Optic neuritis
-
Upload
meenank -
Category
Health & Medicine
-
view
389 -
download
4
description
Transcript of Optic neuritis
![Page 1: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/1.jpg)
Optic neuritisDr. Meenank
![Page 2: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/2.jpg)
Optic Neuritis (ON)
• Inflammation of optic nerve - ON
• Associated with swollen disc – papillitis/ anterior ON
• Normal disc – retro bulbar ON/ neuritis
• Absence of any signs of M.S/ systemic illness –
monosymptomatic/ idiopathic/ Clinically isolated ON
• Subtle clinical signs + electrophysiological evidence –
asymptomatic ON
![Page 3: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/3.jpg)
Two variants 1. Neuroretinitis – infla. Of intraocular + Peripapillary retina –>
disc swelling + retinal oedema + Hx + hard exudates + macular star
2. Optic peri-neuritis – infla. Of optic nerve sheet only –> disc swelling with out Vn complications + large blind spot
• D/D papilledema
Demographic • 2.2 -2.6 per 100,000 cases (or) 115 / 100,00 cases per year• white population • Northern latitude• Females ( 77%)• Age – 15 to 50yr , (children – 10 to 20 )• Mean age – 33yrs
![Page 4: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/4.jpg)
Triad of symptoms • Vision loss• Ipsilateral eye pain• dyschromotopsia
initial attack – unilateral
Associated Symptoms
• Movement phosphens• Sound induced phosphens• Visual obscuration's in bright light • Uhthoff’s syndrome
![Page 5: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/5.jpg)
Loss of vision• Rapid / abrupt loss of vision• According to ONTT • With in hrs – 29%• In 1 to 2 days – 20%• In 3 to 7 days – 23 %• In 1 to 2 weeks – 7 %
• Variant : • Ch. Demyelination of optic neuropathy characterized by slow
progressive vision loss – due to macro-plaques optic nerve – impairment of vision • Micro-plaques chiasma – chiasmal optic neuritis ( rare symptom)
![Page 6: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/6.jpg)
Pain • Freq. of Ipsilateral eye pain in unilateral ON – 55% to 92%• Character – dull aching• ass. With generalized / periocular headache• aggravated by – EOM / touch • Pain precedes vision loss• Max severity – 24 to 36 hr subsides with in 48 to 72 hrs• Pain = vision loss• Pain in retro-bulbar > papillitis > AION ( 93%> 90% > 12% )• Atypical presentation = pain more than 7 days
![Page 7: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/7.jpg)
Dyschromatopsia • Impaired color vision = 94%• Desaturation• – eg: red = dark/ beached
• Distinguishes b/w macular lesion
![Page 8: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/8.jpg)
sparkles
Sound induced flashes
Motion induced flashes
Phosphens• Ring of light • ONTT = 30% positive • 3 observation • Sparkles • Due to disc oedema• Stimulation of Peripapillary retina
• Motion induced • Before / during / months after • Most common – dim illumination, horizontal gaze, closed eyes• Rapid eye movement's – decrease phosphens
![Page 9: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/9.jpg)
• Cause : spontaneous discharge of the partially demyelinated spinal chord axons in min. stress condt.
• Sound induced • Loud noise at rest = phosphens• Pathological variant of hypnogogic hallucinations
![Page 10: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/10.jpg)
Quick recovery
Transient blurring
Hot baths
/climate
Isolated ON (rare) /
M.S.
