Overview of the Syphilis Outbreak Detection Guidance
Transcript of Overview of the Syphilis Outbreak Detection Guidance
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Lynn Sosa, MD
Connecticut Department of Public Health
CSTE STD Subcommittee Chair
Alison Ridpath, MD, MPH
CDC Division of STD Prevention
Outbreak Coordinator
June 25, 2018
Overview of the Syphilis Outbreak Detection Guidance
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Webinar Housekeeping
• Please note that today’s webinar is being recorded
o The webinar recording will be available in the webinar library on CSTE’s website
• Please place your phone line on mute
• There will be a question-and-answer session at the end of the webinar using the chat box
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Webinar Agenda
• Introduction and Overview of the Document
• Introduction to CDC’s Outbreak Coordinator Role
• Examples from Local Jurisdictions
• Question and Answer
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Background
• Issue of outbreak detection first brought up on an STD Subcommittee Call in September 2012
• Smaller workgroup convened to discuss document outline, form and content
o Multiple contributors from CDC and state and local jurisdictions
• Near final draft reviewed during a roundtable discussion at the 2014 CSTE Conference
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Background
• Long delay in collecting examples from state and local jurisdictions to be included in the document
• Regrouped on this document in the fall of 2017
• Final document produced and online in Spring 2018
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Document Intent
“This document was developed to give STD programs a frameworkfor understanding their epidemiology, determining if and when an outbreak might be occurring, and determining when additional resources and activities could be needed to prevent further transmission of disease.”
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Document Outline
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Introduction
• Why focus on syphilis?
o General overview of syphilis trends
o Impact of outbreaks
o Document intent, applicability
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Routine Activities
• Emphasizes the importance of routine review of case data
o Establish baseline data and frequency of reports
o Assess subpopulations of interest
o Providers, laboratories and reporting issues
o Importance of meeting with clinical and field staff
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Defining Outbreaks
• What is an outbreak?
• Identifying data sources
• Different approaches for identifying outbreaks
o Case counts
o Percent change
o Statistical analyses
o Changes within specific groups or areas
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What parameters/criteria should be included in defining an outbreak?
• Defining baselines and establishing thresholds
o Should be done before considering an outbreak
o Establish the time period of reference and of interest
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Approaches to thinking about outbreaks
• Populations
o MSM
o Women
• Geography or venues
o County, town, neighborhood
o New club
• Clinical characteristics
o Ocular syphilis
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Appendix A
• Examples of syphilis outbreak definitions
• Five examples from state and local jurisdictions
• The heart of the document!
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Appendix B
• Resources
o Statistical analysis tools
o Communication tools
o CDC resources
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Appendix C
• Outbreak response
• Relatively brief overview of the steps to consider once an outbreak has been established
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References
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DSTDP’s Outbreak Coordination
Alison Ridpath MD, MPH
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Background
▪ Historically, no clear process internally at CDC for responding to outbreak technical assistance (TA) requests
– Many CDC staff on calls
– Lack of communication
– No point person
▪ Need for sustainability and structure in DSTDP’s response
– Improve support to jurisdictions
– Use time efficiently
▪ Ensure all branches aware of and provide input for responses
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My Role
▪ Establishing and leading the DSTDP’s outbreak group
▪ Coordinating CDC’s response to outbreak related TA requests
▪ Developing documents related to outbreak response
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STD Outbreak Response and Coordination Effort (SOURCE)
▪ Internal DSTDP forum for developing processes and coordinate response
▪ All Division branches represented
▪ Venue for cross-branch discussions for TA requests and provides situational awareness
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SOURCE’s Goals
▪ Establish processes and accountability within DSTDP for monitoring, responding, and addressing TA requests
▪ Coordinate DSTDP’s guidance and assistance to partners in discovering and responding to outbreaks
▪ Help partners identify outbreak response resources
▪ Assess the effectiveness of investigations and interventions
▪ Coordinate response activities with other CDC Divisions and Centers
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Tools developed
▪ Internal SOURCE Operational Plan
– Evaluation component
▪ Syphilis Outbreak Detection Guide
– STD PCHD (PS19-1901) Strategy Area II: Conduct Disease Investigation and Intervention
• Strategy 6: Respond to STD-related outbreaks
• a. Review STD surveillance data by the core epidemiologic variables at regular intervals to identify outbreaks and other significant changes in STD epidemiology
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Currently Working On Tools to assist jurisdictions with outbreak responses (outbreak kit)
▪ Outbreak investigation and response plan template
– STD PCHD (PS19-1901) Strategy Area II: Conduct Disease Investigation and Intervention
• Strategy 6: Respond to STD-related outbreaks
• b. Develop and maintain an outbreak capacity plan to respond to significant changes in STD epidemiology.
▪ Template HANs (LGV, congenital syphilis, treatment resistant GC)
▪ Lab protocols
▪ Best practices for responses
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Final thoughts
▪ Your first point of contact for any program issues or potential outbreaks should always be your prevention specialist/project officer or [email protected].
▪ If you have thoughts on what other types of tools we should be considering that would be helpful to your program please feel free to contact me, [email protected]
▪ We plan to work collaboratively with state and local health departments on these tools and we hope to have a more active role in the future at NCDS to help meet your needs.
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Syphilis Outbreak Response
HIV/STD ProgramTacoma-Pierce County Health Dept
June 25th, 2018
Evelyn Manley Rodriguez: Disease Investigation Coordinator
Corey Betz: DIS II, Team Lead
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OBJECTIVE:
The purpose of the Syphilis Outbreak Response Plan is to ensure a timely, appropriate, and effective program response by the HIV/STD
team at Tacoma Pierce County Health Department.
