PATHOPHYSIOLOGY AND CLINICAL FEATURES OF

HEMOLYTIC ANEMIAPRESENTED BY:-

MOUSHMI BISWAS

Hemolytic anemia = reduced red-cell life span

•The normal red cell life is 110-120 days after which the senile cells are removed by bone marrow and spleenic macrophages.•Reduced red cell survival leads to increased red cell production due to erythropoietin drive that can compensate for the reduced red cell life and maintain a normal Hb level.•The mean red cell life is affected by molecular changes in either the red cell membrane or haemoglobined red cell survival leads to.

How hemolysis occurs?

• Hemolysis occurs through two ways they are-

1.INTRAVASCULAR HEMOLYSIS2.EXTRAVASCULAR HEMOLYSIS

INTRAVASCULAR HEMOLYSIS EXTRAVASCULAR HEMOLYSIS

• PNH,TRANSFUSION RXN• PHYSICAL / MECHANICAL

TRAUMA• TOXIC MICROENVIRONMENT

• HEMOGLOBINOPATHIES•ENZYMOPATHIES•MEMBRANE DEFECTS•MEGALOBLASTIC ANAEMIA•AIHA•DRUG INDUCED

HAEMOLYSIS PATHWAYS ARE OF TWO TYPES

drpankajyadav05@gmail.com

drpankajyadav05@gmail.com

COMPLICATIONS OF HA

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