PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Letter from the Chair Dear Colleagues, This is the period of the year when we look back and reflect on what we have accomplished as a department. We have many reasons to be thankful and appreciate our collective effort to bring excellence to our clinical and research community. Let me first of all thank all of you, Faculty, Trainees and Staff, for your amazing work. Whatever your role is in the department, it matters and is essential for our common success! We may not realize it in the daily hustle of a busy place like NYULH, but we constantly work not just with, but for one another. Our research and clinical labs are both aiming to make new discoveries and to advance diagnoses that benefit patients in our care. This is only possible through a tight collaboration of research and clinical practice. Our faculty and trainees are connected by a symbiotic relationship that results in amazing accomplishments. Often we face challenges along the way, but they are part of the learning process and help us improve our skills and push ourselves to new limits. Last but not least, we have a fantastic administrative team that every day enables all of us to do our jobs well. Their commitment makes the Department work, by submitting grant applications, keeping our finances in good order, supporting our educational mission and administering our clinical practice. Thank you all for your great work and commitment to strengthen our department.

One particular achievement I want to highlight is the first anniversary of the Department of Pathology Newsletter! We started this project in December 2018 with a lot of enthusiasm and expectations but with some uncertainty how this project would develop. A year later, we have published five exciting issues that keep getting better and better. My special thanks go to Dr. Caterina Berti, who is the editor and creative mind behind the Newsletter. Through the Newsletter, we have shared with you important news from all mission areas of the Department (clinical, research & education). The Newsletter is doing a marvelous job to highlight the many achievements our faculty and trainees, to strengthen our community by connecting current members from all areas of the Department and to reinforce the ties with our former trainees. Sharing the stories of our alumni is a great resource for our current trainees who I hope will benefit from their experience to navigate their own career paths. As we begin year two of the Newsletter, please keep sharing your achievements with us and send us feedback & suggestions to make the Newsletter a continued success! These are a few highlights from this issue of the Newsletter:

• We were lucky to recruit several talented attendings, who are experts in different sub-specialties. Please welcome Drs. Negin Shafizadeh (Cytopathology), Deepthi Hoskoppal (Gastrointestinal Pathology), Margaret Cho (Gastrointestinal Pathology and Cytopathology) and Melissa Guzzetta (Autopsy Pathology and Forensic Pathology).

• On the research side, we welcome Dr. Jun Wang, Assistant Professor, who recently joined the department. Discover more about his work on immune checkpoint inhibitors for cancer immunotherapy inside this issue.

• Dr. Matija Snuderl successfully collaborated with the German Cancer Research Center (DKFZ) in Heidelberg on the generation of an epigenetic map of Brain tumors (Nature in 2018) that allowed the development of the first molecular test for brain tumors available to patients.

• Our Postdocs were highly represented at the Research Postdoc Symposium where 7 of them presented their work to the NYU postdoctoral community during the National Postdoc Appreciation week. Read more about their research in the article below.

• The Department is opening a new Ion Channel Core Facility that is part of the Ion Channel & Immunity (ICI) Program headed by Dr. Stefan Feske, Vice Chair for Research of our Department. The core is scheduled to open in mid-December on the 4th floor of the Science Building. Dr. William A. Coetzee, professor in the departments of Pediatrics, Biochemistry & Molecular Pharmacology and Neuroscience & Physiology, will be the core director. Its goal it is to facilitate research in the area of ion channel function in immune cells and other tissues. Read more about the core and ICI program in the New & Notable section of this issue.

I hope to see you all at our Holidays party on December 13th! Wishing you a joyful Holiday season and happy reading! Best regards, Iannis

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Publications

August-October (Alphabetical Order)

Aifantis, Ioannis • Vougas, Konstantinos; Sakelaropoulos, Theodore;

Kotsinas, Athanassios; Foukas, George-Romanos P; Ntargaras, Andreas; Koinis, Filippos; Polyzos, Alexander; Myrianthopoulos, Vassilis; Zhou, Hua; Narang, Sonali; Georgoulias, Vassilis; Alexopoulos, Leonidas; Aifantis, Iannis; Townsend, Paul A; Sfikakis, Petros; Fitzgerald, Rebecca; Thanos, Dimitris; Bartek, Jiri; Petty, Russell; Tsirigos, Aristotelis; Gorgoulis, Vassilis G. 'Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining'. Pharmacology & therapeutics. 2019

• Kloetgen, Andreas; Thandapani, Palaniraja; Tsirigos, Aristotelis; Aifantis, Iannis. '3D Chromosomal Landscapes in Hematopoiesis and Immunity'. Trends in immunology. 2019 Sep;40(9):809-824

• Guillamot, Maria; Ouazia, Dahmane; Dolgalev, Igor; Yeung, Stephen T; Kourtis, Nikos; Dai, Yuling; Corrigan, Kate; Zea-Redondo, Luna; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Tikhonova, Anastasia N; Malumbres, Marina; Gong, Yixiao; Tsirigos, Aristotelis; Park, Christopher; Barbieri, Christopher; Khanna, Kamal M; Busino, Luca; Aifantis, Iannis. 'The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation'. Nature immunology. 2019 20(9):1196-1207

• Lobry, Camille; Bains, Ashish; Zamechek, Leah B; Ibrahim, Sherif; Aifantis, Iannis; Araten, David J. 'Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH)'. Experimental hematology & oncology. 2019 8():17

• Witkowski, Matthew T.; Lasry, Audrey; Carroll, William L.; Aifantis, Iannis. 'Immune-Based Therapies in Acute Leukemia'. Trends in cancer. 2019

• Mandal, Malay; Okoreeh, Michael K; Kennedy, Domenick E; Maienschein-Cline, Mark; Ai, Junting; McLean, Kaitlin C; Kaverina, Natalya; Veselits, Margaret; Aifantis, Iannis; Gounari, Fotini; Clark, Marcus R. 'CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis'. Nature immunology. 2019 20(10):1393-1403 Cangiarella, Joan F

• Cangiarella, Joan; Cohen, Elisabeth; Rivera, Rafael; Gillespie, Colleen; Abramson, Steven. 'Evolution of an Accelerated 3-Year Pathway to the MD Degree: The Experience of New York University School of Medicine'. Academic medicine. 2019 Chattopadhyay, Pratip K

• Chattopadhyay, Pratip K; Chiu, Daniel T. 'The next frontier in single cell analysis: multimodal studies and clinical translation'. Lab on a chip. 2019 19(21):3573-3574

• Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Acs, Andreas; Adam, Dieter; Adam-Klages, Sabine; Agace, William W; Aghaeepour, Nima; Akdis, Mübeccel; Allez, Matthieu; Almeida, Larissa Nogueira; Alvisi, Giorgia; Anderson, Graham; Andrä, Immanuel; Annunziato, Francesco; Anselmo, Achille; Bacher, Petra; Baldari, Cosima T; Bari, Sudipto; Barnaba, Vincenzo;

Barros-Martins, Joana; Battistini, Luca; Bauer, Wolfgang; Baumgart, Sabine; Baumgarth, Nicole; Baumjohann, Dirk; Baying, Bianka; Bebawy, Mary; Becher, Burkhard; Beisker, Wolfgang; Benes, Vladimir; Beyaert, Rudi; Blanco, Alfonso; Boardman, Dominic A; Bogdan, Christian; Borger, Jessica G; Borsellino, Giovanna; Boulais, Philip E; Bradford, Jolene A; Brenner, Dirk; Brinkman, Ryan R; Brooks, Anna E S; Busch, Dirk H; Büscher, Martin; Bushnell, Timothy P; Calzetti, Federica; Cameron, Garth; Cammarata, Ilenia; Cao, Xuetao; Cardell, Susanna L; Casola, Stefano; Cassatella, Marco A; Cavani, Andrea; Celada, Antonio; Chatenoud, Lucienne; Chattopadhyay, Pratip K; Chow, Sue; Christakou, Eleni; Čiĕin -Šain, Luka; Clerici, Mario; Colombo, Federico S; Cook, Laura; Cooke, Anne; Cooper, Andrea M; Corbett, Alexandra J; Cosma, Antonio; Cosmi, Lorenzo; Coulie, Pierre G; Cumano, Ana; Cvetkovic, Ljiljana; Dang, Van Duc; Dang-Heine, Chantip; Davey, Martin S; Davies, Derek; De Biasi, Sara; Del Zotto, Genny; Dela Cruz, Gelo Victoriano; Delacher, Michael; Della Bella, Silvia; Dellabona, Paolo; Deniz, Günnur; Dessing, Mark; ! Di Santo, James P; Diefenbach, Andreas; Dieli, Francesco; Dolf, Andreas; Dörner, Thomas; Dress, Regine J; Dudziak, Diana; Dustin, Michael; Dutertre, Charles-Antoine; Ebner, Friederike; Eckle, Sidonia B G; Edinger, Matthias; Eede, Pascale; Ehrhardt, Götz R A; Eich, Marcus; Engel, Pablo; Engelhardt, Britta; Erdei, Anna; Esser, Charlotte; Everts, Bart; Evrard, Maximilien; Falk, Christine S; Fehniger, Todd A; Felipo-Benavent, Mar; Ferry, Helen; Feuerer, Markus; Filby, Andrew; Filkor, Kata; Fillatreau, Simon; Follo, Marie; Förster, Irmgard; Foster, John; Foulds, Gemma A; Frehse, Britta; Frenette, Paul S; Frischbutter, Stefan; Fritzsche, Wolfgang; Galbraith, David W; Gangaev, Anastasia; Garbi, Natalio; Gaudilliere, Brice; Gazzinelli, Ricardo T; Geginat, Jens; Gerner, Wilhelm; Gherardin, Nicholas A; Ghoreschi, Kamran; Gibellini, Lara; Ginhoux, Florent; Goda, Keisuke; Godfrey, Dale I; Goettlinger, Christoph; González-Navajas, Jose M; Goodyear, Carl S; Gori, Andrea; Grogan, Jane L; Grummitt, Daryl; Grützkau, Andreas; Haftmann, Claudia; Hahn, Jonas; Hammad, Hamida; Hämmerling, Günter; Hansmann, Leo; Hansson, Goran; Harpur, Christopher M; Hartmann, Susanne; Hauser, Andrea; Hauser, Anja E; Haviland, David L; Hedley, David; Hernández, Daniela C; Herrera, Guadalupe; Herrmann, Martin; Hess, Christoph; Höfer, Thomas; Hoffmann, Petra; Hogquist, Kristin; Holland, Tristan; Höllt, Thomas; Holmdahl, Rikard; Hombrink, Pleun; Houston, Jessica P; Hoyer, Bimba F; Huang, Bo; Huang, Fang-Ping; Huber, Johanna E; Huehn, Jochen; Hundemer, Michael; Hunter, Christopher A; Hwang, William Y K; Iannone, Anna; Ingelfinger, Florian; Ivison, Sabine M; Jäck, Hans-Martin; Jani, Peter K; Jávega, Beatriz; Jonjic, Stipan; Kaiser, Toralf; Kalina, Tomas; Kamradt, Thomas; Kaufmann, Stefan H E; Keller, Baerbel; Ketelaars, Steven L C; Khalilnezhad, Ahad; Khan, Srijit; Kisielow, Jan; Klenerman, Paul; Knopf, Jasmin; Koay, Hui-Fern; Kobow, Katja; Kolls, Jay K; Kong, Wan Ting; Kopf, Manfred; Korn, Thomas; Kriegsmann, Katharina; Kristyanto, Hendy; Kron! eis, Thomas; Krueger, Andreas; Kühne, Jenny; Kukat, Christian; Kunkel, Désirée; Kunze-Schumacher, Heike; Kurosaki, Tomohiro; Kurts, Christian; Kvistborg, Pia; Kwok, Immanuel; Landry, Jonathan; Lantz, Olivier; Lanuti,

