Parenteral Nutrition Market to 2018 - MarketResearch · Parenteral Nutrition Market to 2018 ......

Parenteral Nutrition Market to 2018 Rising Incidence of Chronic Diseases such as Cancer, AIDS and Gastrointestinal (GI) Disorders, and Increased Use of Specialty Drugs Drive Growth

GBI Research Report Guidance

GBIHC244MR / Published NOV 2012

© GBI Research. This is a licensed product and is not to be photocopied

GBI Research Report Guidance

Chapter two provides an introduction to the PN market.

Chapter three provides an introduction to the PN market. It describes clinical nutrition and provides an overview to PN guidelines.

Chapter four includes revenue forecasts for 2004-2018 and describes in detail the major drivers and barriers for the market.

Chapter five includes revenue forecasts for the US, the top five countries of Europe (the US, Germany, Italy, France and Spain) and Japan. The chapter also provides analysis of the nutrient market by segment, and the key products for the geographies mentioned above.

Chapter six includes an overview and provides revenues and revenue segmentation by geography for amino acids, lipids, carbohydrates and additives.

Chapter seven provides detailed information of major marketed products by company.

Chapter eight company profiles for six companies.

Chapter nine provides detailed descriptions of major M&A, licensing and co-developmental deals.


© GBI Research. This is a licensed product and is not to be photocopied

Parenteral Nutrition Market to 2018: Executive Summary

Parenteral Nutrition Market to 2018 - Executive Summary

The Parenteral Nutrition Market to Grow at a Compound Annual Growth Rate of XX% in the Forecast Period

The global Parenteral Nutrition (PN) market was estimated at $XX billion in 2011, indicating a Compound Annual Growth Rate (CAGR) of XX% between 2004 and 2011. The market is expected to grow at a CAGR of XX% between 2011 and 2018 to record a sales value of $XX billion by the end of the forecast period. The figure below shows the market’s revenues for 2004-2018.

Parenteral Nutrition Market to 2018, Global, Revenues ($m), 2004-2018

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018

Rev

enue

s ($

m)

CAGR (2004–2011): XX% CAGR (2011–2018): XX%

Source: GBI Research, GBI Research Proprietary Database [Accessed May 5, 2012]

The primary reasons for the expected high growth rate are the increase in the incidence of diseases that require PN as nutritional support, such as cancer, Acquired Immunodeficiency Syndrome (AIDS) and Gastrointestinal (GI) disorders. The rise in the elderly population is another reason for market growth as this group is more prone to chronic diseases and require more PN support in comparison to the young population.

The PN market has a broad portfolio of products, such as single-dose amino acid solutions, lipid emulsions, carbohydrates, vitamins, minerals, trace elements, electrolytes, and ‘all in one’ Multi-Chamber Bags (MCBs).

Growth Potential in the Parenteral Nutrition Market Favors Acquisitions and Licensing Agreements

The Merger and Acquisitions (M&As) and licensing agreements between 2004 and 2012 in the global PN market have remained fairly moderate, with XX acquisitions and XX major licensing deals. Fresenius Kabi participated in XX% of the acquisition deals and XX% of the licensing agreements. The other major players, Baxter and Hospira, accounted for XX% each of the total licensing agreements between 2004 and 2010. B. Braun participated in XX% of the licensing agreements during the same period. With a large majority of deals involving approved drugs, this suggests that the market players are showing a strong interest in expanding their existing product portfolios and presence in the worldwide PN markets, rather than focusing on developing new products for the future.

The global Parenteral Nutrition (PN) market was estimated at $XX billion in 2011, indicating a Compound Annual Growth Rate (CAGR) of XX% between 2004 and 2011

There were XX acquisitions and XX major licensing deals between 2004 and 2012


Page 5 © GBI Research. This is a licensed product and is not to be photocopied

Table of Contents

1 Table of Contents

1 Table of Contents................................................................................................................................. 5 1.1 List of Tables............................................................................................................................. 8 1.2 List of Figures............................................................................................................................ 9

2 Parenteral Nutrition Market to 2018 - Introduction .............................................................................10 3 Parenteral Nutrition Market to 2018 - Overview..................................................................................11

