Perspectives from Academia to Industry to Business...Milestone Development Services, 1998-present !...
Transcript of Perspectives from Academia to Industry to Business...Milestone Development Services, 1998-present !...
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How to be Successful in Your Career
Perspectives from Academia to Industry to Business
February 26, 2018 | Pittsburgh Conference | Orlando, FL
Mike S. Lee Milestone Development Services
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§ What’s your story? "§ You are here! "
- Establish a framework (a strategy) for your story"- Education and experience are good places to start"- Benchmarking – a balance between time and content"
§ Find your story"- Movement to find opportunities, fulfillment and success"
§ Go looking but never forget where you are"- Relationships may be the key to sustained success as well as " contentment and happiness"
"• Sharing Stories Enables Success!! !"
Your Career is a Story – Tell It and Find It (or Vice Versa)!"
Milestone Development Services
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§ Biotechnology Entrepreneur § Integration of new technologies into clinical and industrial settings
§ Over 25 years pharmaceutical industry experience § Bristol-Myers Squibb, 1987-1998 (Buspar®, Serzone®, TAXOL®) § Milestone Development Services, 1998-present § Mozaic Solutions, 2012-present
§ Education and Training § American Chemical Society § American Society for Mass Spectrometry § Eastern Analytical Symposium § Pittsburgh Conference § Symposium on Clinical and Pharmaceutical Solutions through Analysis
§ Annual meetings in USA, China, Brazil and Europe § CPSA Charitable Foundation § CPSA Institute
!
Milestone Development Services!
What’s Mike Lee’s Story?"
• Thinking Big to Change the World!!
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§ Education § B.S. Chemistry, 1982 - University of Maryland, College Park, MD § M.S. Chemistry, 1985 - University of Florida, Gainesville, FL § Ph.D. Chemistry, 1987 - University of Florida, Gainesville, FL
§ Industry Experience § Bristol-Myers Squibb, 1987-1998 § Milestone Development Services, 1998-present
§ Mentors § Rick Yost and Ira Rosenberg
!
Milestone Development Services!
Framework of Your Career – Education, Experience and Mentors"
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§ Revolutionize analytics in the pharmaceutical, " biotechnology and diagnostic industries"
- Movement away from platforms that require expert training to " expert systems that feature pre-set applications dedicated to a " specific solution"
§ Lead the movement toward personalized healthcare "- Analysts, technicians and patients will not need to know how " the technology works; only the information provided and what " to do with it""
"• Digital LC Enables Personalized Healthcare!!"
Find Your Story – Digital LC and Precision Medicine (Mozaic Solutions)"
M.S. Lee, ALDA, 2016 Milestone Development Services
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§ Research & Development Cost"- No guarantee of success"
§ Market and Geographical Shift"- Aging population"- Prevention and diagnosis"- Asia"- Personalized medicine"
§ Diagnostics"- Accurate and efficient"
§ Biotechnology"- Genetic differences"- Precise treatment"
"• On the Brink of a Healthcare Revolution!!"
The Market Story – Global Pharmaceutical Industry Perspectives"
F.B. Humer, Hoffman-La Roche, 2005 Milestone Development Services
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§ Clinical knowledge management"§ Patient information"§ Virtual patient"§ Personalized medicine!§ Disease at the atomic scale" - DNA" - Genetic vaccines" - Biomemetic engineering"§ Stem cells""• The Desire for Longevity is a Key Driver! - Brain" - Aging""
The Opportunity – Considerations in a Post-Genomic Society"
Milestone Development Services
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§ Clinical knowledge management"§ Patient information!§ Virtual patient!§ Personalized medicine"§ Disease at the atomic scale" - DNA" - Genetic vaccines" - Biomemetic engineering"§ Stem cells""• The Desire for Longevity (success) is a Key Driver" - Opportunity redefined""
But Wait! – What Does Opportunity Look Like?"
Milestone Development Services
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Personalized Healthcare"
Milestone Development Services!Roche Diagnostics Ltd.
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§ Early detection of disease"- Leads to earlier treatment"
§ Response-guided medication"- Leads to better treatment"
§ Clinical trials to mirror patient therapy"- Companion diagnostics"
§ Treatments tailored to specific sub-groups"- Personalized medicine"
""• Future Treatments will be Tailored to Specific ! Subgroups!"
Reverse Engineer Success – Solutions for Healthcare"
Milestone Development Services Roche Diagnostics Ltd.
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You Are Here – The Bioanalytical LC/MS/MS Flow Path"
Tandem Mass Spectrometer
The image cannot be displayed. Your computer
Autosampler HPLC UV
Scale-Up & Extraction Fractionation Collection Spectroscopic Analysis
• The Endpoint is the Mass Spectrometer, Regardless! of the Path! – Brad Ackermann, Eli Lilly!
