8/6/2019 Optimization and Analysis of Bacterial Growth Behavior

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MasterProjectsD009/2011

OptimizationandAnalysisofBacterialGrowthBehaviorinaSingleCellBioreactor

Background:Microfluidicsdealswiththemanipulationoffluids inchannelswithdimensionsoftensof

micro meters and has emerged as a distinct new field, and chipbased systems with applications in

chemical synthesis, biological analysis, medical diagnostics, optics and information technology are

commonlyused.SocalledLabona Chipdeviceshavebeendevelopedforfast,accurateandportable

analytical applications, especially for medical diagnosis. Microfluidics provide excellent conditions for

performingbiologicalexperimentsonsinglecellsorsmallpopulationsofcells,especially to investigate

phenomenasuchascellularheterogeneityincellpopulation,stochasticgeneandproteinexpressionetc.

Aboutus:TheMicroScaleBioengineeringGroupispartoftheInstituteofBio andGeosciences(IBGI),located at the Research Center Juelich (Forschungszentrum Jlich GmbH). Our aim is to developcuttingedgemicrofluidicsystemstostudybiologicalprocessesatsinglecelllevel.

Projectdescription:Inthisproject,youwillimproveamicrofluidicchipsystemforsinglecellanalysisofbacteria.The focuswillbeon theoptimizationofbacteria trappingand culturingparameters (e.g.oxygenandnutrientsupplyetc.)for longtimegrowthexperimentsonsinglecell level.Additionally,the

growthbehaviorofdifferentproductionstrainsshouldbecomparedandanalyzed fordifferentgrowth

pattern.Dependingonyourinterestandknowledgewewilltailoryourpersonalproject.

Requirements:Weare lookingforexcellentandhighlymotivatedcandidatesstudying:biotechnology,bioengineering, (bio)chemical engineering, biochemistry, applied (bio)physicsor similar in their finalyear. The candidate should have a strong interest in multidisciplinary research. Knowledge of basic

microbiologicalskillsismandatory.Firstexperienceinfermentationand/culturingofbacteriawillbean

advantage.Experiencesinmicrofluidicswillbehelpful.WorkinglanguageisEnglishand/orGerman.

Wehaveopenpositionsavailableanytime.

FurthermasterandDiplomaprojectsavailableonrequest.

Formoreinformationandapplicationpleasecontact:

Dr.DietrichKohlheyer

InstituteofBioandGeosciences(IBG1)

Micro

Scale

Bioengineering

Group

ForschungszentrumJlichGmbH

52425Jlich,Germany

Phone: +49(0)2461612875

EMail: D.Kohlheyer@fzjuelich.de

WWW: www.fzjuelich.de 01.02.2011

IBG1Biotechnologie