Perspectives on PARP Inhibitors in Ovarian Cancer Has the Time Come for Individualized Care?
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Transcript of Perspectives on PARP Inhibitors in Ovarian Cancer Has the Time Come for Individualized Care?
Perspectives on PARP Inhibitors in Ovarian Cancer
Has the Time Come for Individualized Care?
Activity Goals
Epidemiology: Ovarian Cancer
PARP and DNA Repair
BRCA and DNA Repair
Synthetic Lethality Is Associated With Inhibition of PARP in the Presence of BRCA Deficiency
PARP Inhibition in BRCA-like Solid Tumors
Repair Mechanisms and BRCAness
BRCA Testing: When Should it Be Done?
PARP Inhibition: Mechanism of Action
Clinical Outcomes in Patients With BRCA Mutations
PARP Inhibitors in Clinical Trials
Case Study 1
Treatment Options
Anticipated PFS With Standard Treatment
Olaparib as Maintenance Therapy: Study Design
Results of BRCA Testing
Results
ASCO 2014: Cediranib/Olaparib
PFS With Cediranib/Olaparib Superior to Olaparib Alone
PFS Increased With Cediranib/Olaparib Combination
Phase 2: PLD vs Olaparib
Case Study 2
Treatment Approach
Neoadjuvant Chemotherapy (NACT) vs Primary Debulking
Surgery (PDS)
Dose-Dense Paclitaxel + Carboplatin vs Conventional
Regimen
BRCAness and Response to Chemotherapy
GOG9923
Key Issues for Future Developments
of PARP Inhibitors
Abbreviations
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