PENTAVITIN Feel deep hydration for 72 hours - swissclinic.no · Page 4 Dry skin affects millions of...
Transcript of PENTAVITIN Feel deep hydration for 72 hours - swissclinic.no · Page 4 Dry skin affects millions of...
PENTAVITIN®
Feel deep hydration for 72 hours
Presenter name, Business groupname/department Presentation Date
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Agenda
1 Insights into current consumer trends
22 DSM PENTAVITIN®DSM PENTAVITIN®
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Trend:Pure & Elegant Performance Moods
2
Water-like surfaces, organic shapesand the importance of light
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• Inspiration: water
• Style: elegant and sophisticated
• Belief in science and wish to solvenature´s mysteries
• „Green“ attitude means: mindful needfor change, combination of nature andscience/technology
• Need: individual and premiumproducts that perform
• Individuality focus:something special for me
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Trend:Pure & Elegant Performance Consumers Lifestyle
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Dry skin affects millions of people
• Moisturising/hydrating skin remains the centralfunction of face, neck, body, hand, foot careproducts with 77% of launches positioned toprovide this benefit.
• 17% of products launched featured thelong-lasting claim
• 26% of products launched featured theinstant claim
(Mintel report, July 2011).
• Dry skin is nature’s way of warning you that theprotective elements of your skin barrier is notworking properly anymore
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Face
• softness• smoothness• flakiness
• robustness• tightening
Face
• softness• smoothness• flakiness
• robustness• tightening
Hand
• smoothness• softness• flakiness
• robustness• tightening
Hand
• smoothness• softness• flakiness
• robustness• tightening
Body
• softness• smoothness• flakiness
• itching
Body
• softness• smoothness• flakiness
• itching
Feet
• smoothness• flakiness
• robustness
Feet
• smoothness• flakiness
• robustness
• itching• itching• robustness• tightening• robustness• tightening
Dry skin:uncomfortable skin feelingimpairs healthy skin appearance
• robustness• robustness• robustness• tightening• robustness• tightening
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S. corneumS. corneum
S. granulosumS. granulosum
S. spinosumS. spinosum
S. basaleS. basale
Water contentWater content
70%
65%35%
20%
10%10 – 20
cell layers
Stratum corneum (SC)is the driest skin layer in the skin
1 – 3cell layers
5 – 8cell layers
1 cell layer
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The stratum corneum consists of corneocytesand intracellular lipids.
A corneocyte can hold large amounts of waterwithin the cell.
Each corneocyte is surrounded by a cornifiedcell envelope. Main component is loricrin.
The junctions that hold the corneocytes are thecorneodesmosomes.
Desquamation is the process of cell sheddingfrom the surface of the stratum corneum
NMF is a collection of water-soluble compounds(e.g. sugars, amino acids), that protect skinagainst dehydration.
Filaggrin is the precursor protein for the aminoacids derived components of the NMF.
In the stratum granulosum the lamellar bodiesare formed. The lamellar bodies release lipids(e.g. ceramides)
Stratum corneum and stratum granulosum
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Short termShort term
Medium termMedium term
Long termLong term
Increase SChydration
Improvedesquamation
Strengthenbarrier function
JM Crowther et al.BJD 2008
What „moisturizers“ need to do?
