Organisation and Practice of a Kidney Biopsy Register
description
Transcript of Organisation and Practice of a Kidney Biopsy Register
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Organisation and Practice of a Kidney Biopsy Register
Firenze, 07 September 2009
Cataldo Abaterusso MD, PhD
Division of Nephrology
University of Verona (Italy)
The Italian View
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History of Italian Registry of Renal Biopsies(IRRB)
Start in 1987
Two Surveys published• 1987-1993 (Schena FP. Nephrol Dial Transplant 1997)
• 1996-2000 (Gesualdo L et al. Kidney Int 2004)
Periods N. Renal Units N. Biopsies(native kidneys)
1987-1993 74 13.835
1996-2000 128 14.607
3http://88.59.234.153/irrb/
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0 10 20 30 40 50 60
AUA
NS
CRF
ARF
ANS
RIBR
IRRB 1996-2000
INDICATION TO PERFORM A RENAL BIOPSY:
MAIN CLINICAL PICTUREn. Biopsies:
14607
Gesualdo L. Kidney Int 2004% Biopsies
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DISTRIBUTION OF HISTOLOGIC GROUPS
0
10
20
30
40
50
60
70
PRIM SECON
1987-1993 1996-2000
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IRRB 1996-2000
0
5
10
15
20
25
30
35
40
45%
MG
N
FSGS
MCD
MAIN PRIMARY GN IN NEPHROTIC SYNDROME
Gesualdo L. Kidney Int 2004
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IRRB
The Ending Story
Since 2001 only 4321 renal biopsies collected
1987-1993 13.835 renal biopsies
1996-2000 14.607 renal biopsies
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Renal Biopsies Register
The Philosphy of Building
“You cannot have your cake and eat it”
The Variables of Survival of a Renal Biopsies Register:
– Development of Customer Loyalty– Unambiguous Data (Diagnosis, Definitions, etc.)– Wealth of Data– Time consuming– Updating / Maintenance of Register– Feedback – Having strongly motivated Collaborators
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Since 1998 started the “Renal Biopsies Register of TriVeneto”
RTVBR collect renal biopsies from:
• Adult subjects
• Triveneto Area’s Renal Units
• Native kidneys
• Biopsies of graft not included
RTVBR
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North-East of Italy: the Triveneto Area
At data of 01 January 2008
Resident Population (age >15yrs) : 5.780.020 persons
From ISTAT: http://demo.istat.it/pop2008/
11.4%
Italian Pop.
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YEARS Collaborative Group N. Biopsies
1998 19 344
1999 21 343
2000 22 320
2001 23 336
2002 23 316
2003 23 293
2004 23 326
2005 23 332
2006 24 394
2007 24 335
2008 24 362
Total 3701
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• Personal data• Age• Demographic• Ethnicity • Biopsy date• Blood Pressure
• Clinical Presentation at Biopsy– (SN, AUA, ARF, CRF, etc)
• Main Treatment
Laboratory
• s-Creatinine
• eGFR
• sHb
• Proteinuria (g/day)
• Hepatitis markers
• Complications of Biopsy
• Type of histologic analysis– (LM, IF, EM)
Unequivocal Renal Diagnosis
(from a multiple choice panel)
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Renal Biopsy and Histological Data
RTVBR 1998-2008
Renal Diagnosis
LM + IF more than 85% of biopsies
ME about 50% of biopsies http://rtbr.sined.it
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Laboratory
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Clinical Presentation and Treatment
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On-line search into RTVBR
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Statistics
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Renal Biopsies Register
The RTVBR Experience:
The Variables of Survival of a Renal Biopsies Register:
– Development of Customer Loyalty– Unambiguous Data (Diagnosis, Definitions, etc.)– Wealth of Data– Updating / Maintenance of Register– Time consuming– Feedback (annual report and meetings)– Having strongly motivated Collaborators
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• Epidemiology of GN
• Variation of incidence on time
• Renal Biopsy Policy
• Identification and collection of rare and uncommon renal disease
• Database to perform Surveys/Trials on uncommon nephropathies
• Linkage with other Register (i.e Dialysis and Transplant Register)
The Points of Strenght of a Renal Biopsies Register
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20
30
40
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60
70%
PRIM SECON
1998-2002 2003-2007
DISTRIBUTION OF HISTOLOGIC GROUPS
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10
20
30
40
50
60
70
PRIM SECON
1987-1994 1996-2000
RTVBR
1998-2007
RESULTS OF RTVBR ANALYSIS
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RTVBR 1998 - 2008
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5
10
15
20
25
30
35
40
45%
NSAUA
CRFARF
EMAT.
