PERSONAL INFORMATION ALBERTO G. UGAZIO

University of Rome Tor Vergata – 00135, Rome/ Children’s Hospital Bambino Gesù, Piazza Sant’ Onofrio, 4 - 00165 Roma

06 68592435

agiovanni.ugazio@opbg.netmailto:name.surname@med.uniroma2.it

Sex M | Date of birth 16/11/1944 | Nationality Italy

WORK EXPERIENCE

Research Fellow, Italian Ministry of Education Department of Pediatrics, University of Pavia Assistant Professor of Pediatrics Department of Pediatrics, University of Pavia EMBO Research Fellow Institute of Clinical and Experimental Immunology University of Amsterdam, Amsterdam, The Netherlands Full Professor of Pediatrics Department of Pediatrics, University of Pavia Full Professor of Pediatrics Head Department of Pediatrics and Director Specialty School in Pediatrics, University of Brescia Director, Department Medical Pediatrics Ospedale Pediatrico Bambino Gesù, Roma

EDUCATION AND TRAINING

EDUCATION AND TRAINING

1974 – 1976

1976 – 1978

1978 – 1980

1980 – 1983

1983 – 2000

2000 – to date

1963 – 1969

1969

1972

1981

Alumnus “Almo Collegio Borromeo” University of Pavia MD summa cum laude - School of Medicine University of Pavia Degree of Specialization cum laude in Pediatrics University of Pavia Degree of Specialization cum laude in Clinical Immunology and Allergology University of Florence

1990-1991

1991-1995

Chairman, Commission on Gene Therapy Italian Ministry of Health University of Pavia

Member of the Research Project “Genetic Engineering” National Research Council, Italy

ADDITIONAL INFORMATION

PUBLICATIONS Korthäuer U, Graf D, Mages HW, Brière F, Padayachee M, Malcolm S, Ugazio AG, Notarangelo LD, Levinsky RJ, Kroczek RA: "Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM"_NATURE 361: 539-541, 1993.

Plebani A, Ugazio AG, Meini A, Ruggeri L, Negrini A, Albertini A, Leibovits A, Duse M, Bottaro A, Brusco R, Cariota U, Boccazzi C, Carbonara AO: "Extensive deletion of immunoglobulin heavy chain constant region genes in the absence of recurrent infections: when is IgG subclass deficiency clinically relevant?" CLIN. IMMUNOL. IMMUNOPATHOL. 68: 46-50, 1993

Villa A, Notarangelo LD, Di Santo JP, Strina D, Frattini A, Lucchini F, Patrosso CM, Giliani S, Mantuano E, Agosti S, Nocera G, Kroczed RA, Fischer A, Ugazio AG, Basile G, Vezzoni P: "Organization of the human CD40L gene: implications for molecular defects in X chromosome-linked hyper-IgM syndrome and prenatal diagnosis"_PROC. NATL. ACAD. SCI. USA, 91: 2110-2114,1994.

A. Villa, L. Notarangelo, P. Macchi, E. Mantuano, G. Cavagni, D. Brugnoni, D. Strina, M.C. Patrosso, U. Ramenghi, M.G. Sacco, A.G. Ugazio & P. Vezzoni_”X - linked thrombocytopenia and Wiskott - Aldrich syndrome are allelic diseases with mutations in the WASP gene” NATURE GENETICS, 9: 414-416, 1995 P. Macchi, A. Villa, S. Gillani, M.G. Sacco, A. Frattini, F. Porta, A.G. Ugazio, J. A. Johnston, F. Candotti, J. O'Shea, P. Vezzoni & L. D. “Notarangelo_Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)”_NATURE, 377, 65-68, 1995 C. Bordignon, L.D. Notarangelo, N. Nobili, G. Ferrari, G. Casorati, P. Panina, E. Mazzolari, D. Maggiori, C. Rossi, P. Servida, A.G. Ugazio, F. Mavillo. “Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA-Immunodeficient Patients"_SCIENCE, 270, 470-473, 1995 G.S. Wengler, A. Lanfranchi, T. Frusca, R. Verardi, A. Neva, D. Brugnoni, S. Giliani, M. Fiorini, P. Mella, F. Guandalini, E. Mazzolari, S. Pecorelli, L.D. Notarangelo, F. Porta, A.G. Ugazio: “In-utero transplantation

