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Transcript of Page 1 A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT D. Bolognini,...
Page 1
A new method to measure 10B uptake in lung adenocarcinoma in hospital BNCT
D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan
E. Capelli, P. Chiari
A. Zanini
G. Giannini, E. Vallazza
F. Basilico, P. Mauri
F. BorasioP. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti
Page 2
BNCT
The INFN PhoNeS project
An innovative approach to Boron Imaging
Neutron Autoradiography
Measurements and results
Conclusion
Outline
Page 3
Boron Neutron Capture Therapy
BNCT could become useful for highly-fatal tumours:
•Extended (e.g. liver, lung)•Radioresistant (melanoma)•Localized near vital organs
(glioblastoma)
10B (n,α,γ) 7Libinary technique high LET particles
Page 4
High intensity thermal-epithermal
neutron beam(5·108 n/cm2 s1)
< 10 keV energy range
Gamma contamination < 2 ·10-13 Gy cm2 / n
Low toxicity
High specificity
Non-persistence in the bloodstream
BSH
BPA
Difficulties for BNCT applications
Page 5
Neutron Autoradiography
Nuclear reactor Solid state track detector (CR 39) Sometimes cryogenic temperature during the irradiation Optic microscope for identification and count
Nuclear reactor Solid state track detector (CR 39) Sometimes cryogenic temperature during the irradiation Optic microscope for identification and count
Hospital-based neutron source Real time detector
Hospital-based neutron source Real time detector
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PhoNeS (PhotoNeutronSource)Neutron flux in the treatment cavity: Φ = (1.3 ± 0.1) x 107 n cm-2 s-1
γ-contamination: reduced of 97%
Page 7
Real-time Neutron Autoradiography
0.5 cm CERROBEND
photonconversion
6 cm PMMA
thermalization
IRON BOX
•Samples
•DetectorNeutron flux: Φ = (1.5 ± 0.1) x 105 n cm-2 s-1
Page 8
The imaging detector
Silicon Dimensions (9.5 x 9.5) cm2
Hamamatsu Microstrip Silicon Detector 768 strips
Readout pitch 242 μm
Read-out by 3 self-triggering TAA1 ASICs
Counts vs position
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The Data Acquisition System
• INTER-BUNCH acquisition
• UNDEPLETED silicon detector
to detect α-particles from boronated samples down to 25 ng of 10B
18 MeV electrons
Bunches of 5 μs
Frequency 100 - 300 Hz
Page 10
SPECIMEN SUPPORT
-plastic support (liquid solution)evaporation
-glass slide (blood samples)coagulation process
to prevent crystallizationand self-absorption ofthe α-particles by the sample itself
KNOWN VOLUME
Drops of 5 μl
The samples
SOLUTION HOMOGENEITY
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Calibrating with BSH
500 MU/min –18 MV photons Varian CLINAC 2100 C/D, Sant’Anna Hospital (Como)
Integrated Spot Content (AU) vs Concentration (ppm)
Page 12
The first ever kinetic curves
Special thanks to Dr.Sauerwein
URINEBLOOD
rescaled at the max value obtained by Si-autoradiography
Blood and urine of a patient administered BSH, taken at different times with respect to the administration.
Page 13
Ex-vivo lung perfusion
Human lung affected by adenocarcinoma:
• therapetic resection
• perfusion of blood and BPA
Blood samples taken at different times:
• to estimate 10B uptake
in collaboration with “S.Luigi” Hospital in Orbassano (TO), Italy
Page 14
Kinetic curves
• Blood samples doped with BPA
• Comparison between real-time autoradiography to MS analysis
• The absorption takes place only in the first 90mins
Page 15
CR 39
Healthy tissue
Unhealthy tissue
Special thanks to Dr. Giannini
10B concentration in tumour and healthy tissues of resected lobe
High-resolution images to reproduce the features
of the tissues
CT / CH ~ 1.5 - 2
Page 16
Conclusions
Neutron Autoradiography in a hospital environment successfully performed - Linac
Development of an hospital-base neutron source to perform Boron Imaging with a 1D spatial resolution
Real-time detector to perform pharmacokinetic studies results during the irradiation
Blood samples from a perfused lung affected by adenocarcinoma kinetic curves - 10BPA down to concentrations of 5ppm
Evaluation of 10B concentration in tumour and healthy tissues Si-autoradiography – CR 39
Looking forward to make BNCT possible in every radiotherapic unit
Page 17
A new method to measure 10B uptake in lung adenocarcinoma in hospital BNCT
D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan
E. Capelli, P. ChiariA. Zanini
G. Giannini, E. Vallazza
F. Basilico, P. Mauri
F. BorasioP. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti
Thank you!