P. Darrell Neufer, Ph.D.P. Darrell Neufer, Ph.D. Page 2 Nov-16 . Research Support . Agency Grant ....

P. Darrell Neufer, Ph.D.

Mailing Address East Carolina Diabetes & Obesity Institute 115 Heart Drive, ECHI – Mail Stop 743 East Carolina University Greenville, NC 27858 Tel.: (252) 744-2780 email: [email protected]

Personal DOB: 04/22/1962 Married: Robin L. Neufer Children: Rachel (‘90 ), Kayla (’91), Drew (’95)

Position Director, East Carolina Diabetes and Obesity Institute (http://www.ecu.edu/ecdoi/) Professor, Departments of Physiology and Kinesiology Education 1980-1984 B.S. West Virginia Wesleyan College, Buckhannon, WV 1984-1986 M.S. Exercise Physiology, Human Performance Laboratory, Ball State University,

Muncie, IN 1989-1993 Ph.D. Biochemistry, East Carolina University School of Medicine, Greenville, NC Postdoctoral Training 1993-1996 Molecular Cardiology, Department of Internal Medicine, University of Texas

Southwestern Medical Center, Dallas, TX Professional Experience 1986-1989 Research Physiologist (Civilian GS-11), U.S. Army Research Institute of

Environmental Medicine, Natick, MA 1996-2002 Assistant Fellow, John B. Pierce Laboratory, New Haven, CT 1998-2004 Assistant Professor, Cellular & Molecular Physiology, Yale University School of

Medicine, New Haven, CT 2002-2006 Associate Fellow, John B. Pierce Laboratory 2004-2006 Associate Professor, Cellular & Molecular Physiology, Yale University 2006-2008 Associate Professor, Exercise and Sport Sciences (Primary) and Department of

Physiology, East Carolina University 2009-present Professor, Departments of Physiology (primary) and Kinesiology (joint), East

Carolina University 2009-present Director, East Carolina Diabetes and Obesity Institute, East Carolina University Honors and Awards 2013-2014 Chair, Integrated Physiology of Obesity & Diabetes Study Section Chair, NIH 2007 President’s Lecture Award, American College of Sports Medicine 2005 Alumni Achievement Award, West Virginia Wesleyan College 2002 John and Janice Fisher Visiting Scholar, Ball State University 1993-1996 Postdoctoral Training Grant Fellowship, NIH 1984 Cum Laude Graduate, West Virginia Wesleyan College Research Interests Mitochondrial Bioenergetics, Redox Systems Biology and Metabolic Disease, Cellular and Molecular Control of Skeletal Muscle Metabolism

http://www.ecu.edu/ecdoi/

P. Darrell Neufer, Ph.D. Page 2 Nov-16

Research Support Agency Grant Current NIH R01 DK 110656-01A0 – PI (25%) Organic Cations on Mitochondrial Energetic Driving

Forces. Total budget $2,537,249; 07/01/2016-6/30/2021. NIHR01 DK103562 – PI C Witczak (role Co-I, 5%). Calmodulin Kinases and Control of Skeletal

Muscle Glucose Metabolism. Total budget $1,789,201; 07/01/2015-6/30/2020 Pending NIH R01 AR071263-01 - Multi-PI (25%) with JP Thyfault, Univ of Kansas. Statins, mitochondrial

function and aerobic capacity. Total budget $3,744,698, Subcontract $1,619,714 11/1/2016-10/31/2021 (11th percentile)

NIH R01 DK107397-01- PI Funai (role Co-I, 5%) PE methylation in skeletal muscle energy efficiency. Total budget $ $1,795,261, 09/01/2016-08/31/2021 (16th percentile)

Previous NIH R01 R01 DK096907 – (role: PI) Redox Biology and Muscle Insulin Sensitivity. Total award –

$1,407,336; 07/02/12-06/30/16. NIH R01 DK074825-01 (role: PI) Linking Mitochondrial Bioenergetics to Muscle Insulin

Sensitivity. Total Award - $1,651,639; 02/16/09-01/31/14. WO#10 Stealth Peptides Inc. (PI Brown; role: CoI 0.6 CM). Novel Insight into the Mechanism of

Action for Bendavia. Total Award - $132,009; 04/01/12-03/31/13. NIH R13 AR063496-01 (role: CoPI/Conference Organizer; PI Martin Frank, Ph.D.) Conference on

the Integrative Biology of Exercise VI. Total $30,000 NIH R01 DK073488-01 (role: PI) Mitochondrial Bioenergetics and Etiology of Insulin Resistance.

Total award - $1,187,622; 07/11/07 – 04/30/12 NIH R01 DK074825-01S1 (role: PI) Linking Mitochondrial Bioenergetics to Muscle Insulin

Sensitivity. Total Award - $40,602; 2/16/09-1/13/10. NIH R01 AR 45372-01 (role: PI) Molecular regulation of LPL in skeletal muscle. Total award -

$1,175,968, 99 – 05. Yale Yale Diabetes Endocrinology Research Center Pilot Project Grant. (P.I.) Diet and

hormonal-induced transcriptional regulation of glucose and lipid metabolism genes in skeletal muscle. Total award - $40,000, 98-00.

NIH R01 HL20634-20 (role: Co-I, G.W. Mack P.I.) Blood volume and venous return in thermal strain. Total award - $1,691,657, 98-04.

NIH R01 AG17163-01 (role : Co-I, L. DiPietro P.I.). Exercise and Glucose Regulation in Older Women. Total award - $1,662,560, 99-04.

As Director of ECDOI Golden LEAF (role: Co-PI with W.J. Pories) Building the Economic Future of Eastern North Carolina

by Expanding the Next Generation of Biomedical Researchers. Total Award - $200,000; 10/1/2013-9/31/2015.

HRSA 1C76HF20563 (role: PI) Research Equipment for the East Carolina Diabetes and Obesity Institute (equipment only). Total Award - $219,780; 9/1/10-6/30/12

HRSA 09C76HF15408 (role: PI) Clinical Chemistry Analyzer for the Metabolic Institute (equipment only). Total Award - $188,100; 9/1/09-8/31/10

Golden LEAF (role: Co-PI with W.J. Pories) Development of an Eastern North Carolina Metabolic Institute. Total Award - $1,000,000; 06/07/07-10/31/11

HRSA (role: Co-PI with W.J. Pories) Equipment to Enhance Research at the Metabolic Institute for the Study of Diabetes and Obesity. Total Award - $331,692; 10/2/08-8/31/10

Professional Activities Grant Review Committees


2016 NIH/CSR Ad Hoc – Cellular Mechanisms in Aging and Development (CMAD) - October 2016 NIH/CSR Ad Hoc – Cellular Aspects of Diabetes and Obesity (CADO) - February 2015 NIH/CSR Ad Hoc – Skeletal Muscle and Exercise Physiology (SMEP) - October 2015 NIH/CSR Ad Hoc – Special Emphasis Panel 2015/10 ZAG1 ZIJ-5 (O1) for PPG 2015 Boston Nutrition Obesity Research Center Pilot & Feasibility Program 2015 UTMB Sealy Center on Aging Pepper Pilot Program 2014 Science Foundation of Ireland – site visit review 2014 NIH Common Fund Initiative – Molecular Mechanisms of Physical Activity Induced

Health Benefits, Co-Chair of subgroup on Integrative Physiology 2013-2014 NIH/CSR Study Section Chair – Integrative Physiology of Obesity & Diabetes (IPOD) 2009-2013 NIH/CSR Study Section Member – Integrative Physiology of Obesity & Diabetes (IPOD) 2013 National Health and Medical Research Council (Australia) - Project Grants round 2013 2013 Ireland Health Research Board – 2013 application 2012 California Pacific Medical Center 2011 Science Foundation Ireland – 2011 application 2009 NIH/CSR Ad Hoc – Special Emphasis Panel, ZRG1 EMNR-A 02 M 2008-2009 NIH/CSR Ad Hoc – Integrative Physiology of Obesity & Diabetes (IPOD) Study Section 2008 NIH/CSR Ad Hoc – Program Project to National Institute on Aging 2008 Austrian Science Fund 2008 Agency for Science, Technology and Research’s (A*STAR) Biomedical Research

Council (BMRC), Singapore 2008 University of Michigan Geriatrics Center Pilot Grants Program 2008 The Scientific Committee of the Association Française contre les Myopathies, Paris,

France 2007 NIH/CSR Ad Hoc – Cellular Aspects of Diabetes & Obesity (CADO) Study Section, 6/07

and 10/07 Meetings 2003-2007 NIH/CSR – NRSA Pathophysiology Fellowships (F10) Study Section 2004 NASA – Muscle Biology peer review panel 2004 Programme grant application – The Wellcome Trust, London, UK. 2004 American Diabetes Association 2001 Programme grant application – The Wellcome Trust, London, UK. 2001 Programme grant application – Swiss National Science Foundation National Committees 2016 External Advisory Panel - NIH/Common Fund-sponsored project “Molecular Transducers

of Physical Activity in Humans Consortium (MoTrPAC)” 2014-2016 Chair, Program Committee for American Physiological Society Specialty Conference

entitled Integrative Biology of Exercise-VII, November 2-4, Phoenix, AZ 2016-2018 Co-Organizer Keystone Meeting entitled “Bioenergetics and Metabolic Disease”,

Keystone Resort, January 21-25, 2018, Keystone, CO, USA 2016 Chair, External Advisory Panel for University of Alabama Center for Exercise Medicine,

September 21-22, Birmingham, AL 2015 Chair, Mitochondrial Physiology (MiP) School Aug 9-13, Greenville, NC 2014 Mitochondrial Physiology Society – Board Member 2014 NIH Workgroup for Common Fund application on the “Molecular Mechanisms Whereby

Physical Activity Prevents Disease and Improves Health Outcomes”. Led by Directors of NIA, NIAMS and NIDDK. Co-Chair (with F. Booth), Integrative Physiology Subgroup

2010-2012 Chair, Program Committee for American Physiological Society Specialty Conference entitled Integrative Biology of Exercise-VI, September 21-24, Westminster, CO

2010-2016 Chair, Science Integration and Leadership Committee, American College of Sports Medicine


2002-2008 Program Committee for American Physiological Society Specialty Conference entitled Integrative Biology of Exercise-IV (Fall 2004) & -V (Fall 2008)

2005-2008 Environmental & Exercise Physiology representative to the Nominating Committee, American Physiological Society

2005-2008 Environmental & Exercise Physiology Programming Chair and Representative to the American Physiological Society Joint Programming Committee

2003-2006 Elected Councilor – Exercise & Environmental Physiology Section of the American Physiological Society

2002-2005 Member At Large - Joint Program Committee for Experimental Biology – American Physiological Society

Scientific Journals 2015- Editorial Advisory Board – Comprehensive Physiology 2012-present Editorial Board - Diabetes 2009-2013 Associate Editor – American Journal of Physiology, Regulatory, Integrative and

Comparative Physiology 2008-2009 Consulting Editor – American Journal of Physiology, Regulatory, Integrative and

Comparative Physiology 1999-present Editorial Board – Journal of Applied Physiology 1992-present Reviewer – Aging Cell; American Journal of Physiology (AJP:Cell, AJP:Endo,