comfortableskin feeling
&healthy
skin appearance
comfortableskin feeling
&healthy
skin appearance
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Agenda
11 Insights into current consumer trendsInsights into current consumer trends
2 DSM PENTAVITIN®
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• INCI Saccharide Isomerate (active)Aqua, Citric Acid, Sodium Citrate
• Preservative free
• Appearance: clear, yellowish to slightly ambercoloured, slightly viscous liquid
• Strong focus on sustainability and quality
• DSM named No1 in the Dow Jones World Sustainability Index in2004, 2005, 2006, 2009, 2010 and 2011
• Certification
PENTAVITIN®
ECOCERT approved and NATRUE certified
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PENTAVITIN®’scompositionis very similar
CompoundCarbohydrate
fraction of the SC
Psicose 0.2
Glutose 2.2
Mannose 3
Fructose 31.1
Glucose 46.7
Galactose 2.1
Various 14.7
• Derived from plant based D-glucose
• Unique composition similar to that of thecarbohydrate complex (NMF) found in human skin
PENTAVITIN®
Unique composition
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PENTAVITIN®
Mechanism
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• Unique binding mechanism to the skin that is not washed off
• The removal of PENTAVITIN® occurs only by the natural process of desquamation
• Proven binding to amino acid lysine (free -amino groups) at the corneocytes
PENTAVITIN®
Unique binding ensures a mechanism for deep hydration
G. Padberg, J.Soc.Cosmetic Chemists 23, 271-279, 1972
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PENTAVITIN®
Stimulates key genes playing a role in the skin barrier
PENTAVITIN® upregulates the filaggrin, loricrin, hyaluronansynthase3 and acid sphingomyelinase gene expression levels
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• 12 female subjects, 40±1 y• Evaluated skin area: calf• No application of cosmetics• Standardized shower gel
• 1% aqueous PENTAVITIN• Twice daily application
Wash out phase Treatment phase Regression phase
2 weeks 4 weeks 6 days
• Measurements before andafter 4w treatmentphase:
1. Clinical grading accordingto Kligman
2. Barrier disruption inducedby tape strippingAssessment of barrierrepair by TEWL
3. Macrophotographs
4. Questionnaire before andafter 2w & 4w treatmentphase
• Measurements and clinicalgrading 3d (72 hours) & 6dafter treatment phase
No application of PENTAVITIN
PENTAVITIN® - in-vivo EfficaciesStudy details
T 0 T 4W
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1% PENTAVITIN® reduces dry skin signs by 20% after 4 weeksaccording to Kligman’s clinical grading. After the last treatmentthe effects of PENTAVITIN® last for 72 hours.
PENTAVITIN® - in-vivo EfficacyDeep hydration for 72 hours
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1% PENTAVITIN® strengthens skin barrier functionshown by 20% reduction in TEWL before and after20 subsequent tape strippings after a 28 day application.
PENTAVITIN® - in-vivo EfficacyStrengthens skin barrier function
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• Stratum corneum desquamation has clearly been normalized.
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Volunteer 13 Volunteer 14
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• Macrophotographs demonstrating significant improvementin skin appearance after 4 weeks application of 1% PENTAVITIN®
PENTAVITIN® - in-vivo EfficacySignificant improvement in desaquamation
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PENTAVITIN® - in-vivo EfficacyImproves a comfortable skin feeling & a healthy skin appearance
Consumer panel testing confirms after 2 weeeks that 1% PENTAVITIN®
• improves skin softness and smoothness by more than 50%• reduces flakiness by more than 50%• reduces itchiness by more than 50% and tightening by more than 30%• improves skin robustness by more than 20%
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• female subjects, 35-55 y• No application of cosmetics
1. Skin Hydration Test
