Pasteur Products Catalogue

8/15/2019 Pasteur Products Catalogue

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COCCISTOP SORAL SOLUTION

COMPOSITIONSulfaquinoxaline (as sodium salt) 20 %

PHARMACOTHERAPEUTIC ACTIVITYSulfaquinoxaline is a coccidiostatic sulphonamide acting against thecoccidial metabolism by limiting the action of the paraaminobenzoic acid intheir cells. It is active against the coccidias of the Eimeridae family namelyEimeria acervulina, E. necatrix, E. mitis, E. tenella, E. brunetti of chicks,against E. meleagridis and E. adenoides of turkey poults, and against E.

perforans, E. intestinalis, E. magna of rabbits. Sulphonamides aremetabolised in the liver, being excreted through the kidneys.

INDICATIONSProphylaxis and treatment of all coccidioses found in chicks, turkey poults

and rabbits.Efficient in the treatment of hen and turkey pasteurellosis and pullorumdisease.

ADMINISTRATION AND DOSAGEChicks (5-6 days to 6-10 weeks of age)• Prophylactically: 15 ml in 11 l of drinking water for 2 consecutive days,

followed by 5 days breaks.• Curatively: 45 ml in 22 l of drinking water for 2-3 days, followed by a 3

day break. It is again administered for 2 days at 15 ml in 11 l of drinkingwater followed by a 2-day break, and then by a last treatment with 15 mlin 11 l of drinking water.

Turkey poults (5-6 days to 7 weeks of age)• Prophylactically: 15 ml in 11 l of drinking water for 1 day, followed by 4-

day breaks.• Curatively: 15 ml in 11 l of drinking water in 3 series of 2 consecutivedays each, with 3 days of break in between.

Hens, turkeys (pasteurellosis, pullorum disease)• Curatively: 45 ml in 22 l of drinking water for 3 days. The treatment is

resumed 3 days later at 15 ml in 11 l of drinking water for 2 days.PRECAUTIONS

The concentrations recommended will be observed as to avoidintoxications.The solution will be administered, in hot weather, in the morning drinkingwater; the water consumption will be, for the rest of the day, as usual.The bottle will be shaken before use !

STORAGE At 15-25 oC, protected from light.PACKAGINGBottle of 100, 500, 1000 or 5000 ml.

MANUFACTURER: PASTEUR INSTITUTE, BUCHAREST, ROMANIA


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DEO - VETDISINFECTING DETERGENT

COMPOSITIONCationic tensio-active substance (alkyl C10-C18dimethylbenzylammonium chloride)

4 %Non ionic tensio-active substances up to 100 %

PHARMACOTHERAPEUTIC ACTIVITYThe product is bactericidal, fungicidal and virucidal against a variedmicrobial flora ( Escherichia coli , Aspergillus spp., Penicillium spp.,Saccharomyces cerevisiae , Staphylococcus epidermidis , Staphylococcusaureus , Streptococcus pyogenes , Proteus vulgaris , Shigella spp.,Trichophyton interdigitale , Candida albicans , various viruses).

INDICATIONSCleansing and disinfection of various surfaces (wall and floor tiles,plastics, metal, glass) as to inhibit and eliminate the mould growth andodour respectively.

USES A fresh 2.5 % solution is prepared by dissolving 25 ml in 1000 ml of water.• Cleansing, disinfection, odour removal: The solution is applied on

surfaces by means of a sponge, cloth, or sprayer.• Mould removal: The solution is applied on mouldy walls or floors, allowed

a 30 minutes contact and rinsed in water; a new amount of solution isapplied and left to dry. The application is weekly or whenever the mould

reappears.PRECAUTIONSIt will not be combined with anionic tensio-active substances (commondetergents, soap).It will not be combined with other disinfectants (hydrogen peroxide,sodium hypochlorite) or with strongly alkaline substances.The product ingestion and food contamination will be avoided.The product will be kept out of the reach of children.

STORAGE At 15-25 oC, protected from light.

PACKAGINGPlastic bottle of 1, 2, 5 or 30 l.



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DERMOSEPT OINTMENT

COMPOSITIONIchtyol 10 gZinc oxide 15 gExcipient up to 100 g

PHARMACOTHERAPEUTIC ACTIVITYThe organic and inorganic sulphur in ichtyol ensures the product reducing,antiseptic, keratoplastic and antipruriginous properties. Due to the zincoxide, the product is a good skin protector. Upon performing its adsorbingaction, it slowly solubilises in the acid medium of inflammations becoming

slightly astringent.INDICATIONSTreatment of skin conditions: Burns, chilblains, furunculosis,pododermatites, paronychias, superinfected sores.

ADMINISTRATION AND DOSAGEOnce the affected sites are cleaned, they are thinly applied with theointment 2-3 times a day until lesions remittal.

CONTRAINDICATIONSMucosa, animals that are tar-hypersensitive.

WITHDRAWAL TIMEMeat: 15 days since the last administration on extensive areas.

STORAGE At 2-8 oC.

PACKAGINGTube of 40 g.



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DEXOGENOTIC OILY SUSPENSION

COMPOSITION1 ml contains:Gentamycin (as sulphate) 5 mgDexamethasone 0.85 mg

Albendazole 34 mgPHARMACOTHERAPEUTIC ACTIVITY

The product is antibacterial due to gentamycin that is the most activeantibiotic against the microbial flora present in otites, and anti-

inflammatory due to dexamethasone.INDICATIONS

Dogs, cats: Treatment of auricular acute or chronic inflammatory orallergic conditions.

ADMINISTRATION Auricular instillations: 4-6 drops administered twice a day for 5-6 daysafter the ears are cleaned with OTTO -CLEANS , a cerumenolytic solution.

PRECAUTIONSDogs or cats allergic to one of the components.


PACKAGINGDropper bottle of 20 ml.



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DIAZINOL EXTERNAL ANTIPARASITIC

COMPOSITIONDiazinone emulsifiable concentrate 60 %

PHARMACOTHERAPEUTIC ACTIVITY

Diazinone is a nonsystemic synthetic organophosphoric compound that is parasiticidal againstexternal parasites as it blocks acetylcholine-esterase. Acetylcholine remains unhydrolysed andtherefore accumulates inducing the paralysis of the parasite’s neuromuscular system. Diazinone isa toxicity group III member.

INDICATIONSCattle, sheep, goats, swine: Prophylaxis and control of all ectoparasites (mites, lice, muscids) andof those inducing scabies (the sarcoptic, psoroptic, chorioptic and demodectic ones).

ADMINISTRATION AND DOSAGEThe solution should be prepared and used on the very same day.The treatment is repeated 14 days later in case of need, and 7-9 days since the first dipping in caseof scabietic animals.Cattle• Spraying: 20ml/20 l of water (600 ppm). The entire animal’s body should be sprayed.• Local treatment: 5 ml/l of water (3000 ppm).Sheep, goats• Dipping: 420 ml/1000 l of water (250 ppm). The replenishment is with a 250 ml/200 l of water (750

ppm). The solution height should be 70 and 100 cm for the lambs and young sheep and for theadults respectively. It is essential to maintain the concentration by replenishing when the volumedrops by 10%. The animals should be completely dipped at least once.

• Local treatment: 5 ml/l of water (3000 ppm).• Spraying: 20 ml/20 l of water (600 ppm).Pigs• Spraying: 10 ml/24 l of water (250 ppm).Houses• Spraying: 200 ml/5 l of water/100 m 2 of surface.

CONTRAINDICATIONSIt should not be administered to poultry, cats, young cattle below 6 weeks of age, young sheep lessthan 3 weeks of age and suckling pigs.The animals should not be treated in wet or hot weather.

The sheep within 14 days post shearing, hypothreptic and pregnant animals, those with uncuredshearing-induced wounds and the thirsty ones should not be dipped.

PRECAUTIONSNo copper sulphate or other moisturing agents should be added to the dip.The udder of the suckling ewes, sows and cows should be washed after dipping.The operator should avoid inhaling the vapours when spraying.The antidotes are atropine or toxogonine administered under the veterinarian’s supervision.The product is toxic to poultry, bees and fish.

WITHDRAWAL TIME• Meat: 12 days since the last administration.• Milk: 3 days since the last administration.


PACKAGINGBottle of 500 or 1000 ml.



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DIGESTIMSOLUTION

COMPOSITIONVeratrum extract 15 mlWormwood tincture 15 mlJuniper tincture 15 mlConcentrated hydrochloric acid 12 mlHydromineral excipient up to 100 ml

PHARMACOTHERAPEUTIC ACTIVITYThe product acts on the digestive mucosa (an exciting effect), particularlyin the rumen, reticulum and omasum, leading thus to the intensification orresuming of the gastric compartments movements. Through its action onthe digestive mucosa, it indirectly stimulates rumination and, therefore, thedigestion improvement.