AJP:Reg); American Journal of Pathology; Biochemical Journal; Biochemistry & Biophysica Acta; Biophysical Journal, Cell Metabolism; Cell Transplantation; Comprehensive Physiology; Diabetes; Diabetes & Metabolism Reviews; Diabetologia; European Journal of Physiology; Experimental Physiology; FASEB Journal; FEBS Letters; Free Radical Biology Medicine; Gerontology; Journal of Applied Physiology; Journal of Clinical Endocrinology & Metabolism; Journal of Clinical Investigation; Journal of Physiology; Obesity; Physiological Genomics; Proceedings of the National Academy of Sciences; Science; Translational Research; Trends in Endocrinology & Metabolism;

Other Professional Service 2012-present Advisory Board - UNC Center For Diabetes Translation Research 2008 Symposium Organizer – “Reactive Oxygen Species: Consequences on Cellular

Metabolism”. Integrative Biology of Exercise, Hilton Head, South Carolina. 2008 Symposium Organizer – “Physical Inactivity: A Biological Basis for Metabolic Disease”,

Physiological Society, Cambridge, UK 2006 Symposium Organizer and Co-Chair (DA Hood) – “Linking Mitochondrial Function in

Skeletal To Disease” Experimental Biology, San Franscisco. 2001 Symposium Chair – “Genomics and Molecular Basis of Exercise and Environmental

Physiology: Molecular Control of Thermogenesis” Experimental Biology, Orlando, FL Patents 2016 P.D. Neufer, E.J. Anderson & H.H. Szeto. Methods for Preventing or Treating Insulin

Resistance. Issued Canadian No: 2,713,150. Date of Patent: January 5, 2016. 2014 P.D. Neufer, E.J. Anderson & H.H. Szeto. Methods for Preventing or Treating Insulin

Resistance. Issued China No: ZL 200980104457.4 Date of Patent: Feb 6, 2009 - 2029. 2014 P.D. Neufer, E.J. Anderson & H.H. Szeto. Methods for Preventing or Treating Insulin

Resistance. Issued Japanese No: 5453320. Date of Patent: Jan. 10, 2014. 2012 P.D. Neufer, E.J. Anderson & H.H. Szeto. Methods for Reducing the Risk, Lessening the

Symptom, or Delaying the Onset of Insulin Resistance by Administering SS-31. Issued Patent No: US 8,088,727 B2. Date of Patent: Jan. 3, 2012.


Professional Affiliations 1990-present American Physiological Society 1999-present American Diabetes Association 2009-2016 American College of Sports Medicine Teaching Experience 2013-present Medical Physiology – 4 Lectures Endocrinology/Metabolism 2012-present Graduate Physiology – 6 Lectures in membrane physiology/bioenergetics 2009-2013 BIOC/KINE 8320 “Biochemistry/Bioenergetics II: Regulation of Metabolism” –

Co-Director, ~12 graduate students/yr 2008 KINE 3805, “Exercise Physiology” – 35 undergrads 2007 KINE 7335, Seminar – 8 graduate students. 1996-2006 Yale University: Cellular and Molecular Physiology 550a “Physiological

Systems” – ~80 Graduate/Undergraduate Students – 10 Lectures 1997-2006 Yale University: Medical Physiology Case Conferences: ~10 medical/graduate

students; 1.5 h/wk, 24 weeks 2003-2006 Yale University: CMP 520a, Current Perspectives in Physiology – Lecture and

round table session every other year 1999 August Krogh Institute, Copenhagen, Denmark: “Molecular Muscle Biology” –

18 Graduate Students – 3 Lectures Personnel (Primary Mentor) Postdoctoral Fellows 2013-present Terrence E. Ryan, Ph.D. NRSA Fellowship (F32 HL129632) - Co-mentor with

Joe McClung 2010-2014 Laura Gilliam, Ph.D. NRSA Fellowship (F32 AR061946; 5/22/2012–7/15/2014)

“The role of mitochondria in skeletal muscle fatigue caused by cancer chemotherapy”. Current position: Research Health Scientist, Cincinnati VA Medical Center, Cincinnati, OH.

2008-2011 Christopher Perry, Ph.D. – Current position: Assistant Professor, Department of Biology, York University, Toronto, ON, Canada

2008-2011 Hyo Bum Kwak, Ph.D. (co-mentored with R. Cortright) 2006-2008 Ethan J. Anderson, Ph.D. – Current position: Assistant Professor, Department of

Pharmacology and Toxicology, East Carolina University 2002-2004 Hanae Akeda-Yamazaki, Ph.D. – Associate Professor, Laboratory of Nutrition

Chemistry, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan

2000-2003 Robin Looft-Wilson, Ph.D. (coadvisor w/S. Segal) – Current position: Associate Professor, College of William & Mary

2000-2002 James Stoppani, Ph.D. – Current position: Senior Scientific Editor, Weider Publications, Woodland Hills, CA

1998-2000 Henriette Pilegaard, Ph.D. – Current position: Professor, August Krogh Instititute, Copenhagen, Denmark

Doctoral Students 2016-present Kelsey McLaughlin – Physiology, Brody School of Medicine, East Carolina U. 2012-present Maria Torres – Bioenergetics, East Carolina University 2011-present Cody Smith – Physiology, Brody School of Medicine, East Carolina University 2013-2016 Lauren Reese – Physiology, Brody School of Medicine, East Carolina University


2010-2014 Daniel S. Lark – Bioenergetics, East Carolina University. Current position: Postdoctoral fellow with David Wasserman, Ph.D., Vanderbilt University, Nashville, TN

2009-2013 Kelsey Fisher-Wellman – Bioenergetics, East Carolina University. Current position: Postdoctoral Fellow with David James, Ph.D., Garvan Institute, Sydney, Australia

2010-2012 Rachel Kozy – Bioenergetics, East Carolina University. Withdrew from program. 2007-2010 Chien-Te (Peter) Lin - Bioenergetics, East Carolina University. Current position:

Research Assistant Professor, East Carolina Diabetes and Obesity Institute & Dept of Physiology

2006-2010 Daniel A. Kane (Co-mentor w/R. Cortright) – Bioenergetics, East Carolina University. Current position: Assistant Professor St. Francis Xavier University, Antigonish, Nova Scotia, Canada

2003-2006 Ethan J. Anderson, Cellular and Molecular Physiology, Yale University. Current position: Assistant Professor, Department of Pharmacology and Toxicology, East Carolina University

Masters Students 2011-2013 William J. Mayo – Exercise Physiology, East Carolina University 2008-2010 Daniel S. Lark – Exercise Physiology, East Carolina University. Currently Ph.D.

student, East Carolina University 2007-2009 Oh Sung Kwon –Exercise Physiology, East Carolina University. Currently Ph.D.

student, University of Florida Research Assistants 2013- Cheryl Smith, M.S. 2010-2013 Brook Cathie, M.S. 2008-2010 Connie Tweedie, M.S. 1999-2003 Audrey Hildebrandt, M.S. Undergraduate Students 2013- Katherine Buddo – Biology, Applachian State University 2003-2005 Lydia Finley – Biology, Yale University; Received PhD from Harvard 2011,

currently Post Doctoral Fellow with Craig Thompson, Abramson Cancer Center, University of Pennsylvania

2003-2004 Laura Brenner – Biology, Yale University; Medical School 2003-Summer Jon McClain – Biology, Yale University 2001-2002 Sunita Puri – Biology, Yale University, Recipient of Undergraduate Summer

Research Fellowship Award, American Physiological Society; Rhodes Scholar. 2001-Summer Joyce Sun – Biology, Yale University 1997-1998 Alexa Romberg – Biology, Yale University Visiting Scientists 2015 Bruno Gonzaga Teodoro, Ph.D. student - University of Sao Paulo, Brazil 2014 Juliane Campos, Ph.D. student – University of Sao Paulo, Brazil 2000 David Cameron-Smith, Ph.D. - Deakin University, Victoria, Australia Other Thesis Committees 2016 Catherine Buddo (Masters), Chemistry, East Carolina University Lauren Westerhold (Masters), Chemistry, East Carolina University Melissa Inigo (Doctoral), Physiology, East Carolina University Cameron Schmidt (Doctoral), Physiology, East Carolina University 2015 Anthony Verkerke (Doctoral, Bioenergetics, East Carolina University

Oksana Williams (Doctoral), Physiology, East Carolina University


2014 Calvin Justus (Doctoral), Interdisciplinary Program in Biological Sciences, East Carolina University Jeremie Ferey (Doctoral), Bioenergetics, East Carolina University Stephanie Adams (Doctoral), Biochemistry, East Carolina University Jamie Hibbert (Doctoral), Bioenergetics, East Carolina University

2013 Rick Alleman (Doctoral), Physiology, East Carolina University Stine Ringholm (Doctoral), Biology, University of Copenhagen

2012- Patrick Davis (Doctoral), Bioenergetics, East Carolina University Matt Hinkley (Doctoral), Bioenergetics, East Carolina University Michael Koury (Masters), Interdisciplinary Biomedical Research

2011- Fatiha Moukdar (Doctoral), Physiology, East Carolina University 2011-2013 Brennan Smith (Doctoral), Human Health & Nutritional Sciences, Guelph University

Joshua Stone (Doctoral), Physiology, East Carolina University 2010-2012 Gina Bataglia (Doctoral), Bioenergetics, East Carolina University

Chad Frasier (Doctoral), Physiology, East Carolina University 2010-2011 Ruben Sloan III (Doctoral), Bioenergetics, East Carolina University

Tracey Woodlief (Doctoral), Bioenergetics, East Carolina University Rocio Ellis (Masters), Exercise Physiology, East Carolina University

2008-2009 Jessica L. Dries (Doctoral), Physiology, East Carolina University 2008-2009 Ruben C. Sloan (Masters), Exercise Physiology, East Carolina University 2007-2008 Willam Jesse Price III (Masters), Biology, East Carolina University 2007-2008 Juliet P. Anderson (Masters), Exercise Physiology, East Carolina University 2006-2009 Elizabeth Fonteneau (Doctoral), Physiology, East Carolina University 2006-2009 Benjamin Bickman (Doctoral), Bioenergetics, East Carolina University 2006-2009 Kristen Boyle (Doctoral), Bioenergetics, East Carolina University 2002 Rebecca Tunstall (Doctoral), Deakin University, Victoria, Australia Personel Supervised as Director of ECDOI 2015- Jim Aloor, Ph.D., Research Assistant Professor & Operations Manager 2015- Brennan McCarty, Administrative Assistant 2013-2015 Ashley Busada, Administrative Assistant 2012-2014 B. Drew Rocket, Ph.D. Research Assistant Professor, Current position: Program

Manager, Bayer Corporation, Raleigh, NC 2011-2012 Hyo Bum Kwak, Ph.D., Research Assistant Professor, Current position: Assistant

