Peripheral Vascular Disease: Journey of 1,000...
Transcript of Peripheral Vascular Disease: Journey of 1,000...
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HARVARD MEDICAL SCHOOL
Peripheral Vascular Disease:Journey of 1,000 Steps
Duane Pinto, MD, MPH, FACC
Director, Cardiac Intensive Care Unit
Director, Interventional Cardiology Section
Beth Israel Deaconess Medical Center
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67 Year old woman with chest pain
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HARVARD MEDICAL SCHOOL
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I didn’t tell you the whole story…..That was 23 years ago. Now she is 90 and in
shock with STEMI
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• “My left arm was cold all of the time!”
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• Recovered from MI, Shock and ATN
• Discharged to 12 days later
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Agenda
Epidemiology, Risk Factors
Prognosis
Evaluation: History, Physical, Noninvasive
Medical Therapy
Endovascular Options
Ulcer Disease
Noninvasive Evaluation
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HARVARD MEDICAL SCHOOL
Agenda
Epidemiology, Risk Factors
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PAD is a Common Disorder• Occurs in approximately 1/3 of patients
–Over age 70
–Over age 50 who smoke or have DM
• Strong association with CAD–Obvious associated risk of stroke, MI, cardiovascular death
• Progressive disease in 25% with progressive intermittent claudication/limb threatening ischemia
• Outcomes– Impaired QoL
–Limb Loss
–Premature Mortality
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Risk Factors for PAD: Framingham Heart Study
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What is PVD and What is PAD?Processes
Inflammation Hypercoagulability
Inherited Disease Atherosclerosis
Vascular Disease
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What is PVD and What is PAD?
Disorders & Manifestations
Carotid Disease
Renal Disease
StenosisPeripheral
Arterial Disease
Aortic Disease
Aneurysm & Dissection Thrombosis
Lymphatic DiseaseVenous
Thromboembolic
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Agenda
Prognosis
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Natural History of Atherosclerotic Lower Extremity PAD
PAD Population (50 years and Older)
Initial clinical presentation
Asymptomatic PAD
20%-50%
Atypical leg pain
40%-50%
Critical limb ischemia
1%-2%
Progressive
functional impairment
1-year outcomes
Alive w/ 2 limbs
50%
Amputation
25%
CV mortality
25%
5-year outcomes
Claudication
10%-35%
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Natural History of Atherosclerotic Lower Extremity PAD
Claudication
10%-35%
5-year outcomes
Stable claudication
70%-80%
Worsening claudication
10%-20%
Critical limb ischemia
1%-2%
Amputation
(see CLI data)
Nonfatal CV event
(MI or stroke) 20%
Mortality
15%-30%
CV causes
75%
Non-CV causes
25%
Hirsch AT, et al. ACC/AHA Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal
aortic): A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop
Guidelines for the Management of Patients with Peripheral Arterial Disease [Lower Extremity, renal, Mesenteric, and Abdominal Aortic]). Circulation.
2006;113:e463-654.
Asymptomatic PAD
20%-50%
Atypical leg pain
40%-50%
For each of these PAD clinical syndromes
Weitz JI. Circulation 1996; 3026.
Limb morbidity CV morbidity & mortality
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Agenda
Evaluation: History, Physical, Noninvasive
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Initial Assessment: Symptoms
• Intermittent claudication • (derived from the Latin word for limp)
–A reproducible discomfort of a defined group of muscles that is induced by exercise and relieved with rest.
–Supply ≠ Demand
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Location, Location, Location!
• May Occur Singly or in Combination
• Buttock/hip – Aortoiliac occlusive disease (Leriche's syndrome) manifests with, and, in
some cases, thigh claudication.
– Bilateral disease often associated with erectile dysfunction
• Thigh– Atherosclerotic occlusion of the common femoral artery may induce
claudication in the thigh, calf, or both.
• Calf– Cramping in the upper 2/3 of the calf is usually due to SFA
– Cramping in the lower 1/3 of the calf is due to popliteal disease.
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PAD Differential Diagnosis
• Deep venous thrombosis
• Musculoskeletal disorders – Osteoarthritis
– Restless leg syndrome
• Peripheral neuropathy
• Spinal Stenosis (pseudoclaudication)– Pain with erect posture (lordosis) and relief by sitting or lying down.
– May also find relief by leaning forward and straightening the spine (usually done with pushing a shopping cart or leaning against a wall).
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The Distinct Syndromes of Severe Ischemia
Critical Limb Ischemia: Ischemic rest pain, non-healing wound, or gangrene
Acute limb ischemia: The five “P’s, defined by the clinical symptoms and signs that suggest potential limb jeopardy:
Pain
Pulselessness
Pallor
Paresthesias
Paralysis (& polar, as a sixth “p”).
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Agenda
Ulcer Disease
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Venous Insufficiency
• Venous ulcers develop slowly. • Symptoms may include aching,
heaviness, cramps, itching, burning, and swelling.
