Organic irritant Organic irritant poisoningpoisoning

Toxalbumin / Toxalbumin / phytotoxinphytotoxin

RicinRicin CrotinCrotin Abrin Abrin

Ricinus communisRicinus communis Toxalbumin Toxalbumin

/phytotoxin/phytotoxin Ricin Ricin Castor oil is non Castor oil is non

poisonous poisonous Press cake is Press cake is

poisonouspoisonous MOA – inhibits MOA – inhibits

RNAPRNAP Special BP Special BP Er Er

GIT GIT Diarrhoea Diarrhoea

Croton tigilium Croton tigilium

Crotin Crotin

Abrus precatoriusAbrus precatorius AbrinAbrin Similar to Similar to

viperin snake viperin snake venomvenom

HemagglutininHemagglutinin Lipolytic Lipolytic

enzymesenzymes MOA – inhibits MOA – inhibits Protein Protein

synthesissynthesis

Ergotism Ergotism Ergotoxin,ergotaminErgotoxin,ergotamin

e ,ergometrinee ,ergometrine Stimulate Stimulate

adrenergic adrenergic receptors –receptors –periphery and periphery and centrecentre

Directly stimulate Directly stimulate muscle fibresmuscle fibres

Ergotism – chronic Ergotism – chronic poisoningpoisoning

Capsicum annum Capsicum annum --capsaicin ,capsicincapsaicin ,capsicin

Semicarpus Semicarpus anacardiumanacardium

Semicarpol Semicarpol BhilawanolBhilawanol

Calotropis Calotropis UscharinUscharin CalotoxinCalotoxin CalctinCalctin calotropincalotropin

Cantharides Cantharides

Spanish fly / Blister beetleSpanish fly / Blister beetle CantheridinCantheridin