Professor, Inha University, Incheon, South Korea Institutional Activites/Committees 2015- ECHI Role for the Future 2015- 5-Year Review Committe for Vice Chancellor of Health Science Division 2014-2015 EGRE – NIH Biomedical Research 2014-2016 Brody SOM Fiscal Sustainability Committee 2014- Health Sciences Division Research Council 2014- University Research Council 2014-2015 ECDOI Faculty Search Committee - Chair 2012-2013 Faculty Search Committee, Human Performance Laboratory, Kinesiology 2012-2013 Faculty Search Committee, Department of Physiology 2011- Brody Council Committee – Brody School of Medicine 2011- Brody Research Council – Brody School of Medicine 2011 Research & Graduate Studies Executive Committee 2010-2013 Research Working Group for SACS Reaffirmation


2010 Research & Graduate Studies Strategic Planning Retreat – 8/19-8/20 2010 Joint Appointments Review Committee, ECU 2010 Search Committee, Open Rank Faculty Position, jointly offered through Division of

Health Sciences, College of Health & Human Performance, Human Performance Laboratory, and the East Carolina Diabetes and Obesity Institute

2009-2010 F&A Distribution Review Committee, ECU 2009 LABS Working Group (PI Walter Pories) 2007 ECU Centential Committee 1996-2006 John B. Pierce Laboratory - Safety Committee, Chair; Animal Care Committee; Core

Equipment Committee, Chair; Search Committees Invited Presentations 11/16/2016 “Reactive Oxygen Species” presented in American Society for Nephrology Early Program

entitled “Advances in Research Conference – Metabolic Phenotyping: From Mounse to Man”, Chicago, IL

09/22/2016 “Exercise – It’s Electric” UAB Center ofr Exercise Medicine Symposia Day, Birmingham, AL

08/23/2016 “Controlling Electrical Charge – The Vital Force of Exercise and Health” 2nd Annual Frank Weaver Booth III Lectureship in Physical Activity, Exercise and Health. University of Missouri

07/10/2016 “Direct Real-Time Quantification of Mitochondrial Oxidative Phosphorylation Efficiency in Permeabilized Skeletal Muscle Myofibers”. MitoFit Science Camp 2016, Kuehtai, Austria

06/16/2016 “Bioenergetics: Adaptive Responses to Acute Exercise and Exercise Training” IMPACT II, Busan, South Korea

05/20/2016 “Hey, Mitochondriacs Are People Too – The Science Behind Exercise Is Medicine” Invited speaker in “Exercise Is Medicine 2016: From Research to Prescription”, Kansas University Medical Center, Kansas City, KS

04/29/2016 “Was Mary Shelly a Mitochondriac…Are You?” The Noll Laboratory, Penn State University, University Park, PA

11/20/2015 “Electricity - The Elemental Principle of Life (was Dr. Frankenstein right?)”. 5th Annual Huffines Discussion, Texas A&M University, College Station, TX

11/14/2015 “Viewing Diabetes from a Mitochondrial Bioenergetics Perspective”. 2015 MCB Fall Retreat and Banquet – Keynote Speaker, Ohio University, Athens, OH

8/11/2015 “Equilibrium, Redox and Membrane Potentials” Lecture given at the 9th Mitochondrial Physiology (MiP) School Greenville – Mitochondria Summer Camp, East Carolina University, Greenville, NC

7/15/2015 “Role of Mitochondrial ROS Production and Health”. Presentation in symposium entitled The Mitochondrion: A Powerhouse for the Cell or a Key to Animal Productivity? ASAS-ADSA Joint Annual Meeting, Orlando, FL

6/11/2015 “Exercise, Mitochondria and Metabolic Disease” IMPACT Meeting, Busan, South Korea.

6/6/2015 “Mitochondria Effects on Redox and Other Complexities”. Presentation in symposium entitled Mitochondrial Dysfunction-How important Is It in Insulin Resistance? American Diabetes Association, Boston, MA

6/3/2015 “Mitochondrial Function – New Frontiers” Saltin Symposium: Exercise and Integrative Physiology. Copenhagen, Denmark

5/30/2015 “Eating and Exercise: Creating and Dissipating Electrical Charge”. Presentation in Symposium entitled Mitochondria: An Old Player in new Dramas. American College of Sports Medicine, San Diego, CA


5/12/2015 “Integration of Mitochondrial Bioenergetics & Redox Biology in Metabolic Diseases”. Cardiovascular Research Center, Mass General Hospital & Harvard, Charleston, MA

5/8/2015 “The Electrical Circuitry of Metabolic Disease: Integrating Mitochondrial Bioenergetics and Redox Biology”. Department of Human Physiology, University of Oregon, Eugene, OR.

3/27/2015 “The Electrical Circuitry of Metabolic Disease: Integrating Mitochondrial Bioenergetics and Redox Biology”. Department of Medicine, Boston University, Boston, MA.

10/30/2014 “Integrative Physiological Mechanisms by which Physical Activity Benefits Multiple Tissues and Organ Systems” NIH Workshop. Bethesda, MD

9/9/2014 “Assessing ATP production and oxygen consumption simultaneously in permeabilized fibers: ATP/O” MiP2014 (Mitochondrial Physiology), Obergurgl, Austria

8/27/2014 “Integrating Mitochondrial Bioenergetics and Redox Biology in Metabolic Disease” Stricht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC

5/30/2014 “Integrating Miotchondrial Bioenergetics and Redox Signaling in Chronic Diseases”. Keynote address: Duke Interdisciplinar Colloquium on Mitochondrial Dysfunction in Aging and Disease. Duke University School of Medicine, Durham, NC

5/15/2014 “The East Carolina Diabetes and Obesity Institute”. British American Business Council - NC Eastern Economic Development Healthcare/Biomedical Forum. East Carolina Heart Institute, Greenville, NC

4/10/2014 “Linking Mitochondrial Bioenergetics and Cellular Redox Biology to the Etiology of Insulin Resistance”. Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, OH

3/7/2014 “PDC and NNT Comprise an Energy Consuming Redox Circuit: Implications for Cellular Redox Control”. Presented at Advances in Skeletal Muscle Biology in Health and Disease. University of Florida, Gainsville, FL

2/4/2014 “Energy & Mitochondrial Bioenergetics”. Lecture presented in course entitled Control of Energy Metabolism. University of Missouri, Columbia, MO

1/16/2014 “Comparison of Ex-Vivo Approaches to Assess Mitochondrial Function”. Presented as invited participant at special meeting at the National Institute of Aging entitled Mechanisms of Muscle Aging and Response to Exercise Training. Bethesda, MD.

12/5/2013 “Mitochondrial Function and Regulation of Insulin Sensitivity”. Symposium session entitled Mitochondria. World Diabetes Congress, Melbourne, Australia

11/21/2013 “Insulin Resistance: Is It All About the Yin-Yang of Bioenergetics?” Arkansas Children’s Nutrition Center, Little Rock, AK

10/3/2013 “Mitochondrial Bioenergetics and Metabolic Disease”. American Society of Bone and Mineral Research: Cutting Edge Discoveries in Muscle Biology, Disease and Therapeutics. Baltimore, MD

8/26/2013 “Consideration of experimental parameters and other indices of mitochondrial function”, Mitochondrial Physiology (MiP) Summer School, August 26-30, 2013, Copenhagen, Denmark.

5/21/2013 “Regulation of Insulin Sensitivity via Mitochondrial Bioenergetics and Redox Systems”. Cold Spring Harbor Conference Asia entitled: Metabolism, Obesity, and Obesity-Related Diseases. May 20-24, 2013, Suzhou, China

4/15/2013 "Taxman - Viewing Metabolic Balance/Imbalance from a Cell's Perspective". Department of Biochemistry & Molecular Biology, Virginia Commonwealth University, Richmond, VA

4/5/2013 “Linking Mitochondrial Bioenergetics to Insulin Sensitivity via Redox Systems Biology”. Mitochondria and Metabolism Interest Group, University of Washington, Seattle, WA

3/21/2013 “Bioenergetics, Redox Biology and Insulin Sensitivity”. Oklahoma Medical Research Foundation, Oklahoma City, OK


2/19/2013 “Linking Mitochondrial Bioenergetics to Insulin Sensitivity via Redox Systems Biology”. UNC Chapel Hill McAllister Heart Institute, Chapel Hill, NC

11/28/2012 “Insulin Sensitivity from a Mitochondrial Bioenergetics and Redox Biology Perspective”. Department of Biochemistry, Molecular Biology and Biophysics University of Minnesota, Minneapolis, MN

11/22/2012 “Understanding Metabolic Disease in the Bioenergetic Circle of Life”. University of Sao Paulo Conference, Bauru, Brazil.

10/3/2012 “Redox State and Insulin Sensitivity” in EASD/ADA symposium entitled Mitochondrial Function and Insulin Sensitivity. EASD Meeting, Berlin, Germany

9/30/2012 “Comparison of Ex-Vivo Approaches to Assess Mitochondrial Function”. European Association for the Study of Diabetes (EASD) Satellite Symposium on Mitochondrial Biology, Berlin, Germany

9/28/2012 “Linking Mitochondrial Bioenergetics to the Regulation of Insulin Sensitivity via Redox Systems Biology” August Krogh Institute, Copenhagen, Denmark

6/3/2012 “Exercise-Induced Increases in Mitochondrial Respiratory Sensitivity”. Invited presentation in symposium entitled: Exercise Induced Activation of Bioenergetic Pathways in Skeletal Muscle. American College of Sports Medicine Meeting, San Francisco, CA

5/17/2012 “Mitochondrial Bioenergetics, Redox Systems Biology and the Etiology of Insulin Resistance”. Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, TX

4/24/2012 “Mitochondrial Bioenergetics and the Etiology of Diabetes”. Invited presentation in symposium entitled: Mitochondrial Dysfunction in Human Disease. Experimental Biology 2012, San Diego, CA

4/16/12 “Linking Mitochondrial Bioenergetics to the Etiology of Insulin Resistance” Department of Physiology & Biophysics, Case Western Reserve University, Cleveland, OH.

2/16/12 “Mitochondrial Bioenergetics, Redox Systems Biology and the Etiology of Insulin Resistance” Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA

11/11/11 “High Fat Load from a Mitochondrial Bioenergetic Point of View”. Invited presentation for the 14th Annual International Symposium of the CIHR Research Chair in Obesity, Quebec, Canada.

11/3/11 “Linking Mitochondrial Bioenergetics to the Etiology of Insulin Resistance”. Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, PA

6/28/11 “Muscle Energetics, ROS, and Insulin Resistance”. Invited presentation in symposium entitled: Mitochondrial Regulation of Insulin Action and Metabolism. American Diabetes Association Meeting, San Diego, CA

4/19/11 “Mitochondrial Bioenergetics: At the Crossroads of Cellular Metabolic Balance”. Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC.