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Paola; LaRosa, Francesca; Lehuen, Agnès; LeibundGut-Landmann, Salomé; Leipold, Michael D; Leung, Leslie Y T; Levings, Megan K; Lino, Andreia C; Liotta, Francesco; Litwin, Virginia; Liu, Yanling; Ljunggren, Hans-Gustaf; Lohoff, Michael; Lombardi, Giovanna; Lopez, Lilly; López-Botet, Miguel; Lovett-Racke, Amy E; Lubberts, Erik; Luche, Herve; Ludewig, Burkhard; Lugli, Enrico; Lunemann, Sebastian; Maecker, Holden T; Maggi, Laura; Maguire, Orla; Mair, Florian; Mair, Kerstin H; Mantovani, Alberto; Manz, Rudolf A; Marshall, Aaron J; MartÃnez-Romero, Alicia; Martrus, Glòria; Marventano, Ivana; Maslinski, Wlodzimierz; Matarese, Giuseppe; Mattioli, Anna Vittoria; Maueröder, Christian; Mazzoni, Alessio; McCluskey, James; McGrath, Mairi; McGuire, Helen M; McInnes, Iain B; Mei, Henrik E; Melchers, Fritz; Melzer, Susanne; Mielenz, Dirk; Miller, Stephen D; Mills, Kingston H G; Minderman, Hans; Mjösberg, Jenny; Moore, Jonni; Moran, Barry; Moretta, Lorenzo; Mosmann, Tim R; Müller, Susann; Multhoff, Gabriele; Muñoz, Luis Enrique; Münz, Christian; Nakayama, Toshinori; Nasi, Milena; Neumann, Katrin; Ng, Lai Guan; Niedobitek, Antonia; Nourshargh, Sussan; Núñez, Gabriel; O'Connor, José-Enrique; Ochel, Aaron; Oja, Anna; Ordonez, Diana; Orfao, Alberto; Orlowski-Oliver, Eva; Ouyang, Wenjun; Oxenius, Annette; Palankar, Raghavendra; Panse, Isabel; Pattanapanyasat, Kovit; Paulsen, Malte; Pavlinic, Dinko; Penter, Livius; Peterson, Pärt; Peth, Christian; Petriz, Jordi; Piancone, Federica; Pickl, Winfried F; Piconese, Silvia; Pinti, Marcello; Pockley, A Graham; Podolska, Malgorzata Justyna; Poon, Zhiyong; Pracht, Katharina; Prinz, Immo; Pucillo, Carlo E M; Quataert, Sally A; Quatrini, Linda; Quinn, Kylie M; Radbruch, Helena; Radstake, Tim R D J; Rahmig, Susann; Rahn, Hans-Peter; Rajwa, Bartek; Ravichandran, Gevit! ha; Raz, Yotam; Rebhahn, Jonathan A; Recktenwald, Diether; Reimer, Dorothea; Reis E Sousa, Caetano; Remmerswaal, Ester B M; Richter, Lisa; Rico, Laura G; Riddell, Andy; Rieger, Aja M; Robinson, J Paul; Romagnani, Chiara; Rubartelli, Anna; Ruland, Jürgen; Saalmüller, Armin; Saeys, Yvan; Saito, Takashi; Sakaguchi, Shimon; Sala-de-Oyanguren, Francisco; Samstag, Yvonne; Sanderson, Sharon; Sandrock, Inga; Santoni, Angela; Sanz, Ramon Bellmà s; Saresella, Marina; Sautes-Fridman, Catherine; Sawitzki, Birgit; Schadt, Linda; Scheffold, Alexander; Scherer, Hans U; Schiemann, Matthias; Schildberg, Frank A; Schimisky, Esther; Schlitzer, Andreas; Schlosser, Josephine; Schmid, Stephan; Schmitt, Steffen; Schober, Kilian; Schraivogel, Daniel; Schuh, Wolfgang; Schüler, Thomas; Schulte, Reiner; Schulz, Axel Ronald; Schulz, Sebastian R; Scottá, Cristiano; Scott-Algara, Daniel; Sester, David P; Shankey, T Vincent; Silva-Santos, Bruno; Simon, Anna Katharina; Sitnik, Katarzyna M; Sozzani, Silvano; Speiser, Daniel E; Spidlen, Josef; Stahlberg, Anders; Stall, Alan M; Stanley, Natalie; Stark, Regina; Stehle, Christina; Steinmetz, Tobit; Stockinger, Hannes; Takahama, Yousuke; Takeda, Kiyoshi; Tan, Leonard; Tárnok, Attila; Tiegs, Gisa; Toldi, Gergely; Tornack, Julia; Traggiai, Elisabetta; Trebak, Mohamed; Tree, Timothy I M; Trotter, Joe; Trowsdale, John; Tsoumakidou, Maria; Ulrich, Henning; Urbanczyk, Sophia; van de Veen, Willem; van den Broek, Maries; van der Pol, Edwin; Van Gassen, Sofie; Van Isterdael, Gert; van Lier, René A W; Veldhoen, Marc; Vento-Asturias, Salvador; Vieira, Paulo; Voehringer, David; Volk, Hans-Dieter; von Borstel, Anouk; von Volkmann, Konrad; Waisman, Ari; Walker, Rachael V; Wallace, Paul K; Wang, Sa A; Wang, Xin M; Ward, Michael D; Ward-Hartstonge, Kirsten A; Warnatz, Klaus; Warnes, Gary; Warth, Sarah; Waskow, Claudia;

Watson, James V; Watzl, Carsten; Wegener, Leonie; Weisenburger, Thomas; Wiedemann, Annika; Wienands, Jürgen; Wilharm, Anneke; Wilkinson, Robert John; Willimsky, Gerald; Wing, James B; Winkelma! nn, Rieke; Winkler, Thomas H; Wirz, Oliver F; Wong, Alicia; Wurst, Peter; Yang, Jennie H M; Yang, Juhao; Yazdanbakhsh, Maria; Yu, Liping; Yue, Alice; Zhang, Hanlin; Zhao, Yi; Ziegler, Susanne Maria; Zielinski, Christina; Zimmermann, Jakob; Zychlinsky, Arturo. 'Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)'. European journal of immunology. 2019 49(10):1457-1973 Chiriboga, Luis A

• Chiriboga, Luis. 'The changing landscape of scientific publishing'. Journal of histotechnology. 2019 42(3):95-97 Cotzia, Paolo

• Black, Margaret; Liu, Cheng Z; Onozato, Maristela; Iafrate, Anthony John; Darvishian, Farbod; Jour, George; Cotzia, Paolo. 'Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland'. Head & neck pathology. 2019

• Guo, Robin; Schreyer, Mark; Chang, Jason C; Rothenberg, S Michael; Henry, Dahlia; Cotzia, Paolo; Kris, Mark G; Rekhtman, Natasha; Young, Robert J; Hyman, David M; Drilon, Alexander. 'Response to Selective RET Inhibition With LOXO-292 in a Patient With RET Fusion-Positive Lung Cancer With Leptomeningeal Metastases'. JCO precision oncology. 2019 Darvishian, Farbod