3.1 Clinical Nutrition......................................................................................................................11 3.1.1 Enteral Nutrition ..............................................................................................................12 3.1.2 Parenteral Nutrition .........................................................................................................12

4 Parenteral Nutrition Market to 2018 - Market Characterization and Forecasts......................................16 4.1 Revenue Forecasts...................................................................................................................16 4.2 Parenteral Nutrition Market Drivers .........................................................................................17

4.2.1 Increase in the Incidence of Diseases such as Cancer, AIDS and GI Disorders that Require Nutrition Support .............................................................................................................18

4.2.2 Increase in the Elderly Population will Drive PN Market Growth.........................................18 4.2.3 The Home Parenteral Nutrition Sector will Witness Strong Market Growth ........................18

4.3 Parenteral Nutrition Market Restraints.....................................................................................18 4.3.1 Reimbursement Regulations will Hinder Market Growth in the US .....................................18 4.3.2 Increasing Preference for Enteral Nutrition will Restrain Market Growth............................18 4.3.3 Increasing Preference for Multi-chamber Bags Decreases Cost of Therapy .........................19

5 Parenteral Nutrition Market to 2018 - Geographical Landscape............................................................20 5.1 Revenues by Geographical Segmentation .................................................................................20 5.2 The US.....................................................................................................................................22

5.2.1 Sales Value ......................................................................................................................22 5.2.2 Nutrient Market Segmentation.........................................................................................23 5.2.3 Key Products ....................................................................................................................23

5.3 Top Five Countries in Europe....................................................................................................24 5.3.1 Sales Value ......................................................................................................................24 5.3.2 Nutrient Market Segmentation.........................................................................................25 5.3.3 Key Products ....................................................................................................................25

5.4 Japan.......................................................................................................................................26 5.4.1 Sales Value ......................................................................................................................26 5.4.2 Nutrient Market Segmentation.........................................................................................27 5.4.3 Key Products ....................................................................................................................27

6 Parenteral Nutrition Market to 2018 - Nutrient Market Segmentation..................................................28 6.1 Overview.................................................................................................................................28 6.2 Amino Acids Market.................................................................................................................29

6.2.1 Global Sales Value............................................................................................................29 6.2.2 Sales Value by Geography ................................................................................................29

6.3 Lipids Market...........................................................................................................................30 6.3.1 Global Sales Value............................................................................................................30 6.3.2 Sales Value by Geography ................................................................................................30

6.4 Carbohydrates Market .............................................................................................................31 6.4.1 Global Sales Value............................................................................................................31 6.4.2 Sales Value by Geography ................................................................................................31

6.5 Additives Market .....................................................................................................................32 6.5.1 Global Sales Value............................................................................................................32 6.5.2 Sales Value by Geography ................................................................................................32

7 Parenteral Nutrition Market - Marketed Products................................................................................33 7.1 Baxter International Inc............................................................................................................33

7.1.1 OLIMEL............................................................................................................................33



Table of Contents

7.1.2 Clinimix............................................................................................................................34 7.1.3 ClinOleic 20% ...................................................................................................................35 7.1.4 Clinisol 15%......................................................................................................................36

7.2 B. Braun Melsungen AG ...........................................................................................................37 7.2.1 NuTRIflex System .............................................................................................................37 7.2.2 Lipofundin........................................................................................................................38 7.2.3 Aminoplasmal..................................................................................................................39 7.2.4 FreAmine III .....................................................................................................................40

7.3 Fresenius Kabi AG ....................................................................................................................41 7.3.1 Intralipid..........................................................................................................................41 7.3.2 SmofKabiven....................................................................................................................42 7.3.3 Dipeptiven .......................................................................................................................43 7.3.4 Omegaven .......................................................................................................................44

7.4 Hospira, Inc..............................................................................................................................45 7.4.1 Aminosyn.........................................................................................................................45 7.4.2 Liposyn ............................................................................................................................47

7.5 Otsuka Pharmaceutical Factory Inc...........................................................................................48 7.5.1 Elneopa ...........................................................................................................................48 7.5.2 Neoparen.........................................................................................................................48 7.5.3 B-Fluid .............................................................................................................................49