INDICATIONSCattle, sheep, goats: Indigestions induced by the omasum overcharge,chronic atonias of the rumen, reticulum and omasum, hyposecretorydyspepsias.

ADMINISTRATION AND DOSAGEOrally as follows:

• Adult cattle: 25-50 ml diluted in 1 l of water, 2-3 times a day.

• Calves, sheep, goats: 25 ml in 500 ml of water, 1–2 times a day.CONTRAINDICATIONSTraumatic reticulitis, peritonitis, hyperhydrochloridia.


PACKAGINGBottle of 250 or 500 ml.



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DIZENTERPOWDER

COMPOSITIONLincomycin (as hydrochloride) 11 gSpectinomycin (as sulphate) 11 gOxytetracycline (as hydrochloride) 300 gExcipient up to 1 000 g

PHARMACOTHERAPEUTIC ACTIVITYThe lincomycin-spectinomycin combination creates a broad antimicrobialspectrum. Lincomycin is active against Gram-positive bacterial germssuch as Mycoplasma spp., and Brachyspira ( Serpulina, Treponema ) hyodysenteriae . Spectinomycin acts against many Gram-negative and -

positive bacterial species. Oxytetracycline has a broad activity spectrumagainst various Gram-positive and -negative bacteria.INDICATIONS

Prophylaxis and treatment of dysenteriform syndromes and polymicrobialenteropulmonary infections in suckling and young pigs during weaning.The animals’ competence improvement by their health conditionmaintenance.

ADMINISTRATION AND DOSAGEPremixes are performed for the thorough product homogenisation.• Prophylaxis (sucklers, young pigs): 1 kg/t of feed (1 g/kg of feed), daily

for 3-7 days during weaning.• Treatment: 2 kg /t of feed (2 g/kg of feed), daily for 3-7 days.With chronic cases, therapy may be extended to 2-3 weeks.

CONTRAINDICATIONSRuminants, horses, rabbits.

WITHDRAWAL TIMEMeat: 3 days since the last administration.

STORAGE At 20 oC, protected from humidity.

PACKAGINGSachet of 50, 100, 200 or 500 g, or bag of 1 or 25 kg.

MANUFACTURER: PASTEUR INSTITUTE, BUCHAREST, ROMAN


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ECTOCANIGAL EXTERNAL POWDER

COMPOSITION Azamethiphos 1%

PHARMACOTHERAPEUTIC ACTIVITY Azamethiphos acts against ectoparasites by paralysing them and thus notallowing them to feed.

INDICATIONS• Poultry: Control of lice ( Dermanyssus , Lipeurus ) and bed bugs ( Cimex ).• Dogs: Control of fleas ( Ctenocephalus canis ).

ADMINISTRATION• Hens, ducks, geese, pigeons: Powdering, mostly of heavily parasitedareas, after the feathers are grown.

• Dogs: Spraying the depth of the fur (against the fur) in the areasinaccessible to the animal (the nape, the prepectoral area).

The treatment is repeated after 10 days. The houses are powdered aswell.PRECAUTIONS

The food and feed contamination and the powder inhaling should beavoided.

The antidote is, in case of hypersensitive animals, atropine.STORAGE

At 15-25o

C, protected from light.PACKAGINGBottle of 50-100 g.



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ECVIPASTPASTE

COMPOSITION Albendazole 16 gExcipient up to 100 g

PHARMACOTHERAPEUTIC ACTIVITYThrough albendazole, its active ingredient, the product – administeredorally – is readily absorbed in organs and tissues acting against adult andlarval nematodes, and adult cestodes irrespective of their localisation. It isalso active against nematodes eggs (an ovicidal effect).

INDICATIONSHorses: Parascariosis, trichostrongylosis, strongylosis, cestodosis( Anoplocephala ).

ADMINISTRATION AND DOSAGEThe dose is 8 mg of active ingredient/kg or 5 g of ECVIPAST /100 kg of bodyweight.It is administered orally by the mouth commissure, at the tongue basis,taking care that the mouth is free of feed remnants. The bottle contentshould be homogenised before use.

CONTRAINDICATIONSMares during the first month of gestation.

WITHDRAWAL TIMEMeat: 10 days since the treatment.


PACKAGINGPlastic syringe of 30 g.



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ECVIPAST N PASTE

COMPOSITION Albendazole 8 gNeguvon 35 gExcipient up to 100 g

PHARMACOTHERAPEUTIC ACTIVITYThrough albendazole and neguvon, its active ingredients, the product –administered orally – is readily absorbed being active against adult andlarval nematodes and adult cestodes irrespective of their localisation. It isactive against nematodes eggs (an ovicidal effect).

INDICATIONS

Horses infested with Gasterophilus sp. , Oxyuris equi, Parascaris equorum,Strongylus equinus, vulgaris and edentatus, Trichostrongylus axei, Anoplocephala sp.

ADMINISTRATION AND DOSAGEThe dose is 8 mg of albendazole and 35 mg of neguvon/kg of live weightor 10 g of ECVIPAST N /100 kg of live weight.It is administered orally by the mouth commissure, at the tongue basis,taking care that the mouth is free of feed remnants. The bottle contentshould be homogenised before use.

CONTRAINDICATIONSMares during the first month of gestation.

PRECAUTIONS

In case of allergic reactions to neguvon, atropine sulphate is used as anantidote.WITHDRAWAL TIME

Meat: 10 days since the treatment.STORAGE

At 2-8 oC, protected from light.PACKAGING

Plastic syringe of 30 g.



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EFFERVESCENT AND FOAMINGPESSARIES WITH NEOMYCIN AND OXYTETRACYCLINE

VAGINAL TABLETS

COMPOSITIONOne tablets contains:Neomycin 0.25 gOxytetracycline 0.25 gExcipient up to 5.00 g

PHARMACOTHERAPEUTIC ACTIVITYThe association of two antibiotics, i.e. neomycin and oxytetracycline, leads to a

synergetic bacteriostatic and bactericidal action against a large group of Gram-

negative ( Escherichia coli, Shigella, Salmonella, Proteus ) and Gram-positive

germs ( Streptococcus, Staphylococcus, Clostridium , etc.) frequently involved in

the inflammatory processes of the reproductive organs. Due to the foaming and

effervescence, the active ingredients are uniformly dispersed on the utero-

vaginal mucosal surface, readily diffusing into tissues and humours.

INDICATIONSPlacental retentions, uterine and vaginal prolapse, dystocias attended with tissuelesions, various uterine surgeries, cervicites, vaginites, metrites, acute andchronic endometrites.

ADMINISTRATION AND DOSAGEManually, with a forceps or special devices as follows:• Large animals: 4-6 pessaries/day, for 3-4 days.• Medium sized animals: 2-3 pessaries/day, for 2-3 days.• Small animals: 1/2 pessary/day, for 2-3 days.

STORAGE At 2-8 oC, protected from light and humidity.

PACKAGINGBox of 25 or 150 pessaries.



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ENERGOSOL SOLUBLE POWDER

COMPOSITIONSodium chloride 22.10

g Calcium gluconate 2.10 g Monopotassium

phosphate16.20

g Magnesium sulphate 0.10 g Glycocol 34.00

g Glutamic acid 4.20 g Lactose 21.30

gPHARMACOTHERAPEUTIC ACTIVITY

Due to its mineral salts components, the product ensures the intake of themain ions and of water, replacing the losses caused by diarrhoea. Theplastic and energetic elements ensure the intake of nutrients necessary inthe diseased animal diet, and help restore the hydroelectrolytic andmetabolic balance.

INDICATIONSControl of diarrhoea-induced dehydration of animals, particularly when theanimal is on a diet.

ADMINISTRATION AND DOSAGE236 g are dissolved in 10 l of lukewarm water or herbal plant tea, andorally administered by means of the feeding bottle, syringe or in thedrinking water.• Cattle: 5 l of solution in 2-3 portions/calf/day.• Swine: 5-10 ml of solution twice a day for sucklers, and 20 ml of

solution twice a day for young pigs or as directed by the veterinarian.The solution administration is accompanied by a chemotherapeutic or byantibiotics (depending on the case) to control the intestinal infection (oncethe diarrhoea infectious aetiology is determined and the antibiogramperformed).The ENERGOSOL -based diet lasts a few days, depending on the case,without exceeding 5 days however.


PACKAGING Aluminium foil sachet of 50-1000 g, or hydrophobic paper bag/sack of 1-25 kg.



