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Options for Fertility

Preservation in CancerPatient

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Introduction

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Increasing survival rates for cancers patients and an increasing awarenquality of life after chemo-/radiotherapy have focused attention on the fertility after cancer treatmend.

• The eects of malignant disease on gonadal function are caused in mosindirectly !y the in"uence of cytoto#ic theraphy

• Chemotherapy and/or radiotherapy very often lead to partial or compleof the ovaries and spermato$oa% severly reducing or eliminating fertility

• The gonadoto#ic eects are strongly dependent on the patient&s age 'ocorrelating to higher ris()% the type% dose and duration of chemotherapytherapy

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Options for FertilityPreservation in Women

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 Transposition of the Ovaries'Ovariope#y)•

In patients with *odg(in or non-*odg(in lymphocervical carcinoma% colorectal carcinoma% or othmalignancies which require radiotherapy t the pthe ovaries can !e surgically repositioned away the radiotherapy +eld !efore starting treatment.

•

Ovaries can !e mar(ed with radiopaque metal ctheir location can !e chec(ed during treatment

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,n* nalogues

• ,onadotropin-releasing hormone ',n*) agonis

!e utili$ed to inhi!it the re- lease of follicle-stimuhormone in postpu!ertal women% inducing transhypogonadotropic hypogonadism and placing thovaries in a resting0 state.

•

 *ere!y% it is anticipated that follicles can !e proand fertility !e preserved.

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