7.6 Terumo Corporation ................................................................................................................50 7.6.1 Unicaliq ...........................................................................................................................50 7.6.2 Fulcaliq ............................................................................................................................51

8 Parenteral Nutrition Market to 2018 - Competitive Landscape.............................................................52 8.1 Market Share Analysis: Parenteral Nutrition .............................................................................52 8.2 Competitive Profiling ...............................................................................................................53

8.2.1 Baxter International Inc....................................................................................................53 8.2.2 B. Braun Melsungen AG....................................................................................................55 8.2.3 Fresenius Kabi AG.............................................................................................................57 8.2.4 Hospira, Inc......................................................................................................................59 8.2.5 Otsuka Pharmaceutical Factory Inc. ..................................................................................61 8.2.6 Terumo Corporation.........................................................................................................62

9 Parenteral Nutrition Market to 2018 - Strategic Consolidations............................................................63 9.1 Overview.................................................................................................................................63 9.2 Major Acquisitions in the Parenteral Nutrition Market..............................................................64

9.2.1 Baxter International Completes Acquisition of Prism Pharma for $338m in April 2011........64 9.2.2 Baxter Acquires Willow Healthcare Services in July 2009 ...................................................64 9.2.3 Fresenius Acquires Novartis Nutrition and Nestle Espana in December 2007 ......................64 9.2.4 Fresenius Kabi Acquires Infusia A.S. in December 2004......................................................64 9.2.5 Fresenius Kabi Acquires Clinico GmbH in October 2005......................................................64 9.2.6 Fresenius Kabi Acquires Isotec Nutrition from Alliance Pharmaceuticals in May 2004.........64 9.2.7 Hospira Acquires Clayton Manufacturing Facility from Fresenius Kabi in June 2004............64

9.3 Major Agreements in the Parenteral Nutrition Market..............................................................65 9.3.1 Baxter Signs Agreement with Hanmi Pharmaceuticals in December 2010 ..........................65 9.3.2 Hospira Signs a Five-year Agreement with Novation in October 2010.................................65 9.3.3 B. Braun Signs Agreement with Amerinet Inc in October 2009 ...........................................65 9.3.4 B. Braun Signs Agreement with Premier Purchasing Partners in August 2008.....................65 9.3.5 Hospira Announces New Contract with Premier Purchasing Partners in August 2008..........66 9.3.6 Hospira Announces New Contract with HealthTrust Purchasing Group in February 2008 ....66 9.3.7 Baxter and Novation Sign Two-year Contract Extension in October 2007 ...........................66 9.3.8 Baxter Announces Plans to Form Parenteral Nutrition Joint Venture with Baiyunshan in

China in August 2007 .......................................................................................................66



Table of Contents

9.3.9 B. Braun Signs Agreement with Curlin Medical in March 2006 ...........................................66 9.3.10 Fresenius Kabi and Pharmatel Pty Ltd. Formed a Joint Venture in September 2004.............67

10 Parenteral Nutrition Market to 2018 - Appendix ..................................................................................68 10.1 Market Definitions...................................................................................................................68 10.2 Abbreviations ..........................................................................................................................68 10.3 Bibliography ............................................................................................................................69 10.4 Research Methodology ............................................................................................................70

10.4.1 Coverage .........................................................................................................................70 10.4.2 Secondary Research .........................................................................................................70 10.4.3 Primary Research .............................................................................................................70 10.4.4 Section Methodology .......................................................................................................71 10.4.5 Expert Panel Validation ....................................................................................................71

10.5 Contact Us...............................................................................................................................71 10.6 Disclaimer................................................................................................................................71



Table of Contents

1.1 List of Tables

Table 1: Parenteral Nutrition Market, Global, Nutritional Status Assessment, 2011 ...............................11 Table 2: Parenteral Nutrition Market, The US, A.S.P.E.N. Guidelines for Parenteral Nutrition, 2004........14 Table 3: Parenteral Nutrition Market, Global, Revenues ($m), 2004-2011..............................................16 Table 4: Parenteral Nutrition Market, Global, Revenue Forecasts ($m), 2011-2018................................16 Table 5: Parenteral Nutrition Market, Global, Revenue by Geographical Segmentation ($m), 2004-201120 Table 6: Parenteral Nutrition Market, Global, Revenue Forecasts by Geographical Segmentation ($m),