• Black, Margaret; Liu, Cheng Z; Onozato, Maristela; Iafrate, Anthony John; Darvishian, Farbod; Jour, George; Cotzia, Paolo. 'Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland'. Head & neck pathology. 2019 DeLair, Deborah Fave

• Kemel, Yelena; Chen, Ying-Bei; Musheyev, David; Zehir, Ahmet; Jayakumaran, Gowtham; Brzostowski, Edyta; Birsoy, Ozge; Yang, Ciyu; Li, Yirong; Somar, Joshua; DeLair, Deborah; Pradhan, Nisha; Berger, Michael F; Cadoo, Karen; Carlo, Maria I; Robson, Mark E; Stadler, Zsofia K; Iacobuzio-Donahue, Christine A; Joseph, Vijai; Offit, Kenneth. 'Fumarate hydratase FH c.1431_1433dupAAA (p.Lys477dup) variant is not associated with cancer including renal cell carcinoma'. Human mutation. 2019 Deng, Fang-Ming

• Tang, Moon-Shong; Wu, Xue-Ru; Lee, Hyun-Wook; Xia, Yong; Deng, Fang-Ming; Moreira, Andre L; Chen, Lung-Chi; Huang, William C; Lepor, Herbert. 'Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice'. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 116(43):21727-21731 Duerr, Ralf

• Duerr, Ralf; Gorny, Miroslaw K. 'V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: Controllers or Surrogate Markers'. Vaccines. 2019 7(3)

• Duerr, Ralf; Gorny, Miroslaw K. 'V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: Controllers or Surrogate Markers'. Animals: an open access journal from MDPI. 2019 9(8)

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Gorny, Miroslaw K

• Duerr, Ralf; Gorny, Miroslaw K. 'V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: C! ontrollers or Surrogate Markers'. Vaccines. 2019 7(3)

• Duerr, Ralf; Gorny, Miroslaw K. 'V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: Controllers or Surrogate Markers'. Animals: an open access journal from MDPI. 2019 9(8) Gupta, Mala

• Tian, Chenxi; Clauser, Karl R; Öhlund, Daniel; Rickelt, Steffen; Huang, Ying; Gupta, Mala; Mani, D R; Carr, Steven A; Tuveson, David A; Hynes, Richard O. 'Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and s! tromal cells'. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 116(39):19609-19618 Hajdu, Cristina H

• Kimmel, Jessica; Dikman, Andrew; Hajdu, Cristina. 'Gastric Solitary Fibrous Tumor Causing Upper Gastrointestinal Bleeding'. ACG case reports journal. 2019 6(2) Heguy, Adriana

• Kim, J -C; Perez-Hernandez, Duran M; Alvarado, F J; Maurya, S R; Montnach, J; Yin, Y; Zhang, M; Lin, X; Vasquez, C; Heguy, A; Liang, F -X; Woo, S -H; Morley, G E; Rothenberg, E; Lundby, A; Valdivia, H H; Cerrone, M; Delmar, M. 'Disruption of Ca2+ iHomeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt Arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice'. Circulation. 2019

• Robello, Carlos; Maldonado, Doris Patricia; Hevia, Anna; Hoashi, Marina; Frattaroli, Paola; Montacutti, Valentina; Heguy, Adriana; Dolgalev, Igor; Mojica, Maricruz; Iraola, Gregorio; Dominguez-Bello, Maria G. 'Correction: The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole'. PLoS one. 2019 14(4)

• Snuderl, Matija; Dolgalev, Igor; Heguy, Adriana; Walsh, Michael F; Benayed, Ryma; Jungbluth, Achim A; Ladanyi, Marc; Karajannis, Matthias A. 'Histone H3K36I mutation in a metastatic histiocytic tumor of the skull and response to sarcoma chemotherapy'. Cold Spring Harbor molecular case studies. 2019 5(5) Hernandez, Andrea

• Hernandez, Andrea; Marcus, Alan. 'Mesonephric Remnants With Epididymis-Like Virilization in a Postmenopausal Woman'. International journal of surgical pathology . 2019 Hoda, Syed Tanvir

• Schulberg, Steven P; Lim, Derek; Hoda, Syed T; Vaynblat, Mikhail. 'Intrathoracic Myxoid Spindle Cell Lipoma, A Rare Presentation of a Myxoid Neoplasm'. Annals of thoracic surgery. 2019 Hoskoppal, Deepthi

• Hoskoppal, Deepthi; Epstein, Jonathan I; Gown, Allen M; Arnold Egloff, Shanna A; Gordetsky, Jennifer; Shi, Chanjuan C; Giannico, Giovanna A. 'SATB2 Protein Expression by Immunohistochemistry is a Sensitive and Specific Marker of Appendiceal and Rectosigmoid Well Differentiated Neuroendocrine Tumors'. Histopathology. 2019

Jour, George

• Jour, George; Serrano, Jonathan; Koelsche, Christian; Jones, David T W; von Deimling, Andreas; Allen, Jeffrey; Snuderl, Matija. 'Primary CNS Alveolar Rhabdomyosarcoma: Importance of Epigenetic and Transcriptomic Assays for Accurate Diagnosis'. Journal of neuropathology & experimental neurology. 2019

• Black, Margaret; Liu, Cheng Z; Onozato, Maristela; Iafrate, Anthony John; Darvishian, Farbod; Jour, George; Cotzia, Paolo. 'Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland'. Head & neck pathology. 2019 Khieu, Michelle L

• Khieu, Michelle L; Broadwater, Devin R; Aden, James K; Coviello, Jean M; Lynch, David T; Hall, Jordan M. 'The Utility of Phosphohistone H3 (PHH3) in Follicular Lymphoma Grading: A Comparative Study With Ki-67 and H&E Mitotic Count'. American journal of clinical pathology. 2019 151(6):542-550

• Khieu, Michelle; Beauvais, Alexis; Matz, Rebecca; Bersabe, Adrian; Brown, Patrick; Brown, Alexander; Fillman, Eric; Hall, Jordan. 'Aleukemic Myeloid Leukemia Cutis with a Kikuchi Disease-Like Inflammatory Pattern in Myelodysplastic Syndrome'. Southern medical journal. 2017 110(4):308-313 Koralov, Sergei B

• Blumel, Edda; Willerslev-Olsen, Andreas; Gluud, Maria; Lindahl, Lise M.; Fredholm, Simon; Nastasi, Claudia; Krejsgaard, Thorbjorn; Surewaard, Bas G. J.; Koralov, Sergei B.; Hu, Tengpeng; Persson, Jenny L.; Bonefeld, Charlotte Menne; Geisler, Carsten; Iversen, Lars; Becker, Juergen C.; Andersen, M! ads Hald; Woetmann, Anders; Buus, Terkild Brink; Odum, Niels. 'Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4(+) T cells in cutaneous T-cell lymphoma'. Oncoimmunology. 2019

• Herrera, Alberto; Fredholm, Simon; Cheng, Anthony; Mimitou, Eleni P; Seffens, Angelina; Bar-Natan, Michal; Sun, Amy; Latkowski, Joan; Willerslew-Olsen, Andreas; Buus, Terkild B; G! luud, Maria; Krejsgaard, Thorbjørn; Torres-Rusillo, Sara; Bonefeld, Charlotte Menné; Woetmann, Anders; Geisler, Carsten; Geskin, Larisa J; Ouyang, Zhengqing; Smibert, Peter; Ødum, Niels; Koralov, Sergei B. 'Low SATB1 expression promotes IL-5 and IL-9 expression in Sezary Syndrome'. Journal of investigative dermatology. 2019

• Wong, Jason B; Hewitt, Susannah L; Heltemes-Harris, Lynn M; Mandal, Malay; Johnson, Kristen; Rajewsky, Klaus; Koralov, Sergei B; Clark, Marcus R; Farrar, Michael A; Skok, Jane A. 'B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage'. Nature communications. 2019 10(1):4768 Laal, Suman

• Sakamuri, Rama Murthy; Singh, Krishna Kumar; Ryndak, Michelle B; Laal, Suman. 'Evolution of antibodies to epitopes of PE_PGRS51 in the spectrum of active pulmonary tuberculosis'. Journal of infectious diseases. 2019

• Ryndak, Michelle B; Laal, Suman. 'Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells'. Frontiers in cellular & infection microbiology. 2019 9():299

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

• Abhishek, Sudhanshu; Ryndak, Michelle Beth; Choudhary, Alpa; Sharma, Sumedha; Gupta, Amod; Gupta, Vishali; Singh, Nirbhai; Laal, Suman; Verma, Indu. 'Transcriptional signatures of Mycobacterium tuberculosis in mouse model of intraocular tuberculosis'. Pathogens & disease. 2019 77(5) Lafaille, Juan Jose

• Weinstock, Ada; Brown, Emily J; Garabedian, Michela L; Pena, Stephanie; Sharma, Monika; Lafaille, Juan; Moore, Kathryn J; Fisher, Edward A. 'Single-Cell RNA Sequencing of Visceral Adipose Tissue Leukocytes Reveals that Caloric Restriction Following Obesity Promotes the Accumulation of a Distinct Macrophage Population with Features of Phagocytic Cells'. Immunometabolism. 2019 Liu, Cheng Z

