Paediatric Toxicology SSEM Sept 2012 by Dr. Mark Little 24 th Oct 2012 Dr. Julia Ng Emergency...
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Transcript of Paediatric Toxicology SSEM Sept 2012 by Dr. Mark Little 24 th Oct 2012 Dr. Julia Ng Emergency...
Paediatric ToxicologySSEM Sept 2012 by Dr. Mark Little
24th Oct 2012Dr. Julia Ng
Emergency Physician
Take Home Message
• Most children age 1-2 y.o• Most harmless substance• Most do not need hospital care• Death or serious harm is exceptionally rare• Small list of 1-2 tablets can kill children
Management
• Resuscitation ABCDE• D detect and correct 1) seizure using benzo benzo and benzo, no phenytoin• 2) hypoglycemia• 3) hyper or hypothermia eg serotonin • E emergency antidote - naloxone sodium bicar• • Risk assessment• Agent eg carbamazepine 50mg/kg• Dose• Time since ingestion• Clinical features and progress• Patient factors eg weight, comorbidities• • Supportive• Investigation• Decontamination• Enhanced elimination• Antidote• Disposition
Risk assessment in children
• Dose- response in mg/kg is usually the same as for adults• Children rarely ingested > 2-3 tablets• Exact dose and time may be difficult to estimate• May need to resort to a ' worst case scenario '• Assume the time of ingestion is the latest possible• Assume all missing tablets have been ingested• Do not attempt to account for spillage• If more than one child is involved, assume each child
ingested the amount• Consider NAI in large and repeated dose
Investigation
• Routine investigation :• Paracetamol and ECG for cardio toxicity• Paracetamol can be occult
List of 1-2 tablets lethal in children !
• Amphetamine• Clonidine• Calcium channel• Chloroquine hydrochloride• Dextroproxyphine -VT• Propranolol• Opioids• Sulphonyureas• Theophylline• TCA
Unknown pill
• Admit 12hours for unknown pills• Ability to ETT/BVM• No IVC if alert and running• If flop check BSL• Monitor for level of consciousness and vital
signs•
Case 1
• 2 y.o old was brought to triage by mother, ate 1-2 pellets
Ratsak
• Long acting warfarin - up to 6-8 months
• Kids ingested 1 packet to have significant poison
• Adults 3 packets to be toxic
• Discharged home from triage, no need for blood test
If delibrated self harm,
• Check INR first • no vitamins K• if toxic may need 100mg vit K for 3-6 months• Serial INR check• If INR> 2-3, intervene
Case 2
• 2 y.o brought into ED : • Drowsy• RR 8• Pinpoint pupil
• What is the toxidrome ?
opioid
• Check undisturbed RR• If < 10 , need intervention : naloxone• Dose ?• Alternative vital ETCO• If need a second dose of naloxone , start an
infusion at 2/3 of reversal dose.• Especially if it is overnight
Case 3
• 2.y.o has been playing , possibly ingested grandmother’s antihypertensive medication in a dosette box.
• Grandmother is on a beta blcoker.
• Is this dangerous ?
Case 3
• Atenolol and metoprolol in kids usualy cause slight lower BP and reduced PR
• Settled with fluid
• But propranolol and sotalol the worst :• Propranolol – CNS and class I sodium channel
blockade• Sotalol – K channel blockade, QT prolongation
Case 4
• 2 y.o girl was brought to ED ingested 5mg glipizide.
• Is this a concern ?
Case 4
• Up to 8 hours course of hypoglycaemia
• Dextrose 10% only in adult due to high volume infusion
• Used octretide – stop release of insulin and safe
• Dose ?
Case 5
• 2 y.o boy has ingested 2 lomotil tablets 1 hour ago presented to triage.
• Triage nurse thought it only causes constipation as a result but come to ask you if she can discharge the child and maybe suggest some laxative if constipated.
• What do you do ?
Case 5
• Has anticholinergic ( atropine 23 mcg ) and opioid ( diphenoxylate 2.5mg )
• Symptom onset within 4 hours
Case 6
• 2 children , siblings, had been playing with a bottle of 100% eucalyptus oil and ? ingestion
Case 6
• First sign : coughing• Implies pneumonitis• Within 2 hour drowsy• Then seizure and coma usually short lived• If asymptomatic by 4-6 hours, safe for
discharge
Case 7
• 2 y.o ingested grandfather’s digoxin.
• Is this dangerous ?
• Toxic lethal dose 4mg for child
• Sign of vomiting within 4 hours
Case 8
• 2 y.o ingested unknown amount of iron tablet
Is this a concern ?
Case 8
• If < 40mg/kg elemental iron, no vomiting• AXR to count the tablets to work out dose per
kg• Progressive lowering of Bicarbonate level• Treatment is to maintain HCO > 18
Case 9
• 2 y.o ingested grandfather ‘s colchicine
Case 9
• Vomiting early within 2 hours
• Lethal dose 0.5mg/kg -0.8mg/kg