• 1 in 6 American men will develop prostate cancer

• This year, more than 234,000 men will be diagnosed with prostate cancer

• Every 19 minutes, a man dies from prostate cancer

Prostate cancer often does not cause any symptoms for years. When symptoms do occur, usually the cancerous cells have spread beyond the prostate, this is why regular check up for men age of 40 and above is necessary and recommended.

The symptoms include: Urinary problems: Dull pain in the lower pelvic area, hips, or upper thighs Not being able to urinate

Sensation that your bladder doesn't empties Having a hard time starting or stopping the

urine flow Problems with urgency of urination and

difficulty in starting

Frequent urination, especially at night Weak flow of urine

Urine flow that starts and stops Pain or burning during urination

Difficulty having an erection Pain at ejaculation

Genital pain Blood in the urine or semen

Cancer IncidenceCancer Incidence

* 87% of lung and bronchus are related to smoking

Source: American Cancer Society. Jemal A, et al. Cancer Statistics, 2004. CA Cancer J Clin. 2005;55:10-30

50%

17%

8%6%

3%2% 2% 1% 1%

0%

10%

20%

30%

40%

50%

All

Sit

es

Pro

stat

e

Lu

ng

& B

ron

chu

s

Co

lon

& R

ecta

l

Bla

dd

er

Lym

ph

om

a

Mel

ano

ma

Ora

l

Kid

ney

Risk

A non-smoking man is more likely to get prostate cancer than lung, bronchus, colon, rectal, bladder, lymphoma, melanoma, oral, and kidney cancers combined.

Age-Specific Probability of DiagnosisAge-Specific Probability of Diagnosis

Age-Specific Probability of

Diagnosis

Age

Prostate

Breast

Colon

Lung & Bronchus

Leukemia & Lymphoma

Pancreas0%

2%

4%

6%

8%

10%

12%

14%

16%

18%

25 30 35 40 45 50 55 60 65 70 75 80 85 90

Source: 2000-2002 SEER 13 Registries

150,000

200,000

250,000

300,000

350,000

400,000

450,000

500,000

2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050

Prostate

BreastLung &

BronchusColon

Number of New Cases

Assumes 2002 age-specific incidence rates.

Source: SEER 13 Registries Incidence and Mortality (2004 Submission)

300,000

350,000

400,000

460,000

Historical & Projected Cancer DeathsHistorical & Projected Cancer Deaths

Note: Projections Assume 1999 Age Specific Mortality Rates.

10,000

30,000

50,000

70,000

90,000

110,000

130,000

1975 1980 1985 1990 1995 2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050

Prostate

52,000 deaths in 2020

10,000

30,000

50,000

70,000

90,000

110,000

130,000

1975 1980 1985 1990 1995 2000 2005 2010 2015 2020 2025 2030 2035 2040 2045 2050

Deaths

Breast

40,000 deaths in 2010

52,000 deaths in 2020

80,000 deathsin 2030

Prostate Cancer Foundation / Gillette Men's Health Survey

Prostate Cancer Foundation / Gillette Men's Health Survey

30% of Men & Women Believe 30% of Men & Women Believe Women Can Get Prostate CancerWomen Can Get Prostate Cancer

30%30%

30% of Men & Women Believe 30% of Men & Women Believe Women Can Get Prostate CancerWomen Can Get Prostate Cancer

30%30%

WOMEN

WOMEN

DON’T

DON’T

HAVE

HAVE

PROSTATESPROSTATES

2006 Estimated U.S. Cancer Cases2006 Estimated U.S. Cancer Cases

Prostate 19%

234,460 cases

Breast 18%

212,920 cases

* Excludes basal and squamous cell skin cancers and in situ carcinoma except bladder. Percentages may not total 100% due to rounding.Source: American Cancer Society. Cancer Facts & Figures 2006. Atlanta: American Cancer Society; 2006.

Uterine3%

Pancreas3%

Ovary2%

Kidney3%

Oral Cavity3%

Thyroid3%

Non-Hodgkin Lymphoma5%

Leukemia3%

Melanoma5%

Bladder5%

Colon & Rectum13%

Lung & Bronchus15%

= 1.33 more likely

men will develop prostate cancer

16

18

women will develop breast cancer

Concerned About Prostate Cancer Concerned About Prostate Cancer and Taking Actionand Taking Action

Concerned About Prostate Cancer

Never Discuss Family History or Personal Risk with Doctor

73%

25%

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

Concerned about Pca Discuss with Doc

Women as InfluencesWomen as Influences

More Likely to Talk to Doctor if Urged by Women in Their Lives

MEN

Believe They Can Influence Men to See Doctor

WOMEN

Symptoms and Early Stage Symptoms and Early Stage Prostate CancerProstate Cancer

30%30%

Men believe that there are symptoms associated with early stage prostate cancer

30%30%

EARLY STAGE

EARLY STAGE

PROSTATE CANCER

PROSTATE CANCER

TYPICALLY DOESN’T

TYPICALLY DOESN’T

HAVE SYMPTOMS

HAVE SYMPTOMS

Men believe that there are symptoms associated with early stage prostate cancer

Symptoms and Early Stage Symptoms and Early Stage Prostate CancerProstate Cancer

digital rectal examination

blood test called the prostate specific antigen (PSA).

