Oxford Street 2progress update

Paul CullinanNHLI: Fan Chung/Rudy Sinharay/Peter Collins

KCL: Ben Bradshaw et al.

Exposomics November 2014

Boris Johnson admits London's Oxford Street is one of world's most pollutedLondon mayor makes u-turn over Oxford Street’s pollution levels in a letter to the EAC about research funding for King’s College, that made the original claim on air quality.

13 Nov 201424 comments

cross-over design40 each:• COPD (moderate)• IHD (stable, no COPD)• Healthy (neither of above)

Schedule of measurementstime re. exposure -2hr 0hr +1hr +2hr +3hr +4hr +24hplace lab. site site site lab. lab. lab. lab. lab.time 8am 10am 11am noon 1pm 2pm 3pm 4pm noonsymptoms X X X X X Xarterial stiffness X X X X Xcontinuous ECG Xvenesection X X Xurine collection X Xspirometry X X X X X X X Xios X XEB condensate X X Xinduced sputum X

clinical measurements

pre-exposure questionnaires: geography

postcodes home work significant other today’s date

how did you get here today? tube() bus()

car()

motorbike() bicycle() walk()

Where were you? (tick one or more)

home () work ()significant other

()any other? (describe)

yesterday -2 -3 -4 -5 -6 -7

pre-exposure questionnaires: diet

breakfast lunch supper other

yesterday

time place food and drink

today

time place food and drink

tomorrow

time

blank

placefood and drink

exposures (n=c.120 measurements)

Hyde Park Oxford StreetP

median mediandistance walked 5.3mi 5.3mitemp 18.0 18.9 >.05RH 51.3 50.9 >.05noise 73.4 75.2 <0.001PM2.5 7.5 18.1 <0.0001PM10 16.1 24.7 <0.0001ultrafine n 5709 25472 <0.0001carbon black 1.2 10.4 <0.0001

40

01

02

03

04

0 0006 00021 00081 00042 00003 00063 0002

6331 3107 11724203 8017 114

Mean StDev N

D

ycneuqerF

ata

UelbairaV

SO tnuoc enifartlUPH tnuoc enifartl

H lamroN

SO tnuoc enifartlU ,PH tnuoc enifartlU fo margotsi

70

01

02

03

04

05

06

51- 0 51 03 54 06 5

11.43 11.35 11720.74 11.81 115

Mean StDev N

D

ycneuqerF

ata

PelbairaV

SO 52MPPH 52M

H lamroN

SO 52MP ,PH 52MP fo margotsi

20

01

02

03

04

05

06

07

08

0 4 8 21 61 0

1.582 1.086 10610.32 2.973 117

Mean StDev N

D

ycneuqerF

ata

CelbairaV

SO kcalB nobraCPH kcalB nobra

H lamroN

SO kcalB nobraC ,PH kcalB nobraC fo margotsi

40

01

02

03

04

0 01 02 03 0

9.796 7.042 6718.08 8.396 64

Mean StDev N

D

ycneuqerF

ata

NelbairaV

SO 2ONPH 2O

H lamroN

SO 2ON ,PH 2ON fo margotsi

80

01

02

03

04

06 56 07 57 08 5

71.16 6.004 10374.88 2.907 89

Mean StDev N

D

ycneuqerF

ata

NelbairaV

SO ESIONPH ESIO

H lamroN

SO ESION ,PH ESION fo margotsi

maleN

age FEV1

% predFVC

% predPWVm/s

AI%

IOS 5HzkPa/L/s

COPD 40 19 68 58 88 9.3 26 0.57

IHD 39 35 67 97 100 9.4 25 0.47

healthy 39 19 62 98 106 8.3 25 0.40

participants

1 2 3 5 6 2480

85

90

95*

healthy

1 2 3 5 6 2480

85

90

95***

**

COPD

1 2 3 5 6 2470

72

74

76

78

80

82

84**

IHD

FEV1

4h 24h0.40

0.45

0.50

0.55

4h 24h0.40

0.45

0.50

0.55*

4h 24h0.40

0.45

0.50healthy COPD IHD

impulse oscillometry (5Hz)

3h 5h 6h 24h0.15

0.20

0.25

0.30

0.35* ** *

3h 5h 6h 24h0.15

0.20

0.25

0.30* * **

3h 5h 6h 24h0.15

0.20

0.25

0.30* *

healthy COPD IHD

AI

Next steps

samples to labs‘exposomic’ questionnaire information

analysis …