2011-2018 ..............................................................................................................................21 Table 7: Parenteral Nutrition Market, The US, Revenues ($m), 2004-2011.............................................22 Table 8: Parenteral Nutrition Market, The US, Revenue Forecasts ($m), 2011-2018...............................22 Table 9: Parenteral Nutrition Market, Top Five Countries of Europe, Revenues ($m), 2004-2011 ...........24 Table 10: Parenteral Nutrition Market, Top Five Countries of Europe, Revenue Forecasts ($m), 2011-2018

...............................................................................................................................................24 Table 11: Parenteral Nutrition Market, Japan, Revenues ($m), 2004-2011...............................................26 Table 12: Parenteral Nutrition Market, Japan, Revenue Forecasts ($m), 2011-2018.................................26 Table 13: Parenteral Nutrition Market, Amino Acids Revenue by Geographical Segmentation ($m), 201129 Table 14: Parenteral Nutrition Market, Lipids Revenue by Geographical Segmentation ($m), 2011 ..........30 Table 15: Parenteral Nutrition Market, Carbohydrates Revenue by Geographical Segmentation ($m), 2011

...............................................................................................................................................31 Table 16: Parenteral Nutrition Market, Additives Revenue by Geographical Segmentation ($m), 2011.....32 Table 17: Parenteral Nutrition Market, Global, Product Composition - Lipofundin, 2012..........................38 Table 18: Parenteral Nutrition Market, Global, Product Composition - Aminoplasmal, 2012 ....................39 Table 19: Parenteral Nutrition Market, Global, Product Composition - Aminosyn, 2012...........................46 Table 20: Parenteral Nutrition Market, Global, Strategic Consolidations Overview, 2012 .........................63



Table of Contents

1.2 List of Figures

Figure 1: Parenteral Nutrition Market, Global, Nutritional Support Algorithm.........................................12 Figure 2: Parenteral Nutrition Market, Global, Nutrition Requirements for TPN, 2012.............................13 Figure 3: Parenteral Nutrition Market, Global, Revenues ($m), 2004-2018..............................................16 Figure 4: Parenteral Nutrition Market, Global, Drivers and Barriers, 2012...............................................17 Figure 5: Parenteral Nutrition Market, Global, Revenue by Geographical Segmentation ($m), 2004-201820 Figure 6: Parenteral Nutrition Market, The US, Historic Revenue and Forecasts ($m), 2004-2018............22 Figure 7: Parenteral Nutrition Market, The US, Key Products, 2012 ........................................................23 Figure 8: Parenteral Nutrition Market, Top Five Countries of Europe, Historic Revenue and Forecasts ($m),

2004-2018 ..............................................................................................................................24 Figure 9: Parenteral Nutrition Market, Top Five Countries in Europe, Key Products, 2011 .......................25 Figure 10: Parenteral Nutrition Market, Japan, Revenue Forecasts ($m), 2004-2018................................26 Figure 11: Parenteral Nutrition Market, Japan, Key Products, 2011 ..........................................................27 Figure 12: Parenteral Nutrition Market, Global, Nutrient Market Segmentation (%), 2011 ........................28 Figure 13: Parenteral Nutrition Market, Amino Acids Revenue by Geographical Segmentation ($m), 2011 29 Figure 14: Parenteral Nutrition Market, Lipids Revenue by Geographical Segmentation ($m), 2011 ..........30 Figure 15: Parenteral Nutrition Market, Carbohydrates Revenue by Geographical Segmentation ($m), 2011

