PathoPhysiology Chapter 18
Transcript of PathoPhysiology Chapter 18
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CHAPTER 18
ALTERATIONS IN CARDIAC FUNCTION
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• CHD is characterized by insufficient delivery of oxygenated blood to the myocardium due to atherosclerotic coronary arteries (CADs)
• Sequelae of CHD include:• Angina pectoris• Myocardial infarction• Dysrhythmias• Heart failure• Sudden cardiac death
Coronary Heart DiseaseCoronary Heart Disease
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CORONARY HEART DISEASE (CONT.)
Etiology of Coronary Heart Disease• Known risk factors• Atherosclerosis causes narrowing of the
arterial lumen that can lead to cardiac ischemia through:• Thrombus formation• Coronary vasospasm• Endothelial cell dysfunction
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
Mechanisms of Coronary Atherosclerosis• Lipids are transported via apoproteins• Lipoproteins associated with a greater risk
of atherosclerosis• High-density lipoproteins transport
cholesterol from peripheral tissue back to the liver, clearing atheromatous plaque
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
Mechanisms of Coronary Atherosclerosis• Atherosclerotic plaque formation initiated by
injury to coronary artery endothelium• Endothelium becomes permeable and recruits
leukocytes• LDL insudation occurs with oxidation by
endothelial cells and macrophages• Oxidized lipids are damaging to endothelial and
smooth muscle cells, and stimulate recruitment of macrophages into the vessel
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CORONARY HEART DISEASE (CONT.)
Mechanisms of Coronary Atherosclerosis• Macrophages engulf the lipids; foam cells release
inflammatory mediators and growth factors, attracting more leukocytes and stimulate smooth muscle proliferation
• Excess lipid and debris accumulate within vessel wall and coalesce into lipid core
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CORONARY HEART DISEASE (CONT.)
Mechanisms of Coronary Atherosclerosis• Vulnerable plaques may rupture or become
eroded, which stimulates clot formation on the plaque
• Vulnerable plaques have:• Large lipid core• Thin cap• High shear stress
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
Pathophysiology of Ischemia• Ischemia occurs when oxygen supply is
insufficient to meet metabolic demands• Critical factors in meeting cellular demands
for oxygen include:• Rate of coronary perfusion• Myocardial workload
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CORONARY HEART DISEASE (CONT.)
Pathophysiology of Ischemia• Coronary perfusion can be altered by:
• Large, stable atherosclerotic plaque• Acute platelet aggregation and thrombosis• Vasospasm• Failure of autoregulation by the microcirculation• Poor perfusion pressure
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CORONARY HEART DISEASE (CONT.)
Clinical Features and Management of Coronary Syndromes
• Chronic syndromes with slow progression due to chronic obstruction from stable atherosclerotic plaques• Stable angina pectoris• Ischemic cardiomyopathy
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CORONARY HEART DISEASE (CONT.)
Clinical Features and Management of Coronary Syndromes • Acute coronary syndrome (ACS) associated with
acute changes in plaque morphology and thrombosis• Unstable angina• Myocardial infarction
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CORONARY HEART DISEASE (CONT.)
Angina Pectoris• Chest pain associated with intermittent
myocardial ischemia• May result in inefficient cardiac pumping
with resultant pulmonary congestion and shortness of breath
• Three patterns of angina pectoris• Stable or typical angina• Prinzmetal or variant angina• Unstable or crescendo angina
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CORONARY HEART DISEASE (CONT.)
Acute Coronary Syndrome• Chest pain usually more severe and lasts
longer than typical angina• Plaque rupture with acute thrombus
development• Unstable angina—occlusion is partial• MI—occlusion is complete• ECG and biomarkers used for diagnosis
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
Acute Coronary Syndrome• MI leads to drop in CO, triggering compensatory
responses including sympathetic activation• Sympathetic nervous system activation leads to
increased myocardial workload by increasing:• Heart rate• Contractility• Blood pressure
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CORONARY HEART DISEASE (CONT.)
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CORONARY HEART DISEASE (CONT.)
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Sudden Cardiac Death• Unexpected death from cardiac causes
within 1 hour of symptom onset• Use of external defibrillators and CPR has
increased survival• Lethal dysrhythmia (such as ventricular
fibrillation) is usually the primary cause
Coronary Heart Disease Coronary Heart Disease (Cont.)(Cont.)
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CORONARY HEART DISEASE (CONT.)
Chronic Ischemic Cardiomyopathy• Heart failure develops insidiously due to
progressive ischemic myocardial damage• Typically have history of angina or MI• More common in older adults
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ENDOCARDIAL AND VALVULAR DISEASE
• Endocardial and valvular structures may be damaged by:• Inflammation and scarring• Calcification• Congenital malformations
• Cause altered hemodynamics of the heart and increase myocardial workload
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ENDOCARDIAL AND VALVULAR DISEASE (CONT.)
• Stenosis: failure of the valve to open completely results in extra pressure work for the heart
• Regurgitation: inability of a valve to close completely results in extra volume work for the heart
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ENDOCARDIAL AND VALVULAR DISEASE (CONT.)
