Performance, safety, garantee of results Isagro SpA – Product Development.

Performance, safety, garantee of results

Isagro SpA – Product Development

ISAGRO S.p.A - Product Development

DOMARK is formulated as an emulsifiable concentrate (EC), that is a liquid formulation forming an emulsion after dilution in water

Solvent based formulation where the active ingredient TETRACONAZOLE is dissolted in organic solvents, nonilphenols free, favouring its penetration and biological activity

Excellent stability when stored at either high or low temperatures

FORMULATIONFORMULATION


a broad spectrum systemic triazole fungicide discovered bya broad spectrum systemic triazole fungicide discovered by

Tetraconazole is ISAGRO’s proprietary molecule

At present more than 140 registrations have been obtained in 60 countries and others are pending

TETRACONAZOLETETRACONAZOLE


TECHNICAL FEATURESTECHNICAL FEATURESTECHNICAL FEATURESTECHNICAL FEATURES

• Common name: tetraconazole• Chemical class: triazoles• Mechanism of action: IBS – Sterol Biosynthesis Inhibitor• Mode of action: systemic fungicide

• Common name: tetraconazole• Chemical class: triazoles• Mechanism of action: IBS – Sterol Biosynthesis Inhibitor• Mode of action: systemic fungicide


Tetraconazole, among all the triazoles, is the compound with the best balance between hydrosolubility and liposolubility and thanks to this property it ensures:

Swift penetration and traslocation within the plant

Translaminar movement

Systemicity through the upward lymphatic stream

Homogeneous distribution inside the plant without local

accumulation

Preventive and curative activity

TETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTIONTETRACONAZOLE DISTRIBUTION


Translocation through

the sapHydrosolubility

Liposolubility

Vapour tension

Diffusion through the lipids and the cuticolar waxes

Redistribution on and inside the plant



Excellent balance between hydrosolubility and liposolubility

156

73

142

32

18

100

140

130

6,63

54

15

Tetraconazole

Penconazole

Myclobutanil

Tebuconazole

Esaconazole

Propiconazole

Cyproconazole

Flutriafol

Epoxiconazole

Flusilazol

Metconazole

Hydrosolubility mg/L

3400

5248

900

5000

79405248

813

200

2754

5500

7079

Kow



Treated area2 hours

3 days 7 days

14 days

RADIO LABELED MOLECULE IN SUGAR BEET LEAF

RADIO LABELED MOLECULE IN SUGAR BEET LEAF

DISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANT


RADIO LABELED MOLECULE IN GRAPE LEAFRADIO LABELED MOLECULE IN GRAPE LEAF

2 hours 3 days

7 days 10 days

Treated area

DISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANTDISTRIBUTION IN THE PLANT


SELECTIVITYSELECTIVITYSELECTIVITYSELECTIVITY

Some important biochemical processes, such as gibberellins and phytosterols synthesis, are regulated by cytochrome - P450 – based enzymes; due to its particular molecular structure tetraconazole does not interfere with these processes but only with the ergosterol biosynthesis of the fungus

No phytotoxic effects on the treated plant have ever been seen

Some important biochemical processes, such as gibberellins and phytosterols synthesis, are regulated by cytochrome - P450 – based enzymes; due to its particular molecular structure tetraconazole does not interfere with these processes but only with the ergosterol biosynthesis of the fungus

No phytotoxic effects on the treated plant have ever been seen


TETRACONAZOLE

Germ tube growth

Formation of appressorium

and penetration

Beginning ofmycelial growthand colonization

botrytis_KBR.ppt 08.12.99

Mechanism of ActionMechanism of Action

Colonization of tissues not allowed with TETRACONAZOLE

X

TETRACONAZOLE PREVENTIVE ACTIVITY


Beginning ofmycelial growthand colonization

botrytis_KBR.ppt 08.12.99

Mechanism of ActionMechanism of Action

Tetraconazole

Damage already set (colonization of tissues resulting in cell death and necrosis) but stopped with TETRACONAZOLE application

Tetraconazole

Tetraconazole TetraconazoleTetraconazole

Tetraconazole

TETRACONAZOLE CURATIVE ACTIVITY


CercosporaBipolarisCercosporaBipolaris

P. Mildew, scab

P. Mildew, scab

RhizoctniaPyriculariaBipolaris

RhizoctniaPyriculariaBipolaris

P. mildewP. mildew P. mildewP. mildew

Sclerotinia, AlternariaSclerotinia, Alternaria

P. mildewalternariaP. mildewalternaria

RustRust

Rust, Cercospora, Septoria

Rust, Cercospora, Septoria

MAIN USES OF TETRACONAZOLECrops and diseases

Rusts, Septoria, P. mildew

Rusts, Septoria, P. mildew

Cercospora, RustP. mildew, Ramularia

Cercospora, RustP. mildew, Ramularia

P. mildewP. mildew


» Effective control of several pathogen affecting different crops» Costant performance» Selectivity towards the crop» Inventory optimization

» Effective control of several pathogen affecting different crops» Costant performance» Selectivity towards the crop» Inventory optimization

DOMARK is the solution to farmers and distributor’s needs as it provides:DOMARK is the solution to farmers and distributor’s needs as it provides:


Broad spectrum of action Wide window of application Excellent selectivity Great systemicity granting a uniform protection of the crop Good activity as protectant and curative fungicide Effective and safe at either high or low temperatures Low usage rate Versatility/compatibility with other products Environmentally friendly (good eco-tox profile)

ADVANTAGES OF TETRACONAZOLEADVANTAGES OF TETRACONAZOLEADVANTAGES OF TETRACONAZOLEADVANTAGES OF TETRACONAZOLE


Thank you for your attentionThank you for your attention

Performance, safety, garantee of results Isagro SpA – Product Development.

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