...............................................................................................................................................31 Figure 16: Parenteral Nutrition Market, Additives Revenue by Geographical Segmentation ($m), 2011.....32 Figure 17: Parenteral Nutrition Market, Global, Product Profile - OLIMEL, 2012........................................33 Figure 18: Parenteral Nutrition Market, Global, Product Profile - Clinimix, 2012 .......................................34 Figure 19: Parenteral Nutrition Market, Global, Product Profile - ClinOleic 20%, 2012...............................35 Figure 20: Parenteral Nutrition Market, Global, Product Profile - Clinisol 15%, 2012 .................................36 Figure 21: Parenteral Nutrition Market, Global, Product Profile - NuTRIflex, 2012.....................................37 Figure 22: Parenteral Nutrition Market, Global, Product Profile - Lipofundin, 2012 ...................................38 Figure 23: Parenteral Nutrition Market, Global, Product Profile - Aminoplasmal, 2012..............................39 Figure 24: Parenteral Nutrition Market, Global, Product Profile - FreAmine III, 2012 .................................40 Figure 25: Parenteral Nutrition Market, Global, Product Profile-Intralipid, 2012 .......................................41 Figure 26: Parenteral Nutrition Market, Global, Product Profile - SmofKabiven, 2012 ...............................42 Figure 27: Parenteral Nutrition Market, Global, Product Profile - Dipeptiven, 2012...................................43 Figure 28: Parenteral Nutrition Market, Global, Product Profile - Omegaven, 2012 ...................................44 Figure 29: Parenteral Nutrition Market, Global, Product Profile - Aminosyn, 2012 ....................................45 Figure 30: Parenteral Nutrition Market, Global, Product Profile - Liposyn, 2012........................................47 Figure 31: Parenteral Nutrition Market, Global, Product Profile - Neoparen, 2012 ....................................48 Figure 32: Parenteral Nutrition Market, Global, Product Profile - B-Fluid, 2012.........................................49 Figure 33: Parenteral Nutrition Market, Global, Product Profile - Unicaliq, 2012 .......................................50 Figure 34: Parenteral Nutrition Market, Global, Product Profile - Fulcaliq, 2012........................................51 Figure 35: Parenteral Nutrition Market, Global, Market Share of Top Manufacturers (%), 2011.................52 Figure 36: Parenteral Nutrition Market to 2018, Global, Company Profile - Baxter International Inc., 201253 Figure 37: Parenteral Nutrition Market, Global, SWOT Analysis - Baxter International Inc., 2012...............54 Figure 38: Parenteral Nutrition Market to 2018, Global, Company Profile - B. Braun Melsungen AG, 2012 55 Figure 39: Parenteral Nutrition Market, Global, SWOT Analysis - B. Braun Melsungen AG, 2012................56 Figure 40: Parenteral Nutrition Market, Global, Company Profile - Fresenius Kabi AG, 2012......................57 Figure 41: Parenteral Nutrition Market, Global, SWOT Analysis - Fresenius Kabi AG, 2012 ........................58 Figure 42: Parenteral Nutrition Market, Global, Company Profile - Hospira Inc., 2012 ...............................59 Figure 43: Parenteral Nutrition Market, Global, SWOT Analysis - Hospira Inc., 2012..................................60 Figure 44: Parenteral Nutrition Market, Global, Company Profile - Otsuka Pharmaceutical Factory Inc.,

2012.......................................................................................................................................61 Figure 45: Parenteral Nutrition Market, Global, Company Profile - Terumo Corporation, 2012..................62 Figure 46: Parenteral Nutrition Market, Global, Strategic Consolidations Overview (%), 2012 ...................63



Parenteral Nutrition Market to 2018: Introduction

2 Parenteral Nutrition Market to 2018 - Introduction

The global PN market is growing rapidly, with increasing incidence of diseases such as cancer, AIDS (Acquired Immunodeficiency Syndrome) and GI (Gastrointestinal) disorders, including short bowel syndrome, ischemic bowel disease, pseudo obstruction and Crohn’s disease. The other major factor driving the growth of the global PN market is the increase in the elderly population in developed countries. In 2011, the global PN market was estimated to be worth $XXm, representing a Compound Annual Growth Rate (CAGR) of XX% between 2004 and 2011. The US market, with sales worth $XXm in 2011, accounted for XX% of the total PN market. The market in the top five countries in Europe was estimated to be $XXm, the second largest PN market, and to have grown at a CAGR of XX% between 2004 and 2011. The PN market in Japan registered a share of XX% of the total PN market, accounting for $XXm in sales value in 2011.

