Osteosarkoma Slide
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Oleh
Aida Hastuti
I1A006052
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suatu neoplasma ganas yang berasal darisel primitif ( poorly differentiated cells)
di daerah metafise tulang panjang
Disebut juga osteogenik sarkoma
berasal dari seri osteoblastik selmesensim primitif
neoplasma primer tulang yang terseringkedua setelah myeloma multipel
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Masih belum jelas diketahui. Faktor predisposisi :
� hubungan kekeluargaan
� adanya hereditery retinoblastoma dan sindrom Li-Fraumeni
� Infeksi virus (pd percobaan hewan)
� Radiasi ion� alkyleting agent pada kemoterapi
� Tumor supresor gen yang berperan secara signifikan :protein p53 (kromosom 17) dan Rb (kromosom 13).
� Metastase secara hematogen, paling sering ke paru ataupada tulang lainnya dan didapatkan sekitar 15%-20% telahmengalami metastase pada saat diagnosis ditegakkan.Metastase secara limpogen hampir tidak terjadi.
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� >>> laki-laki,� timbul pada dekade kedua, yaitu umur 5 - 30
tahun, terbanyak umur 10 - 20 tahun.
� Bisa juga pada akhir usia dewasa yang
berhubungan dengan penyakit Paget (Paget·sdisease).
� Letak : metafisis tulang panjang yangpertumbuhannya pesat
� Lokasi tersering distal femur, proksimaltibia dan fibula, dan proksimal humerus.
� jarang pada tulang pipih.
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Nyeri, ringan, tidak sering sangat nyeridan menetap
Gangguan pada sendi
Benjolan berkembang secara cepat
Permukaannya hangat
Dapat terlihat adanya pembuluh darahyang melebar di permukaan tumor
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Ewing·s sarcoma
Osteomyelitis
Osteoblastoma
Giant cell tumor
Aneurysmal bone cyst
Fibrous dysplasia
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Plain photo (X-Ray)
CT Scan
MRI
Bone Scintigraphy
Angiography
Biopsi - Patologi
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Plain PhotoPlain Photo
BisaBisa menunjukanmenunjukan::
a.a. LokasiLokasi lesilesi
b.b. JenisJenis destruksidestruksi tulangtulang
c.c. JenisJenis reaksireaksi periostiumperiostium
d.d. AsalAsal tumortumor
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1. Lokasi lesi1. Lokasi lesi
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2. Jenis destruksi2. Jenis destruksi
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3. Jenis reaksi periosteum3. Jenis reaksi periosteum
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4. Asal tumor 4. Asal tumor
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Lesi permeatif tulang panjangbagian metafise
Reaksi periosteal:
sun ray, segitiga Codman
Pembengkakan jaringan lunaksekitar lesi
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Stage I.Low-grade
Tumor
� I A. Intracompartmental
� I B. Extracompartmental
Stage IIHigh-grade
� II A Intracompartmental
� II B Extracompartmental
Stage IIIAny Grade
withmetastase
� II A Intracompartmental
� II B Extracompartmental
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JenisJenis
1.1. KontrolKontrol sistemiksistemik ((KemoterapiKemoterapi))
2.2. KontrolKontrol LokalLokal :: RadioterapiRadioterapi
PembedahanPembedahan
SifatSifat
1.1. Kuratif Kuratif
2.2. Paliatif Paliatif
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