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ENROBACT TABLETS

COMPOSITION1 tablet contains:

Enrofloxacin 15 mgPHARMACOTHERAPEUTIC ACTIVITYEnrofloxacin is a fluoroquinolone of a wide antibacterial spectrum. It inhibits the proteinic synthesisin the bacterial cell. It is active against the microorganisms resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides and macrolides. It is readily absorbed, the maximum plasmatic andtissular concentration being reached 1-2 hours since the oral administration. The highestconcentrations are in the bile, liver, kidneys, lungs and the genitalia. The therapeutic levels are alsofound in bones, the synovial fluid, skin, muscles, aqueous tumors and the pleural fluid. Enrofloxacinand its active metabolites are excreted through the kidneys and the digestive tract. The half life is 4hours, and 24 hours post the last administration no substance is traced any longer in the bloodserum or tissues. Enrofloxacin is active against Escherichia coli, Salmonella sp. , Campylobactersp. , Haemophilus sp. , Pasteurella sp. , Bordetella sp. , Klebsiella sp. , Proteus sp. , Staphylococcusaureus, Streptococcus sp. , Mycoplasma sp. and against enterococci. Although the antibiotic has awide spectrum of action, anaerobes seem to be resistant. A long-term exposure to subtherapeuticdoses may lead to resistance phenomena.

INDICATIONS• Dogs, cats: Treatment of the bacterial infections of the intestinal, respiratory and uro-genital

apparatus, and of skin infections.• Poultry: Prophylactically and curatively in mycoplasmosis, respiratory infections, colibacillosis,

pasteurellosis, avian infectious coryza, salmonellosis and other conditions induced byenrofloxacin-sensitive bacteria.

ADMINISTRATION AND DOSAGEOrally, twice a day, as such or in the feed.Dogs, cats• Enrofloxacin-sensitive germs infections: 1 tablet ⁄ 6 kg of live weight (2.5 mg of enrofloxacin ⁄ kg),

every 12 hours.• Urinary apparatus infections: 1-2 tablets ⁄ 6 kg of live weight (2.5-5.0 mg of enrofloxacin ⁄ kg),

every 12 hours.• Other systemic infections: 1 tablet ⁄ 6 kg of live weight (2.5 mg of enrofloxacin ⁄ kg), every 12

hours.• Pseudomonas aeruginosa infections: 3 tablets ⁄ 6 kg (7.5 mg of enrofloxacin ⁄ kg), every 12 hours.

The treatment lasts 5-10 days depending on the condition severity. Dehydrations will be avoidedduring the treatment.Poultry1 tablet / 1.5 kg of live weight (10 mg of enrofloxacin / kg of live weight / day) administered as suchor mixed in the feed. Dehydrations will be avoided during the treatment.

CONTRAINDICATIONSSmall and medium-sized dogs below 8 months of age and large dogs younger than 18 months, asit may induce changes in the articular cartilages of growing animals. Pregnant animals.It will not be associated with antiacid drugs, aminoglycosides, cephalosporins, broad-spectrumpenicillins, nitrofuran.

WITHDRAWAL TIME

Poultry meat: 7 days since the last treatment.STORAGE


Bottle of 20 or 50 tablets.



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ENROFLOXACIN 2.5% CONCENTRATED ORAL SOLUTION

COMPOSITION1 ml contains:Enrofloxacin 25 mg

PHARMACOTHERAPEUTIC ACTIVITYEnrofloxacin is a chemotherapeutic of the synthetic fluoroquinolonesgroup efficient against Gram-positive bacteria ( Staphylococcus spp.,Clostridium spp., Erysipelothrix rhusiopathiae , Corynebacterium spp.,Streptococcus spp., Bacillus cereus ), Gram-negative ones ( Escherichiacoli , Klebsiella spp., Salmonella spp., Campylobacter spp., Pasteurella spp., Proteus spp., Serratia spp., Yersinia spp., Pseudomonas spp.,Bordetella spp., Moraxella bovis , Haemophilus spp., Vibrio spp.,

Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against themicroorganisms that are resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides, macrolides and antagonists of the folicacid (sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, after the oral administration, and the excretion is throughthe kidneys and bile.

INDICATIONS• Poultry: Mycoplasmosis, bacterial diseases, chronic respiratory

infections, colibacillosis, pasteurellosis, avian infectious coryza,salmonellosis, staphylococcias, hepatites, arthrites.

• Cattle, sheep, goats, swine: Infections of the digestive and respiratorytracts, secondary bacterial infections found in enterites and respiratorydiseases of viral aetiology.

• Dogs, cats: Respiratory, digestive and uro-genital infections, dermatites. ADMINISTRATION AND DOSAGE

Poultry: Daily, in the drinking water.• Bacteria- and mycoplasmas-induced diseases prophylaxy and treatment:

2 ml/l of drinking water for 3 days.• Salmonella infections treatment: 2ml/l of drinking water for 5 days.Cattle, sheep, goats, swine, dogs: Daily, in the drinking water, milk or milkreplacers.• Bacteria- and mycoplasmas-induced diseases prophylaxy and treatment:

1 ml/10 kg of body weight (2.5 mg of enrofloxacin/kg of body weight) for3 days.

• Severe respiratory diseases and Salmonella infections treatment: 1 ml/5kg of body weight for 5 days.

CONTRAINDICATIONSHorses, young dogs up to 12 months of age, lactating or pregnant bitches,dogs formerly diseased with epilepsy.

WITHDRAWAL TIME• Chicken meat: 7 days since the last administration.• Turkey meat: 10 days since the last administration.• Ruminant meat: 7 days since the last administration.• Pork: 5 days since the last administration.


PACKAGINGPolyethylene bottle of 100 or 500 ml, or can of 1 or 5 l.



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ENROFLOXACIN 5% INJECTABLE SOLUTION


PHARMACOTHERAPEUTIC ACTIVITYEnrofloxacin is a chemotherapeutic of the synthetic fluoroquinolonesgroup efficient against Gram-positive bacteria (Staphylococc us sp.,Clostridium spp., Erysipelothrix rhusiopathiae , Corynebacterium spp.,Streptococcus spp., Bacillus cereus ), Gram-negative ones ( Escherichiacoli , Klebsiella spp., Salmonella spp., Campylobacter spp., Pasteurella spp., Proteus spp., Serratia spp., Yersinia spp., Pseudomonas spp.,Bordetella spp., Moraxella bovis , Haemophilus spp., Vibrio spp.,

Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against microorganismsthat are resistant to beta lactamic antibiotics, tetracyclines,aminoglycosides, macrolides and antagonists of the folic acid(sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, and the excretion is through the kidneys and bile.

INDICATIONS• Cattle, sheep, goats, swine: Infections of the digestive and respiratory

tracts, secondary bacterial infections found in enterites and respiratorydiseases of viral aetiology.


• Cattle: 5 ml/100 kg of body weight (2.5 mg/kg of body weight) daily for 3days by the subcutaneous route.

• Sheep, goats: 1 ml/20 kg of body weight (2.5 mg/kg of body weight) dailyfor 3 days by the subcutaneous route.

• Swine: 1 ml/20 kg of body weight (2.5 mg/kg of body weight) daily for 3days by the intramuscular route.Severe respiratory infections or salmonellosis: The dose is doubled andadministered for 5 days.

• Cats, dogs: 1ml/10kg of body weight (5 mg/kg of body weight) daily for 5days by the subcutaneous route.


PRECAUTIONS Amounts higher than 5, 2.5 and 5 ml will not be administered at one site tocattle, pigs and sows respectively.

WITHDRAWAL TIME• Ruminant meat: 7 days since administration.• Pork: 5 days since administration.STORAGE


Brown bottle of 50 or 100 ml.

MANUFACTURER: PASTEUR INSTITUTE, BUCHAREST , ROMANIA


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ENROFLOXACIN 5 TABLETS

COMPOSITION1 tablet contains:Enrofloxacin 5 mg


Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against themicroorganisms that are resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides, macrolides and antagonists of the folicacid (sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, after the oral administration, and the excretion is throughthe kidneys and bile.



• Sheep, goats, swine: Infections of the digestive and respiratory tracts,secondary bacterial infections found in enterites and respiratory diseasesof viral aetiology.


In the feed, as such or broken, to poultry, pigs, dogs and cats.The daily dose is 1 tablet/kg of body weight (5 mg/kg of body weight)administered for 5 days.

CONTRAINDICATIONSHorses, young dogs up to 12 months of age, lactating or pregnant bitches,dogs formerly diseased with epilepsy.It is antagonistic to chloramphenicol, macrolide antibiotics, tetracyclinesand nonsteroid anti-inflammatories.

WITHDRAWAL TIME• Chicken meat: 7 days since the last administration.• Turkey meat: 10 days since the last administration.

