April 2018 Volume 41, Number 4

In This Issue

643 In This Issue of Diabetes Care

Perspectives in Care

645 Current Challenges and Opportunities in the Preventionand Management of Diabetic Foot UlcersW.J. Jeffcoate, L. Vileikyte, E.J. Boyko, D.G. Armstrong,and A.J.M. Boulton

653 Type 1 Diabetes TrialNet: A Multifaceted Approach to BringingDisease-Modifying Therapy to Clinical Use in Type 1 DiabetesP.J. Bingley, D.K. Wherrett, A. Shultz, L.E. Rafkin, M.A. Atkinson,and C.J. Greenbaum

Commentaries

662 Diabetic Kidney Disease: A Determinant of CardiovascularRisk in Type 1 DiabetesI.H. de Boer and G.L. Bakris

664 Scientific Exploration With Continuous Monitoring Systems:An Early Assessment of Arrhythmias During HypoglycemiaM.C. Riddle and M.E. Miller

667 Are We There Yet? Finding Ways to Work Together on T1DC. Mathieu

Clinical Care/Education/Nutrition/Psychosocial Research

670 Clinical and Patient-Centered Outcomes in Obese PatientsWith Type 2 Diabetes 3 Years After Randomization toRoux-en-Y Gastric Bypass Surgery Versus Intensive LifestyleManagement: The SLIMM-T2D StudyD.C. Simonson, F. Halperin, K. Foster, A. Vernon, and A.B. Goldfine

680 A Low-Fat Dietary Pattern and Diabetes: A SecondaryAnalysis From the Women’s Health Initiative DietaryModification TrialB.V. Howard, A.K. Aragaki, L.F. Tinker, M. Allison, M.D. Hingle,K.C. Johnson, J.E. Manson, A.H. Shadyab, J.M. Shikany,L.G. Snetselaar, C.A. Thomson, O. Zaslavsky, and R.L. Prentice

688 Implementation of a Structured Diabetes ConsultationModel to Facilitate a Person-Centered Approach: ResultsFrom a Nationwide Dutch StudyG.E.H.M. Rutten, H.A. van Vugt, I. de Weerdt, and E. de Koning

696 Occupational Therapy Intervention Improves GlycemicControl and Quality of Life Among Young Adults WithDiabetes: the Resilient, Empowered, Active Living withDiabetes (REAL Diabetes) Randomized Controlled TrialE.A. Pyatak, K. Carandang, C.L.P. Vigen, J. Blanchard, J. Diaz,A. Concha-Chavez, P.A. Sequeira, J.R. Wood, R. Whittemore,D. Spruijt-Metz, and A.L. Peters

705 Precision Medicine in Type 2 Diabetes: Clinical Markers ofInsulin Resistance Are Associated With Altered Short- andLong-term Glycemic Response to DPP-4 Inhibitor TherapyJ.M. Dennis, B.M. Shields, A.V. Hill, B.A. Knight, T.J. McDonald,L.R. Rodgers, M.N. Weedon, W.E. Henley, N. Sattar, R.R. Holman,E.R. Pearson, A.T. Hattersley, and A.G. Jones, on behalf of theMASTERMIND Consortium

Epidemiology/Health Services Research

713 Comparative Safety of Sulfonylureas and the Risk of SuddenCardiac Arrest and Ventricular ArrhythmiaC.E. Leonard, C.M. Brensinger, C.L. Aquilante, W.B. Bilker,D.M. Boudreau, R. Deo, J.H. Flory, J.J. Gagne, M.J. Mangaali,and S. Hennessy

723 Long-term Diet Quality and Risk of Type 2 Diabetes AmongUrban Chinese AdultsD. Yu, W. Zheng, H. Cai, Y.-B. Xiang, H. Li, Y.-T. Gao, and X.-O. Shu

731 Duration of Diabetes and Prediabetes During Adulthoodand Subclinical Atherosclerosis and Cardiac Dysfunctionin Middle Age: The CARDIA StudyJ.P. Reis, N.B. Allen, M.P. Bancks, J.J. Carr, C.E. Lewis, J.A. Lima,J.S. Rana, S.S. Gidding, and P.J. Schreiner

739 High Baseline Levels of Tumor Necrosis Factor Receptor 1Are Associated With Progression of Kidney Diseasein Indigenous Australians With Diabetes: The eGFRFollow-up StudyE.L.M. Barr, F. Barzi, J.T. Hughes, G. Jerums, W.E. Hoy, K. O’Dea,G.R.D. Jones, P.D. Lawton, A.D.H. Brown, M. Thomas, E.I. Ekinci,A. Sinha, A. Cass, R.J. MacIsaac, and L.J. Maple-Brown