1/14/11 “Mitochondrial Bioenergetics, Redox Imbalance and Insulin Resistance” Presented in symposium entitled: Insulin Resistance, Mitochondrial Dysfunction and Lipotoxicity in Humans. Keystone Diabetes and Obesity Meeting, Keystone, CO

11/8/10 “Is Mitochondrial Bioenergetics the Link Between Metabolic Balance and Insulin Sensitivity?” University of Cincinnati, Cincinnati, OH

9/25/10 “Impact of Exercise from a Mitochondrial Bioenergetics Point of View”. Presented in symposium entitled “Signaling Mechanisms Mediating Skeletal Muscle Adaptations to Exercise”, ACSM Conference on Integrative Physiology of Exercise, Miami, FL

6/21/10 “Mitochondrial Function in Permeabilized Skeletal Muscle Fibers: Technical Considerations and New Data”. Pre 1-day meeting before American Diabetes Association meeting, Burnham Institute, Florida


5/13/10 “Mitochondrial Bioenergetics: The Crossroads of Cellular Metabolic Balance” Department of Nutrition, Dietetics, & Food Science, Brigham Young University, Provo, UT

4/6/10 “Mitochondrial Bioenergetics: The Crossroads of Cellular Metabolic Balance” Glaxo-Smith-Kline, Raleigh, NC

4/5/10 “Is Mitochondrial Bioenergetics the Link Between Metabolic Balance and Insulin Sensitivity?” Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA

3/26/10 “Is Mitochondrial Bioenergetics the Link Between Metabolic Balance and Insulin Sensitivity?” Department of Exercise Science, University of South Carolina, Charleston, SC

2/2/10 “Mitochondrial Bioenergetics: The Crossroads of Cellular Metabolic Balance” Graduate Center for Nutritional Sciences. University of Kentucky, Lexington, KY

12/4/09 “Is Mitochondrial Bioenergetics the Link Between Metabolic Balance and Insulin Sensitivity?” Endocrinology/Nutrition Seminar Series, University of Colorado School of Medicine, Aurora, CO

9/24/09 “Linking Mitochondrial Bioenergetics to Insulin Resistance”. 18th Annual Southeast Lipid Research Conference, Callaway Gardens, Pine Mountain, GA

2/25/09 “Mitochondrial Bioenergetics: Linking Metabolic Imbalance to Metabolic Disease”. Department of Kinesiology, Texas A&M University, College Station, TX

2/23/09 “The Engines Inside Cells: Are They the Key to Type II Diabetes?” Science at Starlight Lecture Series, East Carolina University, Greenville, NC

2/19/09 “Mitochondrial Bioenergetics: Linking Metabolic Imbalance to Metabolic Disease”. Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA

2/13/09 “Understanding Physical Activity and Metabolic Balance from the Cell's Point of View”. Keynote Basic Science Lecture, Southeast American College of Sports Medicine, Birmingham, AL

11/16/08 “Linking Mitochondrial Bioenergetics to the Etiology of Insulin Resistance”. Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC

9/26/08 “Linking Mitochondrial Bioenergetics to Insulin Resistance”. Presented in symposium entitled Reactive Oxygen Species: Consequences on Cellular Metabolism. Integrative Biology of Exercise meeting, 2008, Hilton Head, South Carolina.

7/14/08 “Cellular Metabolic Imbalance in the Context of Mitochondrial Bioenergetics” The Physiological Society 2008, Cambridge, United Kingdom

7/11/08 “Mitochondrial H2O2 Emission: The Cell’s Mean Mr. Mustard or Polythene Pam?” Division of Metabolic and Cellular Medicine, Schools of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom

3/26/08 “Linking Mitochondrial Bioenergetics to Metabolic Imbalance-Induced Cellular Dysfunction”. Department of Physiology and Biophysics, University of Alabama, Birmingham, AL

11/14/07 “Mitochondria, Exercise, and Free Radicals in Health and Disease”. Exercise, Muscle & Metabolism 2007, The University of Melbourne, Melbourne, Australia

6/1/07 “The Molecular Basis of Exercise Training: From the Inside Looking Out”. President’s Lecture, American College of Sports Medicine, New Orleans, LA.

3/22/07 “Mitochondrial Bioenergetics and Metabolic Disease”. Stealth Peptides, Inc. Union League Club, New York, NY.

1/25/07 “Linking Mitochondrial Bioenergetics to the Etiology of Metabolic Disease” 10th Biennial Conference on Free Radical Biology, Department of Applied Physiology and Kinesiology, and the Center for Exercise Science, University of Florida, Gainesville, FL


11/13/06 “Linking Mitochondrial Bioenergetics to the Etiology of Metabolic Disease” Department of Health and Kinesiology, Texas A&M University, College Station, TX

10/6/06 “Is Mitochondrial Bioenergetics Linked to the Etiology of Insulin Resistance?” Diabetes Research and Training Center, Vanderbilt University, Nashville, TN

9/28/06 “Acute molecular responses to exercise: the basis for training adaptations” in Symposium entitled “Exercise-Induced Mitochondrial Biogenesis” J.O. Holloszy & D.H. Hood Chairs. ACSM conference on Integrative Physiology of Exercise. Indianapolis, IN

4/3/06 “Regulation of mitochondrial superoxide production in skeletal muscle” in Symposium entitled “Linking Mitochondrial Function in Skeletal Muscle to Disease.” PD Neufer and DA Hood Chairs, Experimental Biology, San Franscisco, CA.

9/29/05 “Mitochondrial Bioenergetics and CHO Metabolism: Pressing on the Gas and Stepping on the Brakes”. Midwest American College of Sports Medicine Annual Conference, 40th Aniversary of the Human Performance Laboratory, Ball State University, Muncie, IN

5/12/05 “Linking mitochondrial bioenergetics to metabolic disease” Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX

3/21/05 “Exercise-induced changes in gene expression: clues to metabolic control in skeletal muscle” Department of Physiology, New York Medical College, Valhalla, NY

11/13/04 “Regulation of mitochondrial function in skeletal muscle.” Departmental Retreat, Cell & Molecular Physiology, Yale University, New Haven, CT

06/10/04 “Exercise-induced changes in gene expression: clues to metabolic control in skeletal muscle”. Department of Exercise & Sport Sciences. East Carolina University, Greenville, NC

10/07/03 “Kinetic Considerations of Muscle Adaptation” presentation as participant in International Olympic Committee Workshop entitled: “Genes, Performance, and Health”, Chairpersons J.O. Holloszy and B. Saltin, Athens, Greece.

05/30/03 “Muscle Glycogen and Gene Expression” symposium presentation at the American College of Sports Medicine, San Franscisco, CA

05/01/03 “Understanding the Acute Molecular Response to Exercise”, Department of Integrative Biology, University of Missouri, Columbia, MO

04/30/03 “Regulation of PDK4 and UCP3 Gene Expression in Response to Exercise: Implications for Energy Metabolism”. Depart. of Physiology, University of Missouri, Columbia, MO

08/21/02 “Muscle Contraction Induced Gene Expression” Baltic Summer School, Copenhagen, Denmark

07/25/02 “By the Sweat of Your Brow or Is it in the Genes?” European Congress on Sports Sciences. Athens, Greece.

06/21/02 “Regulation of Transcription During Recovery from Exercise. 2nd Annual Symposium on Skeletal Muscle. University of Massachusettes, Amerst, MA

05/30/02 “Exercise as a Tool for Specific Gene Activation”, in symposia entitled: “From Genes to Athletic Performance: Augmentation of the Training Response”, Chair B. Saltin, IOC World Congress on Sports Sciences. St. Louis, MO

05/13/02 “Transcriptional Regulation of Metabolic Genes in Response to Exercise”, Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX

03/28/02 “Exercising Our Genes: A Key to the Cure in the 21st Century?” Ball State University, Muncie, IN

10/11/01 “Transcriptional Regulation of Metabolic Genes in Response to Exercise” – Department of Kinesiology & Applied Physiology, University of Colorado, Boulder, CO.

04/04/01 Symposium Chair – “Genomics and Molecular Basis of Exercise and Environmental Physiology: Molecular Control of Thermogenesis” Experimental Biology, Orlando, FL

10/29/99 “Molecular Biology: Application to Exercise Physiology” Tutorial Lecture - New England Chapter of the American College of Sports Medicine, Providence, RI


1/30/99 “Metabolic regulation of gene expression in skeletal muscle” The Dirk Pette Symposium - The Royal Danish Academy of Sciences and Letters, Copenhagen, Denmark

11/12/98 “Regulation of gene expression in skeletal muscle” Department of Biology, Williams College, Williamstown, MA.

7/19/97 “Contractile activity and skeletal muscle gene expression.” Biochemistry of Exercise 10th International Conference, Sydney, Australia.

5/19/97 “Regulation of Lipoprotein Lipase Expression in Skeletal Muscle.” Department of Endocrinology, School of Medicine, Yale University, New Haven, CT.

Abstracts (2000-present only) Torres MJ, Reese LR, Smith CA, Pennington ER, Ryan TE, Shaikh SR and Neufer PD. Estrogen

treatment restores muscle mitochondrial function and redox homeostasis, reversing the pro-diabetogenic state induced by ovariectomy. Experimental Biology, San Diego, CA 2016

Torres MJ, Reese RL, Gilliam LA, Buddo K, Smith CA and Neufer PD. Estrogen treatment restores muscle mitochondrial capacity and reverses pro-diabetogenic state induced by ovariectomy. APS Specialty Conference on Physiology & Gender. Boston, MA 2015

Torres MJ, Gilliam AL, Reese LR, Buddo K, Smith CJ and Neufer PD. Mitochondrial capacity is decreased in skeletal muscle with estrogen depletion. Experimental Biology, Boston, MA 2015

Reese LR, Ryan TE, Jones MJ and Neufer PD. Acute reversal of high fat diet-induced inuslin resistance is accompanied by a restoration of redox status in skeletal muscle. Experimental Biology, Boston, MA 2015

Fisher-Wellman KH, Neufer PD, James DE. Berberine and other organic cations attunuate mitochondrial H2O2 emitting potential. Keystone: Diabetes & Metabolic Dysfunction, Sante Fe, NM 2015

Brown DA, Ryan TE Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD and McClung JM. The mitochondrial targeted peptide MTP-131 restores limb perfusion and reduces pathology in ischemic limb muscle of genetically susceptible mice. Keystone: Diabetes & Metabolic Dysfunction, Sante Fe, NM 2015

Ryan TE, Reese LR, Torres MJ, Lin C-T and Neufer PD. Atorvastatin decreases skeletal muscle mitochondrial respiration and calcium retention in overweight adult humans. Keystone: Diabetes & Metabolic Dysfunction, Sante Fe, NM 2015

Smith CD, Lin C-T, Reese LR, Smith CA, Kurland IJ and Neufer PD. Flux through fatty-acid oxidation alters redox state in muscle. Keystone: Diabetes & Metabolic Dysfunction, Sante Fe, NM 2015

Brown DA, Moukdar F, Alleman RJ, Lark DS, Neufer PD and Saikh SR. The cardiolipin targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes. American Heart Association, Basic Council on Cardiovascular Sciences 2014.

Smith CD, Lin CT, Fisher-Wellman KH, Gilliam LAA, Reese LR, Smith CA, Kwak HB, Neufer PD. Accelerated lipid oxidation increases the rate of mitochondrial H2O2 production in skeletal muscle. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).

Ryan TE, Lin CT, Brophy PM, Hickner RC, McCully KK, Neufer PD. In vivo measurements of mitochondrial respiratory capacity in skeletal muscle. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).

Reese LR, Lark DS, Neufer PD. 2-Hydroxyestradiol as a pro-oxidant regulator of muscle mitochondrial function. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).