• Generalized blurring for 2- 20 min• Cool down vision back with in 5min to 24 hrs ( rare)• Not common in ON but seen in
compressive toxicinflammatoryLHON
In ½ of isolated ON Shows recurrence , sporadic
Uhthoff’s symptoms
![Page 11: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/11.jpg)
Clinical Sign’s
• Acuity • Dyschomatopsia • Contrast sensitivity • Afferent pupillary defect• Optic disc• Retinal finding
• Acuity • Varying degree of visual acuity can be seen ranging from
6/9 to NLP
![Page 12: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/12.jpg)
Dyschromatopsia
• Unilateral Dyschomatopsia with good V.A → ON• Can be detected using • Hardy Rand Ritter• Ishihara pseudo=isochomatic plates • Fans-worth Munsell 100-hue Test
• Ishihara - 20/280• Hardy Randy Ritter – 20/ 100 Dyschromatopsia
• Color sensitivity > V.A• Contrast sensitivity = V.A
![Page 13: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/13.jpg)
Recovered ON with 6/6 but, imperfect Vn
Physiological test •Contrast sensitivity test – Pelli-Robson and Sloan low contrast
Contrast sensitivity
• Pelli- Robson Contrast chart (Sensitivity)• Distance – 1 - good for subclinical ON• Chart – 16 triplet of same letter• Contrast – 96% 10 1% - cannot diff. b/w
• Sloan low Contrast acuity Chart (acuity) ON/ maulopathy/ • Low contrast, light grey organic (or) non- organic
• Like snellen chart
![Page 14: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/14.jpg)
Stereoacuity • Stereoacuity and snellen’s and in linear relationship• Normal Stereoacuity with impaired snellen’s • Snellen's incorrect • Non-organic vision loss
• Pulrich effect • Damaged optic nerve delays transmission to visual cortex from
the unilateral eye
• Oscillating target on the front plane is perceived as elliptical due to stereo –illumination due to impulse delay
![Page 15: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/15.jpg)
• Magnitude of stereo – illumination • Velocity of target• Diff. between retinal illumination b/w two eyes• Basic level of retinal illumination • Distance between the observer and target
• Pulrich – more sensitive indicator of optic nerve dis.
![Page 16: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/16.jpg)
Visual fields • ONTT = all patients show V.F abnormalities in acute phase• Vn loss – central ⁺⁺⁺, peripheral⁺, particular region⁺ • If Vn severely impaired – confrontation test • Vision improved – • Multi-isotropic kinetic Goldman Perimetry ( only central scotoma)• Computer Assisted automated static Perimetry ( Diffused and focal )• Octopus Perimetry
• Focal defect – • Altitudinal • Arcate 42%• Nasal step defect
![Page 17: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/17.jpg)
Afferent pupillary defect • In the absence of an optic nerve lesion in the fellow eye RAPD
can be demonstrated by swinging flash light • RAPD can be graded by neutral density filters – 0.3, 0.6, 0.9,
1.2• -ve RAPD in recurrent attacks
![Page 18: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/18.jpg)
Optic disc • Normal – ⅔• Oedematous - ½ • Temporal pallor – 10% , suggestive of preceding attack• Disc Oedema is without Hx / lipids/ cotton wool • Disc changes α multiple sclerosis • Recovered ON – optic disc • Normal 40%• Temporal pallor 30%• Total pallor 20%
• M.S without ON can have pale optic nerves
Optic disc oedema
![Page 19: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/19.jpg)
Retinal Findings
• Retinal venous sheathing • Small ill-defined/ round confluent white exudates along the
peripheral veins• Most common – systemic illness ( M.S. , sarcoidosis)• Also in asymp. Eye of M.S as an isolated B/l finding • Recurrence – post complete resolution
• RNFL atrophy • Disc atrophy is seen in all types of optic neuropathy• M.S – incidious RNFL atrophy with visual symptoms of optic nerve
dysfuntion • RNFL defects in ON/ M.S – from axonal atrophy
![Page 20: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/20.jpg)
