ontents - Australian Centre for NanoMedicine (ACN) Annual Report 20… · 1 About the ACN 3...

Contents

1 About the ACN

3 Directors’ Report

5 At a Glance

7 Research

8 2016 New Grant Funding

10 2016 New Research Projects

14 High Impact Papers

15 Engagement

16 Media

19 Events

20 Presentation

25 Collaborating Organisations

26 Awards, Prizes and Achievements

28 Governance, Our People & Visitors

29 Steering Committee

30 Organisational Chart

31 ACN Staff and Students

33 Visitors to the ACN

34 Publications

42 Cover Gallery

43 Financial Report

About the ACN

The ACN was established in mid-2011 as a national innovator in NanoMedicine, bringing together a diverse team of

leading researchers in Medicine, Science and Engineering to deliver the next generation of health innovations, and is

dedicated to providing new solutions for therapeutics and diagnostics enabled by nanotechnology.

The key science that underpins all the activities of the Centre is to fully understand and exploit the unique properties of

nanomaterials for various applications (eg. Contrast agents for cell imaging and therapeutics for treating cancer). The

Centre’s strategic vision is to create teams focused on particular diseases using Team ACN’s skills in drug delivery,

diagnostics and imaging.

To succeed in this, it requires an integrated team of researchers coming from diverse backgrounds and we have

assembled a remarkable team of highly distinguished scientists and engineers covering nanotechnology, polymer science,

cancer biology, chemical engineering, microfluidic, chemistry, sensors and imaging, social science and experimental arts

(3D imaging) from five UNSW faculties: Medicine, Science, Engineering, Arts & Social Sciences, and Arts and Design.

Dr Friederike Mansfeld, Senior Research Officer at Children's Cancer Institute

1

Dr. Robert Utama setting up a RAFT polymerization reaction with PhD student Kelly Zong.

2

Directors’ Report

Scientia Professor

Justin Gooding

Professor Maria Kavallaris

Professor Cyrille Boyer

2016 marks the 3rd year of

implementation of the Centre’s

2nd strategic plan of 5 years. We

have grown from the initial 40+

research team from the inception

of the Centre to today’s 120 strong

team spread across five UNSW

faculties, encompassing a huge

amount of activities. We hope this

report gives a flavour of the

achievements we have made in

2016.

The past twelve months has seen

outstanding scientific output,

significant capacity building, the

growth of National and

International collaboration,

leadership in organising and

leading significant research

conference and workshops,

numerous prizes, awards and

fellowships, together with a strong

media profile to communicate our

purpose and successes.

Some areas we would like to

highlight are:

• Research productivity was

extremely impressive in 2016

including high-impact papers in

chemistry, polymer science and

medicine, with increasing focus on

cross-disciplinary output across the

Centre. In 2016, we have over 113

publications, 7 book chapters and 3

patents with a growing number of

papers published from the Centre’s

collaborative research programs.

We published 14 papers with

impact factors above 10 in the

following prestigious journals:

Chemical Reviews, Chemical

Society Reviews, Nano Letters,

Nature Nanotechnology, Science,

Advanced Drug Delivery Reviews,

Journal of the American Chemical

Society, Angewandte Chemie and

Advanced Materials.

• Significant amount of

grant funding for collaborative

research. Total new grant funding

for ACN members reached a record

high of $17M. Including NHMRC

Program Grant APP1091261 2016-

2020 $7M+ awarded to Professors

Kavallaris, Gooding, et al. The aim

of the Program Grants scheme is to

provide support for teams of high

calibre researchers to pursue

broad based, multi-disciplinary and

collaborative research addressing

complex problems.

• Leadership and

participation in the organisation of

major conferences and meetings

including the 7th International

Nanomedicine Conference, held in

Coogee on 27-29 June, where ACN

researchers contributed many

lectures. The Biomedical Futures

workshop organised by Associate

Professor Matthew Kearnes in

December 2016 brought together

primary care networks, clinicians,

care professionals, ACN

researchers, and healthcare

administrators, to co-design major

public events in NSW, Victoria and

Queensland on precision medicine.

