Ottawa’s Biotech and Life Sciences Landscape

June 29, 2004 Vitesse Information Session 1

Ottawa’s Biotech and Life Sciences Landscape

VBP-ITP 2004Information Session

June 29, 2004

Presented by: Rick NorlandExecutive Director

Centre for Biopharmaceutical Manufacturing

June 29, 2004 Vitesse Information Session

Ottawa’s opportunity to play lead role for Canada …

• Excellence in Science– Stem cells/Genomics/Proteomics/Systems

Biology– International Regulome Consortium

(France, UK, US, Singapore, Italy, Canada)

• A National Strategy Biopharmaceutical Manufacturing

– Centre for Biopharmaceutical Manufacturing (CBM)

– International Consortium (Training, Regulatory Foresight, Capacity)– North Carolina, UK and Sweden

• Bioproducts Based Eco-industrial Cluster

– Biofuels, Kyoto, novel bioproducts– Partnerships – Netherlands, North

Carolina, Ontario

North America's Biotechnology Centres

0

50

100

150

200

250

300

350

400

450

Californi

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Quebe

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Ontario

North C

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New York

Texas

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We believe that we can position Ottawa into TOP 10 Biotech Centres in North America


• Epocal (biochips)

• Liponex (Discovery – Cholesterol lowering)

• Stempath (Discovery – stem cells, cardiovascular disease, MD)

• PRA International (CRO)

• Ionolytics (Proteomics, Instrumentation)• Gangagen Biotechnologies (phage

technologies- ID)• Pfizer (Viagra)

A BREADTH OF TECHNOLOGY• MDS Nordion (radiotherapies)

• I-STAT Corporation (Abbott) (biochips)

• Iogen Corporation (enzymes, biofuels)

• Zelos (Discovery - osteoporosis)

• World Heart Corporation(cardiovascular devices)


Ottawa’s R&D Infrastructure

• 6,000 Employees across 44 research institutes:

– Carleton University (9 centres)– University of Ottawa (15 centres)– Ottawa Hospital (3 centres)– University of Ottawa Heart Institute – Royal Ottawa Health Care Group

(ROHCG) – Canadian Stroke Network (CSN) – Canadian Blood Services – Canadian Food Inspections Agency– National Research Council of Canada (4

centres)– Agri-Food & Agriculture Canada - ECORC– Environment Canada– Health Canada– Canadian Institutes of Health Research– National Energy Board– Natural Resources Canada


Ottawa’s Research Focus

Number of Researchers in Top 15 Research Categories

- 50 100 150 200 250 300 350 400

Hormones

Pharmacology

Bio Catalysis

Health care services

Population health

Functional materials

Molecular research

Food preservation and safety

Ecology

Cancer

Environment

Clinical epidemiology

Biopharmaceuticals

Neuroscience

Cardiovascular


Ensuring The Activities/Infrastructures Meet the Needs

Basic Research

Applied Research Technology

DevelopmentProduct

DevelopmentNewco

Development Early Market Bowling Alley Tornado Main Street

Value Creation Value ExpansionValue Capture

Understand the Companies

High Tech

1980s/90s

High Tech

2000 +

Life Sciences

2000 +

High Tech

2005 +

Life Sciences

2010 +Source: Thorington Corporation


The Ottawa Landscape

New firmsattracted tothe region

New companiesand industries

formed in the region

Competitive Clusters

Software

Professional ServicesTourism

Microelectronics

Telecommunications Photonics

New people andideas drawn to the

region

Quality Economic Foundations

PhysicalInfra-

Structure

BusinessClimate

Quality Of Life

Technology Financial Capital

Human Resources/ Education

Capital drawninto the region

Research & Development

Recognized as one of Ottawa’s seven economic generators.

Life Sciences

Health

Bioproducts

Convergence

High Tech


Sector Overview: Ottawa’s Life Sciences Clusters

Life Sciences

Health

Bioproducts

Convergence

Bioproducts

Animal Health

Biochemicals& Plastics

BioFuels/Biomass Conversion

Ag-Biotech

Environmental Technologies

Enzymes and Biomanufacturing

ConvergenceBioinformatics

BiophotonicsBiochips

/Microarrays

Biosensors

Health Informatics

Medical Devices

New people andideas drawn to the

region

HealthPharma/Drug

Discovery

Regenerative Medicine / Stem

Cells Imaging

Biopharma, Biologics &

Vaccines

Genomics /Proteomics

Diagnostics


Ottawa and Eastern Ontario Companies by Sector Grouping, 2003

Health / Therapeutics, 50

Convergence / Devices, 41

Bioproducts, 20

Services/Suppliers/Distributors, 57

0

10

20

30

40

50

60

Health / Therapeutics BioproductsSource: OLSC Database

Ottawa and Eastern Ontario Company Employment by Cluster Grouping, 2003

0 500 1000 1500 2000 2500

Health / Therapeutics

Convergence / Devices

Bioproducts

Services/Suppliers/Distributors

EmployeesSource: OLSC Database

Ottawa’s Life Sciences Sector

For more details on individual clusters see BCIP Part II Document

www.bioplan.ca


Health/TherapeuticsOttawa and Eastern Ontario Health-Related Organizations, 2003

0 10 20 30 40 50 60

Research

Design

Development

Pre-Clinical Research

Clinical Development

Manufacturing

Distribution

Services (Business/other)

