Peptides for Sleep, Improving Telomeres, Libido ... · Diamond L, et al, J Sex Med 2006;3:628–638...

Edwin Lee MD FACE

Institute for Hormonal Balance

Orlando FL

Peptides for Sleep

Improving Telomeres

Libido Testosterone and

Memory

Dr Edwin Lee

DisclosureThe following potential conflict of interest relationships are germane to my presentation

Equipment NA

Speakers Bureau NA

Stock Shareholder NA

GrantResearch Support NA

Consultant NA

Status of FDA devices used for the material being presented NA

Status of off label use of devices drugs or other materials that constitute the subject of this presentation NA

Peptides that will be discussed

Epithalon

Melanotan 1

Bremelanotide PT 141

DSIP

CJC 1295

Kisspeptin

FGL

Semax

Third eye

Pineal Gland

Small gland is located

in the epithalamus

Third eye refers to the

gate that leads to

spaces of higher

consciousness

Pineal Gland ndash Third eye

Pineal gland resembles

like a pine cone

Glandular tissue

predominates in

children and young

adults

Becomes fibrous and

calcified with age


Photosensitive organ

and an important

timekeeper for the

human body

Produces melatonin

Regulates daily body

rhythms day night

cycle prevents jet lag



Involved in growth

puberty fertility and

aging

Besides producing

melatonin it produces

epithalamin

Discovered by

researchers in Russia

in the 1970rsquos

Dilman VM Anisimov VN Biull Eksp Biol Med

1975 Nov80(11)96-8

Khavinson VK et al Exp Pathol (Jena)

197917(9)539-45

Epithalamin Epithalon Epitalon

4 amino acid

Ala-Glu-Asp-Gly

Approved for general

use in the Soviet Union

in 1990 and has been

used in gerontology

No adverse side

effects according to Dr

Khavinson


Epithalamin increases the life span of mice and rats

Without the development of malignant tumors

Anisimov VN1 Khavinson VKh Ross Fiziol Zh Im I M Sechenova 2001 Jan87(1)125-36

Anisimov VN Khavinson VKh et al Bull Exp Biol Med 2002 Aug134(2)187-90

Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410


Epithalamin stimulates telomerase which in turn increases telomeres in our DNA

Increase the telomeres by 33

Anisimov VN1 Khavinson VKh Biogerontology2010 Apr11(2)139-49 doi 101007s10522-009-9249-8

Khavisnon VKh et al Bull Exp Biol Med 2003 Jun135(6)590-2


Study in elderly from 1992 to 2005

Results of 15 year

follow up study

N = 79

Age 60-69 with Stable

CAD

Khavinson VK et al Byulletenrsquo

Eksperimentalrsquonoi Biologii i Meditsiny Vol

151 No 3 pp 343-347 March 2011

Group 1 received

Epithalamin 6 courses

over 3 years 1992 to

1995

10 mg in 2 ml saline IM

every 3 days ndash 5 shots

per course (dose of 50

mg)

6 months intervals

Total dose 300 mg

Epithalamin Epithalon Epitalon3 year treatment Kaplan ndashMeier Survival Curve

Khavinson VK et al Byulletenrsquo Eksperimentalrsquonoi Biologii i Meditsiny Vol 151 No 3 pp 343-347 March 2011

Epithalamin Epithalon EpitalonKhavinson VK et al Byulletenrsquo Eksperimentalrsquonoi Biologii i Meditsiny Vol 151 No 3 pp 343-347 2011

Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing

Vial 2000 mcgml x 5 ml

1 mg (1 ml) sq a day x

50 days = 50 mg

Repeat every 6 months

to 1 year

Libido Booster

Libido Booster Peptide

Men are easy

Men only needs oxygen

and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity


Synthetic melanotropic

peptides initiate

erections in men with

psychogenic erectile

dysfunction

Similar effects on libido

are seen in women

Hypothalamic control of penile erection and

sexual behavior

Pro hormone Pro-opiomelanocortin

Sexual Stimulation

Only ACTH and α -MSH

have shown the ability

to generate sexual

stimulation and penile

erection in various

animal species

including rats rabbits

cats dogs and

monkeys

Giuliano F J Androl 200425(5)683ndash91

Alpha Melanocyte stimulating

hormone (MSH)