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OUTBREAK THRESHOLD
Ten or more cases (P&S, EL) for 3 consecutive months.
Or
Fifteen cases in one month.
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OUTBREAK RESPONSE:
A. Communicate with State DOH, TPCHD Division Director & PIOB. Inform DIS investigation team members of suspected outbreak.
-Realign work priorities as follows:
(1) Chlamydia: untreated cases only
(2) Gonorrhea: untreated, pregnant, MSM cases only
(3) HIV: no change
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OUTBREAK RESPONSE:C. Operations:
(1) Soft response plan:- Pull SME off clinic duties- Assign additional DIS to assist with case investigations
(2) Firm response plan:- Utilize DOH Field Representatives to assist with case
investigations- Maximize DIS from elsewhere within the Department
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OUTBREAK RESPONSE CESSATION:
A. Declaring an end to the outbreak takes place when number of new cases drops below the threshold level
B. Review with Outbreak Response Team what went well and what can be improved
C. Evaluate effectiveness, efficiency, and productivity of Response
D. Implement improvement plan to address findings
E. Communicate findings with Division, Director of Health, DOH & consider broader sharing through publication and presentation at
conferences
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STI/HIV Disease Intervention
Outbreak Detection
Stephanie Green
STI/HIV Section Chief
Our Mission: To protect and improve the health and environment
of all Kansans.
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Classification of Outbreaks
Our Mission: To protect and improve the health and
environment of all Kansans.
Short-Term Incident Outbreak: An increase in morbidity
over 19% in any geographically defined area for a given
time frame when compared to the same geographic
area and a corresponding time frame.
Sustained Incidence Increase: An increase in morbidity
over 19% in any geographically defined area for a given
time frame, where the increase persists for a period of
time longer than six months.
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Identification of Outbreaks
Our Mission: To protect and improve the health and
environment of all Kansans.
▪Passive Surveillance – laboratory reports are used to
monitor disease trends and is used to identify increases in
morbidity by geographic areas by comparing the data with
historical data from previous years.
▪DIS – as soon as any investigator suspects that there may be
an outbreak, they should immediately notify management.
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Southeast Kansas Outbreak
Our Mission: To protect and improve the health and
environment of all Kansans.
8/14/2017 – 10/06/2017
•21 cases of early (infectious) syphilis identified (19 ID)
•356 contacts (contact index 4.19) cluster index (12.76)
•Counties: Allen, Cherokee, Crawford, Labette, Montgomery,
Neosho, Wilson, and Woodson
•Meth use
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Our Mission: To protect and improve the health and
environment of all Kansans.
#2017772744 MP DX: 5/19/2017 730
#2017781953 MG DX: 6/12/2017
730
#2017808770 RH DX: 10/12/2017 720
#2017827859 CC DX: 11/29/2017 720
#2017777257 BL DX: 6/13/2017 730
#2017777223 CM DX: 6/7/2017 730
#2017833044 HW DX: 12/27/2017 720
#2017829971 MH DX: 11/30/2017 710
#2017826377 DS DX:11/8/2017 710
#2017785996 NB DX: 7/5/2017 720
#2017789325 ML DX: 7/17/2017 730
#2017789320 JC DX: 7/17/2017 710
#2017803422 DE DX: 8/31/2017 730
#2017804615 AS DX: 9/12/2017 730
#2017799131 DK DX: 8/31/2017 730
#2017799134 OM DX: 10/13/2017 710
#2017818095 AL DX: 11/2/2017 710
#2017823259 TD DX: 12/20/2017 730
#2017818008 TT DX: 11/3/2017 710
#2017799932 TF DX: 8/23/2017 730
#2017802552 BB DX: 8/59/2017 710
#2017805797 CG DX: 9/13/2017 710
#2017812379 KS DX: 9/28/2017 720
#2017796318 SC DX: 8/15/2017 730
#2017805848 AK DX: 9/7/2017 720
#2017789277 AW DX: 7/17/2017 720
#2017789264 AS DX: 7/17/2017 710
#2017815054 DSB DX: 11/1/2017 710
#2017794618 JS DX: 10/13/2017 730
#2017817731 JE DX: 10/25/2017 730
2017 SE Kansas Outbreak
Circles – Male
Square – Female
Red – Positive Syphilis Case
Blue – Contact that was Positive for Syphilis
Orange – Cluster that was Positive for Syphilis
Blue Arrows – Contact named by Original Patient
Orange Arrow – Cluster Named by Partner
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Our Mission: To protect and improve the health and
environment of all Kansans.
Questions
Stephanie Green
STI/HIV Section Chief
Office: 785-296-5595
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NYC outbreak thresholds;Methodology and examples
Presented by:
Ellen J Klingler, MPH
Bureau of STI
NYC Department of Health and Mental Hygiene
June 2018
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Outbreak thresholdKey principles
• Quarterly examination of surveillance data
• Examine GC and Syphilis– By sex, borough, age group, race/ethnicity
• Compare case numbers for a given quarter, to the average number in the previous 3 time periods (“moving average”)
• Enter outbreak detection mode when > than expected number of cases is sustained over 3 time periods
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Challenges
• What is the optimal observation period?
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Challenges
• What is the optimal observation period?
• When do we re-define baseline?
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Challenges
• What is the optimal observation period?
• When do we re-define baseline?
• Beyond provider and public education, and field services, how can we act on these data?
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Question and Answer