Testing Services

Total Companies

CompaniesSource: OLSC Database

Health-Related Companies in Ottawa and Eastern Ontario, 2003

02468

101214

Dru

g D

isco

very

Cor

pora

te/G

ovR

elat

ions

Offi

ceD

iagn

ostic

s

OTC

/Pha

rma

Dru

g D

eliv

ery

Vacc

ines

/imm

unol

ogy

Stem

cel

ls/c

ell b

iolo

gy

Biol

ogic

s

Imm

unot

hera

py

Hea

lth c

are

serv

ices

Clin

ical

Che

mis

try

Can

cer

Car

diov

ascu

lar

Infe

ctio

us D

isea

ses

Neu

rosc

ienc

e

Bloo

d di

sord

ers

Res

pira

tory

Wou

nd H

ealin

g

Oth

er

Source: OLSC Database

Com

pani

es

01002003004005006007008009001000

Empl

oyee

s

Number Of Companies

Employees

Technology/Activity Market


Source: Pharma 2010: The Threshold of Innovation

“The Re-Tooling of Pharma”


Health Cluster

Cardiovascular Diseases– University of Ottawa Heart Institute

Genomics and Transgenics– Ottawa Genomics Consortium, Children’s

Hospital of Eastern Ontario, Ottawa General Hospital Research Institute, National Research Council

Tissue Engineering/Gene and Cell Therapy/ Xenotransplant

– Apotex Biotechnologies, Ottawa Health Research Institute, University of Ottawa Eye Institute, Children’s Hospital of Eastern Ontario.

Neurodegenerative Diseases– Ottawa Stroke Consortium for Applied

Research, Aegera Oncology, Institute for Biological Sciences-NRC, CroMedica and the Ottawa Health Research Institute.

Nuclear Medicine– MDS Nordion, IS2 Research, Thompson

and Nielsen Electronics, Adherex, AegeraOncology, Occell, Ottawa Regional Cancer Treatment Centre, Institute for Biological Sciences-NRC, and SynChem Research.

Vaccines/Immuno-therapeutics– Coley Pharmaceuticals, Institute for

Biological Sciences-NRC, Ottawa Health Research Institute, University of Ottawa, Health Canada, Canbreal, Merck Frosst, Variation Biotechnologies


Gamma Dynacare January 2003

80,000 sq. ft. Building Spring

2005

OBIC Feb 2004

$40 M OHRI Stem Cell Centre 2004

$11M Apoptosis Research Centre

– CHEO Jan 2004

Health Cluster: OLSTP & the General


ResearchOncolytic Viruses (OHRI), Apoptosis (CHEO), Medicinal Chemistry (U Ottawa, Pharmaceutical Sciences), Nuclear Medicine (ORCC), Medical Physics/Imaging (Carleton U), Radiation Standards (NRC-IRS)

Contract Research Clinical TrialsOttawa Regional Cancer Centre (Trials), Chalmers Research Group (CRO), PRA International (CRO),Canadian Leukemia Study Group (Trials Network)

Diagnostics/Instrumentation/SoftwareCanbreal (Breast Cancer Diagnostics), IS2 Research (Imaging), Gamma Dynacare (Testing),Delft Instruments (treatment software),Thomson & Nielsen (dose monitoring systems)

Therapies and TherapeuticsMDS Nordion (TheraSphere®,,Cobalt Radiotherapy, Zevalin (IDEC), Adherex (Mesna, STS, NAC, Exherin, Angiolytics), Aegera Oncology (XIAP antisense therapy [anti-apoptotic]), Coley Pharmaceuticals (Promune™, CpG oligos),Canadian Blood Services (Cancer and bone marrow therapies)

