of  Health  and  Mental  Hygiene  

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Disclosure  Statement  

Denise  Paone  has  no  financial  rela7onships  with  proprietary  en77es  that  produce  health  care  goods  and  services  

25  

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PMP:  Background    •  Historically  ,  seen  as  a  law  enforcement  tool:  

–  To  iden7fy  pa7ents  and  prescribers  engaged  in  possible  aberrant  behavior    –  To  iden7fy  “doctor  shoppers”    –  To  inves7gate  drug  diversion  &  fraud  

•  NYC  DOHMH  using  PMP  as  a  public  health  surveillance  tool:  –  To  iden7fy  and  describe  palerns  of  opioid  analgesic  use  at  pa7ent  and  prescriber  

levels    

–  To  iden7fy  pa7ents  at  risk  for  fatal  and  non-­‐fatal  overdose  –   To  reduce  prescrip7on  drug  misuse  and  diversion  –   As  a  drug  epidemic  warning  system  

•  NYC  DOHMH  uses  PMP  as  a  pa7ent  care  tool:    –  To  iden7fy  pa7ents  with  possible  substance  use  disorders    –  To  avoid  risky  drug  Interac7ons  –  To  iden7fy  and  reduce  pa7ent  visits  to  mul7ple  prescribers  

•  PMP  not  meant  to  infringe  on  the  legi7mate  prescribing  of    controlled  substances  

Source: http://www.pmpalliance.org/content/prescription-monitoring-frequently-asked-questions-faq

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PMP:  public  health  surveillance  tool  

•  Number  of  prescrip7ons,  pa7ents,  prescriber,  pharmacies  

•  Rate  of  opioid  analgesic  prescrip7ons  filled  overall  and  by  drug  type  

•  Median  day  supply  

•  Rate  of  pa7ents  filling  opioid  analgesic  prescrip7ons  

•  Rate  of  high  dose  opioid  analgesic  prescrip7ons  filled  

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PMP  surveillance  used  to  inform  public  health  ini?a?ves  

•  Opioid  prescribing  guidelines    •  City  Health  Informa7on  (CHI)  –  primary  care    

•  Emergency  Department  guidelines  

•  Staten  Island  detailing  campaign  •  Focused  on  prescribers  

•  Morphine  milligram  equivalent  calculator  

•  Media  campaign  •  Public  Service  Announcement    on  “prescrip7on  painkiller  use”  

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Analy?c  methods  •  Focus  on  schedule  II  prescrip7on  opioid  analgesics  (excluding  codeine-­‐cII)  

•  Exclude  missing  pa7ent  or  prescriber  IDs,  veterinarians,  or  ins7tu7onal  licenses  

•  Report  rates  per  1,000  residents  and  adjust  to  2000  US  Standard  popula7on  

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Descrip?ve  sta?s?cs  

•  Demographic  characteris7cs  of  pa7ent  (gender,  age,  residence,  payment)  

•  Prescriber  profession,  specialty  (if  available),  license  loca7on  

•  Pharmacy  loca7on  

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Prescrip?on  variables  

•  Dura7on  of  ac7on  –  Long-­‐ac7ng  or  short-­‐ac7ng  

•  Day  supply  •  Morphine  Equivalent  Dose  (MED)    

–  Conversion  of  the  daily  dose  of  an  opioid  analgesic  prescrip7on  to  its  morphine  milligram  equivalent    

– High  MED,  or  high  dose,  prescrip7ons  confer  increased  risks  of  overdose,  specifically  when  MED  ≥  100.  

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USING  PMP  TO  DESCRIBE  PATTERNS  OF  OPIOID  ANALGESIC  PRESCRIPTION  USE  IN  NEW  YORK  CITY    

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Opioid  analgesic  (OA)  prescrip?ons  NYC,  2008–2012  

0

500,000

1,000,000

1,500,000

2,000,000

2,500,000

2008 2009 2010 2011 2012

Num

ber o

f Pre

scrip

tions

Year Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2008–2012

Opioid analgesic prescriptions

Oxycodone

Hydrocodone

Note:  Schedule  II  opioid  analgesics  

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From  2008–2012  there  was  a  17%  increase  in  the  number  of  pa?ents  filling  OA  prescrip?ons  

0

100,000

200,000

300,000

400,000

500,000

600,000

700,000

800,000

2008 2009 2010 2011 2012

Num

ber o

f pre

scrip

tions

Year

Patient

Prescriber

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2008-2012

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15%  of  prescribers  wrote  83%  of  opioid  analgesic  prescrip?ons  

48%

2%

37%

15%

14%

49%

1%

34%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Prescribers Prescriptions Prescribing frequency

