Oxidative stress in cvd reactome animated
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non- enzymatic glycosyla tion Extracellular environment Intracellular environment Metal binding proteins Antioxidants Transition metal ions, e.g. Fe ++ Cu ++ Zn++ : ROS + RNS Microbe s Radiati on Chemicals and other environmental factors - ve - ve Oxidative Stress Antioxidant Enzymes: SOD GPx Catalase GSH and other co- factors, e.g. NADP+ - ve Indirect repair: replaceme nt of oxidised molecules Direct repair: reduction of oxidised molecules Oxidised LDL = + circulating monocytes - resident macrophages + foam cell formation - ve Oxidative Reactions Antioxidant Reactio Oxidatively Damaged Cell Apoptosis Necrosis Protein cross- linking DIET - ve Endothelial Cells Endothelial damage (ED) DNA strand breaks / mutations Oxidant s Key DNA
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Transcript of Oxidative stress in cvd reactome animated
non-enzymatic glycosylationEx
trace
llula
r env
ironm
ent
Intra
cellu
lar e
nviro
nmen
t
Metal binding proteins
Antioxidants
Transition metal ions, e.g. Fe++ Cu++ Zn++
:ROS + RNS
Microbes Radiation
Chemicals and other environmental factors
-ve
-ve
Oxidative Stress
Antioxidant Enzymes:SOD GPx Catalase GSH
and other co-factors, e.g. NADP+
-ve
Indirect repair: replacement of oxidised molecules
Direct repair: reduction of oxidised molecules
Oxidised LDL =+ circulating monocytes - resident macrophages+ foam cell formation
-ve
Oxidative Reactions
Antioxidant Reactions
Oxidatively Damaged Cell
Apoptosis
Necrosis
Protein cross-linking
DIET
-ve
Endothelial Cells
Endothelial damage (ED)DNA strand breaks / mutations
Oxidants
Key
DNA