1997-2001

2000-2004

2004-2007

1999-2006

2008

2009-2012

2008 to date

Editor in Chief, Italian Journal of Pediatrics, official journal of the Italian Society of Pediatrics. Member of the European Society for Immunodeficiency Diseases (ESID). Member of the European Society for Pediatric Hemathology and Immunology (ESPHI). Member of the European Board of “Seminars in Clinical Immunology"

Editor in Chief, “Area Pediatrica”, official journal of the Italian Society of Pediatrics for continuing medical education

President, Italian Society for Pediatric Allergology and Immunology (SIAIP)

Member, National Commission on Immunizations, Italian Ministry of Health

Head, Scientific Committee, Europediatrics 2008, EPE/UNEPSA

President, Italian Society of Pediatrics

Chairman, Commission on Immunization Practices, Italian Society of Pediatrics Prof. Alberto G. Ugazio is author of over 400 scientific papers, mostly on peer-reviewed international Journals. His main Scientific Interests include: Primary Immunodeficiency Diseases, mapping and cloning of primary immunodeficiencies (Immunodeficiency with hyper-IgM, SCID due to Jak-3 deficiency, Omenn Syndrome, Common Variable Immunodeficiency), gene therapy of ADA deficiency, in utero transplantation of hematopoietic stem cells. First successful in utero transplantation of Hematopoietic Stem Cells and prenatal reconstitution of the immune system of a foetus affected with Severe Combined Immunodeficiency Disease.