• Black, Margaret; Liu, Cheng Z; Onozato, Maristela; Iafrate, Anthony John; Darvishian, Farbod; Jour, George; Cotzia, Paolo. 'Concurrent Identification of Novel EGFR-SEPT14 Fusion! and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland'. Head & neck pathology. 2019 Lopez, Peter A

• Knudtson, Kevin L; Carnahan, Robert H; Hegstad-Davies, Rebecca L; Fisher, Nancy C; Hicks, Belynda; Lopez, Peter A; Meyn, Susan M; Mische, Sheenah M; Weis-Garcia, Frances; White, Lisa D; Sol-Church, Katia. 'Survey on Scientific Shared Resource Rigor and Reproducibility'. Journal of biomolecular techniques. 2019 30(3):36-44 Marcus, Alan

• Hernandez, Andrea; Marcus, Alan. 'Mesonephric Remnants With Epididymis-Like Virilization in a Postmenopausal Woman'. International journal of surgical pathology. 2019 ():1066896919851209 Maurano, Matthew T

• Laurent, Jon M; Fu, Xin; German, Sergei; Maurano, Matt! hew T; Zhang, Kang; Boeke, Jef D. 'Big DNA as a tool to dissect an age-related macular degeneration-associated haplotype'. Precision clinical medicine. 2019 2(1):1-7 Moreira, Andre Luis

• Nicholson, Andrew G; Sauter, Jennifer L; Nowak, Anna K; Kindler, Hedy L; Gill, Ritu R; Remy-Jardin, Martine; Armato, Samuel G; Fernandez-Cuesta, Lynnette; Bueno, Raphael; Alcala, Nicolas; Foll, M! atthieu; Pass, Harvey; Attanoos, Richard; Baas, Paul; Beasley, Mary Beth; Brcic, Luka; Butnor, Kelly J; Chirieac, Lucian R; Churg, Andrew; Courtiol, Pierre; Dacic, Sanja; De Perrot, Marc; Frauenfelder, Thomas; Gibbs, Allen; Hirsch, Fred R; Hiroshima, Kenzo; Husain, Aliya; Klebe, Sonja; Lantuejoul, Sylvie; Moreira, Andre; Opitz, Isabelle; Perol, Maurice; Roden, Anja; Roggli, Victor; Scherpereel, Arnaud; Tirode, Frank; Tazelaar, Henry; Travis, William D; Tsao, Ming Sound; van Schil, Paul; Vignaud, Jean Michel; Weynand, Birgit; Cree, Ian; Rusch, Valerie W; Girard, Nicolas; Galateau-Salle, Francoise. 'EURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: towards a more multidisciplinary approach'. Journal of thoracic oncology. 2019

• Shih, Angela R; Uruga, Hironori; Bozkurtlar, Emine; Chung, Jin-Haeng; Hariri, Lida P; Minami, Yuko; Wang,

He; Yoshizawa, Akihiko; Muzikansky, Alona; Moreira, Andre L; Mino-Kenudson, Mari. 'Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study'. Histopathology. 2019

• Tang, Moon-Shong; Wu, Xue-Ru; Lee, Hyun-Wook; Xia, Yong; Deng, Fang-Ming; Moreira, Andre L; Chen, Lung-Chi; Huang, William C; Lepor, Herbert. 'Electronic-cigarette smoke induces lung adenocarcinoma and bladder urothelial hyperplasia in mice'. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 116(43):21727-21731 Naik, Shruti

• Jordan, Stefan; Tung, Navpreet; Casanova-Acebes, Maria; Chang, Christie; Cantoni, Claudia; Zhang, Dachuan; Wirtz, Theresa H; Naik, Shruti; Rose, Samuel A; Brocker, Chad N; Gainullina, Anastasiia; Hornburg, Daniel; Horng, Sam; Maier, Barbara B; Cravedi, Paolo; LeRoith, Derek; Gonzalez, Frank J; Meissner, Felix; Ochando, Jordi; Rahman, Adeeb; Chipuk, Jerry E; Artyomov, Maxim N; Frenette, Paul S; Piccio, Laura; Berres, Marie-Luise; Gallagher, Emily J; Merad, Miriam. 'Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool'. Cell. 2019 178(5):1102-1114.e17

• Bukhari, Shoiab; Mertz, Aaron F; Naik, Shruti. 'Eavesdropping on the conversation between immune cells and the skin epithelium'. International immunology. 2019 31(7):415-422 Papagiannakopoulos, Thales Y

• Sayin, Volkan I; LeBoeuf, Sarah E; Papagiannakopoulos, Thales. 'Targeting Metabolic Bottlenecks in Lung Cancer'. Trends in cancer. 2019 5(8):457-459

• McLoughlin, Michael R; Orlicky, David J; Prigge, Justin R; Krishna, Pushya; Talago, Emily A; Cavigli, Ian R; Eriksson, Sofi; Miller, Colin G; Kundert, Jean A; Sayin, Volkan I; Sabol, Rachel A; Heinemann, Joshua; Brandenberger, Luke O; Iverson, Sonya V; Bothner, Brian; Papagiannakopoulos, Thales; Shearn, Colin T; Arnér, Elias S J; Schmidt, Edward E. 'TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy'. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 116(23):11408-11417 Park, Christopher Yongchul

• Guillamot, Maria; Ouazia, Dahmane; Dolgalev, Igor; Yeung, Stephen T; Kourtis, Nikos; Dai, Yuling; Corrigan, Kate; Zea-Redondo, Luna; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Tikhonova, Anastasia N; Malumbres, Marina; Gong, Yixiao; Tsirigos, Aristotelis; Park, Christopher; Barbieri, Christopher; Khanna, Kamal M; Busino, Luca; Aifantis, Iannis. 'The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation'. Nature immunology. 2019 20(9):1196-1207

• Martin, Gaelle H; Roy, Nainita; Chakraborty, Sohini; Desrichard, Alexis; Chung, Stephen S; Woolthuis, Carolien M; Hu, Wenhuo; Berezniuk, Iryna; Garrett-Bakelman, Francine E; Hamann, J rg; Devlin, Sean M; Chan, Timothy A; Park, Christopher Y. 'CD97 is a critical regulator of acute myeloid leukemia stem cell function'. Journal of experimental medicine. 2019 Pei, Zhiheng

• Brown, Stuart M; Chen, Hao; Hao, Yuhan; Laungani, Bobby P; Ali, Thahmina A; Dong, Changsu; Lijeron,

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Carlos; Kim, Baekdoo; Wultsch, Claudia; Pei, Zhiheng; Krampis, Konstantinos. 'MGS-Fast: Metagenomic shotgun data fast annotation using microbial gene catalogs'. Gigascience. 2019 8(4)

• Yang, Yaohua; Zheng, Wei; Cai, Qiu-Yin; Shrubsole, Martha J; Pei, Zhiheng; Brucker, Robert; Steinwandel, Mark D; Bordenstein, Seth R; Li, Zhigang; Blot, William J; Shu, Xiao-Ou; Long, Jirong. 'Cigarette smoking and oral microbiota in low-income and African-American populations'. Journal of epidemiology & community health. 2019 Possemato, Richard L

• Possemato, R. 'Minding the Ls and Qs'. Nature metabolism. 2019 1(3):308-309 Rapkiewicz, Amy V

• Nizami, Sobia; Morales, Cameron; Hu, Kelly; Holzman, Robert; Rapkiewicz, Amy. 'Trends in Mortality From Human Immunodeficiency Virus Infection, 1984-2016: An Autopsy-Based Study'. Archives of p! athology & laboratory medicine. 2019 Reizis, Boris

• Soni, Chetna; Reizis, Boris. 'Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects'. Frontiers in immunology. 2019 10():1601

• Reizis, Boris. 'The Specificity of Conditional Gene Targeting: A Case for Cre Reporters'. Immunity. 2019 51(4):593-594 [Letter] Rostagno-Ghiso, Agueda A

• Orzechowski, Arkadiusz; CywiÅ„ska, Anna; Rostagno, Agueda A; Rizzi, Federica M. 'Oxidative Stress, Chronic Inflammation, and Amyloidoses'. Oxidative medicine & cellular longevity. 2019 2019():6024975- [Editorial] Ryndak, Michelle B

• Ryndak, Michelle B.; Laal, Suman. 'Mycobacterium tuberculosis Primary Infection and Dissemination: A Critical Role for Alveolar Epithelial Cells'. Frontiers in cellular & infection microbiology. 2019 9

• Sakamuri, Rama Murthy; Singh, Krishna Kumar; Ryndak, Michelle B; Laal, Suman. 'Evolution of antibodies to epitopes of PE_PGRS51 in the spectrum of active pulmonary tuberculosis'. Journal of infectious diseases. 2019 Schwab, Susan R

• Collins, Nicholas; Han, Seong-Ji; Enamorado, Michel; Link, Verena M; Huang, Bonnie; Moseman, E Ashley; Kishton, Rigel J; Shannon, John P; Dixit, Dhaval; Schwab, Susan R; Hickman, Heather D; Restifo, Nicholas P; McGavern, Dorian B; Schwartzberg, Pamela L; Belkaid, Yasmine. 'The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction'. Cell. 2019 178(5):1088-1101.e15 Skok, Jane A

• Lhoumaud P, Badri S, Rodriguez-Hernaez J, Sakellaropoulos T, Sethia G, Kloetgen A, Cornwell M, Bhattacharyya S, Ay F, Bonneau R, Tsirigos A, Skok JA. NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains. Nat Commun. 2019 Oct 24;10(1):4843.

