Pa Tho Physiology of Primary Complex
2
PATHOPHYSIOLOGY OF TUBERCULOSIS Precipitating factor - Socio-economic status - Environment (poor hygiene) - Hx of BRONCHITIS - Age: 7 yrs. Old - Previous contact to person with tuberculosis Low immunity/ resistance of the patient M. tuberculosis (tubercle bacilli) enters the body Bacterial invasion at the lung tissue or near the pleurae of the lungs Bacteria is ingested by the macrophage Arrest of the phagosome w/c result to bacterial replication Necrotic degeneration occurs Production of the cavities filled with cheese like mass of tubercle bacilli, dead WBC, and necrotic lung tissue Drainage of the necrotic materials into the tracheobroncial trees Alveoli fluid increase Decreased gas exchange Decreased O 2 supply in the blood Decreased O 2 supply in the body tissue Tubercle bacilli immunity develops (2- 3 wks. Of infection) Tubercle bacilli remain in the body as long as living bacilli remains in the body Acquiring the immunity leads to further growth of infection ACTIVE INFECTION PRIMARY COMPLEX Cough and colds DOB Body malaise Fatigue Loss of appetite Sudden Wt.
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Transcript of Pa Tho Physiology of Primary Complex
5/12/2018 Pa Tho Physiology of Primary Complex - slidepdf.com
http://slidepdf.com/reader/full/pa-tho-physiology-of-primary-complex 1/2
PATHOPHYSIOLOGY OF TUBERCULOSIS
Precipitating factor
- Socio-economic status
- Environment (poor hygiene)
- Hx of BRONCHITIS
- Age: 7 yrs. Old- Previous contact to person with tuberculosis
Low immunity/
resistance of the patient
M. tuberculosis (tubercle
bacilli) enters the body
Bacterial invasion at the lung tissu
or near the pleurae of the lungs
Bacteria is ingested by
the macrophage
Arrest of the phagosome
w/c result to bacterial
replication
Necrotic
degeneration occurs
Production of the cavities filled with
cheese like mass of tubercle bacilli,
dead WBC, and necrotic lung tissue
Drainage of the necrotic materials
into the tracheobroncial treesAlveoli fluid
increase
Decreased gasexchange
Decreased O2
supply in the
blood
Decreased O2
supply in the
body tissue
Tubercle bacilli
immunity develops (2-
3 wks. Of infection)
Tubercle bacilli remain in
the body as long as living
bacilli remains in the body
Acquiring the immunity leads to
further growth of infection
ACTIVE INFECTION
PRIMARY COMPLEX
Cough and
colds
DOB
Body malaise
Fatigue
Loss of
appetite
Sudden Wt.
5/12/2018 Pa Tho Physiology of Primary Complex - slidepdf.com
http://slidepdf.com/reader/full/pa-tho-physiology-of-primary-complex 2/2
