PCR Cardiovascular

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58 Vol. 77 Número 1/Enero-Marzo 2007:58-66 edigraphic.com * Departamento de Inmunología. INCICH. Correspondencia: Rafael Bojalil Parra. Jefe, Departamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez. (INCICH, Juan Badiano Núm. 1, Col. Sección XVI, Tlalpan, México D. F.). Tel. 0155 5573 2911, ext. 1255. Fax. 0155 5573 0994 Recibido: 7 de marzo de 2006 Aceptado: 24 de octubre de 2006 REV ISIÓN DE TEMAS CARDIOLÓGICOS REV ISIÓN DE TEMAS CARDIOLÓGICOS REV ISIÓN DE TEMAS CARDIOLÓGICOS REV ISIÓN DE TEMAS CARDIOLÓGICOS REV ISIÓN DE TEMAS CA RDIOLÓGICOS Proteína C reactiva: aspectos cardiovasculares de una  prot eína de f ase agu da Luis M Amezcua-Guerra,* Rashidi Springall del Villar,* Rafael Bojalil P arra* Summary C- REACTIVE  PROTEIN: CARDIOVASCULAR ISSUES OF  AN  ACUTE-PHASE PROTEIN C-reactive protein (CRP) is a nonspecific acute phase protein that has been used as an inflam- matory marker for de cades. More recently, it has been proposed as a predictor of cardiovascular disease (myocardial infarction, stroke, periph- eral artery disease and sudden heart death). Physiologic functions of CRP as an anti-inflam- matory scavenger molecule have begun to emerge. CRP binds to damaged lipoproteins and facilitates their removal by phagocytes, partially activating the complement cascade. Increased levels of CRP may result in direct effects on vas- cular cells, including the induction of cytokines and prothrombotic factors. Although previous studies suggested a potent independent asso- ciation of CRP levels with cardiac events, the strength of this association has been shown to be weaker than previously reported in a recent large meta-analysis and in prospective studies. Therapy with statins in patients with coronary artery disease has been found to reduce ad- verse outcomes in association with reductions of CRP levels, independently of their effects on the lipid profile. (Arch Cardiol Mex 2007; 77: 58-66) Resumen La proteína C reactiva (PCR) es una proteína inespecífica de fase aguda, utilizada como una medida de inflamación durante décadas. Re- cientemente se ha propuesto como un marca- dor de aterogénesis y como un predictor para el desarrollo de eventos cardiovasculares adver- sos a futuro. La PCR se une a lipoproteín as alte- radas y facilita su remoción por los fagocitos, además de activar parcialmente el sistema del complemento. Los niveles elevados de PCR pueden producir efectos directos sobre las cé- lulas vasculares, incluyendo inducción de cito- cinas y factores protrombóticos. Aunque inicial- mente se había señalado una fuerte asociación entre los niveles de PCR y eventos cardiovas- culares futuros, un meta-análisis reciente y va- rios estudios prospectivos han mostrado que esta asociación, si bien existe, pudiera ser más débil que lo descrito inicialmente. La terapia con estatinas en pacientes con enfermedad arterial coronaria ha mostrado reducir los desenlaces cardiovasculares adversos en asociación con una reducción de los niveles séricos de PCR, independientemente de su efecto sobre el perfil de lípidos. Palabras clave: Proteína C reactiva. Enfermedad cardiovascular. Inflamación. Ateroesclerosis. Key words: C-reactive protein. Cardiovascular disease. Inflammation. Atherosclerosis.  Ar te mi sa medigraphic  en lí ne a

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PCR, RT-PCR, FISH

PCR, RT-PCR, FISH

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PCR and quantitative-PCR protocol Description ... · PCR and quantitative-PCR protocol Description: qPCR is a method of quantifying DNA based on PCR (polymerase chain reaction). qPCR

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Product Category Rules (PCR) (Approved PCR ID: PA-BF …pcr-library.edf.org.tw/data/japan/Vegetables and Fruits.… ·  · 2011-09-20Product Category Rules (PCR) (Approved PCR ID:

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Diagnostic strategy in genetically determined diseases ... Karyotype analysis FISH CGH MLPA QF-PCR Methods: PCR MLPA Sequencing PCR-RLFP PCR-Multiplex PCR-ASO Methods: ... The user

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