• Saldana-Meyer, Ricardo; Rodriguez-Hernaez, Javier; Escobar, Thelma; Nishana, Mayilaadumveettil; Jácome-López, Karina; Nora, Elphege P; Bruneau, Benoit G; Tsirigos, Aristotelis; Furlan-Magaril, Mayra; Skok, Jane;

Reinberg, Danny. 'RNA Interactions Are Essential for CTCF-Mediated Genome Organization'. Molecular cell. 2019

• Wong, Jason B; Hewitt, Susannah L; Heltemes-Harris, Lynn M; Mandal, Malay; Johnson, Kristen; Rajewsky, Klaus; Koralov, Sergei B; Clark, Marcus R; Farrar, Michael A; Skok, Jane A. 'B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage'. Nature communications. 2019 10(1):4768 Snuderl, Matija

• Cordova, Christine; Syeda, Mahrukh M; Corless, Broderick; Wiggins, Jennifer M; Patel, Amie; Kurz, Sylvia Christine; Delara, Malcolm; Sawaged, Zacharia; Utate, Minerva; Placantonakis, Dimitris; Golfinos, John; Schafrick, Jessica; Silverman, Joshua Seth; Jain, Rajan; Snuderl, Matija; Zagzag, David; Shao, Yongzhao; Karlin-Neumann, George Alan; Polsky, David; Chi, Andrew S. 'Plasma cell-free circulating tumor DNA (ctDNA) detection in longitudinally followed glioblastoma patients using TERT promoter mutation-specific droplet digital PCR assays'. Journal of clinical oncology. 2019

• Hidalgo, Eveline Teresa; Snuderl, Matija; Orillac, Cordelia; Kvint, Svetlana; Serrano, Jonathan; Wu, Peter; Karajannis, Matthias A; Gardner, Sharon L. 'Subgroup-specific outcomes of children with malignant childhood brain tumors treated with an irradiation-sparing protocol'. Child's nervous system: ChNS. 2019

• Rozman, Peter A; Benjamin, Carolina G; Kondziolka, Douglas; Sen, Chandranath; Roland, J Thomas; Zagzag, David; Snuderl, Matija; Gordon, David. 'Intraosseous Petrous Apex Schwannoma: Case Report and Review of Literature'. World neurosurgery. 2019 132():182-187

• Johnson, Tory P; Larman, H Benjamin; Lee, Myoung-Hwa; Whitehead, Stephen S; Kowalak, Jeffrey; Toro, Camilo; Lau, C Christopher; Kim, Juyun; Johnson, Kory R; Reoma, Lauren B; Faustin, Arline; Pardo, Carlos; Kottapalli, Sanjay; Howard, Jonathan; Monaco, Daniel; Weisfeld-Adams, James; Blackstone, Craig; Galetta, Steven; Snuderl, Matija; Gahl, William A; Kister, Ilya; Nath, Avindra. 'Chronic dengue virus encephalitis in a patient with progressive dementia with extrapyramidal features'. Annals of neurology. 2019

• Jour, George; Serrano, Jonathan; Koelsche, Christian; Jones, David T W; von Deimling, Andreas; Allen, Jeffrey; Snuderl, Matija. 'Primary CNS Alveolar Rhabdomyosarcoma: Importance of Epigenetic and Transcriptomic Assays for Accurate Diagnosis'. Journal of neuropathology & experimental neurology. 2019

• Johnson, Tory P.; Larman, H. Benjamin; Lee, Myoung-Hwa; Whitehead, Stephen S.; Kowalak, Jeffrey; Toro, Camilo; Lau, C. Christopher; Kim, Juyun; Johnson, Kory R.; Reoma, Lauren B.; Faustin, Arline; Pardo, Carlos A.; Kottapalli, Sanjay; Howard, Jonathan; Monaco, Daniel; Weisfeld-Adams, James; Blackstone, Craig; Galetta, Steven; Snuderl, Matija; Gahl, William A.; Kister, Ilya; Nath, Avindra. 'Chronic Dengue Virus Panencephalitis in a Patient with Progressive Dementia with Extrapyramidal Features'. Annals of neurology. 2019

• Snuderl, Matija; Dolgalev, Igor; Heguy, Adriana; Walsh, Michael F; Benayed, Ryma; Jungbluth, Achim A; Ladanyi, Marc; Karajannis, Matthias A. 'Histone H3K36I mutation in a metastatic histiocytic tumor of the skull and response to sarcoma chemotherapy'. Cold Spring Harbor molecular case studies. 2019 5(5)

• Richardson, Timothy E; Tang, Karen; Vasudevaraja, Varshini; Serrano, Jonathan; William, Christopher M; Mirchia, Kanish; Pierson, Christopher R; Leonard, Jeffrey R; AbdelBaki, Mohamed S; Schieffer, Kathleen

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

M; Cottrell, Catherine E; Tovar-Spinoza, Zulma; Comito, Melanie A; Boué, Daniel R; Jour, George; Snuderl, Matija. 'GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors'. Journal of neuropathology & experimental neurology. 2019 Suarez, Yvelisse N

• Lim, D; Schulberg, S; Suarez, Y; Gadangi, P. 'Osseous metaplasia in a recurrent symptomatic rectal lesion: a rare occurrence'. International journal of colorectal disease. 2019 34(10):1801-1803 Theise, Neil D

• Khandekar, Gauri; Llewellyn, Jessica; Kriegermeier, Alyssa; Waisbourd-Zinman, Orith; Johnson, Nicolette; Du, Yu; Giwa, Roquibat; Liu, Xiao; Kisseleva, Tatiana; Russo, Pierre A; Theise, Neil D; Wells, Rebecca G. 'Coordinated development of the mouse extrahepatic bile duct: implications for neonatal susceptibility to biliary injury'. Journal of hepatology. 2019 Thomas, Kristen

• Saliba, Jason; Belsky, Natasha; Patel, Ami; Thomas, Kristen; Carroll, William L; Pierro, Joanna. 'From Favorable Histology to Relapse: The Clonal Evolution of a Wilms Tumor'. Pediatric & developmental pathology. 2019 ():1093526619875919 Tsirigos, Aristotelis

• Kloetgen, Andreas; Thandapani, Palaniraja; Tsirigos, Aristotelis; Aifantis, Iannis. '3D Chromosomal Landscapes in Hematopoiesis and Immunity'. Trends in immunology. 2019 40(9):809-824

• Guillamot, Maria; Ouazia, Dahmane; Dolgalev, Igor; Yeung, Stephen T; Kourtis, Nikos; Dai, Yuling; Corrigan, Kate; Zea-Redondo, Luna; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Tikhonova, Anastasia N; Malumbres, Marina; Gong, Yixiao; Tsirigos, Aristotelis; Park, Christopher; Barbieri, Christopher; Khanna, Kamal M; Busino, Luca; Aifantis, Iannis. 'The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation'. Nature immunology. 2019 20(9):1196-1207

• Vougas, Konstantinos; Sakelaropoulos, Theodore; Kotsinas, Athanassios; Foukas, George-Romanos P; Ntargaras, Andreas; Koinis, Filippos; Polyzos, Alexander; Myrianthopoulos, Vassilis; Zhou, Hua; Narang, Sonali; Georgoulias, Vassilis; Alexopoulos, Leonidas; Aifantis, Iannis; Townsend, Paul A; Sfikakis, Petros; Fitzgerald, Rebecca; Thanos, Dimitris; Bartek, Jiri; Petty, Russell; Tsirigos, Aristotelis; Gorgoulis, Vassilis G. 'Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining'. Pharmacology & therapeutics. 2019 ():107395

• SaldaÃffla-Meyer, Ricardo; Rodriguez-Hernaez, Javier; Escobar, Thelma; Nishana, Mayilaadumveettil; Jácome-López, Karina; Nora, Elphege P; Bruneau, Benoit G; Tsirigos, Aristotelis; Furlan-Magaril, Mayra; Skok, Jane; Reinberg, Danny. 'RNA Interactions Are Essential for CTCF-Mediated Genome Organization'. Molecular cell. 2019

• Di Giammartino, Dafne Campigli; Kloetgen, Andreas; Polyzos, Alexander; Liu, Yiyuan; Kim, Daleum; Murphy, Dylan; Abuhashem, Abderhman; Cavaliere, Paola; Aronson, Boaz; Shah, Veevek; Dephoure, Noah; Stadtfeld, Matthias; Tsirigos, Aristotelis; Apostolou, Effie.

'KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks'. Nature cell biology. 2019 21(10):1179-1190 Wang, Jun

• Liu, Di; Lu, Qian; Wang, Xing; Wang, Jun; Lu, Ning; Jiang, Zefei; Hao, Xiaopeng; Li, Jianbin; Liu, Jing; Cao, Pengbo; Peng, Guilin; Tao, Yuandong; Zhao, Dianyuan; He, Fuchu; Tang, Li. 'LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3'. Cell research. 2019 29(5):365-378

• Su, Tina Tianjiao; Gao, Xiaobin; Wang, Jun. 'A Tumor-Localized Approach to Bypass Anti-4-1BB Immuno-Toxicity'. Clinical cancer research. 2019 25(19):5732-5734 [Comment] William, Christopher M

• Richardson, Timothy E; Tang, Karen; Vasudevaraja, Varshini; Serrano, Jonathan; William, Christopher M; Mirchia, Kanish; Pierson, Christopher R; Leonard, Jeffrey R; AbdelBaki, Mohamed S; Schieffer, Kathleen M; Cottrell, Catherine E; Tovar-Spinoza, Zulma; Comito, Melanie A; Boué, Daniel R; Jour, George; Snuderl, Matija. 'GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors'. Journal of neuropathology & ex! perimental neurology. 2019 Wu, Ming

• Der, Evan; Suryawanshi, Hemant; Morozov, Pavel; Kustagi, Manjunath; Goilav, Beatrice; Ranabothu, Saritha; Izmirly, Peter; Clancy, Robert; Belmont, H Michael; Koenigsberg, Mordecai; Mokrzycki, Michele; Rominieki, Helen; Graham, Jay A; Rocca, Juan P; Bornkamp, Nicole; Jordan, Nicole; Schulte, Emma; Wu, Ming; Pullman, James; Slowikowski, Kamil; Raychaudhuri, Soumya; Guthridge, Joel; James, Judith; Buyon, Jill; Tuschl, Thomas; Putterman, Chaim. 'Author Correction: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways'. Nature immunology. 2019 Young, Gloria Q

• Zhang, Qingzhao; Young, Gloria Q.; Yang, Zhaoh! ai. 'Pure Discrete Punctate Nuclear Staining Pattern for MLH1 Protein Does Not Represent Intact Nuclear Expression'. International journal of surgical pathology. 2019 Zagzag, David S

• Cordova, Christine; Syeda, Mahrukh M; Corless, Broderick; Wiggins, Jennifer M; Patel, Amie; Kurz, Sylvia Christine; Delara, Malcolm; Sawag! ed, Zacharia; Utate, Minerva; Placantonakis, Dimitris; Golfinos, John; Schafrick, Jessica; Silverman, Joshua Seth; Jain, Rajan; Snuderl, Matija; Zagzag, David; Shao, Yongzhao; Karlin-Neumann, George Alan; Polsky, David; Chi, Andrew S. 'Plasma cell-free circulating tumor DNA (ctDNA) detection in longitudinally followed glioblastoma patients using TERT promoter mutation-specific droplet digital PCR assays'. Journal of clinical oncology. 2019

• Roland, J Thomas; Zagzag, David; Snuderl, Matija; Gordon, David. 'Intraosseous Petrous Apex Schwannoma: Case Report and Review of Literature'. World neurosurgery. 2019 132():182-187 Zhou, Fang

• Basu, Atreyee; Bocz! ek, Nicole J; Robertson, Nahid G; Nasr, Samih H; Jethanamest, Daniel; McPhail, Ellen D;

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Kurtin, Paul J; Dasari, Surendra; Butz, Malinda; Morton, Cynthia C; Highsmith, W Edward; Zhou, Fang. 'First Report of Bilateral External Auditory Canal Cochlin Aggregates ("Cochlinomas") with Multifocal Amyloid-Like Deposits, Associated with Sensorineural Hearing Loss

and a Novel Genetic Variant in COCH Encoding Cochlin'. Head & neck pathology. 2019

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Featured Publications

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains Priscillia Lhoumaud, Sana Badri, Javier Rodriguez-Hernaez, Theodore Sakellaropoulos, Gunjan Sethia, Andreas Kloetgen, MacIntosh Cornwell, Sourya Bhattacharyya, Ferhat Ay, Richard Bonneau, Aristotelis Tsirigos, Jane A. Skok Nature Communications. 2019 Oct. https://www.nature.com/articles/s41467-019-12811-4

CTCF and cohesin play a key role in organizing chromatin into topologically associating domain (TAD) structures. Disruption of a single CTCF binding site is sufficient to change chromosomal interactions leading to alterations in chromatin modifications and gene regulation. However, the extent to which alterations in chromatin modifications can disrupt 3D chromosome organization leading to transcriptional changes is unknown. In multiple myeloma, a 4;14 translocation induces overexpression of the histone methyltransferase, NSD2, resulting in expansion of H3K36me2 and shrinkage of antagonistic H3K27me3 domains. Using isogenic cell lines producing high and low levels of NSD2, here we find oncogene activation is linked to alterations in H3K27ac and CTCF within H3K36me2 enriched chromatin. A logistic regression model reveals that differentially expressed genes are significantly enriched within the same insulated domain as altered H3K27ac and CTCF peaks. These results identify a bidirectional relationship between 2D chromatin and 3D genome organization in gene regulation.

Concurrent Identification of Novel EGFR-SEPT14 Fusion and ETV6-RET Fusion in Secretory Carcinoma of the Salivary Gland Black, Margaret; Liu, Cheng Z; Onozato, Maristela; Iafrate, Anthony John; Darvishian, Farbod; Jour, George; Cotzia, Paolo. Head & Neck Pathology. 2019 https://www.ncbi.nlm.nih.gov/pubmed/31502214

Salivary gland secretory carcinoma, also termed mammary analogue secretory carcinoma (MASC), is a recently described salivary gland neoplasm with characteristic histomorphologic findings similar to those of secretory carcinoma of the breast and harboring recurrent ETV6-NTRK3 fusions. Recent findings have expanded the molecular profile of salivary gland secretory carcinoma to include multiple novel ETV6 fusion partners, including RET, MET, and MAML3. We report a case of cystic MASC harboring two gene fusions, ETV6-RET and EGFR-SEPT14, identified by targeted RNA sequencing.

ETV6-RET and EGFR–SEPT14 fusions were identified by targeted RNA sequencing with Archer FusionPlex Custom Solid Panel, a next-generation targeted RNA sequencing assay utilizing Anchored Multiplex PCR technology to detect gene fusions and oncogenic isoforms in selected protein-coding exons of 86 genes. The presence of both gene fusions was verified by RT-PCR and Sanger sequencing.

To the best of our knowledge, EGFR–SEPT14 translocation has never been reported in salivary secretory carcinoma and has only previously been reported in glioblastomas, where the EGFR–SEPT14 fusion has demonstrated sensitivity to EGFR inhibition by lapatinib and erlotinib. Both the ETV6–RET and EGFR–SEPT14 fusions may act as oncogenic drivers in the current case of MASC, and simultaneous therapy targeting both fusions may have clinical utility.

This is the first EGFR-SEPT14 fusion reported in secretory carcinoma as a single event or in association with an ETV6 rearrangement. This finding adds to the expanding molecular profile of this tumor entity and may translate into novel treatment strategies. Anchored Multiplex PCR technology enables determination of novel fusion partners and can be used to expand our knowledge of the molecular characteristics of a broad range of pathologic entities.

Jane A. Skok, PhD, Priscillia Lhoumaud, PhD, Jason B Wong, PhD

Cotzia, Paolo, MD and Margaret Black, MD

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

The People Behind the Paper: Christopher Y. Park, MD, PhD and Nainita Roy Bhowmick, PhD

CD97 is a critical regulator of acute myeloid leukemia stem cell function Martin, Gaelle H; Roy, Nainita; Chakraborty, Sohini; Desrichard, Alexis; Chung, Stephen S; Woolthuis, Carolien M; Hu, Wenhuo; Berezniuk, Iryna; Garrett-Bakelman, Francine E; Hamann, J rg; Devlin, Sean M; Chan, Timothy A; Park, Christopher Y. Journal of Experimental Medicine. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31371381 Lay summary of the research study CP&NB: Our studies demonstrate that the cell surface protein CD97 is expressed in nearly all cases of acute myeloid leukemia (AML) and associated with poor clinical outcomes. Since CD97 is required to maintain chemoresistant leukemia stem cells, it is a promising therapeutic target in AML. Current position? CP: Associate Professor, Pathology Department, Director of Pathology Education and Translational Research. NB: Post-doctoral fellow in Dr. Christopher Park’s lab. Can you give us your scientific biography and the questions your lab is trying to answer? CP: The goal of our laboratory is to identify the genes that regulate normal and malignant hematopoietic stem cell self-renewal, differentiation, and chemoresistance. We focus on hematologic cancers that such as acute myeloid leukemia and the myelodysplastic syndromes, and strive to develop improved methods to diagnose, monitor, and treat patients. What is the novelty of your study? CP: Our studies identify CD97 as a novel marker and regulator of leukemic stem cell (LSC) self-renewal in AML. Given its high frequency of expression in AML, CD97 is an excellent candidate therapeutic target.

Can you give us the key results of the paper in a paragraph? CP&NB: CD97 is over-expressed in the vast majority of human AMLs (>95%) and high levels of expression are associated with poor clinical outcome. CD97 promotes blast survival, inhibits differentiation, and is required for LSC self-renewal. Where will this work take the Park lab? CP: We are currently testing the ability of antibodies against CD97 to effectively target and eliminate AML and LSCs in xenograft models using AML patient samples. We eventually hope to identify novel therapeutic antibodies against CD97 that can be used to treat AML patients. How did you come to join the Park lab, and what drives your research? NB: I previously worked on muscle stem cells, investigating the molecular mechanisms regulating their function. I became interested in applying stem cell principles to human disease, and that inspired me to study cancer stem cell self-renewal. This led me to the lab of Dr. Christopher Park, which focusses on identifying genes that regulate leukemia stem cell self-renewal, differentiation and chemoresistance. My long-term goal is to understand the molecular basis of how leukemia stem cells can be targeted more efficiently while sparing normal stem cells. Finally, let's move outside the lab – what do you like to do in your spare time in NYC? CP: Play the piano and sing with my beautiful wife and daughter! NB: I like to run (10K and half marathons) and watch Sci-Fi movies and comics.

