171-199 EMBRYOLOGIC AND ANATOMIC BASIS OF DUODENAL SURGERY.pdf
Pediatric Epilepsy Surgery Shields Surgery.pdf · Morrell, 1997 in Epilepsy: A Comprehensive...
Transcript of Pediatric Epilepsy Surgery Shields Surgery.pdf · Morrell, 1997 in Epilepsy: A Comprehensive...
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Pediatric Epilepsy Surgery
W. Donald Shields, MD Emeritus Professor of Neurology and Pediatrics
David Geffen School of Medicine at UCLA
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PEDIATRIC EPILEPSY SURGERY A THING OF BEAUTY…IF DONE RIGHT
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PEDIATRIC EPILEPSY SURGERY But………
MAKE SURE YOU KNOW WHAT YOU ARE DOING
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Overview: Epilepsy Surgery in Pediatric Patients
Surgical candidates Who
Developmental issues When / Why
Evaluation of patients Where
Outcomes What
Other Surgical Gamma knife Approaches VNS CC MSTs
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Gelastic seizures (HH)
Infantile spasms
Epil. encephalopathy
Sturge-Weber
Inf. hemi epilepsy
Lennox-Gastaut
Rasmussen
CPE (tumor / CD)
CPE (MTS)
Trauma
Age of Onset of Epilepsy Disorders That May Lend Themselves to Surgical Approach
Age 0 5 10 15
Uniquely pediatric
“Adult” concepts
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Who Should be Considered for Resective Surgery?
Medically intractable seizures (What defines intractable?)
Localizable brain abnormality
Accessible for Cortical resection
Assessment of anticipated neurologic deficit
Reasonable assumption that the remainder of the brain is normal and / or patient will be significantly improved if seizures are controlled
Good-bad vs. bad-worse
Resection of Hypothalamic Hematoma
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Who Should be Considered for Surgery?
Medically intractable seizures (What defines intractable?)
Do you need to try everything?
21 AED’s currently approved
– 1 new med every 2 months = 3 ½ years
2 drug combinations @ 1 drug change/2 months
– 440 combinations = 72 years
3 drug combinations @ 1 change/2 months
– 8421 combinations = 1400 years
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Who Should be Considered for Surgery?
Medically intractable seizures (What defines intractable?)
Sequential study of 780 adolescents and adults prescribed their first AED
Overall response rates with the first, second and third treatment schedules were 50.4, 10.7 and 2.7%, respectively, with only 0.8% patients responding optimally to further drug trials.
? Applicability to younger patients Mohanraj R, Brodie MJ. Diagnosing refractory epilepsy: response to sequential treatment schedules. Eur J Neurol. 2006 Mar;13(3):277-82
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Overview
Surgical candidates Who
Developmental issues When / Why
Evaluation of patients Where
Outcomes What
Alternatives to Gamma knife cortical resection VNS CC MSTs
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Overview
Developmental issues When / Why
Older children, i.e., those with CPS or similar issues, seizure control or tumor removal is generally the primary goal
Younger Children: Seizure control is important but the real goal of surgery in very young children with catastrophic epilepsies is to provide an opportunity for the child to have the best possible long-term development by removing the noxious effects of seizures and abnormal brain tissue.
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When Should Surgery Become a Consideration?
If seizure control is primary then:
There is time to be circumspect and cautious
Be deliberate in seeking all appropriate medical therapies
Time from intractability to surgery ~ 10 years in typical TLE patients
If improved development is primary then:
There is urgency to make therapeutic decisions before the opportunity for improved development is lost
Clearly can’t spend 10 years getting to surgery!!
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Overview
Surgical candidates Who
Developmental issues When / Why
Evaluation of patients Where
Outcomes What
Alternatives to Gamma knife cortical resection VNS CC MSTs
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EEG ictal onset
PET/SPECT
MRI ABNL
Concept of Epileptic Focus
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Concept of Epileptic Focus: Applicable in Many Pediatric Patients
CPE (MTS)
Some neonatal seizures
Sturge-Weber
Some Infantile hemiplegic epilepsy with partial only seizures. (i.e.,stroke)
Rasmussen
CPE (MTS or tumor)
Trauma
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Case 1
8-year-old girl FC at 14 and 16 months; typical At 2½ yrs, onset of episodes characterized by
Appears frightened Runs to parents to be picked up Babbles, picks at her clothes Stiffens for 20-30 seconds then goes limp Post ictal state for minutes to hours Occur Q 2 weeks
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MTS
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CD and MTS
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8-year-old girl
What else do we need to know before deciding on surgery?
? PET / SPECT
? Neurocogs
? Wada / fMRI for language, memory
Case 1
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Wada Test: Language and Memory Testing
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fMRI for Language
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15-year-old right-handed boy, nl cognitively, excellent student; long-distance runner
Onset of spells at age 12
Sometimes has vague feeling of lightheadedness
20 sec later visual disturbance described as “objects blend together and faces look like a Picasso”
Improved on AEDs but still has 2 / wk
Does not lose awareness, never had T-C seizures
VEEG: vague slowing R hemisphere with some spells, no change with others
MRI
Case 2
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Tumor: Suspect DNET
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15-year-old boy
What else do we need to know before deciding on surgery?