• Pork: 5 days since the last administration.STORAGE At 15-25 oC, protected from light and humidity.

PACKAGINGPolyethylene bottle of 50 tablets.



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ENROFLOXACIN 10%CONCENTRATED ORAL SOLUTION



Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against themicroorganisms that are resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides, macrolides and antagonists of the folic

acid (sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, after the oral administration, and the excretion is throughthe kidneys and bile.



• Cattle, sheep, goats, swine: Infections of the digestive and respiratorytracts, secondary bacterial infections found in enterites and respiratorydiseases of viral aetiology.


Poultry: Daily, in the drinking water.• Bacteria- and mycoplasmas-induced diseases prophylaxy and treatment: 2

ml/l of drinking water for 3 days.• Salmonella infections treatment: 2ml/l of drinking water for 5 days.Cattle, sheep, goats, swine, dogs: Daily, in the drinking water, milk or milkreplacers.• Bacteria- and mycoplasmas-induced diseases prophylaxy and treatment: 1

ml/20 kg of body weight (5 mg of enrofloxacin/kg of body weight) on day 1,and half this dose during the following 4 days.


WITHDRAWAL TIME• Chicken meat: 7 days since the last administration.• Turkey meat: 10 days since the last administration.• Ruminant meat: 7 days since the last administration.• Pork: 5 days since the last administration.STORAGE


Polyethylene bottle of 100 or 500 ml, or can of 1 or 5 l.



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ENROFLOXACIN 10% INJECTABLE SOLUTION



Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against themicroorganisms that are resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides, macrolides and antagonists of the folicacid (sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, and the excretion is through the kidneys and bile.

INDICATIONS• Cattle, sheep, goats, swine: Infections of the digestive and respiratory

tracts, secondary bacterial infections found in enterites and respiratorydiseases of viral aetiology.


• Cattle: 2.5 ml/100 kg of body weight (2.5 mg/kg of body weight) daily for3 days by the subcutaneous route.

• Sheep, goats: 2.5 ml/100 kg of body weight (2.5 mg/kg of body weight)daily for 3 days by the subcutaneous route.

• Swine: 2.5 ml/100 kg of body weight (2.5 mg/kg of body weight) daily for3 days by the intramuscular route.Severe respiratory infections or salmonellosis: The dose is doubled andadministered for 5 days.

• Cats, dogs: 1ml/20kg of body weight (5 mg/kg of body weight) daily for 5days by the subcutaneous route.


PRECAUTIONS Amounts higher than 5, 2.5 and 5 ml will not be administered at one site tocattle, pigs and sows respectively.

WITHDRAWAL TIME• Ruminant meat: 7 days since administration.• Pork: 5 days since administration.STORAGE


Brown bottle of 50 or 100 ml.



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Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against the

microorganisms that are resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides, macrolides and antagonists of the folicacid (sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, after the oral administration, and the excretion is throughthe kidneys and bile.




• Dogs, cats: Respiratory, digestive and uro-genital infections, dermatites. ADMINISTRATION AND DOSAGEIn the feed, as such or broken, to poultry, pigs, dogs and cats.

The daily dose is 1 tablet/5 kg of body weight (5 mg/kg of body weight)administered for 5 days.


WITHDRAWAL TIME• Chicken meat: 7 days since the last administration.• Turkey meat: 10 days since the last administration.• Pork: 5 days since the last administration.


PACKAGINGPolyethylene bottle of 50 tablets.



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Actinobacillus spp., Bacteroides spp., Brucella spp.) and mycoplasmas(Mycoplasma spp.). Enrofloxacin is active mainly against the

microorganisms that are resistant to beta lactamic antibiotics,tetracyclines, aminoglycosides, macrolides and antagonists of the folicacid (sulphonamides, trimethoprim). The absorption and distribution in thetissues are rapid, after the oral administration, and the excretion is throughthe kidneys and bile.




• Dogs, cats: Respiratory, digestive and uro-genital infections, dermatites. ADMINISTRATION AND DOSAGEIn the feed, as such or broken, to poultry, pigs, dogs and cats.The daily dose is 1 tablet/10 kg of body weight (5 mg/kg of body weight)administered for 5 days.


WITHDRAWAL TIME• Pork: 5 days since the last administration.

STORAGE At 15-25 oC, protected from light and humidity.PACKAGING

Polyethylene bottle of 30 tablets.



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EQVAMEC P ANTIPARASITIC PASTE

COMPOSITION1 ml contains:Ivermectin 20 mg

PHARMACOTHERAPEUTIC ACTIVITYIvermectin is active against endo- and ectoparasites of horses. Itstimulates, in nematodes, the gamma aminobutyric acid (GABA)production, thus interrupting the nervous influx transmission to thenervous junctions, paralysing and killing the parasite. In arthropods,ivermectin interrupts the nervous influx in the neuromuscular synapseinducing the parasite’s paralysis and death.

INDICATIONSProphylaxis and treatment of the following parasitoses induced by:• Nematodes: Gastrointestinal ( Strongylus vulgaris, Strongylus edentatus,

Strongylus equinus, Strongylus bidentatus, Triodontophorus spp .,Oxyuris equi, Cyathostomum spp. ), peritoneal (Setaria equina), ocularand cutaneous (Habronema spp.), bronchopulmonary ( Dictyocaulusarnfieldi ), cervical and tendinous ones ( Onchocerca cervicalis,Onchocerca reticulata ).

• Larval insects : Rhinoestrus purpureus , Gasterophilus spp. ADMINISTRATION AND DOSAGE

1 ml of paste/100 kg of body weight (20 mg of ivermectin/100 kg of bodyweight) is administered per os.The syringe is as deeply as possible introduced into the horse’s interdentalspace of the buccal cavity, placing the drug at the tongue basis. Theanimal’s head is lifted for a few seconds immediately post administration.Foals may be treated starting with 6-8 weeks of age.

SIDE EFFECTSThe recommended doses have a very wide margin of protection foranimals.No side effects have been noticed in pregnant mares, studs or young

horses.PRECAUTIONS

Before the paste administration, care should be taken for the buccal cavityto be free from any feeds.It should not be administered to other species.The hands should be washed immediately after handling the paste.There should be no eating or smoking during the paste handling.The eye contact should be avoided.It should be kept out of the reach of children.

WITHDRAWAL TIMEMeat: 14 days since the last treatment.


PACKAGINGPlastic syringe of 6 ml.



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EVOMEC INJECTABLE SOLUTION

COMPOSITIONIvermectin 1%

PHARMACOTHERAPEUTIC ACTIVITYIvermectin acts against the endo- and ectoparasites of cattle, sheep andswine.

INDICATIONS• Cattle: Gastrointestinal (larvae and adults) and pulmonary nematodes,

agents inducing myases and scabies, malophagus lice, mites.• Sheep: Gastrointestinal and pulmonary nematodes, agents inducing

scabies.• Pigs: Gastrointestinal, pulmonary and renal nematodes, lice, scabies

inducing agents. ADMINISTRATION AND DOSAGE

Strictly subcutaneously at various animal species- and weight-dependentdoses:• Cattle: 1 ml (10 mg of ivermectin)/50 kg of live weight.• Sheep: 0.5 ml/25 kg of live weight.• Pigs: 1ml/33 kg of live weight.

The treatment programme recommended for swine:• Breeders (the treatment frequency depends on the exposure to the

infestation):• Sows: 7-14 days before farrowing.• Gilts: 7-14 days before both service and farrowing.• Boars: Twice a year.

• Fatteners: The pigs being transferred to fattening units should betreated before being introduced into clean boxes.

CONTRAINDICATIONSIt should not be inoculated intramuscularly or intravenously.

PRECAUTIONSIn a parasites control programme, it is important that all the animals betreated.It should be kept out of the reach of children.

WITHDRAWAL TIME• Meat: 28 days since the last treatment.• Milk: 28 days since the last treatment.


PACKAGINGBottle of 10, 20, 50, 100 or 500 ml.



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FENAZONTABLETS

COMPOSITION1 tablet contains:Dexamethasone 0.2 mgPheniramine (as maleate) 14 mgBiotin 0.25 mgMethionine 0.4 mg

PHARMACOTHERAPEUTIC ACTIVITYDexamethasone is a potent anti-inflammatory of prolonged action (36-72hours), while pheniramine is an antihistaminic efficient in preventing andtreating allergies of various aetiologies. Biotin (vitamin H) and methioninehave a trophic action on the epidermis and pilous follicles facilitating theirintegrity restoration.

INDICATIONSDogs, cats: Allergic dermatites of various aetiologies (feed, contactectoparasites).

Adjuvant in the treatment of external otites due to its anti-inflammatory andantihistaminic components.

