Pathology 430/826 The Molecular Basis of Disease.
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Transcript of Pathology 430/826 The Molecular Basis of Disease.
Pathology 430/826
The Molecular Basis of Disease
Path 430/826 - 0.5 creditsCourse Coordinator
David Lillicrap
Room 201G Richardson Laboratory
http://clinlabs.path.queensu.ca/path430/
Monday 8.30 – 10.30 am
Room 101 Richardson Laboratory
Will need to start at 8.35 am
Course Format
5 Human Disease Themes
Blood malignancyBleeding diseases
Thrombotic diseasesNeurological disorders
Urological cancer
Course Instructors
Dr. David Lillicrap Coordinator/Anemia/Thrombosis/Bleeding diseases
Dr. Laura Swystun Bleeding diseases/Thrombosis
Dr. Michael Rauh Blood malignancies
Dr. David Good Blood malignancies
Dr. Harriet Feilotter Neurologic disease
Dr. John Rossiter Neurologic disease
Dr. David Berman Urological Cancer
Human Disease Themes
1. Common and rare
2. Inherited and acquired
3. Malignant and benign
4. Different organ systems
Course Objectives
1. To understand the molecular basis of a group of“model” human diseases (molecular pathogenesis).
2. To gain insights into diagnostic and therapeutic strategies for human disease.
Human Disease Pathology/Pathogenesis
Diagnosis of Disease
Treatment of Disease
Central Place of Disease Mechanisms
Human Pathology - Disease
Genetics
ImmunologyBiochemistry
Molecular biologyHistology
Microbiology
Diagnosis and Therapy
Week 1
1. Introduction to Path 430-826/Evaluations/Expectations
2. Introduction to Molecular Medicine/Personalized Medicine
3. A highly prevalent inherited disease – Thalassemia
Week 2
Introductory background to blood malignanciesLymphoma/leukemia
~40 mins - Then 10 min break
Student Presentation #1
20 mins + 15 mins discussion/questions
Week 3
2 X 20 minute students presentations
~15 mins discussion/questions per presentation
Leukemia/Lymphoma - introductory presentation (~30 mins)
Evaluative Components
Path 430 and Path 826
1 oral presentation 30%
1 Term paper 50%
Course Participation 20%
No mid-term or final exam
Term Paper Choice and Format
• 5 paper titles will be distributed just before Reading Week
• 10 pages – double spaced, not including figures/references
• Include at least 1 figure and 15 references
• Return by Monday April 4th 2016 at 4pm.
Path 430
Term Paper Choice and Format
• 1 paper title will be available by Reading Week
• 12 pages – double spaced, not including figures/references
• Include at least 2 figures and 25 references
• Return by Tuesday April 4th 2016 at 4pm.
Path 826
Student Presentations• No longer than 20 mins
• No more than 30 slides
• Focus on• Brief background• Study objectives• Overall study results• Study conclusions• Any study limitations/weaknesses
Do not get distracted/confused by the minutia of results
Better to present a clear representative example from the data - ie. several illustrative graphs or figures
Course Participation
• Expectation that everyone in class has read some of theassigned papers, and can ask relevant questions about the work.
• Each week, every student will be expected to hand to the Course TA, 2 questions pertinent to the papers being presented. Two or three of these questions will be asked during the class.
• In addition, for each paper presentation, two students will be asked at random (everyone will be asked equally over the term)to either comment on a weakness of the work, or to ask the presenter a question.
Course Expectations1. Possession of a good background knowledge of the biological
sciences
2. Show an interest in furthering this knowledge
3. Class involvement –
interest in discussion
responses to questions
4. Demonstrate the ability to communicate scientific knowledge, both orally and in writing, in a clear, precise and succinct manner.