M.S. Lee, Integrated Strategies in Drug Discovery Using Mass Spectrometry, John Wiley & Sons; New York 2005 Milestone Development Services
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§ Standard Methods
§ Template Structure Identification
§ Databases
§ Screening
§ Integration § Miniaturization § Parallel Processing § Visualization"§ Automation "• Transformation of the Mass Spectrometer into a ! Clinical Analyzer"
Method Development Strategies"
M.S. Lee, LC/MS Applications in Drug Development, John Wiley & Sons; New York 2002 Milestone Development Services
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Mass Spectrometry Applications in Drug Discovery & Development
Mike S. Lee ISBN: 978-0-471-46127-2 June 2005 John Wiley & Sons, New York, NY
Integrated Strategies for Drug Discovery Using Mass Spectrometry
LC/MS Applications In Drug Development
Mike S. Lee ISBN: 978-0-471-40520-7 March 2002 John Wiley & Sons, New York, NY
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Applications in Drug Metabolism and Impurity and Degradant Identification
Mike S. Lee and Mingshe Zhu ISBN: 978-0-470-40196-5 May 2011 John Wiley & Sons, New York, NY
Mass Spectrometry in Drug Metabolism and Disposition
Characterization of Impurities and Degradants Using Mass Spectrometry
Ben Pramanik, Mike S. Lee and Guodong Chen ISBN: 978-0-470-38618-7 May 2011 John Wiley & Sons, New York, NY
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Mass Spectrometry, Pharmaceutical and Biotechnology
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Mass Spectrometry, Pharmaceutical and Biotechnology
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Nanospray Ionization"
Milestone Development Services!
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Nanospray Ionization"
Milestone Development Services!
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Nanospray Ionization"
Milestone Development Services!
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Nanospray Ionization"
Milestone Development Services!
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Nanospray Ionization"
Milestone Development Services!
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Nanospray Ionization"
Milestone Development Services!
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Nanospray Ionization: 30 Years Later
Qualitative Quantitative
Courtesy of Dr. Rick King, PharmaCadence LLC
• Diffusion Curve
• Perceived Usefulness – Very small sample volumes
• Limited sample available – Closer to a universal ionization
• More compounds ionize • More compounds have a similar
response
“Nanospray IS Electrospray”"- Rick King, 2006 CPSA"
• Perceived Ease of Use – Difficult to setup initially – Difficult to keep running – Difficult to use with gradient LC
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Integration and Miniaturization – The Future of High Performance LC/MS"
Nathan Yates| University of Pittsburgh
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Integrated and Miniaturized High Performance LC/MS – iPhone Analytics"
PicoFrit Emitter
PicoFrit HPLC Column
Voltage Union
Transfer Line
• Integration and Miniaturization Improves Performance
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Specialized Expertise -
R&D
Universal Productivity –
Clinical Laboratory
• “Ease-of-Use is High Performance!” - Shane Needham, Alturas Analytics
Integration and Miniaturization – New Markets Demand Ease of Use!"
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Specialized Expertise -
R&D
Universal Productivity –
Clinical Laboratory
• “Ease-of-Use is High Performance!” - Shane Needham, Alturas Analytics
Integration and Miniaturization – New Markets Demand Ease of Use!"
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“Chromatography is analog, we need to digitize chromatography.”
Mike S. Lee Milestone Development (Circa 1998)
Bob Kennedy University Michigan
Mozaic Solutions Annual Meeting May 7, 2015
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Partnership for Performance
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Segmented Flow Nanospray"
Anal. Chem. Vol. 82, No. 12,, June 15, 2010 Milestone Development Services
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What can you do with “Infinite” Speed?���������
������������
Collect an Individual QA Curve for Each Sample
Samples for Analysis (triplicate)
QA “Curve” (triplicate)
Lucinda Cohen | Merck
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CPSA – Sharing of Stories on a Worldwide Stage!
Shanghai, China April – International
Boston (MA), USA May – Patient & Physician
Gainesville, (FL) USA March – Clinical/Metabolomics
London, UK February – Technology Development
São Paulo, Brasil August - International
Philadelphia, (PA) USA October – Technology & Solutions
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CPSA 2018 Shanghai, China 15-18 April 2015
Langhorne (PA), USA 5-8 October 2015
São Paulo, Brasil August 3 - 5, 2015
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São Paulo, Brasil August 3 - 5, 2015
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Shanghai, China 15-18 April 2015
Langhorne (PA), USA 5-8 October 2015
São Paulo, Brasil August 3 - 5, 2015
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§ Early detection"- Mass Spectrometer Transformed into a Clinical Analyzer"- A Molecular Microscope"
§ Response-guided medication"- Chromatography-Mass Spectrometry Platforms Evolve into a
Clinical Analyzer"- A Molecular Plate Reader"
""• Mass Spectrometry and Chromatography Uniquely ! Positioned to Enable Personalized Healthcare! - Integration, Miniaturization and Visualization are Critical for " Success! "
Mass Spectrometry and Chromatography for Healthcare"
Milestone Development Services
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§ Early detection"- Mass Spectrometer Transformed into a Clinical Analyzer"- A Molecular Microscope"
§ Response-guided medication"- Chromatography-Mass Spectrometry Platforms Evolve into a
Clinical Analyzer"- A Molecular Plate Reader"
""• Mass Spectrometry and Chromatography Uniquely ! Positioned to Enable Personalized Healthcare! - Hope, care and compassion to make a difference" - Execution of plan (signature)! "
Mass Spectrometry and Chromatography for Healthcare"
Milestone Development Services
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§ Time and Content – Begin Early (but never too late)!"- Transform – from market to industry to self"- Simplify – easier to do (realistic) when based on time"- Solutions – reverse engineer your solution (be realistic)"
§ Response – Opportunity "- Set goals and pursue"- Be realistic and continually measure and feel"- Find it! – or sometimes success finds you (when not looking)"
§ Stay Connected – Treasure Relationships"- Passion – identify and position into a community and
preferred culture allowing for acceptance and growth"- Lead – courage to share and own your story"- Trust – always know where you are"
"• Remember to Share Your Story!! - Looking back on both success and failure can point you in the" right direction! "
Perspectives on Success – Your Story"
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Mass Spectrometry, Pharmaceutical and Biotechnology
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Mass Spectrometry, Pharmaceutical and Biotechnology
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