748 Excess Mortality in Patients With Type 1 Diabetes WithoutAlbuminuriadSeparating the Contribution of Earlyand Late RisksP.-H. Groop, M. Thomas, M. Feodoroff, C. Forsblom, andV. Harjutsalo, on behalf of the FinnDiane Study Group

755 The Impact of Diabetes on Breast Cancer Treatments andOutcomes: A Population-Based StudyI.C. Lega, P.C. Austin, H.D. Fischer, K. Fung, M.K. Krzyzanowska,E. Amir, and L.L. Lipscombe

762 Night Shift Work, Genetic Risk, and Type 2 Diabetes inthe UK BiobankC. Vetter, H.S. Dashti, J.M. Lane, S.G. Anderson, E.S. Schernhammer,M.K. Rutter, R. Saxena, and F.A.J.L. Scheer

770 Type 1 Diabetes in Parents and Risk of Attention Deficit/Hyperactivity Disorder in Offspring: A Population-BasedStudy in SwedenJ. Ji, T. Chen, J. Sundquist, and K. Sundquist

775 Increasing Mortality in Adults With Diabetes and LowEstimated Glomerular Filtration Rate in the Absenceof AlbuminuriaH. Kramer, R.E. Boucher, D. Leehey, L. Fried, G. Wei, T. Greene,S.E. Rosas, R. Cooper, G. Cao, and S. Beddhu

782 Effect of A1C and Glucose on Postoperative Mortalityin Noncardiac and Cardiac SurgeriesW. van den Boom, R.A. Schroeder, M.W. Manning, T.L. Setji,G.-O. Fiestan, and D.B. Dunson

Emerging Technologies and Therapeutics

789 Optimizing Hybrid Closed-Loop Therapy in Adolescentsand Emerging Adults Using the MiniMed 670GSystemL.H. Messer, G.P. Forlenza, J.L. Sherr, R.P. Wadwa, B.A. Buckingham,S.A. Weinzimer, D.M. Maahs, and R.H. Slover

797 Effects of Preceding Ethanol Intake on Glucose Responseto Low-Dose Glucagon in Individuals With Type 1Diabetes: A Randomized, Placebo-Controlled,Crossover StudyA. Ranjan, K. Nørgaard, R. Tetzschner, I.I.K. Steineck, T.R. Clausen,J.J. Holst, S. Madsbad, and S. Schmidt

807 Antisense Inhibition of Protein Tyrosine Phosphatase 1BWith IONIS-PTP-1BRx Improves Insulin Sensitivity andReduces Weight in Overweight Patients WithType 2 DiabetesA. Digenio, N.C. Pham, L.M. Watts, E.S. Morgan, S.W. Jung,B.F. Baker, R.S. Geary, and S. Bhanot

Pathophysiology/Complications

815 Differential Association of Microvascular Attributions WithCardiovascular Disease in Patients With Long Duration ofType 1 DiabetesD. Gordin, V. Harjutsalo, L. Tinsley, W. Fickweiler, J.K. Sun,C. Forsblom, P.S. Amenta, D. Pober, S. D’Eon, M. Khatri, I.E. Stillman,P.-H. Groop, H.A. Keenan, and G.L. King

823 Islet Interleukin-1b Immunoreactivity Is an Early Feature ofCystic Fibrosis That May Contribute to b-Cell FailureR.L. Hull, R.L. Gibson, S. McNamara, G.H. Deutsch, C.L. Fligner,C.W. Frevert, B.W. Ramsey, and S. Sanda

831 Adiposity Impacts Intrarenal Hemodynamic Function inAdults With Long-standing Type 1 Diabetes With andWithout Diabetic Nephropathy: Results From the CanadianStudy of Longevity in Type 1 DiabetesP. Bjornstad, J.A. Lovshin, Y. Lytvyn, G. Boulet, L.E. Lovblom,O.N. Alhuzaim, M.A. Farooqi, V. Lai, J. Tse, L. Cham, A. Orszag,D. Scarr, A. Weisman, H.A. Keenan, M.H. Brent, N. Paul, V. Bril,B.A. Perkins, and D.Z.I. Cherney

Cardiovascular and Metabolic Risk

840 Plasma Connective Tissue Growth Factor (CTGF/CCN2)Levels Predict Myocardial Infarction in the Veterans AffairsDiabetes Trial (VADT) CohortK.J. Hunt, M.A. Jaffa, S.M. Garrett, D.K. Luttrell, K.E. Lipson,M.F. Lopes-Virella, L.M. Luttrell, A.A. Jaffa, and VADT Investigators