By 2018, the global PN market is forecast to be worth $XXm, representing a CAGR of XX% between 2011 and 2018. The US is expected to remain the largest market segment, with $XXm of sales in 2018. The PN market in the top five countries in Europe will be the second largest segment, with $XXm in revenues by 2018. Japan, which was the smallest segment in 2011, is expected to register sales of $XXm in 2018, indicating a CAGR of XX% between 2011 and 2018.

The PN market Merger and Acquisitions (M&As) landscape demonstrated a fairly moderate level of activity between 2004 and 2011, with XX major acquisition deals signed during the period. Of the big pharmaceutical companies that witnessed acquisition activity, Fresenius Kabi was the most involved, participating in XX out of the XX M&A deals. In addition, a strategic analysis of the licensing agreements reveals that the agreements were carried out with the objective of expanding presence in worldwide PN markets.

Overall, the PN market is very attractive and is poised for high growth between 2011 and 2018.



Parenteral Nutrition Market to 2018: Geographical Landscape

5.2 The US

5.2.1 Sales Value

In 2011, the PN market in the US was estimated at $XXm, indicating a CAGR of XX% between 2004 and 2011. The growth in the elderly population and an increase in the incidence of diseases that require PN as nutritional support are the major factors responsible for the high growth of the market. The figure below is an illustration of the US revenue data and forecasts for 2004-2018.

Figure 6: Parenteral Nutrition Market, The US, Historic Revenue and Forecasts ($m), 2004-2018

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018

Rev

enue

s ($

m)

CAGR (2004–2011): XX% CAGR (2011–2018): XX%


Table 7: Parenteral Nutrition Market, The US, Revenues ($m), 2004-2011

Year 2004 2005 2006 2007 2008 2009 2010 2011 CAGR (%)

Revenues ($m)


Table 8: Parenteral Nutrition Market, The US, Revenue Forecasts ($m), 2011-2018

Year 2011 2012 2013 2014 2015 2016 2017 2018 CAGR (%)

The US ($m)


There were a total of XX PN infusions in acute care in-patients in the US in 2007, a rise from XX PN infusions in 2005 (ASPEN, 2010). The rapid uptake of amino acid solutions such as Aminosyn, lipid emulsions such as Liposyn and MCBs such as Clinimix and Clinimix E over the past decade contributed to the market growth. In addition, an increased awareness of PN among physicians and other healthcare professionals has resulted in an increase in the number of people being prescribed PN.



Parenteral Nutrition Market to 2018: Strategic Consolidations

9 Parenteral Nutrition Market to 2018 - Strategic Consolidations

9.1 Overview

The figure illustrates the major companies actively involved in strategic consolidations in 2012.

Figure 46: Parenteral Nutrition Market, Global, Strategic Consolidations Overview (%), 2012

Baxter

Fresenius Kabi

B.Braun

Hospira

Source: GBI Research, GBI Research’s Proprietary Database [Accessed on May 10, 2012]

Table 20: Parenteral Nutrition Market, Global, Strategic Consolidations Overview, 2012

Company Number of Strategic Consolidations

B. Braun

Hospira

Fresenius Kabi

Baxter

Total

Source: GBI Research, GBI Research’s Proprietary Database [Accessed on May 10, 2012]



Parenteral Nutrition Market to 2018: Appendix

10 Parenteral Nutrition Market to 2018 - Appendix

10.1 Market Definitions

The global PN market refers to the top seven markets, namely the US, the UK, Germany, France, Spain, Italy and Japan.

Diseased Population: this refers to the estimated number of people who are affected by diseases such as cancer, AIDS and GI disorders that require PN as nutritional support.

Prescription Population: this refers to the number of people that are on PN therapy.

Nutritional support: nutritional support is “The provision of nutrients orally, enterally, or parenterally with therapeutic intent. This includes, but is not limited to, provision of total enteral or PN support, and provision of therapeutic nutrients to maintain and /or restore optimal nutrition status and health” (ASPEN, 2005).

