Hepatitis Serology Interpretation

Test Value Interpretation Actionanti-HAV Neqative Susceptible to HAV Vaccinate for HAV

anti-HAV Positivelmmune to HAV None RequiredlqM anti-HAV Neqative

anti-HAV PositiveAcute HAV infection Report & CounsellqM anti-HAV Positive

Test Value Interpretation ActionHbsAg Neqative

Susceptible to HBV Vaccinate for HBVanti-HBc Neqativeanti-HBs Negative

HbsAq Negativelmmune to HBV due to vaccination None Requiredanti-HBc Negative

anti-HBs Positive

HbsAs Negativelmmune to HBV due to infection Counsel & Treat as

Clinical ly Indicatedanti-HBc Positiveanti-HBs Positive

HbsAq Positive

Acute HBV infection Report & Counselanti-HBc PositivelqM anti-HBc Positiveanti-HBs Neoative

HbsAq Positive

Chronic HBV infection Repod & Counselanti-HBc PositivelqM anti-HBc Neqativeanti'HBs Neqative

4 Possible InterpretationsHbsAq Neoative 1. Recoverinu from acute HBV

Repoft & Counselanti-HBc Positive 2. Distantlv immune, .1. anti-HBV in serumanti-HBs Neqative 3, False pos anti-HBc-+Susceptible to HBV

4, Chronic, with J level of HbsAg in serum

-,T.€*-* Value: Interpretation Action

anti-HCV Positive Hiqh S/Co Acute, chronic. or past HCV infectionReport & Counsel

F/U Testinq: Genotype

anti-HCV Positive Low S/Co Possible lnfection Requires Confirmation Test

anti-HCV Negative No Current Infection Monitor & repeat test in 3-6months if cl inically indicated.

RIBA Positive Past or Current Infection F/U Testing: PCR or TMA

RIBA Negative False Positive anti-HCV Monitor & repeat test in 3-6months if cl inical ly indicated,

PCR or TMA Positive Current lnfection F/U Testing: Genotype

PCR or TMA Negative Past lnfection or False Positive anti-HCVF/U Testing: RIBA

Genotype 6 Possible Strains Type 1 Most Common in U.S. Guides Treatment Decision

Viral Load Copies/mL Quantifies Current HCV Infection Monitor Treatment

Liver Biopsy Histological Marker Grade the amount of necrosis andinflammation and to stage the degree offibrosis

Monitor Liver lnvolvement