ADMINISTRATION AND DOSAGEOrally, as such or mixed in the feed: 1 tablet/8-10 kg of body weight/dayfor 3-8 days.

CONTRAINDICATIONSDiabetes mellitus, osteoporosis, gestation, glaucoma, very old animals,kidney and heart diseases, obstruction of the bile ducts.

STORAGE At 15-25 oC, protected from humidity.

PACKAGINGBottle of 20 or 50 tablets.



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FTALIPEPS 50 mg TABLETS

COMPOSITION1 tablet contains:Phthalylsulfathiazole 50 mgPepsin 10 mg

PHARMACOTHERAPEUTIC ACTIVITYPhthalylsulfathiazole is a sulphonamide active against the bacteria in thedigestive tract – colibacilli in particular – susceptible to inducegastroenterites. Its absorption is reduced; however, it releases – throughhydrolysis – sulfathiazole that plays a role in the control of the infectionslocalised in the digestive tract. Pepsin is a proteolytic enzyme commonlyfound in the stomach. The product permits the deficiency of pepsinendogenous secretion to be compensated, and facilitates the normalgastric digestion.

INDICATIONS• Dogs, cats: Treatment of gastroenterites.• Dogs: Ulcerative colites.

ADMINISTRATION AND DOSAGEThe tablets are administered as such or triturated and mixed in the feed.Dose: 1 tablet/5 kg of live weight, twice a day, for 3-5 days depending onthe disease course.

CONTRAINDICATIONSKidney or liver insufficiency, sensitivity to sulphonamides.


PACKAGINGBottle of 25 or 50 tablets.



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FTALIPEPS 250 mg TABLETS

COMPOSITION1 tablet contains:Phthalylsulfathiazole 250 mgPepsin 100 mg

PHARMACOTHERAPEUTIC ACTIVITYPhthalylsulfathiazole is a sulphonamide active against the bacteria in thedigestive tract – colibacilli in particular – susceptible to inducegastroenterites. Its absorption is reduced; however, it releases – throughhydrolysis – sulfathiazole that plays a role in the control of the infectionslocalised in the digestive tract. Pepsin is a proteolytic enzyme commonly

found in the stomach. The product permits the deficiency of pepsinendogenous secretion to be compensated, and facilitates the normalgastric digestion.

INDICATIONSTreatment of gastroenterites of all species irrespective of age. Also,preventively in clinically healthy animals in populations where digestiveconditions are present.

ADMINISTRATION AND DOSAGEThe tablets are administered as such or triturated and mixed in water, tea,milk or grists. Preferably, the treatment should be individual.Dose: 1 tablet/5 kg of live weight, twice a day for 3-5 days depending on

the disease course.CONTRAINDICATIONSKidney or liver insufficiency, sensitivity to sulphonamides.

WITHDRAWAL TIME• Meat, organs: 14 days since the last administration.• Milk: 4 days since the last administration.


PACKAGINGBottle of 25 tablets.



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GENTAMYCIN 5%INJECTABLE SOLUTION

COMPOSITION1 ml contains:Gentamycin sulphate 50 mg

PHARMACOTHERAPEUTIC ACTIVITYGentamycin is a bactericidal antibiotic of the aminoglycosides group beingactive both in the germs multiplication and non multiplication phases. Itsactivity spectrum is relatively wide including Gram-positive and -negativegerms [ Enterobacter aerogenes, Escherichia coli, Pasteurella spp .,Pseudomonas aeruginosa, Serratia spp ., Campylobacter coli, Brachyspira(Serpulina, Treponema) hyodysenteriae ], and mycoplasmas ( Mycoplasmaspp.).

INDICATIONSCattle, horses, sheep, goats, swine, dogs, cats, poultry: Prophylaxy andtreatment of respiratory, gastrointestinal and uro-genital infections,septicaemias, arthrites, pyoarthrites, meningites, metrites, mastites anddermatites.

ADMINISTRATION AND DOSAGE• Horses, cows: 8ml/100 kg of live weight, intramuscularly.• Calves, donkeys, swine: 4.0 ml/50 kg of live weight, intramuscularly.• Dogs, cats, piglets: 0.4ml/5 kg of live weight, intramuscularly,

subcutaneously or intravenously.• Poultry: 0.04 ml/kg of live weight, subcutaneously.

0.1 ml/kg of live weight, orally.

The administration is 12 hours apart for 3-5 days.CONTRAINDICATIONS Animals with renal diseases or intolerance to antibiotics, pregnantfemales.Concomitantly with other aminoglycoside antibiotics, anaesthetics ormyorelaxants.The chloramphenicol-associated administration, and the administration ofgentamycin with other antibiotics such as ampicillin, carbenicillin,cephalosporins, erythromycin, or with sulphonamides, the vitamin Bcomplex or heparin in the same syringe should be avoided.



PACKAGINGBottle of 20, 50 or 100 ml.



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GENTAMYCIN 10 % HYDROSOLUBLE POWDER

COMPOSITION1 g contains:Gentamycin (as sulphate) 100 mg

PHARMACOTHERAPEUTIC ACTIVITYGentamycin is a bactericidal antibiotic of the aminoglycosides group beingactive both in the germs multiplication and non multiplication phases.Upon its oral administration, the resorption in the digestive tract isnonsignificant and the excretion is active and mainly via the kidneys. Itsactivity spectrum is relatively wide including Gram-positive and -negativegerms [ Enterobacter aerogenes, Escherichia coli, Pasteurella spp .,Pseudomonas aeruginosa, Serratia spp ., Campylobacter coli, Brachyspira(Serpulina, Treponema) hyodysenteriae ], and mycoplasmas ( Mycoplasmaspp.).

INDICATIONSProphylaxis and treatment of the digestive tract bacterial infections(gastrites, enterites, dysenteries, enterocolites of piglets and calves)induced by gentamycin sensitive germs.

ADMINISTRATION AND DOSAGE• Swine: 5 g/10 l of drinking water/day (5 g/100 kg of body weight/day).

For a constant therapeutic level, the daily dose is divided into two andadministered 12 hours apart or ad libitum . In dysentery, 11-22 g will bedissolved in 100 l of drinking water and administered as above-mentioned. Should the water consumption be higher on account of

microclimatic conditions, the dose will be adequately adapted. Thetreatment lasts 3-5 days.• Young cattle : 5 g/100 kg of body weight administered twice on day I and

4g/100 kg of body weight administered once a day during the followingdays. The treatment lasts 3-5 days.

• Poultry : 5 g/100 l of drinking water for 5-7 days, administered ad libitum .CONTRAINDICATIONS

Gentamycin-hypersensitive animals.Concomitantly with chloramphenicol.



PACKAGINGPolyethylene sachet of 50, 100 or 1000 g, or paper sack of 20 kg.



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GENTAMYCIN 10% INJECTABLE SOLUTION

COMPOSITION1 ml contains:Gentamycin (as sulphate) 100 mg

PHARMACOTHERAPEUTIC ACTIVITYGentamycin is a bactericidal antibiotic of the aminoglycosides group beingactive both in the germs multiplication and non multiplication phases. Itsactivity spectrum is relatively wide including Gram-positive and -negativegerms [ Enterobacter aerogenes, Escherichia coli, Pasteurella spp .,Pseudomonas aeruginosa, Serratia spp ., Campylobacter coli, Brachyspira(Serpulina, Treponema) hyodysenteriae ], and mycoplasmas ( Mycoplasmaspp.).

INDICATIONS

Cattle, horses, sheep, goats, swine, dogs, cats, poultry: Prophylaxy andtreatment of respiratory, gastrointestinal and uro-genital infections,septicaemias, arthrites, pyoarthrites, meningites, metrites, mastites anddermatites.

ADMINISTRATION AND DOSAGE• Horses, cows: 4ml/100 kg of live weight, intramuscularly.• Calves, donkeys, swine: 2 ml/50 kg of live weight, intramuscularly.• Dogs, cats, piglets: 0.2ml/5 kg of live weight, intramuscularly,

subcutaneously or intravenously.• Poultry: 0.02 ml/kg of live weight, subcutaneously.

0.1 ml/ 50 kg of live weight, orally.CONTRAINDICATIONS

Animals with renal diseases or intolerance to antibiotics, pregnantfemales.Concomitantly with other aminoglycoside antibiotics, anaesthetics ormyorelaxants.The chloramphenicol-associated administration, and the administration ofgentamycin with other antibiotics such as ampicillin, carbenicillin,cephalosporins, erythromycin, or with sulphonamides, the vitamin Bcomplex, heparin in the same syringe should be avoided.


STORAGE At 15-25 oC, protected from light.PACKAGING

Bottle of 20, 50 or 100 ml.



