8/7/2019 pathoPhy of Appendicitis

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  Episodes of constipation Low fiber diet

Occlusion of appendix by

fecaloth

Decreased flow/ drainage of 

Increased ILP in the appendix

Vasocongestion

Decreased blood supply in the appendix

Decreased oxgen supply in the appendix

Appendix starts to be necrotic; bacteria

invade the appendix

Start of the inflammatory process

Release of chemical mediators Activation of the vomiting

center in the medulla

Neutrophils to area

Histamine, prostaglandin,

leukotrienes, bradykinin

Swelling of appendix

Prostaglandin, bradykinin

Pain in the RLQ of 

abdomen

Stimulation of vagus

nerve

Nausea & vomiting

Risk for deficient

fluid volume

Pus formation

(phagocytized

bacteria and dead

cells)

Risk for infection (if 

appendix ruptures)

Inflammation of appendix

a endicitis

Acute ain

Interleukin-l

Increased WBC

8/7/2019 pathoPhy of Appendicitis

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