• These symptoms often worsen with prolonged standing and improve with leg elevation
• Venous ulcers represent up to 80% of all ulcers
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Venous Ulcer
• Malleolar Area
• Superficial, Shaggy Borders
• Irregular
• Copious Fibrinous Drainage
• Lipodermatosclerosis, venous stasis dermatitis, and atrophie blanche
Diagnosis Of Leg Ulcers . Int J Dermatol. 2002. Volume 1 Number 2.
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Arterial Ulcers
• Located distally over bony prominences
• Dry Base
• Sharp Borders
• Surrounding skin is pale, shiny, without hair
Diagnosis Of Leg Ulcers . Int J Dermatol. 2002. Volume 1 Number 2.
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Neuropathic Ulcers
• Site of Repetitive Trauma -sites of shoe pressure
• Abnormal monofilament exam
• Variable depth• Surrounding callus• Superimposed infection• Pulse exam can be normal
Diagnosis Of Leg Ulcers . Int J Dermatol. 2002. Volume 1 Number 2.
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Agenda
Noninvasive Evaluation
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The ankle-brachial index is 95% sensitive and 99% specific for PAD
Establishes the PAD diagnosis
Identifies a population at high risk of CV ischemic events
“Population at risk” can be clinically & epidemiologically defined:
The Ankle-Brachial Index
Lijmer JG. Ultrasound Med Biol 1996;22:391-8; Feigelson HS. Am J Epidemiol 1994;140:526-34;
Baker JD. Surgery 1981;89:134-7; Ouriel K. Arch Surg 1982;117:1297-13; Carter SA. J Vasc Surg 2001;33:708-14
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Ankle Brachial Index
• Cornerstone of vascular evaluation of the lower extremities
– Blood pressure cuffs, Doppler
– Ankle (DP or PT) to brachial artery pressure
• Medicare will reimburse for this procedure (CPT 93922), if the ABI is obtained with a Doppler that includes a waveform printout for documentation purposes. Estimated time in office is 3-11 min/patient
Normal 1.00-1.40
Noncompressible >1.40
Borderline 0.91-0.99
Claudication 0.50-0.91
Rest Pain 0.21-0.49
Tissue loss 0.20
Significant change 0.15 or more
Ankle Brachial Index Collaboration
Fowkes FG, Murray GD, Butcher I, et al. Ankle
brachial index combined with Framingham Risk
Score to predict cardiovascular events and
mortality: a meta-analysis. JAMA. 2008;300:197–
208.
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How to Perform ABI
• Patient Supine for 5-10 min
• Continuous Wave Handheld Doppler
• Measure SBP in both arms–Higher # is Denominator of ABI
• Measure SBP in DP and PT–Higher # is Numerator of ABI
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Incidence of CHD Events*Increases With Decreases in ABI
ABI
Leng GC, et al. BMJ. 1996;313:1440-1444.
1.11.0 - 0.910.9 - 0.71 0.7
CH
D E
ven
t O
utc
om
es
per
Year,
%
5-year
risk:
19%
5-year
risk:
10%
4
3
2
1
0
*CHD events defined as fatal or nonfatal MI
May improve the accuracy of cardiovascular risk
prediction beyond the commonly used Framingham
Risk Score and would result in reclassification of risk
in 19% of men and 36% of women
Fowkes FG, Murray GD, Butcher I, et al. Ankle brachial index combined with
Framingham risk score to predict cardiovascular events and mortality: a meta-
analysis. JAMA 2008;300:197–208.
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“Normal ABI” is not Necessarily Normal
Ankle-Brachial Index
Risk of All Cause Mortality
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Exercise ABI
• Confirms the PAD diagnosis
• Assesses the functional severity of claudication
• May “unmask” PAD when resting the ABI is normal
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A screening ABI should be performed in patients with diabetes
The American Diabetes Association recommends screening for PAD in patients with diabetes
1. American Diabetes Association. Diabetes Care 2003; 26: 3333-
3341.
2. Estes JM, Pomposelli FB Jr. Diabet Med 1996: 13: S43- S57.
Those <50 years of age who have other
risk factors associated with PAD
• Smoking
• Hypertension
• Hyperlipidaemia
• Duration of DM >10 years
Those >50 years of age
• If normal an exercise test should be carried out
• The ABI test should be repeated every 5 years
• Foot care is also important in diabetic patients as PAD is a
major contributor to diabetic foot problems2
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ACC/AHA/ADA Class I Recommendations for ABI
• Exertional leg symptoms
• Non-healing Wounds
• Asymptomatic Patients at high risk
–≥65 years (Modified 2011 Guidelines)
–≥50 years with diabetes or tobacco
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Segmental Pressures
• Pneumatic cuffs at multiple levels– Doppler pressure at pedal artery
– Drop >30 mm Hg between levels
– Drop >20 mm Hg between limbs
• Reflects status of artery above drop in pressure
• Inaccurate with calcified vessels
Rose SC. J Vasc Interv Radiol. 2000; 11:1107-1114
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Duplex Doppler
• Non-invasive method of evaluating the blood vessels using sound waves, similar to ultrasonography and echocardiography.
