Palestra 6
description
Transcript of Palestra 6
Partnering on Innovative Health Research in Brazil
March 7, 2012
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Presentation Outline
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• Update on Partnership activities in Brazil
• GCE Initiative Overview and FAP Collaboration
• Next Steps
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Brazil MOH-BMGF Strategic Alliance
Family Health Research
Discovery Research / Grand
Challenges
Joint Global Health Initiatives
Vaccine Development and
Manufacturing
Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation October 2011
Broad Health MoU: Brazilian MoH (SCTIE) and Gates Foundation October 2011
Dengue:
- Field testing of vector control strategy in
partnership with MOH and Fiocruz researchers
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Grand Challenges Brazil
Next steps: Continue dialogue with MOH on Grand Challenges framework and potential Family
Health GC partnership Secure partnership with CNPq for Phase II grants Continue to engage other research funders in Brazil around potential GC partnerships
Joint funding of projects in Brazil as part of international GC initiatives
Focus on global health and development priorities Proposed first cooperation around Family Health GC
GC initiatives pursued and funded by Brazilian sources Focus on national health priorities
Partnership between BMGF and FAPs to provide supplemental funding to Brazilian GCE Phase I grantees formalized in December 2011
Co-funding with CNPq for Phase II grants still under discussion
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The foundation is engaged in conversations with the MOH on a possible GC Brazil focused on:
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In December 2011, the Gates Foundation and the FAPs formed a partnership around Grand Challenges Explorations to invest in high-
risk health and development research.
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Anyone can apply From any country and any discipline and at any level of experience From academia, government, non-profits or industry Review is “blind” and champion-based
Applying is easy Two page application No preliminary data required
Awards are frequent and rapid Two opportunities to apply each year Awards made in 4-6 months Phase I funding of US$100,000 can lead to Phase II funding of up to US$1M
Overview:Grand Challenges Explorations
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GCE Selection Process
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FAP GCE Partnership
1. Grants selected through regular GCE process− Brazilian submissions will be processed by the GCE program’s standard review
mechanism− Selected proposals will be funded by BMGF at US$100,000− Direct grant agreement between grantee and BMGF− FAPs will collaborate with foundation to deepen reach of GCE call into Brazil
2. For participating states, FAP will supplement funding for all grantees based in the state in which it covers− FAPs will formalize their endorsement of BMGF selection process or conduct
expedited diligence to formalize project selection − Respective FAP will provide additional funding equivalent to US$50,000 or $100,000
in Brazilian Reals − FAPs establish separate grant agreement directly with grantee
3. Successful projects can apply for Phase II grants− Coordination with CNPq and others during selection process (TBD)
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March 7, 2012
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Open GCE RFP: Round 9
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Protect Crop Plants From Biotic Stresses From Field to Market
New Approaches for the Interrogation of Anti-malarial Compounds
Aid is Working. Tell the World.
Design New Approaches to Optimize Immunization Systems
Explore New Solutions for Global Health Priority Areas
Round 9 runs from February 29 to May 15, 2012; all applications are welcome in one of these issue areas
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Round 9 GCE Topics
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Protect Crop Plants from Biotic Stresses from Field to Market
Challenge: Soliciting transformative solutions to pest and pathogen pressures faced by smallholder farmers in developing countries; encouraging researchers and entrepreneurs to generate ideas that will revolutionize current approaches to crop protection by focusing on plants, pests, pathogens, weeds and/or their interactions.
New Approaches for the Interrogation of Anti-Malarial Compounds
Challenge: Supporting unconventional and radically new approaches, methods, and assays to analyze, characterize, and prioritize anti-malarial compounds and to glean more information required for the development of next generation malaria drugs.
Aid Is Working. Tell the World.
Challenge: Soliciting new approaches to communications that motivate the public in wealthy countries of the world to change their minds about aid, and take actions to demonstrate their support.
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Design New Approaches to Optimize Immunization Systems
Challenge: Supporting novel approaches to optimizing the performance of immunization logistics and supply systems in low-resource settings which address one or more of these gap areas: vaccine product characteristics, supply system design, environmental impact, information systems, human resources and vaccination acceptance.
Explore New Solutions for Global Health Priority Areas
Challenge: Soliciting new solutions for global health priority areas: malaria, HIV, tuberculosis, pneumonia, enteric disease and diarrhea, polio, maternal and neonatal health, and/or family planning; revolutionary new technologies or improvements upon current technologies; low-cost solutions; and projects with clear and testable scientific plans.
