PCRRT Tûr'mə-nŏl'ə-jē
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Transcript of PCRRT Tûr'mə-nŏl'ə-jē
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PCRRT Tûr'mə-nŏl'ə-jē
Helen Currier BSN, RN, CNNAssistant Director, Renal/PheresisTexas Children’s HospitalHouston, Texas
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History of Continuous Renal Replacement Therapy (CRRT)
1960 Continuous arteriovenous approach first described for treatment of renal failure
1974 Ultrafiltration isolated from hemodialysis circuit and the addition of a hemofilter
1975 Hemofiltration technique proposed
1979-82 SCUF and CAVH used by Paganini (MD) and Whitman (RN) at Cleveland Clinic
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History of Continuous Renal Replacement Therapy (CRRT)
1980s CRRT used in pediatrics 1987 Pump-assisted CRRT introduced 1990 CRRT considered state of the art
therapy for treatment of acute renal failure 1993 Standards of Clinical Practice for
CRRT published by the American Nephrology Nurses’ Association (ANNA) and endorsed by the American Association of Critical Care Nurses (AACN)
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History of Continuous Renal Replacement Therapy (CRRT)
1998 SLEDD introduced as an alternative to CRRT
2000 Continued development of integrated blood pump and fluid balance equipment for CRRT
2002 2nd International pCRRT meeting in Orlando, FL
2004 3rd International pCRRT meeting in Orlando, FL
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History of Continuous Renal Replacement Therapy (CRRT)
2006 4th International pCRRT meeting in Zurich, Switzerland
2008 5th International pCRRT meeting in Orlando, FL
2010 6th International pCRRT meeting in Rome, Italy
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Bunchman Brophy Goldstein Symons Somers
The Founding Five
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Indications for CRRT in the Critical Care Setting Fluid removal
Solute removal
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Basic Concepts of CRRT: Concepts Related to Fluid Removal or Ultrafiltration Blood flow
– Arteriovenous– Venovenous
Hydrostatic pressure– Arteriovenous– Venovenous
Other factors– Hematocrit– Plasma proteins– Transmembrane pressure
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Basic Concepts of CRRT: Concepts Related to Solute Removal or Clearance
Convection – solute drag; hemofiltration
Diffusion – concentration gradient; hemodiafiltration
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Convection
High pressure to low pressure across a membrane
Pressure gradient
Solute dissolved in solvent = solvent drag
Bulk-flow of solute across a semi-permeable membrane together with a solvent in a manner that is dependent on transmembrane pressure and membrane characteristics.
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Basic Concepts of CRRT: Concepts Related to Solute Removal or Clearance
Convection – solute drag; hemofiltration
Diffusion – concentration gradient; hemodiafiltration
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Diffusion
Describes solute transport across a semi-permeable membrane generated by a concentration gradient.
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Hemodiafiltration (HDF)
A technique associated with high ultrafiltration rates and diffusion across a highly permeable membrane. Blood and dialysate are circulated as in hemodialysis, but in addition, ultrafiltration, in excess of the scheduled weight loss, is provided. Replacement fluid is used to achieve fluid balance.http://www.usa-gambro.com/upload/Site_us/Patient%Resources/IC/cvvhdf.gif
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Solute Mass Transfer in CRRT
Post-Dilution CVVH CVVHD
Pre-Dilution CVVH CVVHDF
Qb
Qb Qb
Qb
Qeff Qeff
QeffQeff Qd
Qd
Qr
Qr
Qr
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Solute Molecular Weight and ClearanceSolute (MW) Sieving Coefficient Diffusion Coefficient
Urea (60) 1.01 ± 0.05 1.01 ± 0.07
Creatinine (113) 1.00 ± 0.09 1.01 ± 0.06
Uric Acid (168) 1.01 ± 0.04 0.97 ± 0.04*
Vancomycin (1448) 0.84 ± 0.10 0.74 ± 0.04**
*P<0.05 vs sieving coefficient**P<0.01 vs sieving coefficient
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Definition of Acronyms and Terms
SCUF slow continuous ultrafiltration CAVHCAVH continuous arteriovenous continuous arteriovenous
hemofiltrationhemofiltration CAVHDCAVHD continuous arteriovenous continuous arteriovenous hemodialysishemodialysis CVVH continuous venovenous
hemofiltration CVVHD continuous venovenous hemodialysis CVVHDF continuous venovenous
hemodiafiltration
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Definition of Acronyms and Terms
SLEDD slow low efficient daily dialysis or sustained
low- efficiency daily dialysis
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Intermittent therapies
Are those usually prescribed for a period of 12 hours or less.
Extended Daily Dialysis (EDD)
Slow Low Efficiency Dialysis (SLED)
EDD+SLED=SLEDD
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Continuous Renal Replacement Therapy
Advantages– Slower blood flows– Slower UF rates– Adjust UF rates with hourly patient intake– Increased cytokine (bad humors) removal?
Disadvantages– Prolonged anticoagulation– Increased cytokine (good humors) removal?
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Dialysate
A solution of variable composition designed to facilitate diffusion of solutes into the ultrafiltrate-dialysate compartment of the hemofilter or hemodialyzer.http://www.shodor.org/master/biomed/physio/dialysis/hemodialysis/sixa.htm#hollowfiber
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Peritoneal Dialysis
An intracorporeal therapy where solute and water are transported across the peritoneal membrane based on osmotic and concentration gradients.
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Hemodialysis
An extracorporeal, primarily diffusive therapy, where solute and water are transported across a semi-permeable membrane into dialysate.
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High flux
A dialysis membrane designed to provide high water permeability, thereby increasing solute clearance especially large solute such as beta-2 microglobulin.
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Transmembrane Pressure
The hydrostatic pressure gradient across the membrane. This is the driving force that causes ultrafiltration.
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The Pediatric Ideal: CRRT Circuit
Minimum priming volume with low resistance
Exchangeable components
Biocompatible membrane
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The Pediatric Ideal: CRRT Equipment
Separate and accurate pumps and scales for each component of CRRT
Range of blood flows with a minimum of 20ml/min
Thermoregulation Maximum safety features
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The Pediatric Ideal: CRRT Equipment
Comes with a expert nurse!