10.2 Abbreviations

ASPEN.: American Society for Parenteral and Enteral Nutrition

AIDS: Acquired Immunodeficiency Syndrome

BMI: Body Mass Index

BPNG: British Pharmaceutical Nutrition Group

CAGR: Cumulative Annual Growth Rate

CDC: Centers for Disease Control and Prevention

CN: Clinical Nutrition

COM PN: Compounded Parenteral Nutrition

CVC: Central Venous Catheter

EN: Enteral Nutrition

EPUFA: Essential Poly-Unsaturated Fatty Acids

FDA: Food and Drug Administration

g/kg/day: grams per kilogram per day

GI: Gastro-intestinal

HPN: Home Parenteral Nutrition

ICU: Intensive Care Units

IDE: Investigational Device Exemption

IV: Intravenous

JPEN: Journal of Parenteral and Enteral Nutrition

LOS: Length of Stay

M&A: Mergers and Acquisitions

MCBs: Multi-Chamber Bags

MCT/LCT: Medium Chain Triglycerides and Long Chain Triglycerides

MHRA: Medicines and Healthcare products Regulatory Agency

MUFA: Mono-unsaturated Fatty Acids

MUST: Malnutrition Universal Screening Tool

mosm/l: Milliosmole/liter




NHS: National Health Service

OPM: Out Patient Market

PN: Parenteral Nutrition

R&D: Research and Development

SFA: Saturated Fatty Acids

SGA: Subjective Global Assessment

TPN: Total Parenteral Nutrition

10.3 Bibliography

The following sources were referred to build this report:

ASPEN (2012). ASPEN. Documents Library Table of Contents. American Society for Parenteral and Enteral Nutrition. Available from: http://nutritioncare.org/LContent.aspx?id=3544. [Accessed on May 5, 2012].

Baxter (2012a). Olimel Product Information. Baxter. Available from: http://www.baxter.ca/en/downloads/product_information/olimel_pm_2010jun23_customers.pdf.

Baxter (2012b). Clinoleic 20% Product Information. Baxter. Available from: http://www.baxter.ca/en/downloads/product_information/ClinOleic_PM_EN.pdf.

Baxter (2012c). Clinisol 15% Product Information. Baxter. Available from: http://www.ecomm.baxter.com/ecatalog/browseCatalog.do?lid=10001&hid=10001&cid=10016&key=aea74c29e66d44e724969dbd81e1c159&pid=460877. [Accessed on May 6, 2012]

B. Braun (2012a). Nutriflex System Product Information. B. Braun. Available from: http://www.bbraun.ph/cps/rde/xchg/cw-bbraun-en-ph/hs.xsl/products.html?prid=PRID00000758. [Accessed on May 6, 2012].

B. Braun (2012b). Lipofundin Product Information. B. Braun. Available from: http://www.bbraun.ph/cps/rde/xchg/cw-bbraun-en-ph/hs.xsl/products.html?prid=PRID00000761. [Accessed on May 6, 2012].

B. Braun (2012c). Aminoplasmal Product Information. B. Braun. Available from: http://www.bbraun.ph/cps/rde/xchg/cw-bbraun-en-ph/hs.xsl/products.html?prid=PRID00000741. [Accessed on May 6, 2012].

Claris Lifesciences (2012). Nutrition. Claris Lifesciences. Available from: http://www.clarislifesciences.com/nutrition.asp. [Accessed on May 6, 2012].

Clinimix (2012). Product Information. Clinimix. Available from: http://www.clinimix.com/documents/CLINIMIX__PI.pdf.

FDA (2012). Drugsat_Docs. Food and Drug Administration. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017643s072,018449s039lbl.pdf.

Hospira (2012). Products. Hospira. Available from: http://www.hospira.com/products/aminosyn.aspx. [Accessed on May 6, 2012].

Hospira (2012). Products. Hospira. Available from: http://www.hospira.com/products/liposyn.aspx. [Accessed on May 6, 2012].

Mirtallo J, et al. (2004). Safe Practices for Parenteral Nutrition. Journal of Parenteral and Enteral Nutrition, 28(6):S39-S70.