Age Age is the strongest risk factor for prostate

cancer. Prostate cancer is very rare before the age of 40, but the chance of having prostate cancer rises rapidly after age 50. Almost 2 out of 3 prostate cancers are found in men over the age of 65 .

Family history Prostate cancer seems to run in some families, which suggests that in some cases there may be an inherited or genetic factor. Having a father or brother with prostate cancer more than doubles a man's risk of developing this disease. (The risk is higher for men with an affected brother than for those with an affected father.) The risk is much higher for men with several affected relatives, particularly if their relatives were young at the time the cancer was found

Race/ethnicity Prostate cancer occurs more often in African-American men than in men of other races. African-American men are also more likely to be diagnosed at an advanced stage, and are more than twice as likely to die of prostate cancer as white men. Prostate cancer occurs less often in Asian-American and Hispanic/Latino men than in non-Hispanic whites. The reasons for these racial and ethnic differences are not clear.

Nationality Prostate cancer is most common in North America, northwestern Europe, Australia, and on Caribbean islands. It is less common in Asia, Africa, Central America, and South America. The reasons for this are not clear. More intensive screening in some developed countries likely accounts for at least part of this difference, but other factors are likely to be important as well. For example, lifestyle differences (diet, etc.) may be important: men of Asian descent living in the United States have a lower risk of prostate cancer than white Americans, but their risk is higher than that of men of similar backgrounds living in Asia.

Diet The exact role of diet in prostate cancer is not clear, although several different factors have been studied. Men who eat a lot of red meat or high-fat dairy products appear to have a slightly higher chance of getting prostate cancer. These men also tend to eat fewer fruits and vegetables. Doctors are not sure which of these factors is responsible for raising the risk. Some studies have suggested that men who consume a lot of calcium (through food or supplements) may have a higher risk of developing advanced prostate cancer. Most studies have not found such a link with the levels of calcium found in the average diet, and it's important to note that calcium is known to have other important health benefits.

Obesity Most studies have not found that being obese (having a high amount of extra body fat) is linked with a higher risk of getting prostate cancer. Some studies have found that obese men have a lower risk of getting a low-grade (less dangerous) form of the disease, but a higher risk of getting more aggressive prostate cancer. The reasons for this are not clear. Studies have also found that obese men may be at greater risk for having more advanced prostate cancer and of dying from prostate cancer, but this was not seen in other studies.

Exercise Exercise has not been shown to reduce prostate cancer risk in most studies. But some studies have found that high levels of physical activity, particularly in older men, may lower the risk of advanced prostate cancer. More research in this area is needed

Inflammation of the prostate Some studies have suggested that prostatitis (inflammation of the prostate gland) may be linked to an increased risk of prostate cancer, but other studies have not found such a link. Inflammation is often seen in samples of prostate tissue that also contain cancer. While the link between the two is not yet clear, this is an active area of research.

Infection Researchers have also looked to see if sexually transmitted infections (like gonorrhea or chlamydia) might increase the risk of prostate cancer, possibly by leading to inflammation of the prostate. So far, studies have not agreed, and no firm conclusions have been reached.

Vasectomy Some earlier studies had suggested that men who had a vasectomy (minor surgery to make men infertile) -- especially those younger than 35 at the time of the procedure -- may have a slightly increased risk for prostate cancer. But most recent studies have not found any increased risk among men who have had this operation. Fear of an increased risk of prostate cancer should not be a reason to avoid a vasectomy

Kataja VV, Bergh J. ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of prostate cancer. Ann Oncol. 2005;16 Suppl 1:i34-6.

Chang SS, Benson MC, Campbell SC, Crook J, Dreicer R, Evans CP, Hall MC, Higano C, Kelly WK, Sartor O, Smith JA Jr; Society of Urologic Oncology, Shaumberg, Illinois.

Society of Urologic Oncology position statement: redefining the management of hormone-refractory prostate carcinoma. Cancer. 2005 Jan 1;103(1):11-21.