Global Oncology Molecular Diagnostics – Market Study 2015-2019
Pattern diagnostics 2015
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Transcript of Pattern diagnostics 2015
InnVentis
Pattern Diagnostics & Precision Medicine Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease Committee on a Framework for Development a New Taxonomy of Disease; National Research Council Preparing for Precision Medicine World Economic Forum November 2012
The precision medicine revolution: Targeted treatment zeros in on disease; GE Look ahead 2013
R&D Ecosystem of the Future 2011: By 2020, four out of every five drugs launched will be Precision Medicine drugs.
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Precision Medicine - Paradigm Shift
Symptom-based Cohort-based Algorithm-based
Yesterday
Intuition Medicine
Today
Evidence-based Medicine
Tomorrow
Precision Medicine
DA
TA
AC
TIO
NS
Application of rules, algorithms and reference databases enables ACTIONABLE clinical decision support & PRECISE/EFFICIENT care
Reference Databases (Rules &
Algorithms)
Personal Molecular
Profiles (PMP, multi-omics)
Molecular Imaging
Non-molecular content (waveforms)
Precision Medicine
(prevention,
diagnosis, treatment)
Mobile Information
Communication Technologies
Big Data Analytics
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis PRECISION MEDICINE: Integrating multi-omics, clinical and real world data
Eric Topol, CELL,Volume 157, Issue 1, 27 March 2014, Pages 241–253
‘‘omic’’ Latin suffix ‘‘ome’’ = mass or many.
Creation of topological maps
of health/disease
InnVentis
Convergence of diagnostics with Big-Data & AI: Multi-omics create Personal Molecular Profile, PMP
Genome 25.000 genes
Proteome 1 million
Metabolome > 6000 SM
Microbiom 1-3 % of
body mass
Existing knowledge ?
Precision Medicine © Dr. Thomas Wilckens, InnVentis
Big DATA
Pattern Discovery Reference Database Machine learning Algorithms
Personal Molecular
Profile
InnVentis
Pattern discovery & machine learning: All human senses use this principle
Pattern recognition: • Hearing (Music, Voices,…)
• Odors
• Taste
• Vision
• ……….
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis Patter recognition is an archaic principle Application of pattern discovery to identify hidden disturbances
Pattern diagnostics:
• Host defence and immunity
• Enables greater flexibility
• Follows evolutionary principles
• Artificial Immune Systems in Computing, Fraud analysis etc.
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Disease is a cuckoo‘s egg Application of Pattern discovery to identify hidden disturbances
Pattern recognition algorithm reveals how birds evolve individual egg pattern signatures Nature Communications 2014/5, Article number: 4117
Pattern diagnostics: • Invented by nature
• Enables dynamic differentiation
• Appreciates individuality
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Pattern diagnostics: • Dynamic models
• Identifies „minor“ changes
• Flexible viewpoints
The tools are there: Facebooks deep learning face recognition
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Pattern-diagnostics: • Is independent from baselines
• Reveals “hidden” disturbances
• The more data the better the analysis;
i.e. precise patter recognition from “different angles”
• Machine learning recognizes “fragments” of a pattern
Molecular patterns are like memorable „skylines“
Pattern discovery, Machine Learning in Precision Medicine: Pattern-diagnostics enables flexible, precise diagnostics
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
child
Pattern diagnostics: • Lifetime monitoring
• Prevention
• Early intervention
• What‘s needed? DATA
Patterns are dynamic and flexible: Personal molecular pattern evolution over time
adult
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Detecting criminal organizations in mobile phone networks. Expert Systems with Applications 41(13):5733-5750, 2014
Disrupting biomedical R&D: Machine learning, pattern discovery and algorithm-based analytics
Paradigm shift: • Social networks are like biological
organisms
• There are tools to analyze social networks – user friendly
• Detecting pathologies with machine learning and algorithms in real-time: the future of diagnostics
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis POC: Classification for childhood arthritis with pattern recognition: Relationship between the clusters and ILAR subtypes
The biological basis for clinical heterogeneity in childhood arthritis. Arthritis Rheumatol. 2014 Sep 8
Pattern diagnostics: • ILAR knows 6 (clinical) groups
• 152 and 102 patients
• Multiple molecular analytes
• New: 11 molecular clusters
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Fully automated pattern discovery and classification
Resulting predictive model has an overall accuracy of 92.4%
In cross-validation, 88.4% of never before seen individuals could be assigned the correct class
Pattern discovery & machine learning Facilitating Big DATA management & analytics
Data of 1209 metabolites from 132 patients assigned to three groups: Healthy controls, low risk patients and high risk patients.
InnVentis‘solution reduceds the time for analysis from:
1day to 1min Scalable for Big DATA
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
New data and standardized processes (SOP) Essential prerequisites for success and value creation:
Nature 03 April 2013 If a job is worth doing, it is worth doing twice Researchers and funding agencies need to put a premium on ensuring that results are reproducible
Garbage in
Garbage out
Precision Medicine © Dr. Thomas Wilckens, InnVentis
How much existing „knowledge“ can be used, how?
InnVentis
Standards and SOPs on the horizon to secure value today? The case for vertically integrated lean and fast pilot projects
Launch of a Transformative Health Care Initiative: The National Biomarker Development Alliance (NBDA) 1/2014
Problems with scientific research How science goes wrong Scientific research has changed the world. Now it needs to change itself 10/2013
A sea of standards for omics data: sink or swim? JD Tenenbaum et. al. Am Med Inform Assoc, 09/2013
SOPs
= Value
Precision Medicine © Dr. Thomas Wilckens, InnVentis
Establishing data bases and algorithms requires highest comparability, validity & reliability
InnVentis Challenges: Pros should pave the way
Most biomarker discovery still takes place in government-funded university laboratories that are ill equipped to undertake the myriad procedures required for stringent biomarker profiling on the scale required to achieve the evidence needed to attract larger investment in clinical trials.
National Biomarker Development Alliance 9/2014
Precision Medicine © Dr. Thomas Wilckens, InnVentis
InnVentis
Precision Medicine & Big DATA
InnVentis enabling
PRECISION MEDICINE
Disclaimer: This presentation is for educational purposes only. No copyright violations are intended. Distribution, also in part, for commercial purpose is illigal
Precision Medicine © Dr. Thomas Wilckens, InnVentis