SCINTOMICS

Liquid Chromatography

Always the right system for your needs.

Advanced Research Daily QC Routine and beyond

• High Performance analytical/semi-preparative Radio-HPLC that covers all needs of modern radiopharmaceutical research and quality control.

• Data Acquisition and management with Clarity™ software package.

• Exceptional cost/performance ratio.• Many options and features serve all your needs.

• High Performance analytical Radio-HPLC that makes your daily QC routine as simple as a click.

• With Azura Mobile Control™ SW – the intuitive user interface that runs on mobile devices.

• Your daily routine – always just a click away, always ready, always right.

• Expandable with options (e.g. auto sampler).

SCINTOMICS: Always the right system for your needs

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High-end performance and powerful features in combination with an exceptional cost/performance ratio.

• Encapsulated optics design to protect the optical components from fine dust or harmful gases, providing high detection sensitivity and a very stable baseline.

• Seya-Namioka Monochromator and a new blazed Holographic Concave Grating enhance light intensity, ensuring high sensitivity over the entire wavelength range.

• Automatic seal rinsing for improved longevity.

• Automatic compressibility compensation ensures highly precise flow rates.

• Optional vacuum degasser for complete removal of dissolved gases and air bubbles.

• Column compartment with Peltier elements for ac-curate temperature control (4°C up to 90°C) and high retention time reproducibility.

• Integrated tray to safely house solvent bottles.

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SCI8112 Isocratic Pump

• Operating principle: parallel dual-plunger pump• No mixing valve• Easily upgraded to SCI8110 Quaternary pump

SCI8110 Quaternary Pump

• Operating principle: parallel dual-plunger pump• Low-pressure gradient• Number of solvents: up to 4 solvents• Gradient formation: 4-channel mixing valve• Composition precision: < 0.1 %• Composition accuracy: < 0.5 %

SCI8111 Binary Pump

• Operating principle: parallel dual-plunger pump• High-pressure gradient• Number of solvents: 2

General Pump Specifications

• Automatic compressibility compensation • Flow range:

Analytical: 0.001-10 ml/min Semi-prep: 0.01-50 ml/min

• Flow rate accuracy: ≤± 1 % at 1 ml/min• Flow rate precision: 0.1 % RSD at 1 ml/min• Maximum pressure

Semi-prep. Cell

3500 psi / 240 bar: 0-35ml/min2500 psi / 170 bar: 35-50ml/min

Analytical Cell

6000 psi / 410 bar: 0-5 ml/min3000 psi / 205 bar: 5-10ml/min

• Semi-automatic prime/purge• Leak detection• Diagnostics• Error detection

SCINTOMICS HPLC: Pumps

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SCINTOMICS HPLC: Detectors

SCI8160 PDA Detector

• Slit bandwidth: 1.7 nm• No. of PDA channels: 1024• Pixel resolution: 0.9 nm• Wavelength: 190-950 nm

Semi-prep. Cell

Path-length: 10 mmPressure : < 1,500 psiVolume : 13 µl

Analytical Cell

Path-length: 3 mmPressure : < 1,500 psiVolume : 5 µl

• Noise level: < ± 2•10-5 AU (empty cell, 1 sec rise time, 254 nm)

• Drift: < 2•10-4 AU/hr (baseline correction), 0.001AU/hr (room temp)

• Wavelength accuracy: < 1 nm ( HY-1 Holmium Oxide filter)

• GLP compliance: photometric accuracy, linearity, noise nevel, drift

• System check

SCI8120 UV/Vis Detector

• Wavelength range: 190-900 nm• Data collection rate: up to 50Hz• Light source: Deuterium & Tungsten lamp• Noise level: < ±0.35•10-5 AU, 254 nm, dry cell• Drift: < 1•10-4 AU/hr• Bandwidth: 5 nm• Wavelength accuracy: ±1 nm• Wavelength precision: ±0.1 nm• Linearity: >99.5 % for 2.5 AU (acetone, 254 nm)• Path length: 10 mm (analytical cell) 3 mm (semi-prep cell)• Cell volume: 10 µl (analytical cell) 5 µl (semi-prep cell)• RI range: 1.00 ˜ 1.75 RIU• Noise: ≤ 5•10-9 RIU (analytical) ≤ 10•10-8 RIU (semi-prep)• Flow cell vol: 7 µl (analytical), 9 µl (semi-prep)• Cell pressure: 6 kg/cm2 (5.8 bar, 84 psi)• RS232 control

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Electrochemical Detector (ECD)

ECD is a detector for HPLC applied to variable analyses such as biogenic amines, phenols, vitamins, DNA adducts, inorganic ions and amino acids.

Fluorescence Detector (FLD)

FLD is a highly sensitive, scanning fluorescence detector for liquid chromatography. It provides exceptional optical performance and operational flexibility for routine and trace analysis.

SCI8101 Vacuum Degasser

• Number of channel: 4 channels• Maximum flow rate: 10 ml/min per channel > 0…2.0 ml/

min per channel for removal of 70 % gas from Methanol• Internal volume per channel : 925 µl per channel• Materials in contact with solvent: Teflon and PEEK

SCI8131 Column Compartment

• Temperature range: 4 °C (cooling) - 90 °C• Temperature stability: ±0.05 °C• Temperature accuracy: ±0.5 °C• Temperature programs: 40 Steps• Column capacity:

Analytical: max. 3 of 30 cm column (max. OD 18 mm) Semi-prep: max. 2 of 30 cm column• Heat-up time: 16 minutes from 4 °C to 80 °C• Cool-down time: 13 minutes from 80 °C to 4 °C• Column switching: max. two automatic 6-port valve

(optional)

SCINTOMICS HPLC: Options

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Manual InjectorRheodyne 7725i / 9725i

• Industry standard manual injector• Analytical: 7725i (SUS) and 9725i (PEEK)• Semi-prep: 3725i

Column Switching ValvesMX Series II™ (Stand-alone) automated high-pressure fluidic valves providesproductivity enhancing solutions for today’s demanding analytical methods. Combine MX Series II modular valves with your current instrument to support complex fluid switching and sample injection needs.