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GENTOCIN DOSER ORAL SOLUTION


PHARMACOTHERAPEUTIC ACTIVITYGentamycin is a bactericidal antibiotic of the aminoglycosides group beingactive both in the germs multiplication and non multiplication phases.Upon its oral administration, the resorption in the digestive tract isnonsignificant and the excretion is active and mainly via the kidneys. Itsactivity spectrum is relatively wide including Gram-positive and -negativegerms [ Enterobacter aerogenes, Escherichia coli, Pasteurella spp .,Pseudomonas aeruginosa, Serratia spp ., Campylobacter coli, Brachyspira(Serpulina, Treponema) hyodysenteriae ], and mycoplasmas ( Mycoplasmaspp.).

INDICATIONSPiglets (the first days of life): Prophylaxis and treatment of gastroenteritesinduced by Escherichia coli and other bacteria sensitive to gentamycin.

ADMINISTRATION AND DOSAGE1 ml (5 mg of gentamycin) is orally and daily administered with the pumpspray or a graduated syringe.Should the symptoms not disappear after the first day, the administrationwill be repeated the next day.

CONTRAINDICATIONSPiglets older than a few days.

PRECAUTIONSIt should not be kept within the reach of children.



PACKAGINGPlastic bottle of 100 ml.



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GENTOCIN OPHTHALMIC OPHTHALMIC SOLUTION


PHARMACOTHERAPEUTIC ACTIVITYGentamycin is a bactericidal antibiotic of the aminoglycosides group beingactive both in the germs multiplication and non multiplication phases. Itsspectrum is relatively large, including the Gram-positive and -negativegerms. It is very efficacious against the primary and secondary ocularinfections, particularly against those induced by betalactamic antibiotics-resistant bacteria.

INDICATIONSTreatment of ocular infections such as conjunctivites, keratites,keratoconjunctivites, corneal ulcers, blepharites andblepharoconjunctivites. Prophylaxis of traumata and ophthalmic surgery.

ADMINISTRATION AND DOSAGE1-2 drops are applied into the conjunctival sac 4 hours apart (or, 1-2 hoursin severe infections).The treatment will not exceed 7-10 days.

CONTRAINDICATIONSGentamycin- or other aminoglycoside antibiotics-allergic animals.

SIDE EFFECTS

The long term treatment may favour fungal superinfections.Occasionally, it may induce local irritations or allergic reactions.STORAGE


Bottle of 7.5 ml.



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GENTOCIN OTIC OTIC SOLUTION

COMPOSITIONGentamycin (as sulphate) 0.3 gDexamethasone 0.1 g

PHARMACOTHERAPEUTIC ACTIVITYGentamycin, an aminoglycoside antibiotic, is active against Gram-positive(staphylococci, streptococci, pneumococci) and Gram-negative germs(colibacilli, Proteus , pyocyanic bacillus, salmonellas). Dexamethasone, apotent gluco-corticoid, confers the product anti-inflammatory andantiallergic properties.

INDICATIONSDogs, cats: Polymicrobial external otitis resistant to the treatment withother antibiotics.

ADMINISTRATIONThe ear is cleaned with OTTO -CLEANS , a cerumenolytic solution, and theninstilled with GENTOCIN OTIC into the external auditory meatus. The earbasis is then slightly massaged for a good drug diffusion into the auditorymeatus.2-4 drops are administered every 4 hours.With severe infections, the same dose is administered every hour.

CONTRAINDICATIONS Animals hyperallergic to one of the product components.


PACKAGINGDropper bottle of 7.5 ml.



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GERMOSTOP ANTIMASTITIS ANTIMICROBIAL SOLUTION

COMPOSITIONChlorhexidine digluconate 5 gGlycerine 40 mlExcipient up to 100 ml

PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine digluconate is a bisbiguanide derivative of a broadantibacterial spectrum including Gram-positive ( Staphylococcus aureus,Streptococcus spp.) and Gram-negative germs ( Escherichia coli,Pseudomonas aeruginosa , etc.). The germ colonisation in the milk pellicleremaining at the galactophorus duct entry is mainly prevented. Theproduct is well tolerated.

INDICATIONSProphylaxis of cow mastitis.

ADMINISTRATIONThe udder and the mamillae are washed with a solution of 1 part of theproduct in 9 parts of potable water prepared upon the administration.

At least 3 cm of the length of each mamilla are immersed into the solution.The treatment will be applied immediately after each milking.During the dry period, the mamillae will be immersed into the solutiononce a day for 3-4 more days.

For the preparation of a solution amount for one week, distilled ordeionised water is recommended.

PRECAUTIONSThe solution should not be used undiluted.The contact with the eyes and conjunctival mucosa should be avoided.The product ingestion and food contamination should be avoided.


PACKAGINGPlastic bottle of 200, 1000 or 5000 ml.



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GERMOSTOP BUCCAL ANTISEPTIC AND DEODORISING SOLUTION

COMPOSITIONChlorhexidine digluconate 0.1 %

PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine digluconate is a bisbiguanide derivative having a wideantibacterial spectrum including Gram-positive and -negative germs(Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus ). Italso decontaminates the gingivae and buccal mucosa by diminishing thelive microorganisms counts. The tensio-active substances and glycerinedo not irritate the buccal mucosa and gingivae, while the mint oil confers afresh pleasant odour.

INDICATIONSDogs, cats: Buccal hygiene, gingival conditions, prevention of the dentalplaque, mouth health maintenance by feed residues elimination, apleasant mouth odour.

USESIt may be applied by rinsing or brushing.

A small amount is sprayed into the space between the gingivae and teeth,and the lips are massaged by pressing them against the teeth for theproduct to be displayed all over the teeth surface.The teeth are gently brushed with a tooth brush, with rewetting whenevernecessary for a thorough cleaning.

PRECAUTIONSThe contact with the eyes and conjunctival mucosa should be avoided.The long-term use of chlorhexidine products may stain the teeth. Thesolution application with a tooth brush may prevent it.


PACKAGINGPlastic sprayer bottle of 200 ml.



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GERMOSTOP DERMATOLOGICAL ANTIMICROBIAL EMULSION OINTMENT

COMPOSITIONChlorhexidine digluconate 1 %

PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine digluconate is a bisbiguanide derivative of a wideantibacterial spectrum that includes numerous species of Gram-positiveand -negative germs, fungi and viruses. It acts quickly and hasantimicrobial properties without inducing side effects such as the tissularretention. It has a long-acting effect, and ensures the treated woundantimicrobial protection.

INDICATIONSDogs, cats, horses: Treatment of superficial wounds.

USESThe area of interest is cleaned, the bottle is shaken and then the woundsurface is entirely and daily applied with the product until recovery.

CONTRAINDICATIONSDeep wounds.

PRECAUTIONSThe bottle should be agitated before use.The contact with the eyes and conjunctival mucosa should be avoided.It should be kept out of the reach of children.


PACKAGINGPlastic dropper bottle of 30 ml.



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GERMOSTOP FOR MEDICAL INSTRUMENTSCONCENTRATED SOLUTION

COMPOSITIONChlorhexidine digluconate 10 %PHARMACOTHERAPEUTIC ACTIVITY

Chlorhexidine digluconate is antibacterial against Gram-positive ( Bacillusspp ., Clostridium spp ., Micrococcus spp ., Staphylococcus spp .,Streptococcus spp .), and Gram-negative germs ( Aeromonas aerogenes,Enterobacter cloacae, Escherichia coli, Klebsiella spp ., Pseudomonasspp ., Salmonella spp ., Proteus spp .) and fungi (Aspergillus spp .,Microsporum spp ., Candida spp .). The 0.05-0.1% chlorhexidinedigluconate concentration has a virucidal effect on the viruses tested: DNAviruses with a pericapside (bovine alphaherpesvirus) and without one

(type 3 Mastadenovirus), RNA viruses with a pericapside (type 3Paramyxovirus and Coronavirus) and without one (the infectious bursaldisease virus).

INDICATIONSWhenever the short-term (10-15 minutes) cold sterilisation of medicalinstruments of various materials (rubber, plastic, metal) is needed.

USESThe well washed instruments are 15 minutes immersed into the 0.5%solution obtained by diluting 1 part of the concentrated solution in 19 partsof water.In case the instruments were not well washed or in emergencies, the

instruments are immersed for minimum 10 minutes in the 1% solutionobtained by diluting 1 part of the concentrated solution in 9 parts of water.The instruments need not be rinsed after sterilisation as the sterilisationsolution possibly remaining on them does not negatively influence thewounds course and does not harm the surgeons’ hands.