? PET / SPECT
? Neurocogs
? Wada / fMRI for language
? Other studies
Case 2
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Intracranial EEG Recordings
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Case 2
Resection of tumor in 2008
DNET
Seizures free after surgery
He stopped his LTG on his own; he was told to continue to take it for now
One seizure a year later when he “forgot” to take his LTG. Seizure free after restarting
DRIVER’S LICENSE ISSUE
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Case 3
8-year-old girl Onset seizures at 2; dx: FC Next seizure at 6 CPS c 2O generalization
Eye deviation to right, right focal seizure CPS 5 / day, T-C 1/ month Failed numerous medications
Mild right hemiparesis VEEG: frequent left frontal discharges Major learning set back after each T-C seizure;
language, learning seem to wax and wane
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Perinatal Stroke
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What is it?
5 year old with partial seizures. Infrequent at first but now occur many times per day. Always with the same semiology involving left face and arm.
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RASMUSSEN
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Sturge-Weber
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Pediatric Epilepsy Surgery
CONCLUSIONS
CERTAIN PATIENTS WITH INTRACTABLE HAVE LESIONS SIMILAR ENOUGH TO ADULT PATIENTS THAT THEY CAN BE APPROACHED FOR SURGICAL EVALUATION IN THE SAME WAY.
EXAMPLES: STURGE WEBER SYNDROME INFANTILE HEMIPLEGIC EPILEPSY
(SOME PATIENTS HAVE GENERALIZED SEIZURES) RASMUSSEN ENCEPHALITIS MTS TUMOR
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Concept of Epileptic Focus: But Not Applicable in Others, Especially “Generalized” Seizures
Infantile spasms
Other early-onset epileptic encephalopathies
Gelastic seizures
Lennox-Gastaut syndrome
Therefore a different concept – the Zone of Cortical Abnormality (ZCA)
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Zone of Cortical Abnormality
EEG ictal onset
Increased delta
Decreased beta
PET
MRI abnormal
+/- MEG focus
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VEEG Monitoring There may not be an ictal focus
However, focal changes may precede or follow generalized seizure such as IS
MISD not a contraindication Generalized Hypsarrhythmia not a
contraindication Early EEG may show focus
Interictal EEG abnormalities may be most important in identifying a ZCA Focal slowing Lateralized sleep spindles Localized decrease in beta activity
There may be multiple potential foci, i.e., TS
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Figure 2 MRI of the patient Brain MRI demonstrates the presence of hemimegalencephaly with an enlarged left
hemisphere, colpocephaly (A, B), midline shift of a dysplastic occipital lobe (occipital sign, A, B), white matter
signal intensity changes (B, C) horn (arrow, C).
Bindu P S et al. Neurology 2010;74:e27
© 2013 American Academy of Neurology
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Focal CD, Right Frontal Lobe
At 6 months of age
At 3 years of age
Sankar R et al. AJNR Am J Neuroradiol 16:1265, 1995
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1 8
References to Cortical Dysplasia in the Literature
Number of references
YEARS
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Figure 1 Examples of difficult-to-identify type I cortical dysplasia from two patients with epilepsy (A and B) This 15-year-old patient began with seizures at age 4 years. Interictal scalp EEG disclosed synchronous spikes from F4, C4, and T4 and rarer independent spikes from F3 and C3. Ictal events were associated with broad EEG changes over the right frontal–temporal electrodes. Two previous outside MRI scans had been read as normal, as had his initial fluorodeoxyglucose (FDG)-PET scan (grayscale). FDG-PET/MRI coregistration indicated a well-defined area of focal hypometabolism in the right superior temporal gyrus (B, arrow). Closer inspection of the structural MRI indicated less white matter signal on T2 imaging in the same area (A, arrow). (C and D) This 8-year-old patient presented with seizure onset at age 3 years. The seizures were characterized by right leg and arm tonic events with eye fluttering lasting from 15 to 45 seconds. Scalp EEG showed fairly regular synchronous interictal discharges coming from the Cz, C3, and Pz electrodes, with rarer spikes from C4. Scalp EEG ictal onsets were difficult to localize secondary to movement artifacts. A previous outside MRI scan had been read as normal. University of California, Los Angeles MRI was read as showing a subtle lesion consistent with CD (C, arrow). FDG-PET/MRI coregistration indicated a focal area of hypometabolism in the left superior parietal region just behind the sensory cortex (D, arrow). N Salamon, et al. Neurology. 2008 November 11;71(20):1594-1601. CitationFull text
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Cortical Dysplasia Leading to Surgery at UCLA
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SURGERY FOR CORTICAL DYSPLASIA PATIENTS
UCLA EXPERIENCE
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SURGICAL TREATMENT OF EPILEPSY ASSOCIATED WITH CORTICAL DYSPLASIA
