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External Advisory Committee
Indiana University Cancer Center
September 25, 2006
Overview
Overview
• Continued strong institutional commitment
• Effective and on-going strategic planning
• Highly effective and energetic senior and program leadership team
• Seminal cancer research findings
Points of Emphasis
Strategic planning, leading to:– Key leadership changes– Enhanced prevention and control
research activity– Targeted recruitment– New and unique collaborations, including
with the Purdue Cancer Center– ITRAC is open for business– Improved translational research– New cores
To be a leading, national comprehensive cancer center based on our scientific investigation, health care delivery, and education.
Vision
Mission
IUCC seeks to reduce the burden of cancer through innovation and dissemination
Goals
1. Foster excellence in interdisciplinary translational research through established and developing research programs.
2. Provide the highest quality patient care through interdisciplinary clinical programs.
3. Develop nationally recognized interdisciplinary graduate and post-graduate education and training programs.
4. Facilitate the development and implementation of a statewide cancer control program.
Indiana UniversityBoard of TrusteesIndiana UniversityBoard of Trustees
President:Adam Herbert
President:Adam Herbert
Vice President and Chancellor:
Charles Bantz
Vice President and Chancellor:
Charles Bantz
Dean-IU SOM and VP Life Sciences IU:D. Craig Brater
Dean-IU SOM and VP Life Sciences IU:D. Craig Brater
IU Cancer Center DirectorStephen D. Williams
IU Cancer Center DirectorStephen D. Williams
$0
$10,000,000
$20,000,000
$30,000,000
$40,000,000
$50,000,000
$60,000,000
$70,000,000
NCI Other NIH ACS NSF Other PeerReview
Total
IUCC Peer Reviewed Funding
January 2004
September 2006
Senior Leaders
• Director: Williams• Deputy Director: Loehrer• AD Basic Research: Kelley• AD Clinical Research: Sweeney• AD Strategic Planning: Klaunig• AD Administration: Darling• AD Cancer Programs: Hammoudeh
AD Strategic Planning and Partnerships
• Responsible for coordination of strategic planning activities
• Interacts with other AD’s• External relations
– Purdue University– IU Bloomington including cancer
biology – IUPUI– ISDH,CDC
Purdue Cancer Center
• Monthly meetings (IUPU-L)• Two combined retreats, followed by
two rounds of pilot projects, of which at least one project led to NCI funding
• Policies for shared facility use and indirect costs
• Submission of two complex funding applications, one of which will be funded– Clinical Proteomics– Interdisciplinary Research Centers
(Cancer Care Engineering
Programs
EstablishedBreast Cancer
EDT
Hematopoiesis / Microenvironment and Immunology
Prevention and Control
DevelopingMolecular Carcinogenesis
Tumor Microenvironment
Biological MicroscopyBiostatistics*Clinical Research Office*Flow Cytometry*Tissue bank*
Transgenic and Knockout Mouse*
Transplant and Xenograft Mouse
Vector ProductionCancer
Pharmacology/Analytic*
New Cores: Angiogenesis / Endothelial Cell Translational Genomics* Chemical Genomics
* Administered by IUCC
Shared Facilities
Essential Characteristics
Facilities
•R3: 125,000 sq ft of new research space that will be assigned by IUCC; completion 1/09
“IU Cancer Center”- cancer hospital and ambulatory care facility; completion 8/08
Indiana University Cancer Center
Sam OdleClarian COO
Stephen D. Williams MD
Director, IUCC
Patrick J. Loehrer, Sr. MDDeputy Director, IUCCMedical Director, IUCC
FuadHammoudehAdministrator,
Clarian Cancer Programs
Organizational Capabilities
Organizational Capabilities: Strategic Planning
Weekly senior leaders meetingsFour planning retreats (two,SL’s only;
one with program leaders; one cancer hospital)
Updating of existing written strategic plan
Focused on:-Targeted recruitment and retention-Increasing cancer research funding-Translational clinical research-Core facility development / improvement
Organizational Capabilities: Recruitment
• Sherif Farag, MBBS, PhD (Medicine, H/O)– Director of BMT and malignant hematology– Recent R21 and current NIH funding– Translational cancer research in HMI
• Yan Xu, PhD (Ob Gyn)– Two NCI grants– EDT member focusing on ovarian cancer
• Angelo Cardoso, MD, PhD (Medicine, H/O) – HMI member– Marrow microenvironment / leukemia and
metastasis
• Nadia Carlesso, MD, PhD(Pediatrics, Wells)– HMI member; NIH funding– Notch signaling in leukemia
• Hua Lu, PhD (Biochemistry)– Three NCI grants– Will hold IUCC endowed chair– Basic research with GI focus
Organizational Capabilities:Recruitment
Recruitment (cont)
•Lindsey Mayo, PhD (Pediatrics, Wells)–Basic cancer research–NCI R01 funded
•Prevention and control x 3•Biochemistry x 4
Interdisciplinary and Trans-disciplinary Coordination and Collaboration
Interdisciplinary Collaboration
• All programs meet or exceed guideline requirements for collaborative publications
• Multiple examples will be presented– Pharmacogenetics of tamoxifen and
AI’s– JNK Inhibition in AML– Parthenolide Analogues
Interdisciplinary Collaboration: Prevention and Control
• Narrowed and refined focus• Health services research (several
participants)• Adolescent medicine• Psychology, psychiatry, and clinical
epidemiology• Meetings and retreat• Increased funding and co-publications• Funding of NCI R25 training grant:
“Training in Research for Behavioral Oncology and Cancer Control?”