• Seen as a slit in the nerve fiber striation in the arcate fiber bundle• Slits – M.S 70% - normal eye of ON – 2 sub-clinical optic nerve lesions
• RNFL defects – focal / diffused atrophy Diagnosed through 1. monochromatic red free ophthalmoscopy 2. Red free light magnifying fungus photography3. OCT4. Heidelberg retinal tomography
• RNFL thickness - α neurological function test - ⅟α contrast sensitivity test
![Page 21: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/21.jpg)
RNFL
Normal RNFL
Loss of RNFL
![Page 22: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/22.jpg)
Differential diagnosis• Unilateral ON• NAION• Infectious/ inflammatory
• Neuroretinitis• Viral • Post- viral• Fungal• Syphilis• Toxoplasmosis• Lyme• Herpes zoster• Sarcoidosis• T.B.• Collagen vascular disease• Autoimmune ON
• Leber’s hereditary ON• Compressive
• Meningioma• Glioma• Metastasis• PNS mass
• Infiltrative• Multiple myeloma• Leukemia• Cā meningitis
• Retinopathies• Paraneoplastic ON• Cone dystrophy
![Page 23: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/23.jpg)
• M.C occurring optic neuropathies AION and idiopathic ON• Difficult to distinguish on the basis of • Age, initial presentation, progression, V.F defects, optic nerve
Optic neuritis AION
demographicsMean age, yrs
33 ( 5- 70) 66 ( 11 – 90 )
Gender, % female 70% 45%
Annual incidence, per 100,000
2 -6 1- 6
SymptomsPain 92% 10%
Progression 70% 30% - 45%
Improvement >90% >40%
SignsAcuity 6/6 to NPL 6/6 to NPL
Field defects Central scotoma Inferior altitudinal
Disc oedema 35% 100%
![Page 24: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/24.jpg)
Rhinogenous ON
• From the sinus – posterior ethmoidal (or) sphinodal
• Mimics unilateral idiopathic ON
• Seen in – recurrent attacks of Vn loss with sever head-ach/
febrile illness
• Diff. diagnosis –
• Rx – steroids
• Can lead to steroid sensitive ON
![Page 25: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/25.jpg)
Lyme disease
• Lyme borreliosis
ehrlichosis rarely cause optic neuropathy
• Early stages – optic nerve swollen
• Lyme meningitis- disc swelling – papilledema/ optic
perineuritis
• Diagnosis – serological test (imp. In endemic cases)
• Rx – oral / I.V steroids
![Page 26: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/26.jpg)
Acute syphilitic neuritis• Manifestation of 2⁰ syphilis – uni/ bi lateral Vn loss• Acc. by intraocular inflammation – uveitis , retinal vasculits
• 2⁰ syphilis –> meningeal inflammation –> syphilitic optic perineuritis inflammation of the optic nerve sheet swelling of the optic disc
• 2⁰ syphilis – tertiary syphilis Slow prog. Vn loss with optic atrophy without inflammation
• Check for – palmar and truncal rash ( 2⁰ syphilis)
![Page 27: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/27.jpg)
• Diagnosis• VDRL positive for 2⁰ syphilis• PRP (plasma rapid reagent) normal for tertiary syphilis
• Immunocompetent + syphilis = +ve for life for• Microhemaglutten assay for treponema pallidum (MHA-TP)• Florescent treponemal antibody absorption test ( FTA-AB)
• CSF – normal / inc. WBC
![Page 28: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/28.jpg)
Neuro-retinitis
• ON + swollen disc + macular oedema (ME)
• Resolved ME –> macular star
• Vitreous cells ± mid peripheral choroditis
• Neuroretinitis due to infec./ infla
• Cat-scratch dis
• Syphilis
• Lyme
• Toxoplasmosis
• Sarcoidosis
• Prognosis – good
![Page 29: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/29.jpg)
CancerParaneoplastic • Acute and sub-acute – Vn loss• Auto-antibodies –> retina / &, optic nerve – uni/bi Vn loss with
in 1 week • Optic disc – normal to swollen, vitreous cells • Neurological defects – ataxia, peripheral neuropathy,
movement disorders• Optic nerve – show (CRMP-5) IGg• Antibodies to Collapsing response mediated protein -5
• Tumors associated with Paraneoplastic optic neuropathy • Small cell Ca. lung• Thymoma • Thyroid Ca.