• Numerous high profile

awards and fellowships. ARC

Laureate Fellow and Scientia

Professor Justin Gooding was

elected Fellow of the Australian

Academy of Science. Professor

Maria Kavallaris was awarded the

NHMRC Principal Research

Fellowship and inducted as a

Fellow of the Australian Academy

of Health and Medical Sciences

(AAHMS). Cyrille Boyer won the

ACS Biomacromolecules/

Macromolecules Award and was

awarded the LeFevre Memorial

Prize by the Australian Academy of

Science. It was also great

recognition that Cyrille was

3

promoted to Professor. Dr Jason

Xu from Professor Cyrille Boyer’s

group was awarded the prestigious

ARC Future Fellowship. It is not

possible to list all the awards and

prizes in this highlight section,

more awards are listed in the main

body of the report, clearly

indicating significant outside

recognition of the quality of

research being performed by ACN

researchers.

• ACN researchers have

demonstrated significant

interactions with the media; at the

forefront has been Professor Justin

Gooding and team with numerous

interviews and press releases

relating to “A Paper Based Sensor

for Monitor Sun Exposure”. There

was also great media coverage of

Phoebe Phillips, Joshua McCarroll,

Cyrille Boyer, Maria Kavallaris’

journal paper “New cancer

nanomedicine reduces pancreatic

tumour growth”. Media reached

over 3 million people in Australia

alone.

• Our Centre researchers

gave over 40 plenary, keynote or

invited talks at major international

conferences. Many of these talks

were fully or partially financially

supported.

• It is tremendous that we

are actively hosting a large number

of domestic and overseas visits to

set up collaboration. Eminent

visitors to the Centre include

Professor George Whitesides from

Harvard University and Professor

Vince Rotello from University of

Massachusetts Amherst.

• ACN is attracting

increasing numbers of young

talents to our research team. In

2016 alone, 9 fresh talents joined

the team including Associate

Professor John McGhee, whose

research explores arts-led modes

of visualising complex scientific

and biomedical data using the 3D

CGI techniques.

In Summary, 2016 has seen our

Centre going from strength to

strength. We commend to you this

report on our activities and events

and we look forward to reporting

on more exciting research and

successes in the future.

Justin Gooding

Centre Co-Director

Maria Kavallaris

Centre Co-Director

Cyrille Boyer Centre Co-Director

Dr Parisa Sowti Khiabani wearing a UV-sensitive skin patch developed by the Gooding Group

4

At a Glance

Our People

Research Output

18 Members incl 10 Self-Funded

Fellows

4 Associate Members

7 Self-Funded Research Fellows

15 PostDocs 73 Honours and

PhD Students

8 Administration and Technical

Staff

113 Journal Publications, 7 book chaptors and 3 patents

14 journal publications with impact factors >10

Over $17M new funding to fund 30+ projects

commencing in 2016

47 collaborating organisations, including 3

from China, 5 from USA, 12 from Europe and 27 from Australia & New Zealand

17 interdisciplinary research projects

Over 40 Plenary, Keynote and Invited talks at major

international conferences, many with financial support

36 visitors (including 22 international) visited ACN for

collaboration

15 memberships on Editorial Boards

Numerous awards, prizes and honours, including Eureka

Prize finalist and 2 Fellowships

Approx. 40 seminars, oral presentations and poster

presentations at universities, symposiums and meetings

Over 80 media articles (including TV & Radio) both

in Australia and overseas

ACN hosted 7th International NanoMedicine Conference

where many ACN researchers contributed lectures

5

Professor Cyrille Boyer and his PhD student Sivaprakash Shanmugam grinding spinach leaves to extract

chlorophyll (from plants) to make photosensitive functional polymers.

6

Research

7

2016 New Grant Funding

Total new funding for ACN members’ research has reached a record level of over $17M in 2016.

Below is a list of ACN funding highlights.

NHMRC Program Grant, APP1091261,

Kavallaris, Gooding, et al. Precision

nanomedicine-based diagnostics and

therapeutics for refractory

malignancies. (2016-2020).

$7,088,520

Cancer Council Program Grant, PG16-

01, Kavallaris et al. Improving

outcomes for children with leukaemia

through molecular targeted

therapies. (2016-2020). $2,249,946

NHMRC Project Grant, APP1100202,

Elizabeth Hinde, et al. Regulation of

ERK driven cell proliferation by the

actin cytoskeleton. (2016-2019).

