High resolution MRI at 21.1 T of the hippocampus and temporal lobe white matter

in the differential classification ofAlzheimer’s Disease & Diffuse Lewy Body Disorder

P. Foroutan1,2, M.E. Murray3, S. Fujioka4, K.J. Schweitzer4,D.W. Dickson3, Z.K. Wszolek4 and S.C. Grant1,2

1Chemical & Biomedical Engineering, FAMU-FSU College of Engineering,

2The National High Magnetic Field Laboratory, The Florida State University, Tallahassee, FL, USA; 3Departments of Pathology & Neuroscience, and 4Neurology,

Mayo Clinic, Jacksonville, Florida, USA

Hypothesis

High resolution quantitative MRI performed at high magnetic fields can provide novel pathological information about differential neurodegeneration in LBD and AD related to structural alterations and iron accumulation.

E-Poster #3754 -High resolution MRI at 21.1 T of the hippocampus and temporal lobe white matter in the differential classification of Alzheimer ’s Disease & Diffuse Lewy Body Disorder

Differentiation of dementia 4.6 million new cases of dementia worldwide annually

Two most common types: Alzheimer’s Disease (AD) & Diffuse Lewy Body Disorder (DLBD)

Characteristics: irreversible, progressive, affects mostly males 60 years and older

Symptoms: decline of cognitive functions (learning & memory, language etc.)

AD DLBD

Characteristics:-sheet amyloid (Ab)

plaques & neurofibrillary tangles

-synuclein aggregates

Location: Entorhinal cortex (hippocampus &

amygdala)

dispersed (spares hippocampus & amygdala)

Previous Research: atrophy of hippocampus,linked to iron

disperse atrophy gray matter,

linked to iron

E-Poster #3754 -High resolution MRI at 21.1 T of the hippocampus and temporal lobe white matter in the differential classification of Alzheimer ’s Disease & Diffuse Lewy Body Disorder

Average T2 and T2* times of the HC

* Indicates statistical significance in a one-way ANOVA with LSD test (p<0.05)

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E-Poster #3754 -High resolution MRI at 21.1 T of the hippocampus and temporal lobe white matter in the differential classification of Alzheimer ’s Disease & Diffuse Lewy Body Disorder

Conclusions T2 and T2* quantification of temporal lobe substructures proves a

useful measure for the differential diagnosis of AD and DLBD. In addition, ADC shows significant differences between AD and Controls.

Most promising biomarkers are the parahipocampal gyrus and temporal lobe white matter, which showed differing group patterns of T2 and T2*.

Lower T2 and T2* relaxation in the PHG is more likely a LBD case compared to either AD or normals whereas, higher T2 and T2* values in the white matter would more likely coincides with AD.

T2 times significantly correlated with vacuolation, which is not a pathologic entity, but does reflect the loss of cells or neuropils.

E-Poster #3754 -High resolution MRI at 21.1 T of the hippocampus and temporal lobe white matter in the differential classification of Alzheimer ’s Disease & Diffuse Lewy Body Disorder

Take Home Summary

AD classification correlates with increased T2/T2* and ADC for all deviations from control while DLBD correlates with decreased relaxivity

Acknowledgements The National High Magnetic Field Laboratory FAMU-FSU College of Engineering

Funding provided by: ◦ FSU (CRC-MDS) ◦ NHMFL (NSF DMR-0084173)

E-Poster #3754 -High resolution MRI at 21.1 T of the hippocampus and temporal lobe white matter in the differential classification of Alzheimer ’s Disease & Diffuse Lewy Body Disorder