Lin CT, Gilliam LAA, Brophy PM, Clark AH, Ryan TE, Hickner RC, Neufer PD. Changes in energy state acutely alter insulin sensitivity in healthy humans. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).

Gilliam LAA, Lark DS, Fisher-Wellman KH, Torres MJ, Reese LR, Cathey BL, Neufer PD. Cancer chemotherapy impairs mitochondrial funciton in non-tumor-bearing tissue. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).

Lark DS, Reese LR, Neufer PD. Protein kinase A activity augments skeletal msucle mitochondrial bioenergetics. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).

Torres MJ, Gilliam LAA, Neufer PD. Mitochondrial capacity is decreased in skeletal muscle with estrogen depletion. Presented at Metabolic Orgins of Disease Sanford-Burnham Institute, Orlando, FL (3/3-3/4) and Advances in Skeletal Muscle Biology in Health and Disease, University of Florida, Gainsville, FL (3/5-3/7).

Brown DA, Patel HD, Moukdar F, Shaikh SR, Harris M, Fisher-Wellman K, Neufer PD, Hale SL, Dai W, and Kloner RA. Cardioprotective efficacy of the cardiolipin-targeting peptide Bendavia. Wellcome Trust Conference on Mitochondrial Disease: Translating biology into new treatments; Cambridge UK 2013.

Fisher-Wellmam K, Gilliam LA, Lin C-T, Cathey B, Lark DS, Smith CD, Neufer PD. Loss of functional nicotinamide nucleotide transhydrogenase compromises redox buffering capacity and elevates H2O2 emitting potential in skeletal muscle. Amercian Diabetes Association, Chicago, IL 06/2013.

Perry CGR, Brophy P, Cathey B, Lin C-T, Kane DA, Kane CL, Gavin TP, Hickner RC, Neufer PD. Evidence that insulin sensitivity is regulated acutely through redox biology in response to a single high fat meal in humans. Amercian Diabetes Association, Chicago, IL 06/2013.

Kang L, Dai C, Lustig ME, Bonner JS, James FD, Lin C-T, Perry CGR, Anderson EJ, Neufer PD, Wasserman DH, Powers AC. SOD2: A pivotal regulator of insulin secretion but not insulin action in high fat-fed mice. Amercian Diabetes Association, Chicago, IL 06/2013.

Fisher-Wellman KH, Gilliam LAA, Cathey BL, Lin C-T, Neufer PD. Divergent effects of L-carnitine on pyruvate-supported O2 consumption and H2O2 emission within permeabilized myofibers. Integrative Biology of Exercise VI, Westminster, CO 10/2012.

Lark DS, Neufer PD, Anderson EJ. Glycolytic skeletal myofibers display higher P/O ratios than cardiac myofibers due to adenylate kinase: findings using a novel oxi-fluorometer apparatus. Integrative Biology of Exercise VI, Westminster, CO 10/2012.

Lin C-T, Cathey BL, Perry CGR, Mayo W, Gilliam LAA, Fisher-Wellman KH, Lark DS, Smith CD, Neufer PD. Acute invitro statin exposure alters mitochondrial function in permeabilized skeletal muscle from healthy humans. Integrative Biology of Exercise VI, Westminster, CO 10/2012.

Gilliam LAA, Fisher-Wellman KH, Lin C-T, Maples JM, Neufer PD. Doxorubicin impairs skeletal muscle mitochondrial respiratory capacity in skeletal muscle. Experimental Biology 2012, San Diego, CA (Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award, APS)

Fisher-Wellman KH, Gilliam LAA, Lin C-T, Cathey BL, Neufer PD. Mitochondrial glutathione depletion reveals a novel role for pyruvate dehydrogenase as a key H2O2 emitting source. Experimental Biology 2012, San Diego, CA (EEP Section Predoc Award, APS)

Lin CT, Fisher-Wellman KH, Perry CGR, Kozy R, Lark DS, Gilliam LAA, Smith CD, Neufer PD. Low Intensity Exercise Attenuates Acute Lipid Loading-Induced Alterations in Mitochondrial Function in Rat Skeletal Muscle. Experimental Biology 2012, San Diego, CA

DeBalsi KL, Koves TR, Wittman AH, Seiler SE, Szweda LI, Perry CGR, Gilliam LA, Neufer PD, Muoio DM. TXNIP deficiency disrupts oxidative metabolism without causing inherent defects in respiratory function. Keystone, 2012.


Perry CGR, Kane DA, Lin C-T, Kozy R, Cathey BL, Lark DS, Kane CL, Brophy P, Gavin TP, Anderson EJ, Neufer PD. Inhibiting myosin-ATPase reveals dynamic range of mitochondrial respiratory control in permeabilized skeletal muscle fibers. NHLBI Mitochondrial Conference, Bethesda, MD 5/11.

Gilliam LAA, Cathey BL, Lin C-T, Pittman HK, Verbanac KM, Neufer PD. Mitochondrial respiratory capacity is decreased in muscle fibers from tumor-bearing mice. Experimental Biology 2011, Washington, DC, FASEB J. 2011; 25:lb583

Kwak HY, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN. Overexpression of long chain acyl-CoA synthetase 1 increases fatty acid oxidation in primary human skeletal myotubes. Experimental Biology 2011, Washington, DC, FASEB J. 2011, 25:1104.9.

Perry CGR, Kane DA, Kozy R, Kane CL, Lark DS, Lin C-T, Brophy P, Gavin TP, Anderson EJ, Neufer PD. Contraction increases mitochondrial respiratory sensitivity to ADP at body temperature in human permeabilized myofibers. ACSM Integrative Physiology of Exercise, Miami FL, 10/10

Lin C-T, Kane DK, Lark DS, Fisher-Wellman KH, Zheng D, Perry CGR, Kane CL, Kozy R, Tapscott EB, Ellis RJ, Woodlief TL, Neufer PD. Β-GPA prevents high fat induced mitochondrial H2O2 emission and insulin resistance independent of AMPK in mice. ACSM Integrative Physiology of Exercise, Miami FL, 10/10

Kwak H-Y, Lin C-T, Kane DK, Lee N-S, Boyle KE, Houmard JA, Cortright RN, Neufer PD. Simvastatin increases mitochondrial oxidative stress and reduces mitochondrial Ca2+ retention capacity in human skeletal myotubes. ACSM Integrative Physiology of Exercise, Miami FL, 10/10

Dar M, Pender JL, Chapman WC, Pories W, Neufer PD. Does type 2 diabetes remission, improve insulin sensitivity and incretin effect persist at 10 years post-Roux-en-Y gastric bypass? American Diabetes Association, Baltimore, MD, 6/10

Kang L, Lee-Young RS, Lustig ME, James FD, Lin C-T, Perry CGR, Neufer PD, Wasserman DH. Reduction of mitochondrial ROS by overexpression of antioxidants superoxide dismutase 2 (SOD2) and catalase increases muscle glucose uptake during exercise in chow and high fat fed mice in vivo. American Diabetes Association, Baltimore, MD, 6/10

Kwak H-B, Woodlief TL, Green T, Cox JH, Hickner RC, Neufer PD, Cortright RN. Overexpression of long chain acyl-CoA synthetase increases fatty acid oxidation while altering insulin signaling in primary human skeletal myotubes American Diabetes Association, Baltimore, MD 6/10

Lin C-T, Lark DS, Kane DA, Anderson EJ, Tweedie CL, Perry CGRP, Fisher-Wellman KH, Neufer PD. Metformin treatment protects against calcium-induced opening of the mitochondrial permeability transition pore in skeletal muscle of obese Zucker rats. American Diabetes Association, Baltimore, MD, 6/10

Kang L, Lee-Young RS, Lustig ME, James FD, Lin C-T, Perry CGR, Neufer PD, Wasserman DA. Reduction of mitochondrial ROS by overpression of antioxidants superoxide dismutase 2 (SOD2) and Catalase increases muscle glucose uptake during exercise in chow- and high fat- fed mice in vivo. American Diabetes Association, Orlando, FL 06/09

Kwak H-B, Woodlier TL, Green TD, Cox J, Hickner RC, Neufer PD, Cortright RN. Overexpression of long chain Acyl-CoA Synthetase 5 increases fatty acid oxidation whil altering insulin signaling in primary human skeletal myotubes. American Diabetes Association, Orlando, FL 06/09

Lin CT, Lark DS, Kane DA, Anderson EJ, Tweedie CL, Perry CGR, Fisher-Wellman DH, Neufer PD. Meformin treatment protects against calcium-induced opening of the mitochondrial permeability transition pore in skeletal muscle of obese Zucker rats. American Diabetes Association, Orlando, FL 06/09

Lehr EJ, Kypson A, Rodriguez E, Anderson C, Brown D, Ferguson TB, Chitwood WR, Neufer PD, Anderson EJ. Pre-operative levels of oxidized glutathione and mitochondrial calcium tolerance in right atrial appendage are linked to occurrence of post-operative atrial fibrillation. Canadian Cardiovascular Conference 2009. Edmonton, Canada. October, 24 – 28, 2009. The Canadian Journal of Cardiology 25:283B, 2009.


HB Kwak, A Thalacker-Mercer, EJ Anderson, KE Boyle, JA Houmard, RN Cortright, MM Bamman, PD Neufer. Simvastatin Impairs ADP-Stimulated Mitochondrial Respiration and Alters Apoptotic Signaling and Morphology in Human Skeletal Myotubes. American Diabetes Association, New Orleans, LA 06/09

DA Kane, JH Cox, RC Hickner, RN Cortright, PD Neufer. Fractional Mitochondrial H2O2 Emission is Greater During Glycerophosphate- Versus Succinate- Supported Respiration in Human Skeletal Muscle. American Diabetes Association, New Orleans, LA 06/09

L Kang, ME Lustig, JE Ayala, FD James, A Pozzi, PD Neufer, DH Wasserman. Muscle insulin resistance is tightly associated with extracellular matrix remodeling in vivo. American Diabetes Association, New Orleans, LA 06/09

DA Kane, JH Cox, RC Hickner, PD Neufer, RN Cortright. Ten Days of Exercise Training Increases Fatty Acid- Supported Basal Respiration and Reduces Mitochondrial H2O2 Emission in Human Skeletal Muscle. American Diabetes Association, New Orleans, LA 06/09

L Kang, ME Lustig, EJ Anderson, CT Lin, CGR Perry, PD Neufer, DH Wasserman. Overexpression of catalase in mitochondria improves both exercise- and insulin-stimulated muscle glucose uptake in chow-fed C57BL/6J mice. Experimental Biology. New Orleans, LA 04/09

EJ Anderson, E Rodriquez, AP Kypson, CA Anderson, PD Neufer. Reduced fatty acid metabolism and elevated mitochondrial H2O2 emission are associated with decreased PPARα in diabetic human myocardium. NIH Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, MD 10/08 ($500 travel award winner)

EJ Anderson, PD Neufer. H2O2 generated during submaximal respiration in mitochondria is increased by calcium and is an important regulator of mitochondrial calcium retention capacity. NIH Mitochondrial Biology in Cardiovascular Health & Diseases Conference, Bethesda, MD 10/08

DA Kane, EJ Anderson, CT Lin, PD Neufer. Inhibiting Contraction Causes Temperature-Dependent Increase in Km and Vmax of ADP-Stimulated Mitochondrial Respiration in Permeabilized Skeletal Myofibers. Integrative Biology of Exercise meeting, 2008, Hilton Head, South Carolina.