$920,972

NSW Smart Sensing Network, Justin

Gooding, William Donald. Public

sector grant. (2016-). $900,000

ARC LIEF Projects, LE160100168,

Justin Gooding, Cyrille Boyer, Pall

Thordarson, et al. Facility for

Characterisation of BioNanomaterials

(2016-). $650,000

NHMRC-ARC Dementia Research

Development Fellowship, Adam

Martin. Self-assembled hydrogels as a

model for neurodegeneration (2016-

2019). $594,644

NHMRC Project Grant, APP1104461,

Elizabeth Hinde, et al. The role of

nuclear architecture in the DNA

Damage Response. (2016-2018).

$561,966

ARC LIEF Projects, LE160100033,

Cyrille Boyer, et al. Equipment for

Advanced Surface Analysis. (2016).

$500,000

NHMRC Equipment Grant

(APP9000322): Live cell TIRF

microscope for HILO applications.

Gaus K, Kavallaris M, Phillips P, et al.

(2016). $390,000

Cancer Council NSW project grant,

Phoebe Phillips, Joshua McCarroll,

Cyrille Boyer, et al. Reprogramming

the tumour microenvironment by

therapeutically targeting heat shock

proteins in pancreatic cancer.(2016-).

$360,000

Cancer Institute NSW Equipment

Grant: ‘High throughput five laser

flow cytometer’. Phillips P, et al.

(2016). $339,500

ARC Linkage Projects, LP160100979,

Katharina Gaus. Modulating T cell

responses with novel Lck activating

compounds. (2016-2019). $335,000


Pall Thordarson, Richard Tilley, et al.

Precision luminescent solar

concentrators from robust quantum

dot arrays. (2016-2019). $330,378

NHMRC Equipment Grant – awarded

as part of the UNSW Major Research

Equipment and Infrastructure

Initiative Scheme (MREII): ‘3D Printed

Scape Microscope’. Phillips P, et al.

(2016). $300,000

ARC Discovery Projects,

DP160102681, William Donald.

Rapid, ultra-sensitive protein

structure elucidation by mass

spectrometry. (2016-2018). $299,700


Pall Thordarson, et al. Scaling

manufacture of three-dimensional

microstructures for the medical

devices industry. (2016-2019).

$228,186

Cancer Institute NSW Career Development Fellowship, Joshua McCarroll. Nanomedicine-based treatment for lung cancer.(2016-). $150,000 Cancer Council Program Grant , RG 16-08, Phoebel Phillips, et al. Reprogramming the tumour microenvironment by therapeutically targeting heat shock proteins in pancreatic cancer. $120,000

The Kids Cancer Project, Maria

Kavallaris. Stathmin regulation of

microRNA expression in

neuroblastoma cells. (2016-2017).

$115,173

UNSW MREII, Cyrille Boyer, et al.

Thermal and near ir spectrometers

for material analysis and surface

characterisation. (2016-). $105,000

Ferronova Pty Ltd; Justin Gooding,

Richard Tilley. Industry grant. (2016-

2018). $102,500

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Ross Foundation Grant, Joshua

McCarroll. Nanomedicine-based

treatment to inhibit medulloblastoma

growth.(2016). $100,000

Innovation Grant, Avner Pancreatic

Cancer Foundation: ‘Elucidating the

mechanism by which mutY-homolog

knockdown kills pancreatic cancer

cells. Phillips P, et al. (2016).

$100,000

Steadfast Foundation Grant, Joshua

McCarroll. Nanoparticles carrying

RNA-based therapies to treat

medulloblastoma. (2016-). $50,000

NHMRC Gold Star, Phoebe Phillips,

Cyrille Boyer, Joshua McCarroll, et al.

Reprogramming the tumour micro-

environment by therapeutically

targeting heat shock proteins in

pancreatic cancer. (2016-). $50,000

Ettason Pty Ltd; Pall Thordarson.

Industry grant. (2016-). $50,000

UNSW Goldstar Research Grant:

‘Reprogramming the tumour

microenvironment by therapeutically

targeting heat shock proteins in

pancreatic cancer’. Phillips P,

McCarroll J, et al. (2016). $40,000

Australia-India Council (AIC) Board

grant, Cyrille Boyer, Edgar Wong.

Disinfecting Indian Waters with Novel

Antimicrobial Polymer Membranes.

(2016). $19,000

CCIA SPOT Award, Orazio Vittorio. Targeting copper homeostasis in neuroblastoma. (2016). $12,000

AINSE Award, Orazio Vittorio.

[64Cu]CuCl2 PET imaging to

investigate the effect of Dextran-

Catechin on copper metabolism in

neuroblastoma. (2016). $9,000

Clockwerk Pty Ltd; Pall Thordarson.