![Page 30: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/30.jpg)
Bilateral (or) Simultaneous• Leber’s hereditary ON (LHON)• Chiasmal syndrome• Nutritional • B₁₂ deficiency
• Tobacco – alcohol amblyopia • Toxic • Linezolid• Ethambutol• Amiradone• Tumor necrosis alpha inhibitors
• Neuromylitis optica (NMO)
• Papilledema
![Page 31: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/31.jpg)
Neuromylitis Optica (NMO)• AKA Devic’s diseases • Rare, all ages, bilateral (91%)• Inflammatory CNS demyelinating diseases• Optic nerve • Spinal chord ( only 3 vertebrae )
• In NMO, ON –> transverse myelitis ( weeks)• Acute stage – CSF proteins – CSF pleocytosis• Pleocytosis – predictor of out come • Don’t show oligoclonal bands• No white matter lesions• Incomplete neurological recovery • NMO IGg antibodies – 70% sensitive , 100% specific to NMO
![Page 32: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/32.jpg)
SLE• Affinity - 1%• Vision loss • Acute progressive • Corticosteroid Rx – sub-acute to slow prog. – steroid dependent
and suggestive of collagen vascular disorder• Lab – ANA , anti-cardiolopin (increased)• Biopsy of non-exposed tissue• Peri-vascular infiltrates• Immune-complex deposits in the dermis
• Rx – prolong steroid thx
![Page 33: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/33.jpg)
Tobacco – alcohol amblyopia • AKA Tobacco/ ON of chronic alcohol/ malnutrition ON• Vision loss – slow progressive• Visual field defect – B/L centro-coecal scotoma• Dietary deficiency • Rx – thiamine, B₁₂, folate• Vision imp. Inspite of abuse
Jamaican optic neuropathy • Vn 6/60 ↓, B/l dense central scotoma, W. Africa &
Carrabinan immigrant's • Patient – well nourished, non-toxic, VDRL non-reactive• Rx – no Tx relief, no spontaneous recovery • Cause – unknown
![Page 34: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/34.jpg)
Leber’s hereditary ON (LHON)• 1st disease to inherit mitochondrial mutation in DNA • Maternally inherited • 1 young men, white ( 80% -90% ) with 50% Vn loss• Japanese's • Symptoms • Sub-acute painless bilateral Vn loss• Central (or) ceco-central scotoma• Onset- all ages
• Most common -12 yr to 30 yrs• Vn loss –permanent profound , with in weeks -1 month - 8yrs• Rare – monocular Vn loss • Uhthoff's symptoms ⁺
![Page 35: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/35.jpg)
• Nadir of visual acuity, commonly 6/60 and ↑• Fundus – depending on the stage / normal • Acute• circumpapillary telangiectic microangiopathy with disc hyperemia• Swelling of Peripapillary NFL• Vascular tortuosity • F.A – absence of leak from disc
• Late • Telangiectic microangisums –resolved• Optic atrophy• Loss of NFL striations in papillomacular bundle
• Associated with cardiac anomalies• Diagnosis – DNA analysis• Rx – L-carnitine, Succinate, Vit. B, Vit. E, co-enzyme Q₁₀, idebenon
![Page 36: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/36.jpg)
ON in children Adults ⅓
• Disc oedema Children (50% - 75%) bilateral + optic nerve swelling
• MRI - normal to large enhance white matter lesions• Acute disseminated encephalomyelitis
• Rx – IVMP 1-4 gm./ kg/ day x 3-5 day oral prednisolone 1mg/ kg/ day (taper @ 4 wks)
• Child with ant ON – relapse with steroid• Progress – 80% • Pediatric ON –> M.S, very low (4yrs to 9yrs)
![Page 37: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/37.jpg)
Investigations
Visual evoke potential • ON detects • Sub-clinical abnormalities• Difference between organic and non-organic origin
• Test the central and para-foveal visual field• Flash VEP – areas 17, 18, 19• Wave form VEP – triphasic
• P100 - +ve peak • N75 with N45 - -ve peaks
• Prolong P100 (latency) => changes with ON• P100 (amplitude) => visual acuity, not reliable
![Page 38: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/38.jpg)
• Absolute latency @ P100, > 9 ms = optic nerve dysfunction• Delay in P100 permanent after an attack• Prolong latency in VEP • Compression• Glaucoma• Dopamine def. in central neurodegenerative dis.