Alpha MSH is identical

to the first 13 amino

acids of ACTH

ACTH has MSH like

activity

However ndash MSH has no

ACTH activity

Melanotan derivatives of alpha MSH

Both Melanotan 1 and Melanotan 2 are analogs of alpha melanocytestimulating hormone (MSH)

Malanotan 1 promotes tanning

Melanotan 1 is 26 x more potent than α-MSH

Sawyer TK et al Proc Natl Acad Sci U S A 1980 Oct 77(10) 5754ndash5758

Melanotan 1

Suggested dosing

500 mcg SQ at bedtime for

2 weeks every night then

after 2 weeks reduce it to 2

times a week to maintain

your tan

May help with weight loss

Side effect nausea and dark

spots on the skin will

appear darker

potential risk of Melanotan

in stimulating dysplastic

naevi or possibly malignant

melanoma

Reid C et al Ir Med J 2013 May106(5)148-9

Melanotan 1

Other names Afamelanotide

Melanotan 1 as subcutaneous

implant 16 mg combined UV-

B phototherapy as a

repigmentation therapy in

vitiligo for 4 months

Statistically significant

superior and faster

repigmentation compared to

UV-B monotherapy

Lim HW et al JAMA Dermatol 2015

Jan151(1)42-50

Melanotan 2 and Bremelanotide

Melanotan 2 (7 AA)

Bremelanotide PT 141 is a derivative of melanotan 2

PT-141 is a potent initiator of erection with minimal side effects

King S et al Curr Top Med Chem 2007 7(11) 1098ndash1106

Of the 5 melanocortinreceptor subtypes only the MC3 and MC4 have been identified in CNS regions associated with activation of penile erection

Bremelanotide PT 141 has a strong binding to MC receptors 1 3 and 4

Wikberg JE et al Pharmacol Res 200042 (5)393ndash420

Libido Booster Peptide-


Bremelantotide is a

peptide that activates

the endogenous

pathways involved in

sexual response

Centrally mediated

fast acting

Binds to melanocortin

receptor subtypes MC3 and

MC4



Study of failure of

Sildenafil with PT 141

Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide

as an intranasal spray

45 minutes to 2 hours

prior to sexual

stimulation

use at least 16

dosesattempts

Diamond LE et al Urology

200565(4)755ndash9



Patients in the

bremelanotide group

reported significantly

greater intercourse

satisfaction than those

in placebo group (p =

003)


200565(4)755ndash9

Minor side effects of

nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with

bremelanotide PT 141

18 women

Diamond L et al J Sex Med 20063628ndash638

intranasal dose of 20

mg bremelanotide

More women reported

moderate or high

sexual desire following

bremelanotide

treatment vs placebo

(P = 00114)

Bremelanotide PT 141 Dosing

Many different protocols

PT 141 ndash 1000 mcgml

2 ml vial

Suggested dosing 1 mg sq

prn

Variable response

Libido can increase after

2-6 hours injections

Recommend trying it 12

hour before the event

Careful mixing it with

PDE 5 inhibitor- 12 hour

erections can occur

Bremelanotide PT 141- Future Female

Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a

review date for March

2019

30 clinical trials with

over 2500 patients

Autoinjector

wwwthepharmalettercomarticleama

g-pharma-closes-deal-for-north-

america-rights-to-rekynda

CJC- 1295 (modified GHRH)

Another benefit of CJC

1295 is its ability to

promote slow wave

sleep Slow wave sleep

is responsible for the

highest level of muscle

growth and memory

retention

Perras B et al Psychoneuroendocrinology

1999 Oct24(7)743-57

Dr Edwin Lee

CJC 1295 with Ipamorelin

CJC 1295 non DAC with Ipamorelin

Both are formulated at 2000 mcgml

Start at 100 mcg or 005 ml or 5 units with an insulin

syringe SQ at bedtime from Monday to Friday

Side effect flushing for 5-10 minutes

Can titrate to 200 mcg or 01 ml or 10 units SQ at

bedtime Monday to Friday

Take 2 days off per week to prevent ldquoburn outrdquo

Dr Edwin Lee

Delta Wave- Deep Restorative Sleep

Delta Sleep Induced Peptide

Delta sleep-inducing

peptide was first

discovered in 1974 by

the Swiss scientist who

isolated it from the

cerebral venous blood

of rabbits in an

induced state of sleep

Kovalzon VM et al J Neurochem 2006

Apr97(2)303-9

Delta Sleep Induced Peptide (DSIP)Charnay Y et al Neuroendocrinology 49 (2) 169ndash175