– Can obtain both anatomic and hemodynamic information.
– Anatomical detail
• vessel wall
• intraluminal obstructive lesions
• perivascular compressive structures
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Pulse Volume Recordings
• Pneumatic Cuffs at Multiple Levels
• Inflated to 65 mm Hg
• Extremity Volume Increases with Systole
– Changes pressure in cuff
• Waveform Analysis
• Not Impacted by Calcification
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Digital Subtraction Angiography (DSA)
• “Gold standard” of arterial imaging
• Compares a pre contrast image with a post contrast image using a computer, and "subtracts" elements common to both. –Prevents images of objects like
bones etc from obscuring vascular details.
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MRA vs. DSA
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CTA
• High Quality Pictures
• With significant and dense calcifications, a false diagnosis of patency can result.
• Inconsistent pedal vessel visualization
• Renal failure/contrast allergy
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Agenda
Medical Therapy
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Medical Treatments for PAD
Treatment Effect
Smoking cessation10-year mortality ↓ 54% to 18%;
at 7 years, rest pain drops from 16% to 0%*
Antiplatelet agent22%↓ in vascular events;
possible increase in walking distance
Diabetes control RR=0.94 (0.8 - 1.1) for mortality;
RR=0.51 (0.01 - 19.64) for amputation
BP to <140/85 mm Hg RR=0.87 (0.81 - 0.94) for mortality; effect on PAD not known
ACE inhibitors RR=0.73 (0.61 - 0.86) for MI, stroke, or CV death
Exercise program24% ↓ in CV mortality;
150% further walking distance
Cholesterol decreaseRR=0.81 (0.72 - 0.87) for MI, stroke, or revascularization; no clinical
benefit in PAD†
Cilostazol significant ↑ in walking distance
*Survival Bias
†Excepting Stroke
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Principles of a Walking Exercise
• 3-5 times/week, 30 min sessions
• Maintain at claudication intensity for
3-5 min, stop when pain is moderate
• Resume walking until moderate
discomfort recurs
• Repeat cycle, increase by 5 min each
session for goal 50-60 min/sessions
• Continue program for at least 6
months
• Maintenance program necessary or
gains may be lost
• Walk until moderate to near
maximal claudication pain
• Rest briefly at severe claudication
symptoms
• May rest in a sitting or standing
position
• Resume walking when claudication
symptoms tolerable
• Repeat these cycles for at least 30-
minute sessions, 3-5 times/week
Intermittent Walking Technique
(Self-Administered )
Structured Treadmill Exercise
Program (Supervised)
Stewart K J et al. NEJM 2002; 347 no 24: 1941-51
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HARVARD MEDICAL SCHOOL
Summary
• Prevalence is high– Particularly in CAD patients
• Risk amputation/bypass is low
• Risk MI or death from other causes high
• History and Physical are important
• ABI is cornerstone of Work-up– Exercise can unmask hidden disease
– Non-invasive Imaging is well developed
• MRA and CTA can be used for noninvasive anatomic imaging to plan intervention
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HARVARD MEDICAL SCHOOL
Agenda
Endovascular Options
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HARVARD MEDICAL SCHOOL
When Does Someone Need Revascularization?
•Critical Limb Ischemia–To reduce or avoid tissue loss
–To alleviate pain
•Lifestyle/Medically Limiting Claudication–Improve Quality of Life
–Allow for increased activity to help manage cardiovascular risk factors
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HARVARD MEDICAL SCHOOL
Who Are People with IC Who Do NOT Need a Procedure
•“My legs don’t bother me that much”
•“I get everything done that I want to do”
•“What? I have disease in my legs? I don’t want an amputation! Fix it!”
•“My back is killing me!”
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HARVARD MEDICAL SCHOOL
Iliac and Renal Intervention
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HARVARD MEDICAL SCHOOL
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Infra-inguinal Intervention
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HARVARD MEDICAL SCHOOL
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HARVARD MEDICAL SCHOOL
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Limb Salvage
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HARVARD MEDICAL SCHOOL
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HARVARD MEDICAL SCHOOL
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Treatment Summary
Risk factor modification
tobacco cessation
diabetic control/wound care
lipid/HTN control
Exercise programs effective Endovascular therapy now the norm
Claudication- Quality of Life
Critical Limb Ischemia- Limb Salvage
http://content.onlinejacc.org/cgi/content/full/j.jacc.2011.08.023v1 or Google “PAD
guidelines 2011”
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HARVARD MEDICAL SCHOOL
Agenda
Epidemiology, Risk Factors
Prognosis
Evaluation: History, Physical, Noninvasive
Medical Therapy
Endovascular Options
Ulcer Disease
Noninvasive Evaluation