DIAGNOSTIC ACCURACY EEG: Localizes accurately in 50-66% MRI: Localizes accurately in 70%
Often not helpful in type 1 CD’s FDG-PET 80-90%
MRI-PET fusion >90% Post op OUTCOMES IN CD PATIENTS
Overall 60% seizure free in short term 80% if complete resection
20% if incomplete resection
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Final Surgical Decision
ZCA present
Multiple lines of evidence point to one area or hemisphere as likely etiology of seizures
Risk : benefit assessment
Often most difficult decision; some patients have such disastrous seizures that higher level risk of failure is acceptable
Good : bad vs. bad : worse
Never talk family into surgery; surgery offered as option, not necessity
Resect vs. no resect: decision is usually made in OR with ECoG guidance
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Overview: Epilepsy Surgery in Pediatric Patients
Surgical candidates Who
Developmental issues When / Why
Evaluation of patients Where
Outcomes What
Alternatives to Gamma knife cortical resection VNS CC MSTs
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OUTCOME IN PEDIATRIC EPILEPSY SURGERY PATEINTS
5 YEAR OUTCOME DATA
UCLA patients operated at <18 years between 1986 and 2005
N = 257
Continuously seizure free = 53%
Late seizure recurrence = 18%
Seizure free after initial failure = 3%
Never seizure free = 25%
Hauptman et al. Neurosurg Aug 14, 2012 (epub)
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OUTCOME IN PEDIATRIC EPILEPSY SURGERY PATEINTS
RATE OF SEIZURE CONTROL AND TIME OF
SURGERY
SURGICAL EPOCH % CONTINOUSLY SEIZURE FREE AT 5 YEARS
1986-1990 46%
1991-1995 36%
1996-2000 61%
2001-2005 68%
Hauptman et al. Neurosurg Aug 14, 2012 (epub)
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FIGURE. Box plots comparing for private and government (CCS/MediCal) insurance seizure onset to referral, referral (evaluation) to surgery, and seizure onset to surgery (SZ duration) (A) and pre- and post-surgery Vineland adaptive scores for private and government insurance (B). Mean (±SD) provided above each bar. A, the interval from seizure onset to referral (log-rank; P = .034) and seizure duration (P = .017) was longer for patients with government compared with private insurance. B, pre- (t test; P = .042) and postsurgery (P = .001) Vineland developmental quotients (DQs) were higher (better) for those with private compared with government insurance. Number of cases per blot noted for Vineland scores. CCS, California Children's Services; SD, standard deviation.
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Hypothalamic Hamartoma (HH)
Gelastic seizures begin in infancy
CPS seizures often occur later
May evolve to tonic / drops etc. with slow spike and wave
Associated with:
Cognitive decline
Rage attacks
Precocious puberty
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Treatment of HH
AEDs generally don’t work very well
Surgery
Sub-frontal or temporal approach
Transcallosal approach
Endoscopic / ventricular approach
Gamma knife
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Transcallosal Resection of HH
Success rates, 70-90% reported
Problems with:
Increased appetite / obesity
Some memory disturbances
Somnolence
Temperature instability
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Treatment of HH
AEDs generally don’t work very well
Surgery
Sub-frontal or temporal approach
Transcallosal approach
Endoscopic / ventricular approach
Gamma knife
![Page 60: Pediatric Epilepsy Surgery Shields Surgery.pdf · Morrell, 1997 in Epilepsy: A Comprehensive Textbook. Ch 177 . Multiple Subpial Transection: Conceptual Framework . Alternative Therapies](https://reader033.fdocuments.us/reader033/viewer/2022050300/5f69996d9a919f2fb50a9490/html5/thumbnails/60.jpg)
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Corpus Callosotomy: Indications
Specific seizure considerations Drop attacks
Atonic Tonic
Secondarily generalized tonic-clonic seizures Complex partial seizures
Not utilized much anymore
Alternative Therapies
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Physiologic function based on vertically arranged columns
Minimal volume of transversely arranged contiguous tissue necessary to generate an epileptiform spike
Morrell, 1997 in Epilepsy: A Comprehensive Textbook. Ch 177
Multiple Subpial Transection: Conceptual Framework
Alternative Therapies
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Purpose of surgery must be clearly defined before surgery is performed
Seizure control is important but it is not always the primary goal in young children with catastrophic epilepsy; improved development is often the goal
TAKEAWAY MESSAGES
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Concept of Epileptic Focus: Applicable in Many Pediatric Patients
CPE (MTS)
Some neonatal seizures
Sturge-Weber
Infantile hemiplegic epilepsy (stroke)
Rasmussen
CPE (tumor)
Trauma
TAKEAWAY MESSAGES
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Concept of Epileptic Focus: But Not Applicable in Others, Especially “Generalized” Seizures
Infantile spasms
Other early-onset epileptic encephalopathies
Gelastic seizures
Lennox-Gastaut syndrome
TAKEAWAY MESSAGES
DON’T DEPEND TOO HEAVILY ON THE EEG IN THESE CASES, REMEMBER
THE “ZCA” CONCEPT