ANS
INDICATION TO PERFORM A RENAL BIOPSY:
MAIN CLINICAL PICTURE
N. Biopsies 3701
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RTBR 1998 – 2008
0
10
20
30
40
50
%
<40
41 -
65 >65
AUA
NS
CRF
ARF
EM
INDICATION TO RENAL BIOPSY PER GROUP OF AGE
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PRIMARY GLOMERULONEPHRITIS
DIAGNOSIS %IgAN 31
MGN 25
FSGS 15
Mes. not IgA 11
MCD 7
MPGN 6
Crescentic GN (CGN) 4
RTVBR 1998-2008
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RTVBR 1998 - 2007
0
5
10
15
20
25
30
35%
IgAN MGN FSGS MES MCD MCGN
1998-2002
2003-2007
PREVALENCE OF MAIN PRIMARY GLOMERULONEPHRITIS
25
SECONDARY HISTOLOGIC PICTURES
DIAGNOSIS %SLE 20
DYSGAMMAGL. 20
VASCULITIS 19
DIABETES 15
SHP 5
CRYOGLOB. 4
POST-INFECTIOUS 4
RTVBR 1998-2008
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RTVBR 1998 - 2007
0
5
10
15
20
25%
Vasculit
isSLE
Dysgam
mag
l.
Diabet
es
1998-2002
2003-2007
PREVALENCE OF MAIN SECONDARY HISTOLOGIC PICTURES
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RTBR 1998 - 2008
0
5
10
15
20
25
30
35
40
45%
< 20 21-40 41-65 > 65
ACUTE RENAL FAILURE STRATIFIED FOR AGE
N. Cases 485
M: 60% F: 40%
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RTBR 1998 - 2008
0
5
10
15
20
25
30
35
40
45%
SECON PRIM TIN VASC Other
ACUTE RENAL FAILURE
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RTVBR 1998-2008
ACUTE RENAL FAILURE
0
5
10
15
20
25
30
35
40
45
50
<40 41-65 >65
Age (yrs)
Second
Primit
TIN
Vascul.
%
30
RTBR 1998 - 2008
0
5
10
15
20
25%
Vascu
l.AIN
Dysgam
.
ExGN
IgAN
Other
s
ACUTE RENAL FAILUREMain Histologic Diagnosis
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RTBR 1998-2008
NEPHROTIC SYNDROME
N° Pts 1462
Male (%) 62
Female (%) 38
Mean Age (yrs±SD)
52±5
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RTBR 1998 - 2008
0
10
20
30
40
50
60
70
80%
PRIM SEC VASC TIN Other
NEPHROTIC SYNDROME
N. 1462 biopsies
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RTVBR 1998-2008
NEPHROTIC SYNDROME
0
5
10
15
20
25
30
35
Main Histologic Diagnosis
%
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RTVBR 1998-2008
NEPHROTIC SYNDROME
Class of Age (y) 21 - 40 41 - 65 > 65
MGN (%) 22 34 40
FSGS 14 11 8
MCD 13 6 7
IgAN 12 6 3
SLE 10 4 1
MesGN 8 5 4
MPGN 6 4 6
Diabetes 2 8 7
Dysgam. 1 8 11
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CONCLUSIONS
• The management and survival of a Renal Biopsy Register (RBR) are a compromise solution between multiple conditions
• Management demands and time consuming by Collaborators have to be lower than their advantages (feedback)
• RBR could facilitate the development of a network of Renal Units
• The RBR’s strenght is strictly linked to continuity of providing the data
• A RBR well managed could be an effective tool to perform trials and surveys