9 Amino Acid Peptide

It has been found in

both free and bound

forms in the

hypothalamus limbic

system and pituitary

However the Gene for

DSIP and where it is

made is still unknown

Delta Sleep Induced Peptide (DSIP) in

chronic insomniacs

DSIP appears to help

promote sleep in

humans

Study of 6 chronic

insomniacs were given

IV DSIP 25 nmoleskg

improved sleep quality

Schneider-Helmert D amp Schoenenberger

GA Experientia (1981) 37 913


Narcolepsy

Repeated injections of

DSIP was given to a 35-

year-old male

narcoleptic which

reduced the frequency

of sleep attacks

Schneider-Helmert D Eur Neurol

198423(5)353-7

Delta Sleep Induced Peptide (DSIP) on

LH

In rat studies DSIP has been shown to increase LH

DSIP-may activate the hypothalamic neural circuitry responsible for stimulation of LH release reported to occur during sleep

Sahu A et al Life Sci 1987 Mar 2340(12)1201-6


To prevent

tachyphylaxis it is best

to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime

Puberty begins with a KissRhie YJ et alAnnals of Pediatric Endocrinology amp Metabolism 18 (2) 55ndash59

Kisspeptin is a neuroendocrinepeptide than stimulates the release of Gonadotropin Releasing Hormone (GnRH) and is involved in the start of puberty

KisspeptinLee JH et al Journal of the National Cancer Institute 88 (23) 1731ndash7

Kisspeptin is a peptide that is encoded by the KISS1 gene

Originally identified as a human metastasis suppressor gene for melanoma and breast cancer metastasis

KISS1 gene was discovered in Hershey Pennsylvania in 1966

Kisspeptin- Released from KNDyPasquier J et al Molecular evolution of GPCRs Kisspeptinkisspeptin receptors Journal of Molecular

Endocrinology 52 (3) T101ndash17

Kisspeptin is released

together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making

kisspeptin dynorphin

and neurokinin B are

popularly referred to

as KNDy

Kisspeptin increases LH and FSH

Kisspeptin interacts

with the KISS1

receptor or the GPR54

receptor

Kisspeptin stimulates

the release of GnRH

and thus increase LH

and FSH

Rhie YJ et alAnnals of Pediatric

Endocrinology amp Metabolism 18 (2) 55ndash59

Kisspeptin initiates Puberty

Kisspeptin levels w hypogonadismMasato Kotani et al Endocrine Journal 2014 61 (11) 1137-1140

fmolml

Normal controls (7 men) 12

Kallmanrsquos syndrome 43

Azoospermia (elevated FSH and

LH)

41

Hypergonadotropic hypogonadism 323

Hypogonadotropic hypogonadism 6

Kisspeptin 54 increases testosterone

Double blind placebo

controlled crossover

study

N = 6

90 minute infusion 4

pmolkg x min

LH increased from 42

to 108

Testosterone increased

from 625 ngdl to 718

ngdl (p lt 0001)

Dhillo WS et al J Clin Endocrinol Metab 2005

Dec90(12)6609-15

Response to Kisspeptin -54 is

preserved in 60 year old men (Older men)

5 men 60 years old

compared to 5 men 29

years old

3 hour intravenous

infusion kisspeptin-54

01 03 10

nmolkgh

Abbara A et al Neuroendocrinology 2018

Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)

Kisspeptin -10 increases Testosterone

Kisspeptin-10 is the

minimal kisspeptin

sequence with full

intrinsic bioactivity

Infusion of kisspeptin-

10 at 4 μgkg middot h for

225 hours

George JT et al Clin Endocrinol Metab 2011

Aug96(8)E1228-36

Elicited an increase in

LH from 5 to 21

Increase in

Testosterone from 478

ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency

Kisspeptin- 10 in Type 2 Diabetics

5 men with low

testosterone and with

type 2 diabetes were

compared to 7 healthy

men

Age is 336 years old

BMI of 406

George JT et al Clin Endocrinol (Oxf) 2013

Jul79(1)100-4

Intravenous infusion of

kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl

Response to Kisspeptin for idiopathic

hypogonadotropic hypogonadism (IHH)