Christopher Y. Park, MD, PhD and Nainita Roy Bhowmick, PhD

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Academic Achievements

Grants

Eva Hernando- Monge, PhD ACS-MRA Role of Amyloid beta in Brain Metastasis

Navneet Narula, MD Sub Cornell-K. Min_R01 Patient-Specific Coronary Hemodynamics by 3D Printing-- Resubmission - 1

Richard Possemato, PhD ACS Targeting Cell Cycle and Transformation Specific Metabolic Processes SPORE - CEP Awardee

Ralf Duerr, MD, PhD FDA Genetic Characterization of HIV-1 Strains from Cameroon and Their Implication in HIV Diagnosis

Shruti Naik, PhD V Foundation For Cancer Research Uncovering the role of inflammatory memory in tumorigenesis Whitehead Fellowship for Junior Faculty in Biomedical and Biological Sciences Understanding the influence of in utero inflammation on epidermal stem cells and skin development

Stefan Feske, MD NIH/NCATS R03 Calcium channel CACNB1 in T cell function and immunity

Tsirigos Aristotelis, PhD NYU Perlmutter Cancer Center Developmental Projects Program

Integrated characterization of

histological and molecular tumor

heterogeneity using deep

learning

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Spotlights

Clinical Whole Genome DNA Methylation Profiling Improves the Diagnostics of Brain Tumors

Brain tumors are clinically and biologically highly diverse, encompassing a wide spectrum of diseases. Molecular profiling has established several distinct subgroups within each histological type of tumor. Methylation of CpG dinucleotides is a key epigenetic regulator of gene function during development and disease and DNA methylation can be used for molecular subclassification of brain tumors. In 2014, Snuderl Laboratory and NYU Molecular Pathology and Diagnostics started developing epigenetic DNA methylation based map of brain tumors to improve diagnostics and classification of brain tumors. In April 2019, NYU finished full clinical validation and received regulatory approval for DNA methylation. This is the first clinical test utilizing whole genome DNA methylation and machine learning for diagnostics approved in the CLIA laboratory by the NY State department of Health. Snuderl lab and collaborators created an epigenetic map of all brain cancers and deployed it into the clinic, as the first CLIA laboratory in the world to receive such regulatory approval.

This is a paradigm shifting approach in diagnosing cancer, as we have shown retrospectively that traditional diagnostics has 12-14% of misdiagnosis rate (Figure 1). Consequences of over/under diagnosis in pediatric brain tumors are severe. A wrong diagnosis can lead to wrong treatment including unnecessary radiation, or a wrong chemotherapy regimen with worse than expected survival. Misdiagnosis and grading can also lead to unnecessary overtreatment. Long- term morbidity of radiation and chemotherapy is well-established including secondary cancers, cognitive and IQ decline and neuroendocrine deficits. It must also be noted that unnecessary treatment and unnecessary follow up by MRI or CT scans increase costs of health care. Brain tumors are often difficult to diagnose requiring variety of immunohistochemical and molecular tests, while DNA methylation is one-size-fits-all molecular test that can save time and resources delineating the accurate tumor type with a single test. Accurate diagnostics at the time of presentation can therefore also has a significant potential to reduce healthcare costs. NYU is currently the only CLIA certified lab with clinically validated DNA methylation test and can provide this testing to centers that currently do not have this testing available.

Matija Snuderl, MD

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Spotlights

Celebrating Pathology Trainees at Postdoc Research Day!

Twenty-two postdocs presented their work at the Postdoc Research day on September 25th, and among them seven were Pathology postdocs (pictured left to right): Axel R. Concepcion (Feske lab), Christina Glytsou and Matthew Witkowski (Aifantis lab), Harold Elias (Park lab), Sarah E. LeBoeuf (Papagiannakopoulos lab) Ioanna Tiniakou and Samik Upadhaya (Reizis lab). The event was part of a series of initiatives organized by the Postdoctoral association to celebrate accomplishments and hard work of our postdoctoral fellows during the National Postdoc Appreciation week. Presentation ranged from the characterization of the immune microenvironment in Lymphoblastic Leukemia to the effect of oxidative stress in cancer and Genome-wide analysis of dendritic cell differentiation. Read More View Abstracts View Program

Post-docs presenting. Ioanna Tiniakou (top left), Christina Glytsou (top right), Matthew Witkowsk (bottom left) and Sarah E. LeBoeuf (bottom right)

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

New & Notable

Jun Wang, PhD, New Research Faculty!

Dr. Jun Wang recently joined our group of talented faculty as Assistant Professor in our department. His lab is located on the 3rd floor of Smilow Building. Jun joined NYU after a really productive postdoc in the Chen lab at Yale, where he published remarkable results studying immune suppressors for cancer immunotherapy. We are

thrilled to have him on our team and we are looking forward to seeing his impressive research skills further strengthen our core of talented investigators.

Dr. Wang is currently an assistant professor at Department of Pathology and the Laura and Isaac Perlmutter Cancer Center of NYU Langone Health who has been working on cancer immunology and immunotherapy for over fifteen years. He finished his postdoctoral research in Dr. Lieping Chen’s laboratory at Johns Hopkins Medicine and the Yale Department of Immunobiology, and was promoted as a research faculty and a research member at Yale Cancer Center. While his stay at Yale and Hopkins, he was focused on the characterization the immunological function of novel receptor-ligand pathways and how to best utilize them as potential targets for cancer immunotherapy. He discovered Siglec-15, an immune suppressive molecule highly expressed on tumor cells/tumor-associated macrophages, which represents an unique immune evasion mechanism with mutually-exclusive expression pattern to PD-L1 in human cancers. The related phase I/II clinical trials targeting the Siglec-15 pathway are currently ongoing at Yale and NYU, in addition to other sites, and have showed some promising single agent activities in PD-1 refractory cancers. He also discovered FGL1 as a major and high-affinity ligand for LAG-3, another important T cell inhibitory receptor, and is responsible for LAG-3

immune inhibitory function independent of its canonical ligand---MHC-II. FGL1 was found to be abundant in several human cancers including lung adenocarcinoma, and has important prognostic value for immunotherapy. Moreover, Dr. Wang also examined the mechanisms of anti-tumor efficacy versus liver toxicity of agonistic anti-CD137 (4-1BB) therapy and provided new insights for alleviating liver pathology without disruption of anti-tumor immunity. Those discoveries, along with several genome-scale proprietary screening platforms built by Dr. Wang, led to valuable industrial partnerships, some of which formed the basis of Yale spin-out, NextCure, Inc.

The advent of immunotherapy has revolutionized the current cancer treatment. The durable clinical success of PD-1/PD-L1 blockade illustrates the key concept of targeting immune-evasion mechanisms within the tumor microenvironment to restore tumor-specific immunity. However, given that a substantial subset of patients does not respond to or develop resistance to anti-PD-1/PD-L1 therapy, there is a great unmet need to discover novel mechanisms that enable immune escape and to utilize these pathways to modulate anti-tumor immunity within the tumor-site for cancer immunotherapy.

The Jun Wang laboratory at NYU is interested in further understanding the immunobiology of FGL1/LAG-3, Siglec-15 pathways, and more; developing suitable disease model systems as well as precise biomarkers to facilitate their clinical utilization. In parallel, the Wang Lab is developing more cancer-relevant discovery strategies to identify key pathways responsible for immune evasion within the tumor microenvironment, especially those beyond tumor-T cell interactions.

With the mission of designing innovative therapeutic programs that fine-tunes immunity in the disease lesion for the optimal control of cancer with minimal immune toxicities, the Wang Laboratory is complementary to the vibrant research environment at Department of Pathology, and to the larger NYU Langone Health Community. In collaboration with both basic and clinical researchers at NYU, Dr. Wang’s laboratory will define key immune modulatory pathways and potentially contribute to the next-generation cancer immunotherapies.

Jun Wang, PhD

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

New & Notable

Ion Channels & Immunity (ICI) Program Opens a New Core Facility! Dr. Stefan Feske, Jeffrey Bergstein Professor of Medicine, Vice Chair of the Department of Pathology and Dr. William A. Coetzee, Professor in the Department of Pediatrics, Biochemistry and Molecular Pharmacology, Neuroscience and Physiology, have worked together to open a new Ion Channels & Immunity core facility at NYU Langone Health. The core is part of the new Ion Channel & Immunity (ICI) Program and is meant to facilitate research in the area of ion channel function in immune cells. “Our goal is to understand the basic mechanisms by which ion channels and transporters (ICTs) regulate the function of immune cells and immune responses in infections, tumors, and autoimmune disorders” said Dr. Coetzee, core facility director. “Our vision is to create an interdisciplinary research team where basic science and translational research are fully integrated to facilitate the discovery of new treatment approaches for immune-related disorders” explained Dr. Feske, Director of the Program, speaking about the initiative.

The Ion Channel & Immunity core facility will open in mid-December and will be located on the 4th floor

of the Science Building. It will be available to all investigators of the NYU Langone community and to collaborating investigators within the larger NYC area, regardless whether they have prior experience measuring ion channel function. The core offers several resources such as manual patch clamp facilities, a CytoPatch automated patch clamp system, a Flexstation microplate reader and other equipment. We are currently seeking to hire an experiences electrophysiologist to be the assistant core director. More information about core resources and daily operations can be found here.