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Round 9 GCE Topics
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“Open Topic”
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February 2012 - Round 9 Topics: New Approaches for the Interrogation of Anti-malarial Compounds Aid is Working. Tell the World Protect Crop Plants from Biotic Stresses From Field to Market Design New Approaches to Optimize Immunization Systems Explore New Solutions in Global Health Priority Areas
August 2011 - Round 8 Topics:
Protect Crop Plants from Biotic Stresses From Field to Market Design New Approaches to Optimize Immunization Systems Explore New Solutions in Global Health Priority Areas Explore Nutrition for Healthy Growth of Infants and Children Apply Synthetic Biology to Global Health Challenges
March 2011 - Round 7 Topics:
The Poliovirus Endgame: Create Ways to Accelerate, Sustain and Monitor Eradication
Create the Next Generation of Sanitation Technologies Create Low-Cost Cell Phone-Based Solutions for Improved Uptake and
Coverage of Childhood Vaccinations Design New Approaches to Cure HIV Infection Explore Nutrition for Healthy Growth of Infants and Children Apply Synthetic Biology to Global Health Challenges
August 2010 - Round 6 Topics:
Create New Ways to Protect Against Infectious Disease Create New Technologies for Contraception Design New Approaches to Cure HIV Infection Create the Next Generation of Sanitation Technologies Create Low-Cost Cell Phone-Based Applications for Priority Global
Health Conditions The Poliovirus Endgame: Create Ways to Accelerate, Sustain and
Monitor Eradication Create New Technologies to Improve the Health of Mothers and
Newborns
March 2010 - Round 5 Topics: Create Low-Cost Cell Phone-Based Applications for Priority Global
Health Conditions Create New Technologies to Improve the Health of Mothers and
Newborns Create New Ways to Protect Against Infectious Disease Create New Technologies for Contraception
September 2009 - Round 4 Topics:
Create New Technologies for Contraception Create New Ways to Induce and Measure Mucosal Immunity Create Low-Cost Diagnostics for Priority Global Health Conditions Create New Ways to Protect Against Infectious Disease
March 2009 - Round 3 Topics:
Create Low-Cost Diagnostics for Priority Global Health Conditions Create New Ways to Induce Mucosal Immunity Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and TB Create New Tools to Accelerate the Eradication of Malaria
September 2008 - Round 2 Topics:
Explore the Basis For Latency in Tuberculosis Create New Ways to Protect Against Infectious Disease Create New Vaccines for Diarrhea, HIV, Malaria, Pneumonia, and TB Create New Tools to Accelerate the Eradication of Malaria Create Drugs and Delivery Systems to Limit Drug Resistance Create New Ways to Prevent or Cure HIV Infection
March 2008 - Round 1 Topics:
Create Drugs and Delivery Systems to Limit Drug Resistance Create New Ways to Prevent or Cure HIV Infection Explore the Basis For Latency in Tuberculosis
Create New Ways to Protect Against Infectious Disease
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Brazilian Submissions by City:Rounds 1 – 8
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GCE Phase I Grants to Brazil:Rounds 1 – 6
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Increasing Vaccination Efficacy with ACE InhibitorsJulio Scharfstein at Universidade Federal do Rio de Janeiro
Idea: Interfere with innate homeostasis at the onset of vaccination by re-purposing ACE inhibitor (Captopril) to boost efficacy of vaccination
Large-scale MHC: Epitope Analysis for Vaccine DevelopmentGustavo Fioravanti Vieira at Universidade Federal do Rio Grande do Sul
Idea: Use bioinformatic approach to identify MHC and immune response features among viral peptides through the comparison of immunogenic epitopes already in the literature
"Lego" like Sanitation System: Pit Latrines Made of BiocompostAntonio Avila at Universidade Federal de Minas Gerais
Idea: Develop a biodegradable “Eco-blocks” assemblage system for pit latrines to replace concrete slabs or conventional brick/cement materials
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Proposals by City – Rounds 1-8
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About Tableau maps: www.tableausoftware.com/mapdata
Number of Proposals
1
100
200
300
400
501
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Funded Projects by City – Rounds 1-8
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About Tableau maps: www.tableausoftware.com/mapdata
Number of Proposals
1
5
10
15
21
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Proposals by City – S. America Rounds 1-8
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About Tableau maps: www.tableausoftware.com/mapdata
Number of Proposals
1
100
200
300
400
501
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Funded Projects by City – S. America Rounds 1-8
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About Tableau maps: www.tableausoftware.com/mapdata
Number of Proposals
1
5
10
15
21
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Outreach to researchers makes a difference
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www.grandchallenges.org/brp
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Next Steps
Comments on the “Implementation Plan”
Outreach and Marketing – March, April (May 15 deadline)
• Email Outreach to networks – Point of contacts?
• Potential for Announcement of Partnership Mid-April
Information Exchanged – Gates <-> FAPS
• What information is desired
• Past & Present Applicants
Proposal Development
Preparing for grantmaking
• Speed
• Flexibility in grant terms
Managing Expectations – Long-term investment in success
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Thank You
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Proposals by City – Africa Rounds 1-8
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About Tableau maps: www.tableausoftware.com/mapdata
Number of Proposals
1
100
200
300
400
501
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Funded Projects by City – Africa Rounds 1-8
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About Tableau maps: www.tableausoftware.com/mapdata
Number of Proposals
1
5
10
15
21