• Noteworthy scientific collaborations and accomplishments
• David Haggstrom, MD– General internist co-recruited with RI HSR– GIM and NCI prevention fellowship– Focuses on GI cancer screening and QOL
• Karen Hudmon, DrPh– NCI funded researcher – Focuses of tobacco control– Co-recruited with RI / HSR and Purdue
• Andrew Saykin, PsyD– NCI funded senior investigator– Director of IUSM Neuroimaging– “Chemobrain” in breast cancer patients
Interdisciplinary Collaboration: Prevention and Control
Interdisciplinary Collaboration: Prevention and Control
• With Regenstrief health services resarch group: mid-senior level cancer HSR researcher
• With Peds adolescent medicine: cancer researcher who focuses on risky behaviors, preferably smoking
• With Center of Environmental Health and Genetics, epidemiology group
Cancer Focus
Cancer Focus
• Increase cancer research funding– Recruitment– Pilot projects– Budget supplements
• ITRAC• Protocol specific research and R21
working group• HMI program
– Translational research meetings– Recruitment of Dr. Farag
Institutional Commitment
Institutional Commitment
• Top priority: cancer research• New buildings and role of the IU
Cancer Center– R3: 125+k sq ft ($85 m)– Cancer hospital: “IU Cancer Center”
($150 m)
• Annual support of about $1.25 m• Additional $4.4m for recruitment
Institutional Commitment: Development
• IUCC development staff increased from two to three FTE’s
• Development for both hospital and SOM managed by this staff; report to IUCC director
6/03 9/06Endowment $4.1m $12.7m*Non-endowed $1.1m $3.4m
*includes 7 chairs and professorships
Institutional Commitment: 3D
• SOM initiative to more equitably allocate resources and indirect costs
• Departments will receive a significant proportion of indirect costs, but will be responsible for rent
• Rent for space of investigators occupying IUCC space will be passed through to departments as will indirects
• Bottom line: IUCC will continue to receive annual support and with departments will allocate space efficiently to most productive investigators
Institutional Commitment
• Center of Environmental Health– Director: Jim Klaunig– “Genes, the environment and cancer”
• IUB cancer biology program– Medical sciences program– Director and up to eight faculty slots– IUCC members and senior leaders lead
search– Mission is to add to the research
capability of the IU Cancer Center
Center Director
Director
• Reports to Dean; status similar to chairs
• Assigns space; allocates budget• Membership decisions• Appoints senior and program
leaders• Leads development• Represents Indiana University
Examples
• Chair: Radiation Oncology Search• School-wide leadership in bio-
specimen management and ITRAC• IUB cancer biology program and
search• Identifying and initiating critical core
facilities– Clinical pharmacology and analytic core– Translational genomics– Angiogenesis and endothelial cell
Summary
• Diligent strategic planning in the setting of a supportive institution, leading to:– Highly interactive programs– Novel local and state-wide collaborations– Key recruitments– Sophisticated new shared facilities– Important discoveries for the prevention,
detection, and treatment of cancer
Future Directions
• Biospecimen management– Informatics– Pathology
• ITRAC• Translational research• Unique state-wide collaborations
– Purdue– HOG– Indiana Cancer Consortium
Future Directions
• Continued targeted recruitment– Prevention and control– Breast cancer metastasis /
genomics– Epidemiology– Radiation oncology– Clinical investigators