• Static test, provides information about the skin hydration• Measurements before/after 2weeks treatment• Evaluated skin area: calf (= dry skin); volar forearm (= normal
skin
2. Moisture Accumulation Test (MAT)
• Dynamic test, provides informations about the hydrationretention capacity of skin
• Measurements after 2weeks• Evaluated skin area: forearm
PENTAVITIN® - in-vivo EfficaciesStudy details
Wash out phase Treatment phase
1 week 2 weeks
• Test formulations:• a) 5% PENTAVITIN® containing cream• b) 6% Glycerin containing cream
• Application: twice daily• Test device: NOVA DPM 9003
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PENTAVITIN® retains instantly more moisturein the skin than glycerin
PENTAVITIN® - in-vivo EfficacyInstant deep hydration
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5% PENTAVITIN® outperforms 6% glycerin significantlyafter a 14-day application
• by 43% more hydration on dry skin and• by 42% more hydration on normal skin
PENTAVITIN® - in-vivo Efficacy14-day hydration
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Anti-Irritant test:
• 12 female volunteers, aged 40 to 60 with normal to dry andslightly sensitive skin
• Formulation containing 5% AHA (lactic acid) with andwithout 5% PENTAVITIN®, pH 3.0
• Application on the left and right sides of their faces, duringfour weeks
• Measurements at day 0, 5, 10, 15, 20, 25 and day 28
• Efficacy evaluated with stinging scores
PENTAVITIN® - in-vivo EfficacyStudy details
Smith, W., Reduction of AHA irritation potential by inclusion of a saccharide isomerate.SFÖW, 1995. 121(14): p. 1013-1017
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PENTAVITIN® reduces AHA induced irritationby approximetely 22 % after 28 days
PENTAVITIN® - in-vivo EfficacyReduces AHA induced irritation
Smith, W., Reduction of AHA irritation potential by inclusion of a saccharide isomerate.SFÖW, 1995. 121(14): p. 1013-1017
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• Easy to formulate
• 100% water-soluble
• No preservative
• Processed either warm (< 60°C) or cold
• Compatible with ethanol up to 60%
• Recommended use level for skin care applications: 1 to 5%
• Guide formulations are available upon request
• Formulations are available:
• 72 hours Deep Hydration Cream for dry skin• Deep hydration cleanser for dry skin
PENTAVITIN®
Formulation guidelines
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softness
flakiness
tightening
robustness
smoothness
PENTAVITIN
Face/neck care Hand care Body care
PENTAVITIN®
Applications
Can be used for face, neck, foot, hand and body careproducts for a comfortable skin feeling anda healthy skin appearance
softness
flakiness
tightening
robustness
smoothness
PENTAVITIN
softness
flakiness
itching
smoothness
PENTAVITIN
Feet care
flakiness
robustness
smoothness
PENTAVITIN
comfortable skin feelinghealthy skin appearance
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Unique product features
1. Unique skin identical carbohydrate complex
2. Unique binding mechanism
3. Outperforms glycerin by nearly 50%
4. ECOCERT approved and NATRUE certified
Benefits
1. Instant, deep hydration
2. Deep hydration for 72 hours
3. Strengthens skin barrier function
4. Stimulates key genes for skin barrier improvement
5. More than 50% improvement in skin smoothness andsoftness and more than 50% reduction of flakiness anditchiness after only 2 weeks application
PENTAVITIN®
Feel deep hydration for 72 hours – Summery
Back up
various
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3.00Saccharide Isomerate & Aqua & Citric Acid &Sodium CitratePENTAVITIN®C
82.10AquaWater demin
q.s.PreservativePreservative
0.10Xanthan GumKeltrol CG-TB
3.50Hydrogenated Coco-GlyceridesLipocire Na 10 Pastilles
3.00Caprylic/Capric TriglycerideMyritol 318
2.00Cetearyl AlcoholLanette O
0.30Acrylates/C10-30 Alkyl AcrylateCrosspolymerCarbopol Ultrez 21
2.00TriethylhexanoinCrodamol GTEH-LQ-(MV)
3.00Cetearyl IsononanoateCetiol SN
1.00Potassium Cetyl PhosphateAMPHISOL® KA
% w/wINCI NameIngredientsPhase
PENTAVITIN®
72 hours Deep Hydration Creamfor dry skin
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1.00Saccharide Isomerate & Aqua &Citric Acid & Sodium Citrate