LH response to iv

boluses of kisspeptin

(024ndash24 nmolkg)

In the future

Kisspeptin may be used

to access and to treat

hypogonadotropic

hypogonadism

Lippincott MF et al J Clin Endocrinol Metab

2016 Aug 101(8) 3061ndash3069

Peptide FGL (15 amino acids)

FGL is a Synthetic

peptide derived from

neural cell adhesion

molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier

FGL reduces inflammation

FGL reduces

neuroinflammation Downer EJ et al J Neurochem 2009

Jun109(5)1516-25

FGL prevent age-

related structural

changes in synapses Ojo B et al Brain Behav Immun 2011

Oct 2

FGL enhance memory

FGL has been shown to enhance memory or protect neurons in

Chronic stress Borcel E et al Behav Pharmacol 2008

Feb19(1)41-9

Depression Aonurm-Helm A et al Eur J Neurosci 2008

Oct28(8)1618-28

Ischemia Skibo GC et al Eur J Neurosci 2005

Oct22(7)1589-96

Traumatic Brain Injury Pedersen MV et al Neurosci Lett 2008 May

30437(2)148-53

Peptide FGL potential treatment for

Alzheimerrsquos disease

Klementiev B et al Neuroscience 2007 Mar 2145(1)209-24

Peptide Abeta 25-35 induces Alzheimers disease in rats

FGL given subcutaneous was able to prevent or if already manifest strongly reduce all investigated signs of Abeta25-35-induced neuropathology and cognitive impairment

After FGL treatment showing fewer amyloidplaques and better memory

FGL mechanism

FGL that binds to the Fibroblast Growth Factor Receptor 1 (FGFR-1) has been shown to have a beneficial impact on normal memory functioning Dellerac G et al Learn Mem 2011 18

306-313

FGL treatment stimulates activity-dependent delivery of glutamate receptors to synapses leading to a long-term enhancement of synaptic transmission in hippocampalneurons

Knafo S et al PLoS Biol 2012 Feb10(2)e1001262

FGL Phase 1 study

8-day open-label phase I

study 24 healthy male

volunteers

received single intranasal

doses of FGLL (25 100 and

200mg) ascending dose

All three doses were well

tolerated

Avand R et al Clinical Pharmacokinetics April

2007 Volume 46 Issue 4 pp 351ndash358

FGL Phase 2 study

Dec 2011

A biotech company in

Europe was awarded 6

million Euros to do a

phase 2a study with

FGL in Alzheimerrsquos

wwwinvestegatecoukarticleaspxid=20111

2080700475661T

Semax (7 amino acid analog to ACTH 4-10)

Semax (analogue of ACTH (4-10))

Discovered and research in Russia (unfortunately a lot of studies are all in Russian without an abstract)

7 Amino acid

Has no hormonal activity

Tsai SJ Med Hypotheses 200768(5)1144-6 Epub 2006 Sep 25


Study in rat brains

occluding the middle

cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)

Neurotrophic tyrosine

kinase receptor type 2

(TrkB) which has the

highest affinity for brain-

derived neurotrophic factor

(BDNF) and is involved in

neuronal plasticity

Dmitrieva VG et al Cell Mol Neurobiol 2010

Jan30(1)71-9

Semax is nootropic

1997 a paper published 15 years experience

Semax significantly improves memory and attention in healthy men under extreme conditions of activities

intranasal administration doses 0015-0050 mgkg

Asmarin IP et al Zh Vyssh Nerv Deiat Im I P Pavlova 1997 Mar-Apr47(2)420-30

Semax in stroke

Study of 30 patients with

acute ischemic stroke

Semax improved in the

recovery of stroke clinically

and by EEG

12 mg for moderate stroke

18 mg for severe stroke

Tx course--5 and 10 days

Gusev El et al Zh Nevrol Psikhiatr Im S S

Korsakova 199797(6)26-34

Semax is neuroprotective

Study on neurons with

glutamate toxicity

Semax improved

neuronal survival by on

average 30

Storozhevykh TP et al Bull Exp Biol Med

2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders

Semax has a high affinity

for copper and may be a

chelating agent

Semax reduced copper

induced cytotoxicity

Tabbi G et al J Inorg Biochem 2015 Jan14239-

46

Semax

Semax has a poor oral

deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal

spray in each nostril

once a day (total

dose of 1500 mcg)