The Ion Channel & Immunity program includes a seminar series and an annual symposium that provides a unique opportunity for scientists studying ion channels and transporters in immune cells to discuss their research. The program also features a joint lab meeting to discuss ongoing ion channel-related projects of labs at NYU. More information about the program can be found here.

The ICI program and the Department of Pathology are currently conducting a nationwide search for a scientist at the assistant, associate, or full professor level. We seek candidates with a research background in various aspects of ion channel function and innate or adaptive immunology. The successful candidate will join the Ion Channels and Immunity Program and is expected to participate in program activities. More info on the application process can be found at Ion Channel & Immunity Program - Job Opportunities.

Stefan Feske, MD and William Coetzee, PhD

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Who is New

Nicholas Adams Postdoctoral Fellow Reizis Lab

Wafa Al-Santli Assistant Research Scientist Aifantis Lab

Chidiebere Uzodinma Awah Postdoctoral Fellow Skok Lab

Piotr Konieczny Predoctoral Fellow Naik Lab

Qiao Lu Postdoctoral Fellow Wang Lab

Lichun Weng Research Scientist Gorny Lab

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Alumni News

Diego Acosta-Alvear, PhD Assistant Professor Department of Molecular, Cellular, and Developmental Biology University of California, Santa Barbara daa@lifesci.ucsb.edu Website 1. Position at NYU/supervisor/when position started–ended? DAA: I was a PhD student in the laboratory of Dr. Brian D. Dynlacht from 2003-2008 2. Present position/ when did you start? DAA: I am an Assistant Professor in the Department of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara (UCSB). Is started my lab at UCSB in January of 2017. 3. How did you get where you are today and how did the experience in the pathology department and Hernando lab help you get there? DAA: I got to UCSB after my postdoctoral work in the laboratory of Dr. Peter Walter (UCSF). When I was a PhD student in the laboratory of Brian Dynlacht, I worked with Dr. Alexandre Blais, a postdoc in the lab who identified that transcription factors governing muscle differentiation delegated functions

to stress response transcription factors. One of these transcription factors is known as XBP1. XBP1 is master regulator of the stress response of the endoplasmic reticulum (ER), which is also known as the “Unfolded Protein Response” or UPR. This finding fascinated me and I started wondering, why is XBP1 involved in the developmental program of muscle cells?. This question laid the foundations for my PhD dissertation work in which we found that XBP1 controls different and condition-specific and cell-type specific transcriptional regulatory networks. This work demonstrated that the UPR not only maintains ER functions but also allows cells to make developmental decisions. I became hooked on the UPR, and I got a postdoc position in the laboratory of Peter Walter, who co-discovered the UPR. It was a perfect match. I’ve been fascinated by stress biology and by the UPR ever since. 4. What was the most difficult moment in your scientific career and how were you able to bypass it and succeed? DAA: I have had many difficult moments in my career. I came to the US as an international scholar, so being away from family has always been hard. Learning to deal with frustration was also hard at the beginning. As you mature in your scientific career you discover that perseverance is key and that failure brings opportunities for learning and for growth. My spouse, is also a scientist and an NYU alumna; we have been down the same career path since graduate school. A major difficulty for us to overcome was the “two body problem”. We always saw it more as a “two body opportunity”, and thinking around this issue in a positive way helped us tremendously. We both had successful postdoctoral positions in prestigious labs, and we both managed to obtain faculty positions

at UCSB. It has been a ride with many ups and downs, but I find that there is always something to look forward to, which allows you to bypass difficulties and succeed. 5. What advice would you give a postdoc to find their way? DAA: Do not overlook perseverance. Try to find motivation every day, and in every experiment you do. Science fails most of the time, but when you succeed, you’ve managed to unlock one of Nature’s secrets, and this is the most rewarding feeling one can have as a scientist. Approach your scientific question playfully; there is no recipe for success and there is no substitute for curiosity to drive your creativity. Creative, curiosity-driven science moves the field forward and is essential for carving a successful career.

Jordan Seth Laser, MD Director of Molecular Pathology at Northwell Health Website 1. Position at NYU/supervisor/when position started–ended? JSL: I was an anatomic/clinical pathology resident at NYU Pathology from 2005 to 2009.

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

2. Present position/ when did you start? JSL: Since graduating from NYU Pathology, I was privileged enough to get a molecular genetic pathology fellowship at Mount Sinai School of Medicine. Back in 2009, there were a limited number of molecular pathology fellowships in the country, and only one in NYC. From there, I was hired by Northwell Health based in Long Island NY as the Director of Molecular Pathology. I have been at Northwell Health since July 2010 and have gained additional responsibilities throughout the years. My current positions at Northwell Health include Medical Director of Pathology and Laboratory Medicine at Long Island Jewish Medical Center, Associate Medical Director at Core Laboratories, Senior Director Division of Cytogenetics and Molecular Pathology and Director of the Division of Near Patient Testing. All of these responsibilities has provided opportunities for me to impact the world around me and improve patient care in the inpatient and outpatient environments. 3. How did you get where you are today and how did the experience in the pathology department help you get there? JSL: I think it is pretty intuitive that intelligence and hard work underpin success…..but we are pathologists…..the doctor’s doctor….. we are all intelligent and work hard! What I believe separates someone from the rest of the field is a balanced mixture of risk taking and mentorship. Risk taking certainly can be in excess, so balance is a crucial word. When I refer to risk taking, I refer to pushing yourself into professional situations you may not be entirely comfortable. For example, seeking or accepting a project that stretches your

abilities. I think passion drives success, so when selecting or creating stretch projects/goals for yourself, choose something that is important to you. That passion helps drive you to complete the task at hand. Of course, that has to be balanced with mentorship. Being driven and willing to challenge yourself is even more impactful when you have someone invested in your success. Having a mentor/mentee relationship (be it formal or informal) is important to nourish your inner risk-taker, assist in identifying opportunities, alleviating barriers, and make sure you navigate the organization respectfully and responsibly. When I think of my time as an NYU AP/CP resident, I can think of several attendings that ‘took me under their wing’ and helped develop me into the laboratorian and leader I am today. Thinking back, one of the many special elements of NYU Pathology was that there was really no shortage of mentorship…..to that I am forever grateful. 4. What was the most difficult moment in your scientific career and how were you able to bypass it and succeed? JSL: Professionally, I recall one of the most stressful times was when I became the Medical Director of Pathology and Laboratory medicine at Long Island Jewish Medical Center. That year was full of challenges well beyond ‘typical’ laboratory leadership. Within months, I was faced with a potential union strike of all the laboratory technologists as well as the risk and management of potential Ebola patients. Many support systems helped me overcome these stressful times, some within, some external. Personally, and aligning with my previous comment about risk taking, I like chaos. While

stressful, when able to step back, observe, decide on and implement a tactic/strategy to manage the chaos, there are few moments in a career as satisfying. Another key component to success has always been emotional intelligence, or the ability to recognize, discern, and manage/adjust the emotions of myself and others. Understanding your own emotions and the emotions of those around you can really help you bring a degree of calmness, support and clarity to help achieve your goals or conquer the chaos. Beyond myself, external support systems are critical. I mentioned mentorship before, but I also cannot underestimate the invaluable support of friends and family. As for the doubly challenging time as the new medical director, all of these elements enabled myself and the team to prepare thoroughly, think clearly and implement successful strategies. 5. What advice would you give a trainee to find their way? JSL: I would give advice in two arenas. First, in your professional space, invest in emotional intelligence training, forge meaningful relationships with coworkers all around you and find mentorship. Those elements would be the soil to sprout some passion driven projects. Some of those passion projects you will conquer, some you will fail, but I am a firm believer in opportunity begets opportunity. In your personal space, I would suggest to find an activity that ‘feeds your soul’ and prioritize it. For me, it is nature. Spending time outdoors in the woods is truly nourishing and gives me the strength and clarity to be at the top of my game, both in and outside of work.

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Upcoming Events

Department of Pathology Holiday Party 12/13/2019

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Suggested by You

HHMI - Investigator Program HHMI has announced a competition to select the next group of Investigators to join our community. Applications are due March 18, 2020.

The Hanna H. Gray Fellows Program Supports early career life scientists in academic labs across the U.S. The 2020 competition is currently open.

A diversity Recruitment Event for MSK Scientific Laboratories Held on Monday, January 27, 2020. The application deadline is December 31, 2019.

The Young Scientist Seminars (YSS) Video series produced by iBiology that features early-career scientists giving talks about their discoveries.

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Meet the Team

Caterina Berti, PhD Manager Research Laboratory Operations Caterina.Berti@nyumc.org

Jennifer Molde Residency & Fellowship Program Coordinator Jennifer.Molde@nyumc.org

Stefanie Castanza Administrative Supervisor stefanie.castanza@nyumc.org

Remy Moon Administrative Assistant remy.moon@nyulangone.org

Adrienne Dolginko Program Manager, Education Division adrienne.dolginko@nyumc.org

Ben Zapp Webmaster Ben.Zapp@nyulangone.org

Lyllian Mundo Research Submissions Coordinator Lyllian.Mundo@nyulangone.org

PATHOLOGY DEPARTMENT NEWSLETTER – DECEMBER, 2019

Fun