Otsuka Pharmaceutical (2009). Release. Otsuko. Available from: http://www.otsuka.com/jp/hd_release/release/pdf.php?news=103. [Accessed on May 6, 2012].

The Merck Manual (2012). Nutritional Disorders. Available from: http://www.merckmanuals.com/professional/nutritional_disorders/nutritional_support/total_parenteral_nutrition_tpn.html - global nutrition guidelines for TPN. [Accessed on May 3, 2012].




Terumo Corporation (2012). About us. Terumo. Available from: http://www.terumo.com/about/terumostory/1921_2001/cat6_2.html. [Accessed on May 3, 2012].

10.4 Research Methodology

GBI Research’s dedicated research and analysis teams consist of experienced professionals with a pedigree in marketing, market research, consulting backgrounds in the medical devices industry and advanced statistical expertise.

GBI Research adheres to the codes of practice of the Market Research Society (www.mrs.org.uk) and the Strategic and Competitive Intelligence Professionals (www.scip.org).

All GBI Research databases are continuously updated and revised. The following research methodology is followed for all databases and reports.

10.4.1 Coverage

The objective of updating GBI Research’s coverage is to ensure that it represents the most up to date vision of the industry possible.

Changes to the industry taxonomy are built on the basis of extensive research of company, association and competitor sources.

Company coverage is based on three key factors: Revenues, products and media attention/innovation/market potential.

The estimated revenues of all major companies, including private and governmental, are gathered and used to prioritize coverage.

Companies which are making the news, or which are of particular interest due to their innovative approach, are prioritized.

GBI Research aims to cover all major news events and deals in the pharmaceutical industry, updated on a daily basis.

The coverage is further streamlined and strengthened with additional inputs from GBI Research’s Expert Panel (see below).

10.4.2 Secondary Research

Secondary research was carried out on internal and external sources to source qualitative and quantitative information in the report.

The secondary research sources that are referred to in this report include but are not limited to:

Company websites, annual reports, financial reports, investor presentations and US Securities and Exchanges (SEC) filings for the 20 companies covered in this report;

Industry trade journals, scientific journals and other technical literature

Relevant patent and regulatory databases

National government documents, statistical databases and market reports

News articles, press releases and web-casts specific to the companies operating in the market.

10.4.3 Primary Research

GBI Research conducts hundreds of primary interviews each year with industry participants and commentators, in order to validate its data and analysis. A typical research interview fulfills the following functions:

It provides first-hand information on the market size, market trends, growth trends, competitive landscape and future outlook.

Helps in validating and strengthening the secondary research findings

Further develops the analysis team’s expertise and market understanding




Primary research involves email interactions, telephone interviews, and face-to-face interviews for each market, category, segment and sub-segment across geographies.

The participants who typically take part in such a process include, but are not limited to:

Industry participants: CEOs, VPs, marketing/product managers, market intelligence managers and national sales managers

Outside experts: Research analysts specializing in specific parenteral nutrition

Key Opinion Leaders: Researchers specializing in PN corresponding to different kinds of biodefense research.

10.4.4 Section Methodology

The report consists of the following four major sections:

Nutrient Market Segmentation - This section contains the sales value of amino acids, carbohydrates, lipids and additives for the US, the UK, France, Spain, Germany, Italy and Japan.

Marketed Products - The product descriptions here were sourced from company websites and GBI research’s proprietary database.

Competitive Landscape - This chapter includes company profiles and SWOT analyses for major companies active in the PN market. This section is sourced from company websites, company annual reports and internal databases

10.4.5 Expert Panel Validation

GBI Research uses a panel of experts to cross-verify its databases and forecasts.

GBI Research’s expert panel comprises marketing managers, product specialists, international sales managers from medical device companies, academics from research universities, KOLs from hospitals, consultants from venture capital funds and distributors/suppliers of medical equipment and supplies.

Historic data and forecasts are relayed to GBI Research’s Expert Panel for feedback and adjusted in accordance with their feedback.

10.6 Disclaimer

All Rights Reserved.

No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisher, GBI Research.

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