Very Frequent Prescribers 530-10,185 Rx/year

Frequent Prescribers 50-529 Rx/year

Occasional Prescribers 4-49 Rx/year

Rare Prescribers 1-3 Rx/year

Prescrip7ons  filled  by  NYC  residents,  2012  

15%

83%

Perc

ent

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012 35  

Note:  Schedule  II  opioid  analgesics  

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In  2012,  10%  of  prescribers  (n  =  5,384)  wrote  75%  of  prescrip?ons  (n  =1,623,157)  

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

0-29 30-39 40-49 50-59 60-69 70-79 80-89 90-99

Perc

ent o

f pre

scrip

tions

Percent of prescribers

Note: Schedule II opioid analgesics

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012

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Two-­‐thirds  of  pa?ents  filled  only  one  prescrip?on;  one-­‐third  filled  78%  of  all  opioid  analgesic  

prescrip?ons  

63%

22%

14%

9%

5%

6%

8%

14%

10%

49%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Patients Prescriptions Prescription Frequency

15 prescriptions 5 prescriptions 3 prescriptions 2 prescriptions 1 prescription

Prescrip7ons  filled  by  NYC  residents,  2012  

Perc

ent

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012 37  

37%

78% Note:  Schedule  II  opioid  analgesics  

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Pa?ents  visi?ng  mul?ple  prescriber  and  mul?ple  pharmacies  are  rare  

•  In  2012,  1.2%  (9,137)  of  pa7ents  visited  4+  prescribers  and  4+  pharmacies  

– Filled  7.9%  (170,282)  of  all  prescrip7ons  – Visited    15,042  unique  prescribers  – Visited  2,913  unique  pharmacies  

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012

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Two-­‐thirds  of  opioid  analgesic  prescrip?ons  filled  were  paid  with  commercial  Insurance  

67%  

14%  

8%  

6%  4%  

1%  

Commercial  Insurance  

Private  Pay  (Cash,  Charge,  Credit  Card)  

Medicare  

Other  

Medicaid  

Workers  Comp  

Note:  Schedule  II  opioid  analgesics  

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012

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Staten  Islanders  filled  OA  prescrip?ons  at  higher  rates  in  2012  

0

50

100

150

200

250

300

350

400

450

500

NYC Bronx Brooklyn Manhattan Queens Staten Island

Age

-adj

uste

d ra

te o

f pre

scrip

tions

fille

d pe

r 1,

000

resi

dent

s

Borough of Residence

Opioid Analgesics Oxycodone Hydrocodone

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012

Note:  Schedule  II  opioid  analgesics  

Rates are adjusted to 2000 US Census population    

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OA  prescrip?ons  filled  by  Staten  Islanders  have  longer  median  day  supply  

0

5

10

15

20

25

30

NYC Bronx Brooklyn Manhattan Queens Staten Island

Med

ian

Supp

ly, D

ays

Borough of Residence Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2012

Note:  Schedule  II  opioid  analgesics      Median  day  supply  is  calculated  from  day  supply  of  each  prescrip7on  filled  in  the  year.    

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OA  prescrip?ons  filled  by  Staten  Islanders  are  more  frequently  high  dose  (>100  MED)  

0

20

40

60

80

100

120

140

160

NYC Bronx Brooklyn Manhattan Queens Staten Island

Age

-adj

uste

d ra

te o

f hig

h do

se p

resc

riptio

ns

fille

d pe

r 1,0

00 re

side

nts

Borough of Residence

2008 2009 2010 2011 2012

Note:  Schedule  II  opioid  analgesics    

High  dose  is  any  opioid  analgesic  prescrip7on  with  a  calculated  morphine  equivalent  dose  (MED)  greater  than  100.  Among  pa7ents  receiving  opioid  prescrip7ons,  overdose  rates  increase  with  increasing  doses  of  prescribed  opioids.  

Source: New York State Department of Health, Bureau of Narcotic Enforcement, Prescription Drug Monitoring Program, 2008–2012

Rates are adjusted to 2000 US Census population    

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PMP  PUBLIC  HEALTH  SURVEILLANCE  AND  DATA  DRIVEN  INITIATIVES  

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Neighborhoods  with  high  rates  of  OA  prescrip?ons  have  high  rates  of  uninten?onal  (overdose)  deaths  

involving  opioid  analgesics      

*Paone D, Bradley O’Brien D, Shah S, Heller D. Opioid analgesics in New York City: misuse, morbidity and mortality update. Epi Data Brief. April 2011. Available at http://www.nyc.gov/html/doh/downloads/pdf/epi/epi-data-brief.pdf .