TitanHP™

consists of an integrated driver/actuator and a removable liquid-end (Rapid Replacement Pod™) to provide a single, flexible space saving design. DuraLife® wear surfaces extends valve lifetime, which means reduced field service and more customer analysis time between replacements of the wetted surfaces

SCI8150 Autosampler

a high-throughput autosampler with state of the art in-jection technology, fast injection and wash cycles, and an optional Peltier chiller/heater for samples. Full or partial loop injection along with Pressure-Assisted-Sample-As-piration (PASA) is possible. The highly efficient needle and internal capillary wash virtually eliminates sample carry-over. Cycle time, including wash, is less than one minute. 96 standard 2 ml vials (32 mm x 12 mm) or well plates (96 or 384 capacity, deep or shallow) can be used.

• Sample capacity: analytical: 2 micro well plates according to SBS standards; semi-prep: 24 vials of 10 ml (LSV)

• Loop volume: 1 - 9999 µl programmable• Reproducibility:

RSD ≤ 0.3 % for full loop injections RSD ≤ 0.5 % for partial loopfill injections, RSD ≤ 1.0 % for µl pickup injections

• Carry-over: < 0.05 %• RS232 Control• Cooling/Heating option: 4 °C ˜ 40 °C

SCINTOMICS HPLC: System

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a robust Radio-HPLC System for a wide range of standard applications.

Controlled via Mobile Control™ tablet app or Clarity Chrom™ Software.

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AZURA Compact HPLC system is based on the multifunctional element ASM 2.1L. This element integrates up to 3 modules in one functional and space-saving unit, e.g.

° A degasser for a smooth baseline,

° a precise isocratic pump with low pulsation,

° and a variable UV wavelength detector.

The system is supported by the Clarity Chrom™ software package and can also be controlled directly via the intuitive Mobile Control™.

Ultimate flexibility: Choose from a variety of integratable modules:

° P 4.1S: Pump with pressure transducer

° P 2.1S: Pump without pressure transducer

° DG 2.1S: Degasser 2-channel or 4-channel

° UVD 2.1S: UV/VIS detector

° V 2.1S: Valve drives

° VICI Valco valve drives

° Manual injection valve

AZURA: For a wide range of standard applications.

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AZURA Mobile Control™

Mobile Control™ is an intuitive soft-ware solution, easy-to-understand and to use, even for less experienced users.

• Controls and monitors AZURA devices and systems and performs measurements and methods.

• Detector traces, auxiliary traces and method parame-ters can be recorded, graphically depicted, analyzed, reported and exported at the click of a button.

• System overview provides instant insight into device and system status and allows to adjust key parameters with a fingertip.

• Smart user management makes the Mobile ControlTM

safe; ensuring that device parameters only be changed by authorized operators.

• Graphical display helps to avoid problems and unexpected downtime and to plan maintenance controls.

• Hand-held Mobile ControlTM option to check the system remotely, allowing to oversee multiple systems from the comfort of your office

• Regular updates enable you to take advantage of new devices, features and functions as soon as they are released.

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COMPACT Radio-HPLC: The ideal partners for GRP-Modules

UV-DETECTOR 2.1S• Wavelength range: 190 - 500 nm• Deuterium (D2) lamp with integrated GLP chip • Noise: ± 2.0 • 10-5 AU at 254 nm• Drift: 3.0 • 10-4 AU/h at 254 nm• Linearity: > 2.0 AU at 270 nm• input 100 - 240 V, output 24 V DC, 60 W• 121 x 129 x 187 mm3 (W x H x D), 1.5 kg

Double-piston PUMP P4.1S• Integrated pressure sensor• 0.1 - 10 ml/min or 0.1 - 50 ml/min, ceramic/stainless steel• Max. pressure: 400 bar (#1), 150 bar (#2)• Flow rate accuracy: deviation ±1.0%, measured at

5 - 50% of flow range using ethanol/water 10:90 • Precision: 0.5% RSD (1 ml/min ,12 MPa), measured at

1 ml/min using ethanol/water 10:90• 113 x 135 x 225 mm3 (W x H x D), 2.4 kg

Injection Valve V2.1S 6-Port/2-positions• Stainless steel, Valcon E3, 1/16” capillary connection• 105 x 100 x 185 mm3 (W x H x D), 1.9 kg, both without valve• External DC 24V, 60 W

Degasser DG 2.1S 2 channels• Gas permeation through fluoropolymer membrane, max 10 ml/min• Dead volume approx. 285 µl per channel• Maximum pressure stability 7 bar• Wetted materials PEEK, glass-filled PTFE, Teflon AF®• 121 x 138 x 190 mm3 (W x H x D), 2,3 kg, 85 - 265 V, 50 - 60 Hz, 20 W• Ambient conditions temperature range: 4 - 40 °C, 39.2 - 104 °F• Air humidity: below 90%, non-condensing

Compact-HPLC devices with modern technology and impressive performance, directly controllable by Scintomics Control Center (SCC) Software and GRP User Interface. The ideal partners for GRP-Modules.

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SCINTOMICS GmbH Global Radiopharmacy TechnologyLindach 482256 Fürstenfeldbruck / Germany

T +49 (0) 8141 150 55 - 0F +49 (0) 8141 150 55 - 15

info@scintomics.com

www.scintomics.com