EJ Anderson, KE Boyle, JA Houmard, PD Neufer. Obesity is Associated with Reduced Glutathione Content, Increased Mitochondrial H2O2 Emitting Potential and a More Oxidized Redox Environment in Human Skeletal Muscle. American Diabetes Association, San Francisco, CA 06/08

EJ Anderson, E. Rodriquez, R Lust, PD Neufer. Evidence of Abnormal Mitochondrial Function in Permeabilized Fibers from Diabetic Human Myocardium. American Diabetes Association, San Francisco, CA 06/08

ME Conniff, FD James, T-T Huang, PS Rabinovitch, PD Neufer, DH Wasserman. A genetic increase in mitochondrial antioxidant capacity improves insulin action in the conscious mouse. American Diabetes Association, San Francisco, CA 06/08

EJ Anderson, KE Boyle, JA Houmard, PD Neufer. Excess dietary fat depletes glutathione, increases mitochondrial oxidant emitting potential and shifts redox balance to a more oxidized state in human skeletal muscle. Experimental Biology, San Diego, CA 04/08

DA Kane, EJ Anderson, TL Woodlief, JW Price, BT Bickman, RN Cortright, PD Neufer. Metformin Attenuates a Complex I Mediated Increase in Mitochondrial Oxidant Emitting Potential in Skeletal Muscle of Obese Zucker Rats. Experimental Biology, San Diego, CA 04/08

RY Prasad, W Yang, TL Woodlief, RN Cortright, PD Neufer, B Cathey, CJ Wingard. Metformin restores aortic ring responses of obese-diabetic Zucker rats. Experimental Biology, San Diego, CA 04/08

EJ Anderson, HA Yamasaki, and PD Neufer. UCP3 attenuates mitochondrial H2O2 production in skeletal muscle during recovery from exercise. Integrative Physiology of Exercise, Indianapolis, IN 09/06

EJ Anderson and PD Neufer. High fat diet markedly elevates mitochondrial oxidant producing potential in skeletal muscle. (Environmental & Exercise Physiology Section Graduate Student Abstract Award) Experimental Biology, San Franscisco, CA 04/06.


EJ Anderson and PD Neufer. Mitochondrial superoxide production varies in different skeletal muscle fiber types. International Union of Physiological Sciences, San Diego, CA 04/05

L Finley, H Yamazki, EJ Anderson, and PD Neufer. Transient increase in PDH phosphorylation during recovery from exercise in rat skeletal muscle. International Union of Physiological Sciences, San Diego, CA 04/05

H Pilegaard, J Birk, PD Neufer, B Saltin, M Sacchetti, M Mourtzakis, G Hardie, G van Hall and JFP Wojtaszewski. Influence of intralipid infusion on PDH regulation in human skeletal muscle at rest and during exercise. Integrative Biology of Exercise, Austin, TX, 10/04

C. Lundby, M. Gassmann, P.D. Neufer, and H. Pilegaard. Normoxic exercise increases HIF-1α mRNA transiently, and this response is decreased by endurance training. ECSS, Athens, Greece 08/04.

S. B. Jørgensen, J. F. P. Wojtaszewski, B. Viollet, F. Andreelli, P. Scherling, S. Vaulont, P. D. Neufer, E. A. Richter and H. Pilegaard. Knockout of the α2-ampk isoform regulates exercise-induced increase in muscle IL-6 mRNA but not HKII, GLUT4 or PDK4 mRNA. AMPK meeting, Melbourne, Australia, 08/04

S. B. Jørgensen, J. F. P. Wojtaszewski, B. Viollet, F. Andreelli, P. Scherling, S. Vaulont, P. D. Neufer, E. A. Richter and H. Pilegaard. Effect of α2-AMPK Isoform Knockout and Exercise on IL6, CPT1 and PGC1 mRNA in skeletal muscle. ADA, San Antonio, TX 06/04

Akeda-Yamazaki H and Neufer PD. Carbohydrate Rapidly Reverses High Fat Diet-Induced Transcriptional Activation of the PDK4 Gene in Skeletal Muscle of Rats. Experimental Biology, Washington, DC 04/04

Akeda-Yamazaki H, Hildebrandt AL, and Neufer PD. Carbohydrate Reverses Transcriptional Activation of the PDK4 Gene in Muscle During Recovery From Exercise. Experimental Biology, San Diego, CA 04/03

Pilegaard H, van Hall G, Sacchetti M, Saltin B, and Neufer PD. Effect of Free Fatty Acids on Transcriptional Regulation of Metabolic Genes During Rest and Exercise in Human Skeletal Muscle. Experimental Biology, San Diego, CA 04/03

Pilegaard H, Saltin B, and Neufer PD. Effect of endurance training on transcriptional regulation of metabolic genes in human skeletal muscle. Experimental Biology, New Orleans, LA 04/02

Stoppani J, Hildebrandt AL, Sun J, and Neufer PD. Exercise training alters the transcriptional activity of metabolic genes in rat gastrocnemius muscle. Experimental Biology, New Orleans, LA 04/02

Swoap SJ, Stephens NA, Garber GB, Sun J, Stoppani J, and Neufer PD. Effect of torpor on UCP expression in mouse tissues. Experimental Biology, New Orleans, LA 04/02

Looft-Wilson RC, Neufer PD, and Segal SS. Expression of connexin mRNA isoforms in hamster microvessels. Experimental Biology, New Orleans, LA 04/02

Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, Neufer PD. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle – influence of muscle glycogen availability. International Society of Experimental Immunology, Baltimore, MD 05/01

Pilegaard, H, Helge JW, Saltin B, and Neufer PD. Effect of Diet on the Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle During Recovery From Exercise. Experimental Biology, Orlando, FL 04/01

Pilegaard, H, Helge JW, Saltin B, and Neufer PD. Effect of Preexercise Glycogen Content on Transcriptional Regulation of Metabolic Genes in Human Skeletal Muscle During Recovery from Exercise. Experimental Biology, Orlando, FL 04/01

Stoppani, J, Hildebrandt, AH, and Neufer PD. Activation of AMP-Activated Protein Kinase Increases Transcription of Metabolic Genes in Rat Gastrocnemius Muscle. Experimental Biology, Orlando, FL 04/01

Hildebrandt AL and Neufer PD. Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle. Experimental Biology, San Diego, CA 04/00.


Pilegaard H, Ordway GA, Saltin B, and Neufer PD. Transcriptional regulation of metabolic genes during recovery from exercise in humans. Experimental Biology (Featured Presentation), San Diego, CA 04/00.


Publications 1. Neufer PD, Costill DL, Fink WJ, Kirwan JP, Fielding RA, Flynn MG. Effects of exercise and

carbohydrate composition on gastric emptying. Med Sci Sports Exerc 18(6):658-62,1986. 2. Neufer PD, Costill DL, Fielding RA, Flynn MG, Kirwan JP. Effect of reduced training on

muscular strength and endurance in competitive swimmers. Med Sci Sports Exerc 19(5):486-90,1987.

3. Neufer PD, Costill DL, Flynn MG, Kirwan JP, Mitchell JB, Houmard J. Improvements in exercise performance: effects of carbohydrate feedings and diet. J Appl Physiol 62(3):983-8,1987.

4. Flynn MG, Costill DL, Hawley JA, Fink WJ, Neufer PD, Fielding RA, Sleeper MD. Influence of selected carbohydrate drinks on cycling performance and glycogen use. Med Sci Sports Exerc 19(1):37-40,1987.

5. Neufer PD, Young AJ, Sawka MN, Muza SR. Influence of skeletal muscle glycogen on passive rewarming after hypothermia. J Appl Physiol 65(2):805-10,1988.

6. Kirwan JP, Costill DL, Flynn MG, Mitchell JB, Fink WJ, Neufer PD, Houmard JA. Physiological responses to successive days of intense training in competitive swimmers. Med Sci Sports Exerc 20(3):255-9,1988.

7. Neufer PD, Young AJ, Sawka MN. Gastric emptying during exercise: effects of heat stress and hypohydration. Eur J Appl Physiol 58(4):433-9,1989.

8. Neufer PD, Young AJ, Sawka MN. Gastric emptying during walking and running: effects of varied exercise intensity. Eur J Appl Physiol 58(4):440-5,1989.

9. Neufer PD. The effect of detraining and reduced training on the physiological adaptations to aerobic exercise training. Sports Med 8(5):302-20,1989.

10. Young AJ, Sawka MN, Neufer PD, Muza SR, Askew EW, Pandolf KB. Thermoregulation during cold water immersion is unimpaired by low muscle glycogen levels. J Appl Physiol 66(4):1809-16,1989.

11. Kirwan JP, Costill DL, Flynn MG, Neufer PD, Fink WJ, Morse WM. Effects of increased training volume on the oxidative capacity, glycogen content and tension development of rat skeletal muscle. Int J Sports Med 11(6):479-83,1990.

12. Sawka MN, Neufer PD. Interaction of water bioavailability, thermoregulation and exercise performance. In: Fluid Replacement and Heat Stress: National Academy of Sciences Workshop. Washington, DC: National Academy Press, 1990: 85-98.

13. Friedman JE, Neufer PD, Dohm GL. Regulation of glycogen resynthesis following exercise. Dietary considerations. Sports Med 11(4):232-43,1991.

14. Houmard JA, Egan PC, Neufer PD, Friedman JE, Wheeler WS, Israel RG, Dohm GL. Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men. Am J Physiol 261(4 Pt 1):E437-43,1991.

15. Neufer PD, Sawka MN, Young AJ, Quigley MD, Latzka WA, Levine L. Hypohydration does not impair skeletal muscle glycogen resynthesis after exercise. J Appl Physiol 70(4):1490-4,1991.

16. Levine L, Rose MS, Francesconi P, Neufer PD, Sawka MN. Fluid replacement during sustained activity in the heat: nutrient solution vs. water. Aviat Space Environ Med 62(6):559-64,1991.

17. Houmard JA, Egan PC, Johns RA, Neufer PD, Chenier TC, Israel RG. Gastric emptying during 1 h of cycling and running at 75% VO2max. Med Sci Sports Exerc 23(3):320-5,1991.

18. Neufer PD, Shinebarger MH, Dohm GL. Effect of training and detraining on skeletal muscle glucose transporter (GLUT4) content in rats. Can J Physiol Pharmacol 70(9):1286-90,1992.

19. Sawka MN, Young AJ, Latzka WA, Neufer PD, Quigley MD, Pandolf KB. Human tolerance to heat strain during exercise: influence of hydration. J Appl Physiol 73(1):368-75,1992.

20. Young AJ, Sawka MN, Quigley MD, Cadarette BS, Neufer PD, Dennis RC, Valeri CR. Role of thermal factors on aerobic capacity improvements with endurance training. J Appl Physiol 75(1):49-54,1993.