of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDXI)”_THE LANCET, 348, 720-724, 1996 Candotti F., Oakes SA, James A, Johnston JA, Giliani S, Schumacher RF, Mella P, Fiorini M, Ugazio AG, Badolato R, Notarangelo LD, Bozzi F, Macchi P, Strina D, Vezzoni P, Blease RM, O’Shea JJ, Villa A: “Structural and functional basis for JAK3-Deficient severe combined immunodeficiency” BLOOD, 90, 3996-4003, 1997 Brugnoni D, Notarangelo LD, Sottini A, Airò P, Pennacchio M, Mazzolari E, Signorini S, Candotti F, Villa A, Mella P, Vezzoni P, Cattaneo R, Ugazio AG, Imberti L: “Development of Autologous, Oligoclonal, Poorly Functioning T Lymphocytes in a Patient with autosomal recessive severe combined immunodeficiency caused by defects of the Jak3 Tyrosine Kinase”_BLOOD, 91, 949-955, 1998 Badolato R., Sozzani S., Malacarne F., Bresciani S., Fiorini M., Borsatti A., Albertini A., Mantovani A., Ugazio A.G., Notarangelo L.D.: “Monocytes from Wiskott-Aldrich patients desplay reduced chemotaxis and lack of cell-polarization in response to MCP-1 and fMLP.”_J. IMMUNOL. 161: 1026-1033, 1998 A.G. Ugazio, A. Lanfranchi, K. Tettoni, F. Porta: "Intrauterine stem cell transplantation for severe combined immunodeficiencies" REVIEWS IN CLINICAL AND EXPERIMENTAL HEMATOLOGY, 8, 41-57, 1999 Signorini S., Imberti L., Piovesano S., Villa A., Facchetti F., Ungari M., Bozzi F., Albertini A., Ugazio A.G., Vezzoni P., Notarangelo L.D.: "Intrathymic restriction and peripheral expansion of the T-cell repertoire in Omenn syndrome"_BLOOD, 94:3468-78, 1999 S. Ferrari, S. Giliani, A. Insalaco, A. Al Ghonaium, A.R. Soresina, M. Loubser, M.A. Avanzini, M. Marconi, R. Badolato, A.G. Ugazio, Y. Levy, N. Catalan, A. Durandy, A. Tbakhi, L.D. Notarangelo, A. Plebani: “Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM”_PNAS 98, 12614-12619, 2001. M. Fiorini, W. Vermi, F. Facchetti, D. Moratto, G. Alessandri, L. Notarangelo, A. Caruso, P. Grigolato, A. G. Ugazio, L.D. Notarangelo and R. Badolato: “Detective migration of monocyte-derived dendriticcells in LAD-A immunodeficiency”_Journal of Leukoeyte Biology vol72, pag. 650-656 october 2002 S. Pirovano, L.D. Notarangelo, M. Valotti, A.G. Ugazio, A. Albertini, L. Imberti: “Mutations of the T-cell receptor constant region after in utero stem cell transplantation_Immunogenetics 2004, 56(3): 214-219 E. Cortis, F. De Benedetti, A. Insalaco, S. Cioschi, F. Muratori, L.E. D’Urbano, A.G. Ugazio. “Abnormal production of the tumor necrosis factor inhibitor etanercept and clinical efficacy of tumor in a patient with PAPA syndrome”_The Journal of Pediatric 2004, dic;145(6):851-855. M.G. Gagliardi, M. Bevilacqua, C. Bassano, B. leonardi, R. Boldrini, F. Diomedi Camassei, A. Fierabracci, A.G. Ugazio, G.F. Bottazzo: “Long term follow up of children with myocarditis treated by immunosuppression and of children with dilated cardiomyopathy”_Heart 2004; 90(10):1167-1171 L. Fiore, A. Plebani, G. Buttinelli, S. Fiore, V. Donati, J. Marturano, A. Soresina, B. Martire, C. Azzari, G. Nigro, F. Cardinale, A. Trizzino, C. Pignata, P. Alvisi, E. Anastasio, G. Bossi, A.G. Ugazio. “Search for poliovirus long-term excretors among patients affected by agammaglobulinemia” Clinical Immunology 2004; 111(1):98-102 M. Fiorini, R. Franceschini, A. Soresina, R. Schumacher, A.G. Ugazio, A. Rossi, A. Plebani, L.D. Notarangelo. “BTK:22 novel and 25 recurrent mutations in european patients with x-linked agammaglobulinemia”_Human Mutation 2004 mar; 23 (3): 286. S. Pirovano, L.D. Notarangelo, F. Malacarne, E. Mazzolari, F. Porta, A. Lanfranchi, S. Giliani, S. Zucca, S. Pecorelli, A. Albertini, A.G. Ugazio: “Reconstitution of T-cell compartment after in utero stem cell transplantation:analysis of T-cell repertoire and thymic output”_Haematologica 2004;89(4):450-461 E. CORTIS, F. MURATORI, A. LANDOLFO, A.G. UGAZIO, F. DE BENEDETTI, “Extracorporeal photopheresis (ECP) and induction of regulatory T cells: a lesson from Ipex sindrome”. Annals of the rheumatic diseases, July 2006, Vol 65, Supplem 11 (EULAR 2006) E. CORTIS, C. BRACAGLIA, A. INSALACO, A. CAMPANA, A.G. UGAZIO: “Side effects of etanercept in a cohort of 76 children with rheumatic diseases”_Annals of the rheumatic diseases, July 2006, Vol 65, Supplem 11 (EULAR 2006) F. DE BENEDETTI, A. INSALACO, A. DIAMANTI, E. CORTIS, F. MURATORI, A. LAMIONI, R. CARSETTI, R. CUSANO, R. DE VITO, L. PERRONI, M. GAMBARARA, M. CASTRO, GF. BOTTAZZO, A.G. UGAZIO: “Mechanistic Associations of a Mild Phenotype of Immunodysregulation, Polyendocrinopathy, Enteropathy, X-Linked Sindrome”_Clinical Gastroenterology and Hepatology. May 4 (5): 653-9 2006. Macheroni E, Digilio MC, Cortis E, Devito R, Sarkozy A, Capolini R, Dallapiccola B, Ugazio AG “Pigmented villonodular synovitis in a patiente with Noonan syndrome and SOS1 gene mutation” Am J Med Genet A 2008 Nov 15; 146 A (22): 2966-7