PRECAUTIONSThe contact with the eyes and conjunctival mucosa should be avoided.Should an accidental contact occur, a water flush will be used for rinsing.It should be kept out of the reach of children.

REMARKSIt does not attack suture materials and it is not corrosive for metals.

STORAGE At 15-25 oC, protected from light.PACKAGING

Plastic bottle of 200, 1000 or 5000 ml.



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GERMOSTOP FOR THE UDDER CONCENTRATED DISINFECTING SOLUTION


PHARMACOTHERAPEUTIC ACTIVITYThe product combines the wash action of the tensio-active substanceswith the complex antimicrobial effect of chlorhexidine digluconate,ensuring a clean sterile udder and mamillae surface before milking. Theconsistent disinfection application leads to the mammary glanddecontamination, to the milk microbial burden reduction.

INDICATIONSPrevention of the mammary gland infection and milk contamination.

USES A fresh dilute solution will be prepared before each milking by introducing30 ml (cca 2 spoonfuls) of the concentrated solution into 5 l of water.

A clean paper napkin is wetted with the dilute solution and then used towash the udder and mamillae, that are afterwards wiped with a clean drypaper napkin and coupled to the milking device.The udder and mamillae should be washed before each milking.

PRECAUTIONSThe solution will not be used undiluted.The solution will not be used to wash the milking equipment.

The contact with the eyes and conjunctival mucosa should be avoided.It should be kept out of the reach of children.





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GERMOSTOP HEXASOL SCRUB ANTISEPTIC LIQUID SCRUB


PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine gluconate is a bisbiguanide derivative having a wideantibacterial spectrum that includes many species of Gram-positive and -negative bacteria, and fungi. Due to its tensio-active and protectivecomponents, the product is not irritant, and it does not change thesuppleness, elasticity, turgor and colour of the skin, or the tactilesensitivity.

INDICATIONSPre- and post-operative asepsia and antisepsia of the hands, surgicalarea, superficial wounds on a restricted surface. Whenever a cleansingwith antimicrobial effect is necessary. Routine hygienisation anddecontamination.

USES• Pre-operative hands washing: 5 ml for cca 3 minutes, followed by

another 5 ml for another 3 minutes. Finally, the hands are rinsed in waterand dried.

• Pre-operative surgical area washing: 1-5 ml are applied with the spongeuntil a rich foaming is obtained. The foam is allowed to act for 3-5minutes, then the excess foam is wiped off and the procedure isrepeated. Finally, water is used to rinse.

• Wounds cleaning and antisepsia: 1-2 ml are applied, followed by rinsing.• Medical staff’s current hands scrubbing: Cca 5 ml for cca 15 seconds,

followed by water rinsing, and drying.PRECAUTIONS

It is only for external use.The contact with the eyes and conjunctival mucosa should be avoided.It should be kept out of the reach of children.





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GERMOSTOP HEXASOL SURGICAL ANTISEPTIC SOLUTION


PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine digluconate is a bisbiguanide derivative having a broadantimicrobial spectrum that includes many sporulated and nonsporulatedGram-positive and -negative germs, fungi and viruses. The productdestroys bacteria, fungi and viruses in 15 minutes.

INDICATIONSWhenever an aseptic area (surgeons’ hands, operating area) isnecessary; wounds asepsia and antisepsia.The suture threads treated with the product meet the safety parametersfor mechanical characteristics (the resistance to traction, the elongationdegree during an effort, the knot safety).

USES• Surgeons’ hands: The hands and forearms are washed with a common

soap or with GERMOSTOP HEXASOL SCRUB , thoroughly rinsed in water, andwiped; the hands are then wetted with a sufficient amount of the solutionfor a thin film all over the surface. The solution will not be wiped offbefore putting the gloves on.

• Surgical area: The area of interest is covered with a sufficient solutionamount. The excess is wiped off with sterile gauze.

PRECAUTIONSIt is only for external use.The contact with the eyes and conjunctival mucosa should be avoided.It should be kept out of the reach of children.





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GERMOSTOP LDISINFECTING SOLUTION

COMPOSITIONChlorhexidine digluconate 20 %PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine digluconate has a wide antimicrobial spectrum againstmany species of Gram-positive germs ( Bacillus spp ., Clostridium spp .,Staphylococcus spp ., Streptococcus spp .), Gram-negative ones(Escherichia coli, Klebsiella spp ., Pseudomonas spp ., Salmonella spp .,Proteus spp.), fungi ( Aspergillus spp ., Candida spp .) and viruses (bovineα -herpesvirus, Mastadenovirus, Paramyxovirus, Coronavirus, infectiousbursal disease virus, etc.). It has a markedly long-lasting activity, withoutinducing residual effects such as the tissular retention. It does not inducelocal irritations or allergic sensitisation.

INDICATIONS• Disinfection of surfaces, installations and equipment used in the food

industry.• Disinfection of the eggs for hatching and of incubators.• Disinfection of the drinking water and drinkers.• Decontamination of the animals’ skin for blood sampling, products

inoculation, etc.• Syringes decontaminaton in the field.

USES• Food industry disinfection: 1 l/300-1000 l of water.• Eggs disinfection: Spraying of 1 l/150 l of water at 45 oC, or eggs

immersion into 1l/150 l of water for 30-60 seconds.• Animal houses and equipment disinfection: 1 part of the product in 39

parts of potable water.• Drinking water prophylactic disinfection: 1 l/1000 l of water.• Drinkers and water supplying devices disinfection: 1l/200 l of water.• Animal skin decontamination: Painting with a cotton wool pad soaked inthe product diluted 1:10 ( i.e. 2% active ingredient) in water.• Syringes, needles, mammary probes, trocars, etc. decontamination:

They are 10 minutes immersed in a 1% chlorhexidine digluconatesolution obtained by diluting 1 part of the product in 19 parts of water.The syringes need not be rinsed after decontamination as thechlorhexidine digluconate traces do not impair the antimicrobial effect ofantibiotics and chemotherapeutics.

PRECAUTIONSIt is not recommended for the disinfection of syringes used in vaccinationcampaigns where live vaccines are used.

After preparation, the dilute solution will be used within 72 hours at themost.The contact with the eyes and conjunctival mucosa should be avoided. Incase of accidental contact, a water flush will be used for rinsing.It should be kept out of the reach of children.





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GERMOSTOP P BIOSTIMULATING PREMIX

COMPOSITIONChlorhexidine dihydrochloride 0.5%

PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine dihydrochloride has a wide antimicrobial spectrum includingnumerous species of Gram-positive ( Bacillus spp ., Clostridium spp .,Micrococcus spp ., Staphylococcus spp ., Streptococcus spp.), and Gram-negative germs ( Enterobacter cloacae, Escherichia coli, Klebsiella spp .,Pseudomonas spp ., Salmonella spp ., Proteus spp.), fungi ( Aspergillusspp ., Microsporum spp ., Candida spp.) and viruses. It is not absorbed inthe intestine and it, therefore, neither enters the blood circulation, nordeposits in the tissues. 99% of the amount ingested is excreted –completely and unmetabolised – through the faeces.

INDICATIONSPrevention of infections induced by Gram-positive and -negative germs onpig and poultry farms; reduction of morbidity and mortality; increase in theweight gain and decrease in the specific consumption; increase in the eggproduction.

ADMINISTRATION AND DOSAGEThe uninterruptedly administered treatment ensures a permanent weightgain increase.Broiler chickens• Starters: 3.0 kg/t of feed (15 ppm).• Growers: 4.0 kg/t of feed (20 ppm).

• Finishers: 2.0 kg/t of feed (10 ppm).Breeders and layers• Young birds: 4.0 kg/t of feed (20 ppm).• Adult birds: 3.0-4.0 kg/t of feed (15-20 ppm).Pseudomonosis prevention and control• All categories: 6.0 kg/t of feed (30 ppm).Pigs• Growers, finishers: 4.0-6.0 kg/t of feed (20-30 ppm).• Finishers: 3.0 kg/t of feed (15 ppm).

PRECAUTIONSIt should be thoroughly homogenised in the feed before administration.


PACKAGINGPaper sachet of 100 or 500 g, or paper bag of 1 or 5 kg.



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GERMOSTOP SHAMPOO ANTIMICROBIAL AND DEODORISING SHAMPOO

COMPOSITIONChlorhexidine digluconate 0.75 %

PHARMACOTHERAPEUTIC ACTIVITYChlorhexidine digluconate is a bisbiguanide derivative active againstGram-positive and -negative germs and fungi. The antimicrobial effect isquick, being manifest in cca 10-15 minutes. The product does not changeits suppleness, elasticity, colour or sensitivity. It confers the fur lustre anda pleasant touch.

