Organic converstions: an aid in perspective
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Transcript of Organic converstions: an aid in perspective
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Lewis Whitehead
Senior Investigator & Computational Medicinal Chemist
Global Discovery Chemistry Novartis Institutes for Biomedical Research
Cambridge, Massachusetts
I knew Rae Lawrence & David Bardsley were listening, but I didn’t expect there to be ANY constructive follow up. I was wrong....
Organic Conversions: An Aid in Perspective
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The importance & value of common sense reagent selection & procurement protocols, to me.
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PI 3-kinase, Novartis Horsham Research Centre, 2001.
NH
ON
HH
$111.36/g from Aldrich
Moiety contained or referenced in 45 patents (2004-2014)
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The importance & value of common sense reagent selection & procurement protocols, to me.
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Elongation Factor Tu, NIBR Cambridge, 2006.
OO
OH
H$0/g from NIBR-Basel
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A Common FieldStere / Spark experience
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I perform the detective work of where an EXCITING fragment came from.....
....only to discover that the disconnection isn’t the same... ...or the reagent my team needs is P.O.A...
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Organic Conversions: An Aid in Perspective
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Fond memories of ‘learn-by-rote’ undergraduate & A-level chemistry
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Organic Conversions: An Aid in Perspective
6 of 9
Rae, David & I had an hour in my office to talk about Cresset
7 Tiers of selection in my own protocol - Laboratory bench storage - Local Stockrooms - Compound Handling Centre - Intermediates Archive - Global Stockrooms (USEM, GBHO, CHBS, CNIBR, NITD) - Preferred vendors - Everything
Reduces wait time & increases feedback
Sometimes 2-4 weeks is too long...
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Organic Conversions: An Aid in Perspective
7 of 9. Is he finishing soon?
12 months later I learn that a new module had been developed!!
I knew Rae Lawrence & David Bardsley were listening, but I didn’t expect there to be ANY constructive follow up. I was wrong....
Thank you.
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Organic Conversions: An Aid in Perspective
8 of 9, yes, I’m nearly finished.
Where do I see this going?
What I would like to see..... - Sigma-Aldrich, Thermo-Fisher, Acros, Nagase.... - Reactions?
What I intend to do.... - Accessible to my colleagues
in medicinal chemistry - Avoiding me,
for simplistic tasks....
What would you like to see.....?
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Lewis Whitehead
Computational Medicinal Chemist Global Discovery Chemistry
Novartis Institutes for Biomedical Research Cambridge, Massachusetts
Rae Lawrence David Bardsley Tim Cheeseright Sue Peffer
Organic Conversions: An Aid in Perspective
Ololomutiek, Maasai-Mara, Kenya.