21. Megeney LA, Neufer PD, Dohm GL, Tan MH, Blewett CA, Elder GC, Bonen A. Effects of muscle activity and fiber composition on glucose transport and GLUT-4. Am J Physiol 264(4 Pt 1):E583-93,1993.

22. Houmard JA, Hortobagyi T, Neufer PD, Johns RA, Fraser DD, Israel RG, Dohm GL. Training cessation does not alter GLUT-4 protein levels in human skeletal muscle. J Appl Physiol 74(2):776-81,1993.

23. Neufer PD, Carey JO, Dohm GL. Transcriptional regulation of the gene for glucose transporter GLUT4 in skeletal muscle. Effects of diabetes and fasting. J Biol Chem 268(19):13824-9,1993.

24. Neufer PD, Dohm GL. Exercise induces a transient increase in transcription of the GLUT4 gene in skeletal muscle. Am J Physiol 265(6 Pt 1):C1597-603,1993.

25. Carey JO, Neufer PD, Farrar RP, Veerkamp JH, Dohm GL. Transcriptional regulation of muscle fatty acid-binding protein. Biochem J 3:613-7,1994.

26. Neufer PD, DeVente JE, Tapscott EB, Dohm GL. Hindlimb perfusion induces GLUT1 and immediate early gene expression in skeletal muscle. Am. J. Physiol. 268:E866-E872, 1995.

27. Li K, Neufer PD, Williams RS. Nuclear responses to depletion of mitochondrial DNA in human cells. Am J. Physiol. 269: C1265-1270, 1995.

28. Garry DJ, Bassel-Duby RS, Richardson JA, Grayson J, Neufer PD, and Williams RS. Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. Developmental Genetics. 19:146-156, 1996.

29. Neufer PD, Benjamin IJ. Differential expression of αB-crystalin and Hsp27 in skeletal muscle during continuous contractile activity: relationship to myogenic regulatory factors. J. Biol. Chem. 271:24089-24095, 1996.

30. Neufer PD, Ordway GA, Hand GA, Shelton JM, Richardson JA, Benjamin IJ, Williams RS. Continuous contractile activity induces fiber-type specific expression of Hsp70 in skeletal muscle. Am. J. Physiol. 271:C1828-C1837, 1996.

31. Neufer PD, Ordway GA, Williams RS. Transient regulation of c-fos, αB-crystallin, and hsp70 in muscle during recovery from contractile activity. Am. J. Physiol: Cell Physiology. 274:C341-346, 1998.

32. Neufer PD. Contractile activity and skeletal muscle gene expression. In: Biochemistry of Exercise X. edited by M. Hargreaves and M. Thompson. Champaigne, IL: Human Kinetics, 1998.

33. Ordway PD, Neufer PD, Chin ER, DeMartino GN. Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle. J. Appl. Physiol. 88:1134-1141, 2000.

34. Hildebrandt AL and Neufer PD. Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 278: 278:E1078-1086, 2000.

35. Pilegaard H, Ordway GA, Saltin B, and Neufer PD. Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol. Endocrinol Metab. 279: E806-E814, 2000.

36. Keller C, Steensberg A, Pilegaard H, Osada T, Saltin B, Pedersen BK, and Neufer PD. Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J. 15:2748-2750, 2001.

37. Pilegaard H, Keller C, Steensberg A, Helge JW, Pedersen BK, Saltin B, and Neufer PD. Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J. Physiol. 541:261-271, 2002.

38. Stoppani J, Hildebrandt AH, Sakamoto K, Cameron-Smith D, Goodyear LJ, and Neufer PD. 5’AMP-activated protein kinase activates transcription of metabolic genes in red and white skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 283:E1239-E1248, 2002.

39. Pilegaard H, Saltin B, and Neufer PD. Exercise induces transient transcriptional activation of the PGC-1 gene in human skeletal muscle. J. Physiol. 546:851-858, 2003.


40. Pilegaard H, Saltin B, and Neufer PD. Effect of short-term fasting and re-feeding on transcriptional regulation of metabolic genes in human skeletal muscle. Diabetes 52:657-662, 2003.

41. Hildebrandt AL, Pilegaard H, and Neufer PD. Effect of exercise intensity and duration on the transcriptional activation of metabolic genes in rat skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 285:E1021-E1027, 2003.

42. Pilegaard, H, and Neufer PD. Transcriptional regulation of PDK4 in skeletal muscle during and after exercise. Proceedings of the Nutrition Society 63:221-226, 2004.

43. Looft-Wilson R, Moffo A, Neufer PD, Segal SS. Independence of connexin mRNA and conduction from sympathetic innervation in hamster microvessels. Microcirculation. 11:397-408, 2004.

44. Jensen L, Pilegaard H, Saltin B, Neufer PD, and Hellsten Y. Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle. Am. J. Physiol.: Reg. Integ & Comp. 287:R397-402, 2004.

45. Jørgensen S, Wojtaszewski JFP, Viollet B, Andreelli F, Hellsten Y, Schjerling P, Vaulont S, Neufer PD, Richter EA and Pilegaard H. Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J. 19:1146-1148, 2005.

46. Pilegaard H, Osada T, Heldge JW, Saltin B, and Neufer PD. Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. Metabolism. 54, 1048-1055, 2005.

47. Lundby C, Nordsborg N, Kusuhara K, Moller Kristensen K, Neufer PD, Pilegaard H. Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies. Eur. J Appl. Physiol. 95:351-360, 2005

48. DiPietro L, Dziura J, Yeckel CW, and Neufer PD. Exercise and Improved Insulin Sensitivity in Older Women: Evidence of the Enduring Benefits of Higher Intensity Training J. Appl. Physiol. 100:142-149, 2006.

49. Anderson EJ, and Neufer PD. Type II skeletal myofibers possess unique properties that potentiate mitochondrial H2O2 generation. Am. J. Physiol.: Cell Physiology 290:C844-C851, 2006. PMID: 16251473

50. Wu JJ, Hong E-G, Roth R, Anderson EJ, Hong E-G, Lee M-K, Neufer PD, Shulman GI, Kim JK, and Bennett AM. Mitogen activated protein kinase phosphatase-1 is a key regulator of metabolic homeostasis. Cell Metabolism. 4:61-73, 2006.

51. Pilegaard H, Birk JB, Sacchetti M, Mourtzakis M, Hardie DG, Stewart G, Neufer PD, Saltin B, van Hall G, and Wojtaszewski JFP. PDH-E1α dephosphorylation and activation in human skeletal muscle during exercise; effect of intralipid infusion. Diabetes. 55:3020-7, 2006.

52. Anderson EJ, Yamasaki HA, and Neufer PD. Induction of endogenous UCP3 suppresses mitochondrial oxidant emission during fatty-acid supported respiration. J. Biol. Chem. 282:31257-31266, 2007. PMID: 17761668

53. Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin C-T, Price JW III, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH and Neufer PD. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J. Clin. Invest. 119:565-574, 2009.

54. Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD. Substrate-specific derangements in mitochondrial metabolism and redox balance in atrium of type 2 diabetic human heart. J. Am. Coll. Cardiol. 54:1891-1898, 2009. PMID: 19892241

55. Bikman BT, Zheng D, Kane DA, Anderson EJ, Woodlief TL, Price JW, Dohm GL, Neufer PD, and Cortright RN. Metformin improves insulin signaling in obese rats via reduced IKKβ action in a fiber-type specific manner. J. Obesity Volume 2010, Article ID 970865.


56. Kane DA, Anderson EJ, Price JW, Woodlief TL, Lin C-T, Bickman BT, Cortright RN, Neufer PD. Metformin Selectively Attenuates Mitochondrial H2O2 Emission without Affecting Respiratory Capacity in Skeletal Muscle of Obese Rats. Free Radical Biology Medicine 49:1082-1087, 2010.

57. Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Muoio DM, Houmard JA. A high fat diet elicits differential responses in genes coordinating oxidative metabolism in the skeletal muscle of lean and obese individuals. J. Clin. Endo. Metab. 96:775-781, 2011.

58. Kang L, Ayala JE, Lee-Young RS, Zhang Z, James FD, Neufer PD, Nanney LB, Pozzi A, Zutter MM, and Wasserman DH. Diet-induced Muscle Insulin Resistance is Coupled to Extracellular Matrix Remodeling through Integrin α2β1 in Conscious Mice. Diabetes 60:416-426, 2011.

59. Kane DA, Lin C-T, Anderson EJ, Kwak HB, Cox JH, Brophy PM, Hickner RC, Neufer PD, Cortright RN. Progersterone Increases Skeletal Muscle Mitochondrial H2O2 Emission in non-Menopausal Women. Am. J. Physiol Endocrinol Metab. 300:E528-35, 2011.

60. Perry CGR, Kane DA, Lin C-T, Kozy R, Cathey BL, Lark DS, Kane CL, Brophy P, Gavin TP, Anderson EJ, Neufer PD. Inhibiting Myosin-ATPase Reveals Dynamic Range of Mitochondrial Respiratory Control in Skeletal Muscle. Biochemical Journal 437:215-222, 2011.

61. Boyle KE, Zheng D, Anderson EJ, Neufer PD, and Houmard JA. Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. International Journal of Obesity. 36:1025-31, 2012.

62. Kwak H-B, Thalacker-Mercer A, Anderson EJ, Lin C-T, Kane DA, Lee N-S, Boyle KE, Houmard JA, Cortright RN, Bamman MM, Neufer PD. Simvastatin Impairs ADP-Stimulated Mitochondrial Respiration and Increases Mitochondrial Oxidative Stress in Primary Human Skeletal Myotubes. Free Radical Biology & Medicine. 52:198-207, 2012.

63. Fisher-Wellman KH, Neufer PD. Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends in Endocrinology and Metabolism 23:142-153, 2012.

64. Muoio DM, Neufer PD. Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metabolism 15:595-605, 2012.

65. Gilliam LAA, Neufer PD. Transgenic mouse models resistant to diet-induced metabolic disease: is energy balance the key? Journal of Pharmacology and Experimental Therapeutics 342:631-6, 2012.

66. Kang L, Lustig ME, Lee-Young RS, Mayes WH, James FD, Lin C-T, Perry CGR, Neufer PD, Wasserman DH. Mitochondrial Oxidative State Sensitivity Regulates Muscle Glucose Uptake during Exercise in Mice with Normal and Impaired Insulin Action. Journal of Applied Physiology 113:1173-1183, 2012.

67. Lark DS, Fisher-Wellman KH, Neufer PD. High Fat Load: Mechanism(s) of Insulin Resistance in Skeletal Muscle. International Journal of Obesity 2:S31-36, 2012.

68. Perry CGR, Kane DA, Herbst EAF, Mukai K, Lark DS, Wright WC, Heigenhauser GJF, Neufer PD, Spriet LL and Holloway GP. Mitochondrial creatine kinase acitivity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle. Journal of Physiology 590:5475-5486, 2012.

69. Smith BK, Perry CGR, Koves TR, Wright DC, Smith JC, Neufer PD, Muoio DM and Holloway GP. Identification of a novel malonyl-CoA IC50 for CPT-1: implications for predicting in vivo fatty acid oxidaton kinetics. Biochemical Journal 15:13-20, 2012.