INDICATIONSDogs, cats, horses: Skin diseases (dry and wet seborrhoea, eczemata) oruncomplicated superficial wounds.

USESThe entire surface is well massaged allowing the foam to be in contactwith the fur for 15-20 minutes, and then water rinsed. The procedure isresumed only if necessary.

PRECAUTIONSThe contact with the eyes and conjunctival mucosa should be avoided.In case of accidental contact, a water flush will be used to rinse.The product ingestion and food contamination should be avoided.

It should be kept out of the reach of children.STORAGE


Plastic bottle of 200 ml.



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GLUCOSE 10% INJECTABLE SOLUTION

COMPOSITION1 ml contains:Monohydrate glucose 100 mg

PHARMACOTHERAPEUTIC ACTIVITYIt is energising and readily absorbable; it improves the liver trophicity andmyocardial function, and increases diuresis.

INDICATIONSLiver trophicity and support of the myocardial function of exhausted andhypoglycaemic animals having been affected by intoxications,enteropathies, ketonaemias, hepatites, myocardites and haemorrhages.

Also, traumatic or surgical shocks, burns, septicaemias, convalescentanimals.

ADMINISTRATION AND DOSAGE5-10 ml of the hypertone 10% glucose solution are administered to pigseither orally, or subcutaneously at 2 separate sites, or intraperitoneally butonly antibiotic-added for bacterial infections prevention. These doses maybe repeated 24 hours later if need be.The isotone 5% glucose solution obtained by diluting 1:1 the 10% solutionwith sterile distilled water (100 ml of the 10% solution are mixed, understerile conditions, with 100 ml of distilled water) is administeredsubcutaneoulsy, intraperitoneally or intravenously for young animalsrehydration in enterites, bronchopneumonias, heavy haemorrhages andas an energetic substrate.• Small animals: 2-10 g of glucose/day, i.e. 40-200 ml of the 5% solution or

20-100 ml of the 10% solution.• Medium sized animals: 10-40 g of glucose/day, i.e. 200-800 ml of the 5%

solution or 100-400 ml of the 10% solution.• Large animals: 20-120 g of glucose/day, i.e. 400-2400 of the 5% solution

or 200-1200 ml of the 10% solution.STORAGE


Bottle of 50, 100, 250 or 500 ml.



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GLUCOSE 33% INJECTABLE SOLUTION

COMPOSITION1 ml contains:Monohydrate glucose 330 mg

PHARMACOTHERAPEUTIC ACTIVITYIt is energising and readily absorbable; it improves the liver trophicity andmyocardial function, and increases diuresis.

INDICATIONSLiver trophicity and support of the myocardial function of exhausted andhypoglycaemic animals having been affected by intoxications,enteropathies, ketonaemias, hepatites, myocardites and haemorrhages.

Also, traumatic or surgical shocks, burns, septicaemias, convalescentanimals.

ADMINISTRATION AND DOSAGEStrictly intravenously (perivenously it induces necrosis) in daily doses of60-400, 30-120 and 7-30 ml in large, medium sized and small animalsrespectively. The treatment is repeated after 24 hours.It may be subcutaneously or intraperitoneally inoculated to small andmedium sized animals after its dilution to 5% in distilled water or sterilephysiological saline.

CONTRAINDICATIONS Renal insufficiencies.


PACKAGINGBottle of 50, 100, 250 or 500 ml.



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HELMIZOL A 2.5 ANTIPARASITIC SUSPENSION

COMPOSITION Albendazole 2.5 %PHARMACOTHERAPEUTIC ACTIVITY Albendazole is an antiparasitic of wide action spectrum and high efficacyin controlling trematodes, cestodes and nematodes in all their evolutionalforms (eggs, larvae, adults). Due to its low toxicity, albendazole does notinduce side effects even if the dose is 5 times higher.

INDICATIONSSheep, goats, young cattle: Prevention and treatment of gastrointestinalnematodes ( Haemonchus spp ., Ostertagia spp ., Trichostrongylus spp .,Cooperia spp ., Nematodirus spp ., Toxocara spp . Bunostomum spp .,Oesophagostomum spp .), and pulmonary ones ( Dictyocaulus spp .,Protostrongylidae spp .), Moniezia teniae, adult trematodes ( Fasciola spp .,

Dicrocoelium spp .). ADMINISTRATION AND DOSAGEOrally, as follows:Sheep, goats: 2 ml/10 kg of live weight (5 mg of albendazole/kg of live

weight).• Treatment of mature trematodes, Protostrongylidae infestations: 3 ml/10

kg of live weight (7.5 mg of albendazole/kg of live weight).• Wild ruminants: 3-4 ml/10 kg of live weight (7.5-10 mg of albendazole/kg

of live weight).Young cattle: 30 ml/100 kg of live weight (7.5 mg of albendazole/kg of liveweight).• Treatment of mature trematodes, larval Ostertagia : 40 ml/100 kg of live

weight (10 mg of albendazole/kg of live weight).• Wild ruminants: 28-40 ml/100 kg of live weight.Depending on the infestation type and intensity, the treatment may berepeated 24 or 48 hours post administration I.No special diet is needed before or after treatment.

CONTRAINDICATIONSFemales during the first gestational third.

PRECAUTIONSThe bottle should be well shaken before use.It should be kept out of the reach of children.






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HELMIZOL A 10 ANTIPARASITIC SUSPENSION

COMPOSITION Albendazole 10 %

PHARMACOTHERAPEUTIC ACTIVITY Albendazole is an antiparasitic of wide action spectrum and high efficacyin controlling trematodes, cestodes and nematodes in all their evolutionalforms (eggs, larvae, adults). Due to its low toxicity, albendazole does notinduce side effects even if the dose is 5 times higher.

INDICATIONSSheep, cattle: Prevention and treatment of gastrointestinal nematodes(Haemonchus spp ., Ostertagia spp ., Trichostrongylus spp ., Cooperia spp .,Nematodirus spp ., Toxocara spp . Bunostomum spp ., Oesophagostomumspp .), and pulmonary ones ( Dictyocaulus spp ., Protostrongylidae spp .),Moniezia teniae , adult trematodes ( Fasciola spp ., Dicrocoelium spp .).

ADMINISTRATION AND DOSAGEThe administration is oral: 1 ml of suspension corresponds to 85 mg ofalbendazole.• Cattle, sheep: 10 ml/100 kg of body weight.• Treatment of mature trematodes and larval Ostertagia: 12 ml/100 kg of

body weight (10 mg of albendazole/kg of body weight).Depending on the infestation type and intensity, the treatment may berepeated 24 or 48 hours post administration I.

CONTRAINDICATIONSFemales during the first gestational third.

PRECAUTIONSThe bottle should be well shaken before use.It should be kept out of the reach of children.






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HELMIX ANTIPARASITIC PREMIX

COMPOSITION1 gram contains:

Albendazole 60 mgPHARMACOTHERAPEUTIC ACTIVITY

Albendazole is a broad spectrum anthelmintic active against cestodes,trematodes and nematodes in all their evolutional forms (eggs, larvae,adults). Albendazole blocks the enzymatic systems that activate glucosemetabolism. Orally administered, it is readily absorbed and spreads to allthe organs and tissues inducing the helminths lysis, irrespective of theanimal species and category and of the parasites localisation. It is mainly

excreted through urine. This product toxicity is low, doses 5 times higherthan the common therapeutic ones being tolerated.INDICATIONS

Prophylaxy and treatment of nematodes in:• Poultry: Ascaridia galli, Heterakis gallinae, Capillaria spp ., Syngamus

trachea. • Pigs: Ascaris suum, Oesophagostomum, Trichocephalus suis,

Metastrongylus, Trichinella spiralis. ADMINISTRATION AND DOSAGE

• Pigs: 1.7-2 g/10 kg of body weight/day fed for 2 consecutive days, withrepetition every trimester.

Trichinellosis control (all the herd): Treatment I for 3 consecutive days;treatments II, III and IV for 2 consecutive days each month; treatment Vfor 1 day each month for 5-6 months. The treatment is discontinued atleast 3 months since the last case of trichinellosis was recorded.

• Poultry: 1 g/6 kg of body weight/day (10 mg of albendazole/kg of bodyweight/day), or 2 kg/t of feed, with repetition the following day.

CONTRAINDICATIONS Animals during gestation month I, or during service.


STORAGE

At 15-25o

C, protected from light and humidity.PACKAGINGPlastic bottle of 100 g, or can of 1, 5 or 20 kg.



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INDOMETHACIN SUPPOSITORIES

COMPOSITIONIndomethacin 0.020 g

PHARMACOTHERAPEUTIC ACTIVITYIndomethacin is anti-inflammatory, -rheumatic, -pyretic, and analge

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