Pathology of Prostate Cancer - canm-acmn.ca Speaker Presentations/2017 PET... · Pathology of...
Transcript of Pathology of Prostate Cancer - canm-acmn.ca Speaker Presentations/2017 PET... · Pathology of...
“Pathology of Prostate Cancer”
Dr Michelle Downes MD FRCPC, Urologic Pathologist
Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto
Laboratory Medicine and Pathobiology, University of Toronto
Financial Disclosures
Advisory board member for PDL-1 testing/implementation for Hoffman-La Roche and
Astra Zeneca
Conflicts of Interest
None to declare
Overview
• Gleason Grading
• ISUP grade groups
• Intraductal carcinoma & cribriform architecture carcinomas
Dr Donald F. GleasonUniversity of Minnesota, VA Medical CenterMinneapolis
Gleason DF. Classification of Prostatic Carcinomas. Cancer Chemother Rep 1966; 50:125-128.
2005 ISUP Modifications
Small cribriform glands: previously pattern 3 now pattern 4
2014 ISUP Modified Gleason System
Cribriform should ALL be considered pattern 4
Glomeruloid glands should be considered pattern 4
Mucinous carcinomas graded on architectural pattern
Intraductal carcinoma is not graded
Mucinous carcinoma: previously pattern 4 now pattern 3
AJSP 2016; 2:244-252
Gleason Grading 2017…..
2014 modified ISUPGleason schematic
Original Gleason schematic
Main change is the Gleason grade 3 and 4 groups.
AJSP 2016; 2:244-252
Gleason 4 patterns
ISUP Grade Groups
• 5 tiered grading prognostic system (1-5)
• >7,800 radical prostatectomy cases
ISUP Grade Groups 1-5GS 6
GS 7 (3+4)
GS 7 (4+3)
GS 8
GS 9-10
Reporting % 4/5 pattern
Intraductal Carcinoma
• ~ 20% of radical prostatectomies
• Associated with– ↑ Tumour volume
– ↑ Stage
– ↑ Gleason score
– + Surgical margins
• Independent prognosticfactor
Cribriform Architecture
• More frequent in men with nodal metastasis
• Associated with biochemical recurrence
Intraductal Carcinoma and Cribriform Architecture Carcinoma
Frequently associated with each other
Large Cribriform Intraductal Carcinoma
Cribriform Gleason Pattern 4- May occur concurrently with IDC-P
- Associated with biochemical recurrence
- Seen more frequently in radical prostatectomies with lymph node mets
Patients with CR/IDC on biopsy associated with worse disease specific survival
Gleason 7/10 with no CR/IDC have similar BCRFS as Gleason score 6/10
% 4/5
Intraductal carcinoma
Cribriform architecture
Sunnybrook Synoptic Report for Prostate Biopsy
Thank You!
www.isupweb.org