70. Perry CGR, Kane DA Lanza IR and Neufer PD. Methods for assessing mitochondrial function in diabetes. Diabetes 62:1041-1053, 2013.

71. Fisher-Wellman KH, Mattox TA, Thayne K, Katunga LA, La Favor JD, Neufer PD, Hickner RC, Wingard CJ, and Anderson EJ. Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle. Journal of Physiology 591:3471-86, 2013.

72. Smith BK, Perry CGR, Herbst EAF, Richie IR, Beaudoin M-S, Smith JC, Neufer PD, Wright DC, and Holloway GP. Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol. J. Physiol. 591:6089-101, 2013.


73. Rogers C, Davis B, Neufer PD, Murphy MP, Anderson EJ, and Robidoux J. A Transient Increase in Lipid Peroxidation Primes Preadipocytes for Delayed Mitochondrial Inner Membrane Permeabilization and ATP Depletion During Prolonged Exposure to Fatty Acids. Free Radical Biology and Medicine 67:330-341, 2014. PMID: 14017970

74. Gilliam LAA, Fisher-Wellman KH, Lin C-T, Maples JM, Cathey BL, and Neufer PD. The anticancer agent doxorubicin-based disrupts mitochondrial energy and redox balance in skeletal muscle. Free Radical Biology and Medicine 65:988-96, 2013. PMID: 24017970

75. Fisher-Wellman, KH, Gilliam LAA, Lin C-T, Cathey BL, Lark DS and Neufer PD. Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2 emitting source under conditions of nutrient overload. Free Radical Biology and Medicine. 65:1201-1208, 2013. PMID: 24056031

76. Fisher-Wellman KH, Weber TM, Cathey BL, Brophy PM, Gilliam LAA, Kane CL, Maples JM, Gavin TP, Houmard JA, and Neufer PD. Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans. Diabetes 63:132-141, 2014. PMID: 23974920

77. Brown DA, Hale SL, Baines CP, Del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Foukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, and Kloner RA. Reduction of early reperfusion injury with the mitochondria-targeting peptide Bendavia. Journal of Cardiovascular Pharmacology and Therapeutics 19:121-132, 2014. PMID: 24288396

78. DeBalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CGR, Lark DS, Hui ST, Szweda L, Neufer PD, and Muoio DM. Targeted Metabolomics Connects TXNIP to Mitochondrial Fuel Selection and Regulation of Specific Oxidoreductase Enzymes in Skeletal Muscle. Journal of Biological Chemistry 289:8106-8120, 2014. PMID: 24482226

79. Bamman, MM, Cooper DM, Booth FW, Chin ER, Neufer PD, Trappe SW, Lightfoot T, Kraus WE, Joyner MJ. Exercise Medicine: Exercise Biology and Medicine: Innovative Research to Improve Global Health. Mayo Clinical Proceedings 89:148-53, 2014. PMID: 24485128

80. Jackson KC, Gidlund E-K, Norrbom J, Thomson DM, Schuh RA, Neufer PD, and Spangenburg EE. BRCA1 is a Novel Regulator of Metabolic Function in Skeletal Muscle. Journal of Lipid Research 55:668-80, 2014. PMID: 24565757

81. Nopparat J, Zhang J, Lu J-P, Chen Y-H, Zheng D, Neufer PD, Fan JM, Hong H, Boykin C, Lu Q. δ-catenin, a Wnt/β-catenin modulator, reveals inducible mutagenesis promoting cancer cell survival adaptation and metabolic reprogramming. Oncogene 34:1542-52, 2015. PMID: 24727894

82. Ryan TE, Brophy P, Lin C-T, Hickner RC, and Neufer PD. Assessment of in vivo skeletal muscle mitochondrial respiratory capacity in humans by near infrared spectroscopy: a comparision with in situ measurements. J. Physiol. 592:3231-3241, 2014. PMID: 24951618.

83. Kang L, Dai C, Lustig ME, Bonner JS, Mayes WH, Mokshagundam S, James FD, Thompson CS, Lin C-T, Perry DGR, Anderson EJ, Neufer PD, Wasserman DH, and Powers AC. Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but not Insulin Action in High Fat-Fed Mice. Diabetes 63:3699-3710, 2014. PMID:24947366.

84. Fisher-Wellman KH, Lin C-T, Ryan TE, Reese LR, Gilliam LA, Cathey BL, Lark DS, Smith CD, Muoio DM, Neufer PD. Pyruvate dehydrogenase complex and nicotinamide nucleotide transhydrogenase constitute an energy consuming redox circuit. Biochem J. 467:271-280, 2015. PMID: 25643703.

85. Ludzki A, Paglialunga S, Smith BK, Herbst EAF, Allison MK, Heigenhauser GJ, Neufer PD, and Holloway GP. Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle signaling. Diabetes 64:2769-79, 2015. PMID: 25845660.

86. Lark DS, Li K, Lustig ME, Bonner JS, James FD, Lin C-T, Perry CGR, Anderson EJ, Neufer PD, and Wasserman DH. Enhanced mitochondrial superoxide scavenging does not improve muscle insulin action in conscious, high fat-fed mice. PLoS One. 2015 May 19;10(5):e0126732, PMID:25992608


87. Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham, RH, Krotoski D, Garcia-Cazarin M, McGowan JA, and Laughlin MR. Understanding the cellular and molecular mechanisms of physical activity-induced health benefits. Cell Metabolism 22:4-11, 2015. PMID:26073496

88. Ferdaoussi M, Dai X, Jensen M, Wang R, Peterson B, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle, C, Spigelman AF, Wright, RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning-Fox JE, Colmers WF, Shirihai O, Neufer PD, Yeh ETH, Newgard CB, and MacDonald PE. Isocitrate-to-SENP1 pathway amplifies insulin secretion and rescues dysfunctional β cells. J. Clin. Invest. 125:3847-60, 2015 PMID: 26389676

89. Lark DS, Reese LR, Ryan TE, Torres MJ, Smith CD, Lin C-T, and Neufer PD. Protein kinase A governs oxidative phosphorylation kinetics and oxidant emitting potential at complex I. Frontiers in Physiology 6:332, 2015. PMID: 26635618

90. Ryan TE, Schmidt CA, Alleman RJ, Reese LR, Green TD, Brown DA, Neufer PD and McClung JM. Mitochondrial regulation of the muscle microenvironment in critical limb ischemia. Frontiers in Physiology 6:336, 2015. PMID: 26635622

91. Murashov AK, Pak ES, Koury M, Ajmera A, Jeyakumar M, Parker M, Williams O, Ding J, Walters D, and Neufer PD. Paternal chronic exercise programs offspring for low energy expenditure and increased risk for obesity in mice. FASEB J. 30:775-784, 2016. PMID: 26506979

92. Alleman RJ, Tsang AM, Ryan TE, Patteson D, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD and Brown DA. Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am. J. Physiol: Heart & Circ. Physiol. 310:H1360-H1370, 2016. PMID: 26945082

93. Morad SAF, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan S-F, Feith DJ, Loughran Jr. TP, Kester M, Claxton DF, Barth BM, Deering TG and Cabot MC. Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. Journal of Lipid Research 57(7):1231-42, 2016. PMID: 27140664

94. Heden TD, Neufer PD, Funai K. Looking beyond structure: membrane phospholipids of skeletal muscle mitochondria. Trends in Endocrinology and Metabolism 27(8):553-62, 2016. PMID: 27370525

95. Ryan TE, Schmidt CA, Alleman RJ, Reese LR, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM. Mitochondrial therapy rescues limb perfusion and myopathy in hindlimb ischemia. Journal of Molecular and Cellular Cardiology 97:191-196, 2016. PMID: 27262673

96. Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, and McClung JM. Targeted overexpression of mitochondrial catalase protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-2568, 2016. PMID: 27284110

97. Lark DS, Torres MJ, Lin C-T, Ryan TE, Anderson EJ, and Neufer PD. Determination of Mitochondrial Oxidative Phosphorylation Efficiency in Permeabilized Skeletal Muscle Myofibers. Am. J. Physiol.: Cell Physiology 311:C239-C245, 2016. PMID: 27335172

98. Gilliam LAA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin C-T, Cathey BL, Neufer PD. Targeted overesptression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am. J. Physiol.:Endocrinology and Metabolism 311:E293-301, 2016. PMID: 27329802

99. Fisher-Wellman KH, Ryan TE, Smith CD, Gilliam LAA, Lin C-T, Reese LR, Torres MJ, and Neufer PD. Short-term high fat feeding reveals stark differences in susceptibility of hyperinsulinemia and redox homeostasis in C57 BL/6J versus C57BL/6N mice. Diabetes 65:3249-3261, 2016. PMID: 27495226.


100. Teodoro BG, Sampaio IH, Bomfim LH, Queiroz AL, Silveira LR, Souza AO, Fernandes AM, Eberlin MN, Huang TY, Zeng D, Neufer PD, Cortright RN, and Alberici LC. Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle. J Physiol. (in press) PMID: 27647415.

Book Chapters: Williams RS, and Neufer PD. Regulation of gene expression in skeletal muscle by contractile activity.

In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. edited by L.B. Rowell and J.T. Shepherd. Bethesda, MD: American Physiological Society, 1996.

Booth FW, and Neufer PD. “Exercise Physiology” In: Integrative Physiology: Physiology in the Age of Genomics and Proteomics. edited by Wolfgang Waltz., Humana Press Inc., 2005.

Booth FW, and Neufer PD. “Exercise Genomics and Proteomics” In: ACSM Advanced Exercise Physiology. edited by CM Tipton and C Tate. Lippincott, Williams & Wilkins, 2005.

Booth FW and Neufer PD. “Molecular mechanisms of adaptations to training” In: Olympic Textbook of Sports Sciences. Edited by Ron Maughan, 2006.

Booth FW, and Neufer PD. “Exercise Genomics and Proteomics” In: ACSM Advanced Exercise Physiology (2nd Edition). edited by P. Farrell. Lippincott, Williams & Wilkins, 2012.

Neufer PD, and Tipton CM. “Select Historical Milestones: Ph.D. Specialization and Incorporating Molecular Biology into Exercise Biology and Physiology Research.” In: The History of Exercise Physiology. Edited by C.M. Tipton. 2014.

Other Publications: Booth FW, and Neufer PD. Exercise controls gene expression. American Scientist 93:28-35, 2005 Neufer, D. (2007), "Mitochondrial Biogenesis as a Result of Exercise", in Hood, D. (ed.), Mitochondrial

Biogenesis: Processes, Regulation, Functions and Disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at http://www.hstalks.com/?t=BL0151509-Neufer)

Manuscripts: Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, and Cortright RN. Overexpression

of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes (submitted).

http://www.hstalks.com/?t=BL0151509-Neuferhttp://www.hstalks.com/?t=BL0151509-Neufer

Research Support

P. Darrell Neufer, Ph.D.P. Darrell Neufer, Ph.D. Page 2 Nov-16 . Research Support . Agency Grant ....

Documents

Transcript of P. Darrell Neufer, Ph.D.P. Darrell Neufer, Ph.D. Page 2 Nov-16 . Research Support . Agency Grant ....