• Altered amplitude and latency in normal individuals• Defocusing• Looking away
![Page 39: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/39.jpg)
Pattern Electro-retino-gram • PERG is used to evaluate the function of the macula or central
retina• PERG refines VEP’s abnormal interpretations • To R/o the cause isn’t from a ant. Lesion • Waves – P50 (+ve), N95( large –ve), N35 ( small early –ve)• In ON –• Delayed VEP P100 latency • Near-normal PERG N50 amplitude • Small/ absent PERG N95 amplitude
• Ant. Visual pathway dysfunction/ maculopathy – • Delayed/ small P100 • Reduced P50 • Normal N95
![Page 40: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/40.jpg)
Magnet Resonance Imaging
• Not always imp. but, help R/o other disorders• MRI brain and orbit with fat suppression and gadolinium• In ON – • Optic nerve – abr STIR signals• Gadolinium enhancements• Single white matter lesion in AMON – high risk for M.S
• Abnormality > 3mm, oval, in peri-ventricular white matter, radially oriented towards the ventricular spaces on a unenhanced MRI
![Page 41: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/41.jpg)
DISSEMINATION IN SPACE DISSEMINATION IN TIME
One or more gadolinium enhanced lesions/ 9 hyper intense white matter lesion
Gadolinium enhanced lesion > 3month post initial evaluation
One or more infra-tentorial lesion New T2 lesion > 30 days after baseline MRI
Three/ more prei-ventricular lesions
A spinal chord lesion can substitute for one infra-tentorial lesion
Revised McDonalds Criteria
Need to fulfill atleast 3Lesion should be 3mm or more
![Page 42: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/42.jpg)
Prognosis and Recurrence
Prognosis • although 85% show irreversible nerve damage• Visual out come is in 92% - 6/9
• Recurrence• Two group’s • Existing M.S – 45%• People using oral prednisolone
![Page 43: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/43.jpg)
Multiple Sclerosis• MS is an inflammatory demyelinating disorder of the CNS white
matter• Ophthalmic presentation • ON, inter-nuclear ophthalmaoplegia, nystagmus • Uncommon presentation – homonymous V.F loss, gaze palsy, isolated
ocular motor palsy• Diagnostic –• Two or more lesions in nervous system in separate locations
occurring at diff. time – separation of time and space, with no explanation
• MRI - New gadolinium enhancement > 3months after ON attack• CSF - oligoclonal bands in the gamma-globulin region of the
fractioned protein • Also seen in – neurosyphilis, neurosarcoidosis, meningitis
• Abnormal IGg index
![Page 44: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/44.jpg)
Treatment
Corticosteroid's
• ONTT (optic neuritis treatment trial) 3 groups1. Oral prednisolone (1mg/kg) daily for 14 days2. Oral placebo (1mg/kg) daily for 14 days 3. IVMP (1gm/d) for 3 days followed by oral prednisolone (1mg/kg) for 11 days
• Faster recovery with IVMP, but no diff. in final result• Recurrence with oral prednisolone• IVMP – 50% reduction in development to M.S
![Page 45: Optic neuritis](https://reader034.fdocuments.us/reader034/viewer/2022052303/547b2612b4af9f11138b45a2/html5/thumbnails/45.jpg)
Interferon therapy
• CHAMPS – Controlled High Risk Subjects Avonex M.S. prevention• Multicenter , randomized, double-blinded, placebo-controlled
clinical trial • Inclusion – abnormal MRI + 2 white matter lesions • Rx – systemic corticosteroids + weekly IM (interferon beta 1a)
IFNβ1-a (or) placebo • Result @ 3yrs – 35% of IFNβ developed MS , no progression in
MRI abnormalities
• BENEFIT – Beteferon in Newly Emerging MS for Initial Treatment• Subcutaneous IFNβ1b reduces conversion ( 45%)