PATHOLOGY of ENDOCRINE, SKELETAL SYSTEM …...Dermatomyositis, Verruca vulgaris, Molluscum...
Transcript of PATHOLOGY of ENDOCRINE, SKELETAL SYSTEM …...Dermatomyositis, Verruca vulgaris, Molluscum...
PATHOLOGY of ENDOCRINE, SKELETAL SYSTEM
and SKIN (Diabetes mellitus – kidney, Goiter, Feochromocytoma, Carcinoid.
Osteomyelitis, Osteodystrophy.
Dermatomyositis, Verruca vulgaris, Molluscum contagiosum, Atheroma,
Basal cell papilloma)
General medicine
Prof. MUDr. Pavel Babál, CSc.
Department of Pathology FM CU
Sasinkova 4, Bratislava
Prof. MUDr. Ľudovít Danihel, CSc.
PATHOLOGY of ENDOCRINE SYSTEM
Diabetes mellitus (159)
= chronic disease with permanent hyperglycemia in relative
or absolute absence of insuline
1.) Type I DM (total insuline deficiency)
2.) Type II DM (relative insuline deficiency)
3.) Other types of DM
4.) Gestational DM
Intercapillary glomerulosclerosis and artheriolosclerosis
calcifiication
artheriolosclerosis
Interkapilárna glomeruloskleróza a artérioloskleróza Intercapillary glomerulosclerosis and artheriolosclerosis
Interkapilárna glomeruloskleróza a artérioloskleróza Intercapillary glomerulosclerosis and artheriolosclerosis
Intercapillary glomerulosclerosis leading to glomerular fibrosis
PATHOLOGY of ENDOCRINE SYSTEM
GOITER (STRUMA) (69, 70, 240)
• Hashimoto disease (thyroiditis)
• Graves disease (Basedow struma,
autoimmune hyperthyreodism)
• Nontoxic goiter - diffuse
- nodular
Hashimoto disease
Hashimoto disease
Hashimoto disease
Graves disease
Graves disease
Nodular goiter
Nodular goiter
PATHOLOGY of ENDOCRINE SYSTEM
Feochromocytoma (193)
• more frequent in adults
chromaffinity of cytoplasm (catecholamines)
• in children prevalence of neuroblastoma (sympatoblastoma)
Feochromocytoma
Kôra nadobličky
Feochromocytoma
PATHOLOGY of ENDOCRINE SYSTEM
Neuroendocrine tumor (carcinoid) (184)
• large intestine, small intestine, bronchi, pancreas, other...
• (serotonin, callicrein... „carcinoid syndrome“)
Carcinoid in large intestine
mucosa
C A R C I N O I D
Carcinoid in large intestine
Carcinoid in large intestine
CARCINOID
mucosal gland
PATHOLOGY of SKELETAL SYSTEM
Osteomyelitis (139)
= infectious bone inflammation
• nonspecific (purulent)
• specific, granulomatous (Tbc, syphylis, sarcoidosis; brucellosis, typhoid)
Osteomyelitis
Osteomyelitis
leukocytes
PATHOLOGY of SKELETAL SYSTEM
Osteodystrophy (156)
(ostitis deformans Paget)
(paramyxovirus)
- osteoclasts (large), later osteoblasts ... chaotic remodelling of bone tissue
- resorptive lacunae, osteoid, irregularly thickened compact bone,
fibrous bone marrow
- complication – osteosarcoma (IL6)
Paget disease
Paget disease
Bone
trabecule
Fibrosis
Paget disease
BT
F
BT
F
PATHOLOGY of SKELEAL SYSTEM
Dermatomyositis (polymyositis) (226)
• autoimmune disease (Ag ... capillary endothelium ?)
• in the skin - perivascular and periadnexal lymphocytic infiltrates
• lymphocyte-plasmocytic infiltrate, degenerative changes of muscle
fibres, fibrosis (scarring)
Dermatomyositis
Dermatomyositis
SKIN PATHOLOGY
Viral infections
• Verruca vulgaris (HPV 2,4,7) (197)
• Molluscum contagiosum (poxvirus) (142)
Verruca vulgaris
Verruca vulgaris
Molluscum contagiosum
SKIN PATHOLOGY
Psoriasis (318)
• hyperkeratosis with scales
• PMN pseudoabscesses
in stratum corneum
• papilomatosis
• acanthosis
Psoriasis
SKIN PATHOLOGY
Atheroma (200)
• epidermal cyst from skin adnexal epithelium
• hair follicle cyst, from sebaceous gland
Atheroma
Atheroma
SKIN PATHOLOGY
Basal cell papiloma (178)
• benign tumor
• senile verruca, seborrheic keratosis
Senile verruca
Senile verruca
Senile verruca