PENTAVITINC
78.10AquaWater demin
q.s.Preservative
3.00Lauryl GlucosidePlantacare 1200 UP
0.10Xanthan GumKeltrol CG-TB
1.00Stearic AcidStearic Acid
1.00Butyrospermum Parkii, Shea ButterCetiol SB-45
6.00Caprylic/Capric TriglycerideMyritol 318
1.50Myristyl MyristateCetiol MM
2.00Cetearyl AlcoholLanette O
0.30Acrylates/C10-30 Alkyl AcrylateCrosspolymer
Carbopol Ultrez 21
5.00Cetearyl IsononanoateCetiol SN
1.00Potassium Cetyl PhosphateAMPHISOL KA
% w/wINCI NameIngredientsPhase
PENTAVITIN®
Deep hydration cleanser for dry skin
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VideomicrophotographVisible light
SEM micrograph
Hydrated Skin Dry SkinDry Skin
Flakiness, scalinessFlakiness, scalinessIncreased translucencydarker, more pinkish
Rough and uneven surfaceRough and uneven surfaceSmooth and even surface
D MohammedUniversity of London
40 m 40 m
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Primary induction of dry skin
Low environmentaltemperature and humidity
Low environmentaltemperature and humidity
Abrupt changes inenvironmental condition
Abrupt changes inenvironmental condition
Modern indoor, climate-controlled environmentModern indoor, climate-controlled environment
Surfactant dissolution ofSC lipids and NMF loss
Surfactant dissolution ofSC lipids and NMF loss
Chronological (intrinsic)aging
Chronological (intrinsic)aging
Psychological stressPsychological stress
GeneticsGenetics
Skin pHSkin pH
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Hydrated SkinDry SkinDry Skin
Corneocytes arereleased one at a time
Leeson, IJCS 2006
Accumulation of corneocytesas structurally disordered
flakes
Accumulation of corneocytesas structurally disordered
flakes
Epidermal function is disturbed desquamation in dry skin
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Natural Moisturing factor (NMF):natural protection shield against dehydration
filaggrinfilaggrin amino acidsamino acids
UCA(urocanic acid)
UCA(urocanic acid)
PCAPyrrolidone
carboxylic acid
PCAPyrrolidone
carboxylic acid
sweatsweat
glutamic acidcyclization
histidine /histidase
ureaurea
lactatelactate
inorganic saltsinorganic salts
sugars
12%
40%
7%
12%
19%
8%glycosylceramides
glycoproteinsproteoglycans
glycosylceramidesglycoproteinsproteoglycans
profilaggrinprofilaggrin
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C HardingIJCS 2000
Changes in ceramide contentof stratum corneum with increasing skin dryness
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• Oriflame• Soothing Eye Gel
• The Body Shop•Camomile Soothing Eye Serum
• Unilever• Vaseline After Sun Aloe Vera Gel• Dove Sensitive Skin Day Lotion
• Amway•Artistry Essentials Replenishing Eye Crème
• DM Balea•Alverde Naturkosmetik Anti-Aging Goji Berry Vitamin
• Clinique•Self Sun Body Daily Moisturiser
• Estée Lauder•Bronze Goddess Golden Perfection Self-Tann
• P&G•Dermagram Swiss Herbal Cosmeceuticals SensitiveSolution
• Watsons• Cracked heel cream
All products mentioned below do containPENTAVITIN® !!!!SK
INSK
IN
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Disclaimer
Page
Copyright © 2011 DSM Nutritional Products AG, CH-4002 Basel, Switzerland. Allrights reserved. No part of this brochure may be reproduced, distributed ortranslated in any form or by an means, or stored in a database or retrieval system,without prior written permission of DSM Nutritional Products AG (“DSM”). Whilemaking reasonable efforts to ensure that all information in this brochure is accurateand up to date, DSM makes no representation or warranty of the accuracy,reliability, or completeness of the information. Use of this information shall be atyour discretion and risk. Nothing herein relieves you from carrying out your ownsuitability determinations and tests and from your obligation to comply with allapplicable laws and regulations and to observe all third party rights. The uses andclaims for DSM’s products recommended in the brochure should be adapted to thecurrent local regulatory environment. We disclaim any and all liability in connectionwith your product or its use.