847 Prognostic Value of the Acute-to-Chronic Glycemic Ratio atAdmission in Acute Myocardial Infarction: A Prospective StudyG. Marenzi, N. Cosentino, V. Milazzo, M. De Metrio, M. Cecere,S. Mosca, M. Rubino, J. Campodonico, M. Moltrasio, I. Marana,M. Grazi, G. Lauri, A. Bonomi, F. Veglia, R. Manfrini, andA.L. Bartorelli

854 Diagnosis and Significance of Pulmonary MicrovascularDisease in DiabetesT.J. Roberts, A.T. Burns, R.J. MacIsaac, A.I. MacIsaac, D.L. Prior, andA. La Gerche

862 Low-grade Inflammatory Marker Profile May Help toDifferentiate Patients With LADA, Classic Adult-Onset Type 1Diabetes, and Type 2 DiabetesE. Castelblanco, M. Hern�andez, A. Castelblanco, M. Gratac�os,A. Esquerda, À. Molló, A. Ramírez-Morros, J. Real, J. Franch-Nadal,J.-M. Fern�andez-Real, and D. Mauricio

869 Disordered Eating Behaviors Are Not Increased by anIntervention to Improve Diet Quality but Are AssociatedWith Poorer Glycemic Control Among Youth With Type 1DiabetesM.H. Eisenberg Colman, V.M. Quick, L.M. Lipsky, K.W. Dempster,A. Liu, L.M.B. Laffel, S.N. Mehta, and T.R. Nansel

876 Characteristics and Prognosis in Women and MenWith Type 1Diabetes Undergoing Coronary Angiography: A NationwideRegistry ReportV. Ritsinger, C. Hero, A.-M. Svensson, N. Saleh, B. Lagerqvist,K. Eeg-Olofsson, and A. Norhammar

884 Elevated Serum Xanthine Oxidase Activity Is Associated Withthe Development of Type 2 Diabetes: A Prospective CohortStudyX. Li, X. Meng, X. Gao, X. Pang, Y. Wang, X. Wu, X. Deng, Q. Zhang,C. Sun, and Y. Li

891 Limb- and Person-Level Risk Factors for Lower-LimbAmputation in the Prospective Seattle Diabetic Foot StudyE.J. Boyko, A.D. Seelig, and J.H. Ahroni

899 Risk of Cardiovascular Disease and Death in Individuals WithPrediabetes Defined by Different Criteria: The Whitehall II StudyD. Vistisen, D.R. Witte, E.J. Brunner, M. Kivim€aki, A. Tab�ak,M.E. Jørgensen, and K. Færch

Novel Communications in Diabetes

907 Leptin Replacement Reestablishes Brain Insulin Action in theHypothalamus in Congenital Leptin DeficiencyS. Frank-Podlech, J. von Schnurbein, R. Veit, M. Heni, J. Machann,J.M. Heinze, S. Kullmann, J. Manzoor, S. Mahmood, H.-U. H€aring,H. Preissl, M. Wabitsch, and A. Fritsche

Clinical Images In Diabetes

911 Diagnosis at a Glance: Acquired Perforating DermatosisH. Kosumi, H. Iwata, M. Tsujiwaki, and H. Shimizu

Errata

913 Erratum. Impact of Lifestyle and Metformin Interventions onthe Risk of Progression to Diabetes and Regression toNormal Glucose Regulation in Overweight or Obese PeopleWith Impaired Glucose Regulation. Diabetes Care2017;40:1668–1677W.H. Herman, Q. Pan, S.L. Edelstein, K.J. Mather, L. Perreault,E. Barrett-Connor, D.M. Dabelea, E. Horton, S.E. Kahn, W.C. Knowler,C. Lorenzo, X. Pi-Sunyer, E. Venditti, and W. Ye, for the DiabetesPrevention Program Research Group

913 Erratum. Validation of the Diabetes Prevention Trial–Type 1Risk Score in the TrialNet Natural History Study. DiabetesCare 2011;34:1785–1787J.M. Sosenko, J.S. Skyler, J. Mahon, J.P. Krischer, C.A. Beam,D.C. Boulware, C.J. Greenbaum, L.E. Rafkin, C. Cowie,D. Cuthbertson, J.P. Palmer, and the Type 1 Diabetes TrialNetand Diabetes Prevention Trial–Type 1 Study Groups