OA PRESCRIPTION RATES OA MORTALITY RATES

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Opioid  prescribing  guidelines  •  Less  oqen:  avoid  prescribing  opioids  for  

chronic  non-­‐cancer,  non-­‐end-­‐of-­‐life  pain    e.g.,  low  back  pain,  arthri7s,  headache,  

fibromyalgia  •  Shorter  dura7on:  when  opioids  are  

warranted  for  acute  pain,  3-­‐day  supply  usually  sufficient  

•  Lower  doses:  if  dosing  reaches  100  Morphine  Milligram  Equivalents  (MME)  ,  reassess  and  reconsider  other  approaches  to  pain  management  

•  Avoid  whenever  possible  prescribing  opioids  in  pa7ents  taking  benzodiazepines  Cita7on:  Paone  D,  Dowell  D,  Heller  D.  Preven7ng  misuse  of  prescrip7on  opioid  drugs.  City  Health  Informa7on.  2011;  30(4):  23-­‐30  

New  York  City  Opioid  Treatment  Guidelines,  Clinical    Advisors:  Nancy  Chang,  MD;  Marc  N.  Gourevitch,  MD,  MPH;  Mark  P.  Jarrel,  MD,  MBA;  Andrew  Kolodny,  MD;  Lewis  Nelson,  MD;  Russell  K.  Portenoy,  MD;  Jack  Resnick,  MD;  Stephen  Ross,  MD;  Joanna  L.  Starrels,  MD,  MS;  David  L.  Stevens,  MD;  Anne  Marie  S7lwell,  MD;  Theodore  Strange;  MD,  FACP;  Homer  Venters,  MD,  MS    

45  

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New  York  City  Emergency  Department  Discharge  Opioid  Prescribing  Guidelines  Clinical  Advisory  Group:  Jason  Chu,  MD,  Brenna  Farmer,  MD,  Beth  Y.  Ginsburg,  MD,  Stephanie  H.  Hernandez,  MD,  James  F.  Kenny,  MD,  MBA,  FACEP,  Nima  Majlesi,  DO,  Ruben  Olmedo,  MD,  Dean  Olsen,  DO,  James  G.  Ryan,  MD,  Bonnie  Simmons,  DO,  Mark  Su,  MD,  Michael  Touger,  MD,  Sage  W.  Wiener,  MD.  

Emergency  Department  guidelines  

Released  January,  2013  

Adopted  by  35  NYC  emergency  departments  

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Staten  Island  public  health  “detailing”  campaign  

•  1-­‐on-­‐1  “detailing”  visits  from  Health  Department  representa7ves  

•  Deliver  key  prescribing  recommenda7ons,  clinical  tools,  pa7ent  educa7on  materials  

•  ~1,000  Staten  Island  physicians,  nurse  prac77oners,  physicians  assistants  

•  June–August  2013  •  PMP  data  analyzed  to  evaluate  

prescribing  palerns  pre-­‐  and  post-­‐campaign  

47  

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48  

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Morphine  Milligram  Equivalent  (MME)  calculator  

•  A  tool  to  calculate  total  MME  per  day  

•  Gives  alert  for  dosages  >100  MME  •  Quick  and  easy  to  use  •  Web-­‐based  applica7on  

–  Search  for  “NYC  MME  Calculator”  hlp://www.nyc.gov/html/doh/html/mental/MME.html  

•  Smartphone  app  

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50  

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Media  campaigns  •  Campaign  One:    

–  Goal:  Increase  awareness  of  risk  of  opioid  analgesic  overdose  –  Ran  twice  (2012,  2013)  

•  Campaign  Two:    –  Goal:  Reduce  s7gma  and  raise  awareness  of  opioid  analgesic  

misuse  –  2  tes7monials  

•  Mom  lost  son  to  opioid  analgesic  overdose  •  NYC  resident    in  recovery  

–  Ran  2013  and  2014  

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Summary  •  PMPs  can  be  used  as  a  public  health  surveillance  tool  to  understand  palerns  of  opioid  analgesic  prescrip7on  use  

•  New  Yorkers  filled  ~2  million  opioid  analgesic  prescrip7ons  per  year  from  2008-­‐2012  

•  From  2008-­‐2012  Staten  Island  residents  filled  high  dose  prescrip7ons  (>100  MED)  at  highest  rates  

•  High  rates  of  opioid  analgesic  prescrip7on  use  mirror  high  rates  of  opioid  analgesic  overdose  mortality  

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Improving  Outcomes  while  Deterring  Misuse,  Abuse,  &  

Diversion  Tom  Kelly,  R.Ph.,  B.Sc.  