Mitral Stenosis• Blood flow from the left atrium to the left
ventricle is impaired during ventricular diastole
• Increased pressure of the left atrium leads to atrial chamber enlargement and hypertrophy
• Can lead to chronic pulmonary hypertension, right ventricular hypertrophy, and right-sided heart failure
• Low-pitched, rumbling diastolic murmur
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ENDOCARDIAL AND VALVULAR DISEASE (CONT.)
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Mitral Regurgitation• Backflow of blood from the left ventricle to
the left atrium during ventricular systole• Left atrium and ventricle dilate and
hypertrophy due to extra volume• May lead to left-sided heart failure• High-pitched, pansystolic, blowing murmur
Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Mitral Valve Prolapse• Displacement of the mitral valve leaflets
into the left atrium during ventricular systole
• Typically asymptomatic• Complications may include infective
endocarditis, sudden cardiac death, cerebral embolic events, and progression to mitral regurgitation
• Midsystolic click or systolic murmur
Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Aortic Stenosis• Predominant cause is age-related calcium
deposits on the aortic cusps• Results in obstruction of aortic outflow from
the left ventricle into the aorta during systole
• May result in ischemia and left-sided HF• Crescendo-decrescendo murmur during
ventricular systole with prominent S4
Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Aortic Regurgitation• Incompetent aortic valve allows blood to
leak back from the aorta into the left ventricle during diastole
• Leads to left ventricle hypertrophy and dilation with eventual left-sided HF
• High-pitched blowing murmur during ventricular diastole
Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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Diseases of the Endocardium• Rheumatic heart disease
• Acute inflammatory disease that follows infection with group A β-hemolytic streptococci
• Antibodies against the streptococcal antigens damage connective tissue in joints, heart, and skin
• Occurs mainly in children
Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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• Infective endocarditis• Invasion and colonization of endocardial
structures by microorganisms with resulting inflammation—vegetations
• Most common bacteria• Streptococcus• Staphylococcus
• Predisposing risk factors typically present
Endocardial and Endocardial and Valvular Disease Valvular Disease (Cont.)(Cont.)
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MYOCARDIAL DISEASES• Myocarditis: inflammatory disorder of the
heart muscle characterized by necrosis and degeneration of myocytes
• Cardiomyopathy may be genetic or acquired and is noninflammatory
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MYOCARDIAL DISEASES (CONT.)Myocarditis• Causes include microbial agents, immune-
mediated diseases, physical agents• Viral etiology most common• Characterized by left ventricular
dysfunction and general dilation of all four chambers
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Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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Cardiomyopathy• Classified by cause or functional
impairment• Primary: dysfunction of unknown cause• Secondary: known cause• Dilated• Hypertrophic• Restrictive
Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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Dilated Cardiomyopathy• Cardiac failure associated with dilation of
one or both ventricular chambers• May be related to:
• Alcohol toxicity• Pregnancy• Postviral myocarditis• Genetic abnormality
• Slow progression of biventricular heart failure with low ejection fraction
Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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Hypertrophic Cardiomyopathy• Thickened, hyperkinetic ventricular muscle
mass• Septum may be affected, leading to
idiopathic hypertrophic subaortic stenosis• Genetic abnormality• Clinical course is variable, typically slow
progression
Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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Restrictive Cardiomyopathy• Rarest form of cardiomyopathy• Stiff, fibrotic ventricle with impaired
diastolic filling• Most commonly associated with
amyloidosis• Decreased cardiac output and left-sided
heart failure can result
Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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Specific Cardiomyopathy• Presumed known origin• Present functionally as dilated,
hypertrophic, or restrictive disorders
Myocardial Diseases Myocardial Diseases (Cont.)(Cont.)
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PERICARDIAL DISEASES• Typically sequelae of other disorders such
as:• Systemic infection• Trauma• Metabolic derangement• Neoplasia
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PERICARDIAL DISEASES (CONT.)Pericardial Effusion• Accumulation of noninflammatory fluid in
the pericardial sac• Composition of usual fluids
• Serous• Serosanguineous• Chylous• Blood
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PERICARDIAL DISEASES (CONT.)Cardiac Tamponade• When fluid accumulation in the pericardial
sac is large/sudden it can lead to external compression of the heart chambers such that filling is impaired
• Symptoms include:• Reduced stroke volume• Compensatory increases in heart rate
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PERICARDIAL DISEASES (CONT.)Pericarditis• Acute or chronic inflammation of the
pericardium• Categories:
• Idiopathic• Infectious• Immune-inflammatory• Neoplastic• Radiation induced
Early postcardiac sxEarly postcardiac sx HemopericardiumHemopericardium TraumaTrauma CongenitalCongenital MiscellaneousMiscellaneous
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PERICARDIAL DISEASES (CONT.)Acute Pericarditis• Most cases idiopathic and presumed viral• Uncomplicated form resolves spontaneously• Complicated forms involve pericardial
effusion, or persistent/recurrent inflammation
• Typically presents as chest pain
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PERICARDIAL DISEASES (CONT.)Chronic Pericarditis• Two principal forms:
• Adhesive mediastinopericarditis— pericardial sac is destroyed and the external aspect of the heart adheres to surrounding mediastinal structures
• Constrictive pericarditis—pericardial sac becomes dense, nonelastic, fibrous, and scarred
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CONGENITAL HEART DISEASES• Abnormality of the heart that is present
from birth• Different congenital heart anomalies result
in two primary pathologic processes:• Shunting of blood through abnormal pathways in
the heart or great vessels• Obstruction to blood flow because of abnormal
narrowing
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CONGENITAL HEART DISEASES (CONT.)