Issues and Events

914 Issues and Events

e-Letters – Observations

e40 Successful Treatment of Scleredema Diabeticorum WithTranilast: Three Case ReportsM. Sun, F. Yang, and M. Hou

e42 Metformin and Helicobacter pylori Infection in Patients WithType 2 DiabetesC.-H. Tseng

e44 Insulin Detemir Use Is Associated With Higher Occurrence ofHypoglycemia in Hospitalized Patients With HypoalbuminemiaI. Hochberg

e47 SGLT2 Inhibitor–Associated Euglycemic DiabeticKetoacidosis: A South Australian Clinical Case Series andAustralian Spontaneous Adverse Event NotificationsE.J. Meyer, G. Gabb, and D. Jesudason

e50 Physical Activity in Patients With Type 2 Diabetes: The Casefor Objective Measurement in Routine Clinical CareN. Oosterom, C.M. Gant, N. Ruiterkamp, B.-J.F. van Beijnum,H. Hermens, S.J.L. Bakker, G. Navis, M.M.R. Vollenbroek-Hutten, andG.D. Laverman

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e52 Weekly Versus Daily Dipeptidyl Peptidase 4 Inhibitor Therapyfor Type 2 Diabetes: Systematic Review and Meta-analysisT. Yamada, N. Shojima, H. Noma, T. Yamauchi, and T. Kadowaki

e56 Rethinking the National Diabetes Prevention Program forLow-Income WhitesN.D. Ritchie, K.A. Sauder, P. Phimphasone-Brady, and C.R. Amura

e-Letters – Comments and Responses

e58 Comment on Burrows et al. Declining Rates ofHospitalization for Selected Cardiovascular DiseaseConditions Among Adults Aged $35 Years With DiagnosedDiabetes, U.S., 1998–2014. Diabetes Care 2018;41:293–302J.M. de Miguel-Yanes, M. Méndez-Bailón, R. Jiménez-García,and A. López-de-Andrés

e59 Response to Comment on Burrows et al. Declining Rates ofHospitalization for Selected Cardiovascular DiseaseConditions Among Adults Aged $35 Years With DiagnosedDiabetes, U.S., 1998–2014. Diabetes Care 2018;41:293–302N.R. Burrows, Y. Li, L.S. Geiss, and E.W. Gregg

e60 Comment on Santema et al. Hyperbaric Oxygen Therapy inthe Treatment of Ischemic Lower-Extremity Ulcers in PatientsWith Diabetes: Results of the DAMO2CLES MulticenterRandomized Clinical Trial. Diabetes Care 2018;41:112–119M. Mutluoglu

e61 Comment on Santema et al. Hyperbaric Oxygen Therapy inthe Treatment of Ischemic Lower-Extremity Ulcers in PatientsWith Diabetes: Results of the DAMO2CLES MulticenterRandomized Clinical Trial. Diabetes Care 2018;41:112–119E. Huang

e62 Response to Comments on Santema et al. HyperbaricOxygen Therapy in the Treatment of IschemicLower-Extremity Ulcers in Patients With Diabetes: Results ofthe DAMO2CLES Multicenter Randomized Clinical Trial.Diabetes Care 2018;41:112–119K.T.B. Santema, R.M. Stoekenbroek, M.J.W. Koelemay, andD.T. Ubbink, on behalf of the DAMO2CLES Study Group

e64 Comment on Novodvorsky et al. Diurnal Differencesin Risk of Cardiac Arrhythmias During SpontaneousHypoglycemia in Young People With Type 1Diabetes. Diabetes Care 2017;40:655–662P. Home and J. Lachin

e65 Response to Comment on Novodvorsky et al.Diurnal Differences in Risk of Cardiac ArrhythmiasDuring Spontaneous Hypoglycemia in Young PeopleWith Type 1 Diabetes. Diabetes Care 2017;40:655–662M. Campbell, S.R. Heller, and R.M. Jacques

e67 Comment on Ooi and Wong. Twin Pregnancy WithGestational Diabetes Mellitus: A Double Whammy?Diabetes Care 2018;41:e15–e16R.T. McGrath, G.R. Fulcher, and S.J. Glastras

e68 Response to Comment on Ooi and Wong. TwinPregnancy With Gestational Diabetes Mellitus:A Double Whammy? Diabetes Care 2018;41:e15–e16S. Ooi and V.W. Wong

e69 Comment on de Carvalho et al. ProproteinConvertase Subtilisin/Kexin Type 9 (PCSK9)Inhibitors and Incident Type 2 Diabetes:A Systematic Review and Meta-analysis WithOver 96,000 Patient-Years. Diabetes Care2018;41:364–367Y.-X. Cao and J.-J. Li

e70 Response to Comment on de Carvalho et al.Proprotein Convertase Subtilisin/Kexin Type 9(PCSK9) Inhibitors and Incident Type 2 Diabetes:A Systematic Review and Meta-analysis With Over96,000 Patient-Years. Diabetes Care 2018;41:364–367L.S.F. de Carvalho, A.M. Campos, and A.C. Sposito

Cover: Credit: Jing Jing Tsong. For more information, please visit theispot.com. For further information on foot complications, please visit http://www.diabetes.org/living-with-diabetes/complications/foot-complications/.