C.E.O./Partner:  

Medicine  To  Go  Pharmacies,  PPTP.net  

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Disclosures  

•  Thomas  Kelly  has  financial  rela7onships  with  proprietary  en77es  that  produce  health  care  products  and  services.    These  financial  rela7onships  are:    

•  President/C.E.O.  Medicine  To  Go  Pharmacies  – Retail  pharmacies    

•  President/C.E.O./Partner,  PPTP.net,  LLC  – Online  due  diligence  tool  for  preven7on  of  misuse,  abuse,  and  diversion    

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Learning  Objec7ves  

1.  PMP's  and  PDMP's  are  valuable  clinical  tool  promo7ng  improved  outcomes.  

2.  There  is  a  difference  between  healthcare  and  enforcement.  

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How  Did  We  Get  Here?  

•  1980  prehistoric  •  1996  Oxycon7n  launched  “less  poten7al  for  addic7on  and  

abuse”,  chronic  pain  pa7ents  undertreated.  •  Non  profits  funded  by  opiate  pharma  manuf.  (Am.  Pain  

Founda7on)  •  8/31/2000  FDA  approves  NDA  for  Roxicodone  15mg  &  30mg  •  Current  Trends:    

–  6/3/2011  Fla:  HR  7095  an7-­‐pill  mill  legisla7on  signed  by  Gov.  Rick  Scol    

–  DEA  suspends  permits  for  2  CVS  and  6  Walgreens  pharmacies  and  some  independent  pharmacies  in  Fla.    

–  DEA  suspends  permits:    3  Cardinal  Health  distribu7on  centers,  Walgreen’s,  Juniper,  Fl.,  AmerisourceBergen,  Orlando,  Fl.,  Harvard  Drug  Group,  Livonia,  Mi.    

–  McKesson  pays  $13  million  in  fines  for:  Fl.,  Tx.,  Md.,  Ut.,  Co.,  Ca.  

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The  Strange  Down  Stream  Trends  

•  Viola7ons  everywhere,  wholesale  distributors:  “But  how  much  can  we  sell?”  

•  Blind  speed  limits  •  Contrac7on  in  opioid  analgesic  distribu7on  •  Some  pa7ents  struggle  to  get  medica7ons,  really?  

–  4.8%  of  worlds  popula7on  consumes  80%  opioid  analgesics  but  significant  hitches  in  supply  stream  

•  Wholesalers  using  numbers,  not  encouraging  or  establishing  the  use  of  sound  clinical  guidelines  –  Place  pharmacist  on  review  team  

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Unfortunate  Reali7es  •  Growing  popula7ons  trends  for  chronic  pain  pa7ents  

–  Advanced  trauma  care  leading  to  more  survivors    (fortunate  reality)  –     Diabetes  explosion  CDC  1980-­‐2011  2.5  to  6.9%  -­‐  genera7ng  more  neuropathies?  –     Arthri7s  rates  increasing  –     Obesity  increasing  

•  As  they  say  in  enforcement:  “Follow  the  money”  –  2008  recession  compounds  problem,  economic  relief  in  black  market  

•  60%  of  diverted  medica7ons  sourced  from  friends  and  family,  Get  Rx  for  120,  use  40  divert  80.    Difficult  to  detect.    

–  Is  black  market  larger  than  legal  market?    •  #120  oxycodone  15mg  @  $60  legal  via  insurance,  black  market  at  $1/mg  @$1,800      

–  Heroin  cheap,  easy  to  turn  •  Prescrip7on  opioid  analgesics  &  heroin  more  valuable  than  cash  

•  We  cannot  enforce  our  way  out  •  What  are  liabili7es  for  not  performing  due  diligence?  •  Fewer  Fellowships  offered  in  pain  management,  family  prac7oners  

and  GP’s  are  prescribing  –  Only  a  couple  of  extra  pain  pa7ents  per  prescriber  add  up  

•  Not  my  pa7ents  

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Its  busy,  What  Can  I  Do?  (opportuni7es)  •  Promote  and  u7lize  PMPs  as  a  tool  to  achieve  posi7ve  outcomes  

(healthcare  term,  not  enforcement,  &  not  an  excuse  to  dispense!)  