• 16 products in cancer pipeline

• 10 products on market

• Over 60 clinical trials

Ottawa Cancer Strengths


BioproductsOttawa and Eastern Ontario Bioproducts Companies, 2003

0 5 10 15 20 25

Research

Design

Development



Manufacturing

Distribution


Testing Services

Total Companies


Ottawa and Eastern Ontario Bioproduct Companies, 2003

01234567

Fine

Che

mic

als

Biom

ass

Cro

ps/p

lant

s

Biof

uel

Anim

al H

ealth

Food

/food

safe

ty

Envi

ronm

ent

Nat

ural

Prod

ucts

Feed

Addi

tives

Cos

met

ics

Nut

race

utic

als


Com

pani

es

-100200300400500600700800

Empl

oyee

s

Number OfCompaniesEmployees

Technololgy/Activity Target Market


Bioproducts & Industrial Biotechnology

ResearchNRC-ICPET (processing), Agriculture and Agirfood Canada (bioprocessing, genomics, proteomics, earth sciences), Canadian Food Inspection Agency (animal health, diagnostics), Environment Canada (environmental technologies), Carleton University (biology, environmental technologies ), University of Ottawa (chemistry, catalysis, biology, environmental genomics), Kemptville College(agriculture), collège d‘Alfred (agriculture)

Contract ResearchAgExcel (identity-preserve, molecular farming), AgBios(regulatory), Xenos Laboratories (regulatory testing)

Products/processing expertiseEnsyn (pyrolysis), Iogen (industrial enzymes, fermentation and biofuels), Topeia (biodiesel), Gangagen (agriculture/ environmental phage technologies), Casco (bioproducts), Alltech(specialty feeds), Tricounty Protein (cold crushing), Natunola (cosmetics, gels, nutraceuticals), BASEF (chemicals), McEwen(ethanol), Seaway Valley (ethanol).

• OBIC Farm/Greenbelt Research Farm

• Bioproducts Strategy


Convergent TechnologiesOttawa and Eastern Ontario Convergent Technology and

Device Companies, 2003

0 10 20 30 40 50

Research

Design

Development



Manufacturing

Distribution


Testing Services

Total Companies


Ottawa and Eastern Ontario Companies in the Convergent Technology Sector, 2003

02468

1012141618

Med

ical

dev

ices

Hea

lth in

form

atic

s

Inst

rum

enta

tion

Dia

gnos

tics

Biop

hoto

nics

/bio

sens

ors

Imag

ing

Assi

stiv

e D

evic

es

Bioc

hips

Sepa

ratio

nTe

chno

logi

esPa

ckag

ing

and

Com

plia

nce


Com

pani

es

-2004006008001,0001,2001,400

Empl

oyee

s

Number Of Companies

Employees


Convergent Technologies Cluster

Cluster 1 –Human Health

(Health, Biotech andBio-medical)

Cluster 2 –Bioproducts

(Ag-Biotech, Environmental Technologies,

Biomanufacturing)

Genomics Proteomics

BiophotonicsBiochips

Biosensors BioinformaticsBioProducts

Hi tech Clusters – IT and Telecom

ImagingTelemedicine

Medical DevicesRemote Sensing

Environment


ResearchICPET, NRC – SIMS, IBS, IMS (nanotechnology, microelectronics, biochips, biophotonics, informatics), University of Ottawa/OHRI (biophotonics), Carleton University (medical physics)

Technical TrainingAlgonquin College (photonics, computer engineering), NCIT (information Technologies), Vitesse (biophotonics, IT), Carleton University (computer engineering, biomedical engineering), University of Ottawa(biomedical engineering, computer engineering)

Contract ResearchPhotonics Fabrication Facility (prototypes), U of Ottawa Heart Institute (device evaluation, telemedicine), World Heart Corporation (device evaluation), Carleton University Design Centre (prototypes), Mosaid (chip design), Design 1st (prototype)

ProductsEpocal (biochips), Iatroquest (biosensors/biophotonics), Ionalytics (mass-spectrometry), Zarlink (chips), QNX Software (embedded software development tools), I-stat (clinical biochips), Gridiron (bioinformatics), March Networks (telemedicine), CDC (telemedicine)

• Advanced Biophotonics Consortium

Convergent Technologies


Biotech-related Service Companies in Ottawa and Eastern Ontario, 2003

0 10 20 30 40 50 60

Research

Design

Development



Manufacturing

Distribution


Testing Services

Total Companies


Ottawa and Eastern Ontario Companies Offering Biotech-Related Services

0

2

4

6

8

10

12

Proj

ect

man

agem

ent

Con

sulta

ntSe

rvic

esM

edic

alEq

uipm

ent

Test

ing

Serv

ices

Lab

Equi

pmen

t

Prot

otyp

ing

Pate

nt S

ervi

ces

Labo

rato

ryR

eage

nts

Reg

ulat

ory

Con

sultin

gFi

nanc

ing

advi

ce

Reg

ulat

ory/

CR

OC

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esea

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Mar

ket

Res

earc

hSo

ftwar

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evel

opm

ent

Busi

ness

Dev

elop

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Com

pani

es

-50100150200250300350400450

Empl

oyee

s

Number Of Companies

Employees

Support Services Cluster


Questions?

Ottawa’s Biotech and Life Sciences Landscape

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