Embryologic Development• Heart defects commonly associated with
these abnormalities:• Development of atrial septum• Development of the ventricular septum• Division of the main outflow tract (truncus
arteriosus) into the pulmonic and aortic arteries• Development of the valves
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CONGENITAL HEART DISEASES (CONT.)
Etiology and Incidence of Congenital Heart Disease• Congenital heart disease is the most
common heart disorder in children• Overall incidence is 0.8% of all live births• May be attributed to
• Maternal rubella during first trimester of pregnancy
• Exposure to cardiac teratogens• Genetic influences
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CONGENITAL HEART DISEASES (CONT.)
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Pathophysiology of Congenital Heart Disease• Result in two primary pathologies
• Shunt: abnormal path of blood flow through the heart or great vessels
• Obstruction: interference with blood flow leading to increased workload of affected chamber
Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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Acyanotic Congenital Defects• Disorders that result in left-to-right shunting
of blood or obstruction to flow are generally acyanotic
• These disorders include:• Atrial septal defect• Ventricular septal defect• Patent ductus arteriosus• Coarctation of the aorta• Pulmonary and aortic stenosis or atresia
Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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Atrial Septal Defect• Majority of atrial septal defects occur at the
location of the foramen ovale• Long-term increase in pulmonary blood flow
may eventually lead to pulmonary hypertension, right ventricular hypertrophy, and reversal to a right-to-left shunt
Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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CONGENITAL HEART DISEASES (CONT.)
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Ventricular Septal Defect• Most common congenital cardiac anomaly• Typically located in the membranous
septum, near the bundle of His• Increase in pulmonary blood flow can result
in pulmonary hypertension, right ventricular hypertrophy, and reversal of the shunt
Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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Patent Ductus Arteriosus• Conditions that cause low blood oxygen
tension may contribute to continued patency
• No clinical significance in early life• Continued patency identified by harsh,
grinding systolic murmur or thrill• Results in pulmonary hypertension, and can
lead to right-sided heart failure
Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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PATENT DUCTUS ARTERIOSUS
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CONGENITAL HEART DISEASESCoarctation of the Aorta• Narrowing or stricture of the aorta that
impedes blood flow• Commonly located just before or after the
ductus arteriosus• Preductal coarctation usually more severe
and associated with other anomalies• Usually accompanied by systolic murmurs
and ventricular hypertrophy
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COARCTATION OF THE AORTA
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CONGENITAL HEART DISEASESPulmonary Stenosis or Atresia• Pulmonary atresia—blood must enter the
lungs by traveling through a septal opening and a patent ductus arteriosus
• Pulmonary stenosis—usually due to abnormal fusion of the valvular cusps and can lead to right ventricular hypertrophy
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CONGENITAL HEART DISEASES (CONT.)
Aortic Stenosis or Atresia• Aortic atresias are not compatible with
survival• Aortic stenosis may involve the valvular
cusps or the subvalvular fibrous ring and results in high left ventricular afterload with left ventricular hypertrophy
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CONGENITAL HEART DISEASES (CONT.)
Cyanotic Congenital Defects• Disorders that result in right-to-left shunting
of blood result in cyanosis• These disorders include
• Tetralogy of Fallot• Transposition of the great arteries• Truncus arteriosus• Tricuspid atresia
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Tetralogy of Fallot• Four defining features
• Ventricular septal defect• Aorta positioned above the ventricular septal
opening• Pulmonary stenosis that obstructs right ventricular
outflow• Right ventricular hypertrophy
Congenital Heart Diseases Congenital Heart Diseases (Cont.)(Cont.)
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TETRALOGY OF FALLOT
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CONGENITAL HEART DISEASESTransposition of the Great Arteries• Aorta arises from the right ventricle and the
pulmonary artery arises from the left ventricle
• Results in two separate, noncommunicating circulations
• Incompatible with life unless mixing of blood occurs through other defects
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TRANSPOSITION OF THE GREAT ARTERIES
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CONGENITAL HEART DISEASESTruncus Arteriosus• Failure of the pulmonary artery and aorta to
separate; results in formation of one large vessel that receives blood from both the right and left ventricles
• Results in systemic cyanosis• High pulmonary blood flow may cause
pulmonary hypertension and right ventricular hypertrophy
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TRUNCUS ARTERIOSUS
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CONGENITAL HEART DISEASESTricuspid Atresia• Usually associated with underdevelopment
of the right ventricle and an atrial septal defect
• Allows blood to bypass right ventricle• A patent ductus arteriosus is required to
perfuse lungs• Cyanosis present at birth, mortality high