•  Establish  PMP  review  in  workflow,  promote  states  to  allow  registered  technicians  and  nurses  to  access  data  bases  

•  Reduce  liability  with  due  diligence  

•  Verify  pa7ent  iden7ty  at  drop  off:  government  issued,  commercial  services  •  Collaborate,  let  prescribers  know  around  the  clock  IR  meds  for  pain  control  

not  illegal  but  frowned  upon,  decrease  #  doses  on  the  street,  use  sound  clinical  judgment  

•  Collaborate,  perform  random  medica7on  counts  for  pa7ents  exhibi7ng  adherent  behavior  for  your  prescribers  

•  Review,  review,  review  clinical  risks  with  pa7ents,  par7cularly  those  who  are  opiate  naive  

•  Counsel  all  regarding  secure  storage,  i.e.  dental  rxs,  loaded  gun  in  medicine  cabinet  analogy  

•  Ins7tute  a  treatment  agreements,  aka  narco7c  contract  

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But  What  Can  I  Do?    Con7nued…  (more  opportuni7es)  

•  Market  topically  compounded  analgesics-­‐  far  lower  poten7al  for  abuse  •  Partner  with  adver7zing  vendors  to  include  medica7on  guide  specific  for  

commonly  abused  medica7on,  i.e.  LDM  Group,  CarePoints  (slide)  •  Increase  sensi7za7on:  Use  social  media  &  poster  up,  “Who  Knew  Grandma  

Kept  a  Stash”,  Partnership  for  a  Drug  Free  New  Jersey,  DEA’s  Na7onal  Prescrip7on  Drug  Take  Back  Day,  etc.  (slide)  

•  Partner  with  teaching  ins7tu7ons.    Sponsor  substance  abuse  CE  +  CME’s  for  health  care  providers,  including  pediatricians,  den7sts,  and  oral  surgeons  (slide)  

•  Get  involved,  collaborate,  join  work  groups,  encourage  community  based  ac7on,  no  one  group  can  defeat  this  scourge  alone  (slide)  –  Form  local  coali7ons,  churches,  schools,  enforcement,  civic  groups,  

etc.    •  Sponsor  a  local  drop  off  box  for  unused  medica7ons  

–  www.americanmedicinechest.com/_media/permcollec7on1.pdf  

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Provide  Naloxone  Rescue  Kits  (opportunity)    

•  A  lille  work  results  in  most  significant  outcomes  alainable  

•  Develop  collabora7ve  prac7ce  agreements  

•  Trails  already  blazed,  follow  the  footsteps  – hlp://stopoverdose.org/index.htm  – hlp://harmreduc7on.org/  

– hlp://prescribetoprevent.org/about-­‐us/  

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Educa7on  Opportuni7es:  Pharmacy  Student  and  Technician  Training  

•  Establish  and  teach  clinical  guidelines  for  counseling  pa7ents  to  avoid  issues  associated  with  controlled  medica7ons.      

•  Encourage  training  in  detec7ng  evidence  of  misuse,  substance  abuse,  addic7on,  pseudo  addic7on,  and  diversion  in  pa7ent  popula7ons.  

•  Amplify  the  value  of  PMPs  as  a  clinical  tool.    •  If  a  palern  of  abuse  is  detected,  provide  outline  on  how  to  assist  the  pa7ent  and  associated  healthcare  providers  move  forward  toward  posi7ve  outcomes.    i.e.  addic7on  services,  mental  health  services,  etc.    

•  Provide  protocols  on  when  and  how  to  engage  enforcement.  

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Big  Ideas-­‐  Opportuni7es  to  do  beler?  

•  Develop  systems  for  ease  of  use  for  busy  prac7ces,  pharmacies  and  prescribers  alike.  Current  models  D+  –  Allow  nurses  and  pharmacy  technicians  access?  

•  Reward  health  care  professionals  for  accessing  PMPs.  –  Direct  compensa7on,  rebate  professional  license  fees,  tax  credits?    

•  Establish    and  encourage  realis7c  reimbursements  to  pharmacies  for  Medica7on  Therapy  Management  (MTM)  reviews  for  chronic  pain  pa7ents.  

•  Develop  Accountable  Care  Organiza7on  (ACO)  models  for  how  dispensing  pharmacies  can  partner  with  ACOs    &  manage  chronic  pain  pa7ents  to  improve  outcomes  and  subsequently  reduce  costs.  

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DEA  Na?onal  Drug  Take  Back  Day  

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Who  Knew  Grandma  Kept  a  Stash!  Partnership  for  a  Drug  Free  New  Jersey  

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A  local  church  adver?zed  on  OUR  prescrip?on  bags!  

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Thank  you!    Tom  Kelly,  R.Ph.,  B.Sc.    PPTP.net/Medicine  To  Go  Pharmacies    PO  Box  2253    Long  Beach  Branch    Beach  Haven,  NJ  08008    1-­‐609-­‐242-­‐1400  voice    [email protected]  email    www.PPTP.net  website