Peptides that was discussed

Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

DisclosureThe following potential conflict of interest relationships are germane to my presentation

Equipment NA

Speakers Bureau NA

Stock Shareholder NA

GrantResearch Support NA

Consultant NA

Status of FDA devices used for the material being presented NA

Status of off label use of devices drugs or other materials that constitute the subject of this presentation NA


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Third eye

Pineal Gland


in the epithalamus


gate that leads to

spaces of higher

consciousness



like a pine cone

Glandular tissue

predominates in

children and young

adults

Becomes fibrous and

calcified with age



and an important

timekeeper for the

human body

Produces melatonin


rhythms day night




Involved in growth


aging

Besides producing


epithalamin

Discovered by


in the 1970rsquos


1975 Nov80(11)96-8


197917(9)539-45


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Third eye

Pineal Gland


in the epithalamus


gate that leads to

spaces of higher

consciousness



like a pine cone

Glandular tissue

predominates in

children and young

adults

Becomes fibrous and

calcified with age



and an important

timekeeper for the

human body

Produces melatonin


rhythms day night




Involved in growth


aging

Besides producing


epithalamin

Discovered by


in the 1970rsquos


1975 Nov80(11)96-8


197917(9)539-45


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Third eye

Pineal Gland


in the epithalamus


gate that leads to

spaces of higher

consciousness



like a pine cone

Glandular tissue

predominates in

children and young

adults

Becomes fibrous and

calcified with age



and an important

timekeeper for the

human body

Produces melatonin


rhythms day night




Involved in growth


aging

Besides producing


epithalamin

Discovered by


in the 1970rsquos


1975 Nov80(11)96-8


197917(9)539-45


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



like a pine cone

Glandular tissue

predominates in

children and young

adults

Becomes fibrous and

calcified with age



and an important

timekeeper for the

human body

Produces melatonin


rhythms day night




Involved in growth


aging

Besides producing


epithalamin

Discovered by


in the 1970rsquos


1975 Nov80(11)96-8


197917(9)539-45


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



and an important

timekeeper for the

human body

Produces melatonin


rhythms day night




Involved in growth


aging

Besides producing


epithalamin

Discovered by


in the 1970rsquos


1975 Nov80(11)96-8


197917(9)539-45


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



Involved in growth


aging

Besides producing


epithalamin

Discovered by


in the 1970rsquos


1975 Nov80(11)96-8


197917(9)539-45


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


4 amino acid

Ala-Glu-Asp-Gly




used in gerontology

No adverse side


Khavinson






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax






Control Epithalon

Lifetime

Mean

days

289 328

Lifetime

Max days

360 410








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax








Results of 15 year

follow up study

N = 79


CAD



151 No 3 pp 343-347 March 2011

Group 1 received



1995




mg)

6 months intervals

Total dose 300 mg




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




Control Epithalamin

Cardiovascular

Death

2024 (83) 613 (462)

Survival 1640 (40) 2639 (667)



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



over 3 years




mg)

6 months intervals

Total dose 300 mg

Optional dosing



50 days = 50 mg


to 1 year

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Libido Booster


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Men are easy


and a pulse


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Women are a little

more complicated

Sincerity

Reliability

Commitment

Integrity



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



peptides initiate



dysfunction


are seen in women


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


sexual behavior


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Sexual Stimulation



to generate sexual


erection in various

animal species


cats dogs and

monkeys



hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


hormone (MSH)



acids of ACTH

ACTH has MSH like

activity


ACTH activity






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax






Melanotan 1

Suggested dosing





your tan




appear darker




melanoma


Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Melanotan 1




B phototherapy as a




superior and faster


UV-B monotherapy


Jan151(1)42-50


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Melanotan 2 (7 AA)









Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



Bremelantotide is a


the endogenous


sexual response

Centrally mediated

fast acting



MC4



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



Study of failure of


Randomized Double

Blind Placebo

controlled study

N = 342 married men

10 mg bremelanotide



prior to sexual

stimulation

use at least 16

dosesattempts


200565(4)755ndash9



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



Patients in the

bremelanotide group


greater intercourse



003)


200565(4)755ndash9


nausea flushing and

headaches



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



Study in

Premenopausal women

with sexual arousal

disorder with


18 women



mg bremelanotide

More women reported

moderate or high


bremelanotide


(P = 00114)




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




2 ml vial


prn

Variable response







erections can occur


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Viagra

June 2018

FDA accepted a new

drug application of

bremelanotide for

female sexual

dysfunction with a


2019


over 2500 patients

Autoinjector







promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




promote slow wave




growth and memory

retention


1999 Oct24(7)743-57

Dr Edwin Lee










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax










Dr Edwin Lee




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




peptide was first





of rabbits in an



Apr97(2)303-9




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




both free and bound

forms in the

hypothalamus limbic






chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


chronic insomniacs


promote sleep in

humans

Study of 6 chronic


IV DSIP 25 nmoleskg





Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Narcolepsy



year-old male

narcoleptic which


of sleep attacks


198423(5)353-7


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


LH





To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


To prevent


to give the

hypothlamus a break

1-2 nights a week

100 mcg to 800 mcg

Subcutaneous at

bedtime










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax










together with two

other hormones

neurokinin B and

dynorphin

Consequently the

nerve cells making




as KNDy



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



with the KISS1


receptor


the release of GnRH


and FSH





fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



fmolml




LH)

41






study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




study

N = 6


pmolkg x min


to 108



ngdl (p lt 0001)


Dec90(12)6609-15



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



5 men 60 years old


years old

3 hour intravenous


01 03 10

nmolkgh


Mar 15 doi 101159000488452

Dose dependent

LH and FSH response

to Kisspeptin was

preserved


with Kisspeptin but

less compared to

younger men (age of

29)



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



minimal kisspeptin

sequence with full




225 hours


Aug96(8)E1228-36


LH from 5 to 21

Increase in


ngdl to 692 ngdl

(p lt 0001)

Also increased LH

pulse frequency


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


5 men with low




men


BMI of 406


Jul79(1)100-4


kisspeptin-10

(4 mcgkgh) was

administered for

11 hours

Increase in LH from

39 to 207 IUl

Increase in


to 329 ngdl



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



LH response to iv


(024ndash24 nmolkg)

In the future



hypogonadotropic

hypogonadism


2016 Aug 101(8) 3061ndash3069


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


FGL is a Synthetic



molecule

Developed in 2004

FG Loop peptide

FGL can cross the

blood brain barrier


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


FGL reduces


Jun109(5)1516-25

FGL prevent age-

related structural


Oct 2

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

FGL enhance memory



Feb19(1)41-9


Oct28(8)1618-28


Oct22(7)1589-96


30437(2)148-53







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax







FGL mechanism


306-313



FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

FGL Phase 1 study



volunteers





tolerated



FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

FGL Phase 2 study

Dec 2011




phase 2a study with



2080700475661T




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax




7 Amino acid




Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Study in rat brains


cerebral artery

Shown to increase

brain-derived

neurotrophic factor

(BDNF) NGF (Nerve

growth factor) TrkB

(tyrosine kinase

receptor type 2)







neuronal plasticity


Jan30(1)71-9

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Semax is nootropic





Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Semax in stroke





and by EEG





Korsakova 199797(6)26-34



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax



glutamate toxicity

Semax improved


average 30


2007 May143(5)601-4


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Heavy Metals are

involved in several

neurodegenerative

disorders



chelating agent




46

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Semax


deliverly

Can be delivered by

Subcutaneous or

intranasal

Suggested dosing

750 mcg per nasal


once a day (total

dose of 1500 mcg)


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax


Epithalon

Melanotan 1


DSIP

CJC 1295

Kisspeptin

FGL

Semax

Peptides for Sleep, Improving Telomeres, Libido ... · Diamond L, et al, J Sex Med 2006;3:628–638...

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Transcript of Peptides for Sleep, Improving Telomeres, Libido ... · Diamond L, et al, J Sex Med 2006;3:628–638...