Martire B, Rondelli R, Soresina A, Pignata C, Broccoletti T, Finocchi A, Rossi P, Gattorno M, Rabusin M, Azzari C, Dellepiane RM, Pietrogrande MC, Trizzino A, Di Bartolomeo P, martino S, Carpino L, Cossu F, Locatelli F, Maccario R, Pierani P, Putti MC, Stabile A, Notarangelo LD, Ugazio AG, Plebani A, De Mattia: “Clinical features, long term follow-up and out come of a large color of patients with Chronic Granulomatous Disease:an Italian multicenter study”_Clin Immunol. 2008 Feb;126 (2): 155-64 Tozzi AE, Ravà L, Stat D, Pandolfi E, Marino MG, Ugazio AG: “Attitudes towards HPV immunization of Italian mothers of adolescent girls and potential role of health professionals in the immunization program” Vaccine. 2009 Apr 28;27(19):2625-9. doi: 10.1016/j.vaccine.2009.02.050. Epub 2009 Feb 24. Linezolid therapy of brain abscess. Krzysztofiak A, Bozzola E, Lancella L, Quondamcarlo A, Gesualdo F, Ugazio AG. Pediatr Infect Dis J. 2010 Nov;29(11):1063-4. doi: 10.1097/INF.0b013e3181f20ed5 Committed osteoclast precursors colonize the bone and improve the phenotype of a mouse model of autosomal recessive osteopetrosis. Cappariello A, Berardi AC, Peruzzi B, Del Fattore A, Ugazio A, Bottazzo GF, Teti A. J Bone Miner Res. 2010 Jan;25(1):106-13. doi: 10.1359/jbmr.090715 Relapsing polychondritis: new therapeutic strategies with biological agents. Buonuomo PS, Bracaglia C, Campana A, El Hachem M, Diociaiuti A, Insalaco A, De Benedetti F, Testa BC, Cortis E, De Vincentiis GC, Ugazio AG. Rheumatol Int. 2010 Mar;30(5):691-3. doi: 10.1007/s00296-009-0981-9. Epub 2009 Aug 15 Infliximab therapy in pediatric Takayasu's arteritis: report of two cases. Buonuomo PS, Bracaglia C, Campana A, Insalaco A, Pardeo M, Cortis E, Ugazio AG. Rheumatol Int. 2011 Jan;31(1):93-5. doi: 10.1007/s00296-009-1147-5. Epub 2009 Oct 23 Pediatric allergy and immunology in Italy. Tozzi AE, Armenio L, Bernardini R, Boner A, Calvani M, Cardinale F, Cavagni G, Dondi A, Duse M, Fiocchi A, Marseglia GL, del Giudice MM, Muraro A, Pajno GB, Paravati F, Peroni D, Tripodi S, Ugazio AG, Indinnimeo L. Pediatr Allergy Immunol. 2011 May;22(3):267-76. doi: 10.1111/j.1399-3038.2011.01157.x. Use of the internet by Italian pediatricians: habits, impact on clinical practice and expectations. Romano M, Gesualdo F, Pandolfi E, Tozzi AE, Ugazio AG. BMC Med Inform Decis Mak. 2012 Mar 28;12:23. doi: 10.1186/1472-6947-12-23. Parental perception of influenza in Italy: a web survey. Tozzi AE, Gesualdo F, Ugazio AG. Vaccine. 2012 Mar 9;30(12):2041. doi: 10.1016/j.vaccine.2011.10.077. Epub 2011 Nov 7. Longitudinal myelitis in systemic lupus erythematosus: a paediatric case. Campana A, Buonuomo PS, Insalaco A, Bracaglia C, Di Capua M, Cortis E, Ugazio AG. Rheumatol Int. 2012 Aug;32(8):2587-8. doi: 10.1007/s00296-011-2061-1. Epub 2011 Jul 27 Clinical features and follow-up in patients with 22q11.2 deletion syndrome Cancrini C1, Puliafito P2, Digilio MC3, Soresina A4, Martino S5, Rondelli R6, Consolini R7, Ruga EM8, Cardinale F9, Finocchi A2, Romiti ML2, Martire B10, Bacchetta R11, Albano V12, Carotti A13, Specchia F6, Montin D5, Cirillo E14, Cocchi G15, Trizzino A16, Bossi G17, Milanesi O18, Azzari C19, Corsello G20, Pignata C14, Aiuti A21, Pietrogrande MC22, Marino B23, Ugazio AG24, Plebani A4, Rossi P2; Italian Network for Primary Immunodeficiencies. J Pediatr. 2014 Jun;164(6):1475-80.e2. doi: 10.1016/j.jpeds.2014.01.056. Epub 2014 Mar 20. I authorize the processing of my personal data pursuant to Legislative Decree 30 june 2003, n. 196 "Code concerming the protection of personal data”.