Industry grant. (2016). $7,500

RR Medsciences Pty Ltd; Pall

Thordarson. Industry grant. (2016).

$5,000

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2016 New Research Projects

Nanomedicine-Based Treatment for

Lung Cancer

Dr Joshua McCarroll, Prof Maria

Kavallaris, Prof Tom Davis, A/Prof

Phoebe Phillips

This new project will use

nanoparticles to package and deliver

RNA-based drugs to silence the

expression of key genes in lung

cancer cells which regulate tumour

growth, metastases and

chemotherapy drug resistance. This

project involves collaboration with

chemists at the Australian Centre for

NanoMedicine, UNSW and Monash

University as well as cancer biologists

at the Children’s Cancer Institute and

UNSW Australia. This study has the

potential to produce a new class of

nanomedicines which inhibit lung

cancer growth and improve patient

survival.

The Use of Nanoparticles for the

Treatment of Pancreatic Cancer

A/Prof Phoebe Phillips, Dr Joshua

McCarroll, Prof Maria Kavallaris, Prof

Tom Davis, Prof Cyrille Boyer

Pancreatic cancer is the 4th

leading

cause of cancer death in the world. It

is predicted to be number 2 by 2030.

This project will use star

nanoparticles developed by our team

to deliver siRNA to pancreatic cancer

cells to silence the expression of

genes which promote aggressive

tumour growth. To examine the

therapeutic potential of our novel

nanomedicines we will use mouse

models which closely mimic the

clinical setting. This project has great

potential to generate a new class of

therapeutic drugs which inhibit

pancreatic cancer growth and

improve the survival and quality of

life for patients.

Development of Nanomedicines for

the Treatment of Medulloblastoma

Dr Joshua McCarroll, Prof Maria

Kavallaris, Prof Tom Davis, Ms Helen

Forgham

Medulloblastoma is the most

common form of childhood brain

cancer. Despite an improvement in 5

year survival patients often suffer

from long-term off-target toxicity

from the treatments which has a

negative impact on their quality of

life. This multidisciplinary project

involves chemists from the Australian

Centre for NanoMedicine and

Monash university as well as cancer

biologists from the Children’s Cancer

Institute to develop novel

nanoparticles as delivery vehicles for

therapeutic drugs to treat

medulloblastoma.

[64

Cu]CuCl2 PET Imaging Revealed

that a Natural Derived Compound

Dextran-Catechin Mediates Its

Anticancer Activity by

Downregulating Copper Metabolism

in Neuroblastoma

A. Parmar , O. Vittorio, A. Charil, M.

Brandl, K. Kimpton, G. Cirillo, M.

Kavallaris, G. Pascali

Neuroblastoma is a very aggressive

cancer with high mortality rate in

children. Our group studies the

effects of a novel treatment based on

a Dextran-Catechin conjugate on

animal models of neuroblastoma;

survival and behavioural results have

demonstrated the efficacy of this

treatment.

We have found evidence that the

mechanism of action of this drug is

linked to intracellular copper (Cu)

trafficking and distribution. Our aim

was therefore to employ [64

Cu]CuCl2 to

monitor Cu distribution in-vivo in

neuroblastoma xenograft mouse

models, both with and without

treatment.

A pilot study will be carried out in

normal healthy female BALB/c‐Fox1nu/

Ausb mice (n=4, 6-8 weeks of age) to

understand the clearance of [64

Cu] over

2 days. For these pilots, 7-10MBq of

[64

Cu]CuCl2 in 100 µL will be injected via

lateral tail vein and imaged at time

points 0-2 h, 5 h, 24 h and 48 h (Inveon

PET/CT scanner). The human

neuroblastoma BE(2)-C xenograft

mouse model used for the study will be

obtained by injecting 2X106 human

neuroblastoma cells subcutaneously

into female BALB/ c‐Fox1nu/Ausb mice

(6-8 weeks of age).

When the tumours size reach to 0.3 to

0.5 cm, typically after 12 days, the mice

will be divided in to two groups: 1)

saline treated 2) dextran-catechin

treated; PET/CT scans were performed

on both groups.

On the day of imaging, either saline

(100 µL) or dextran-catechin (300 µg in

100 µL of saline) will be injected in the

mice 1 h prior to PET scan, and then

anaesthesia will be performed using 2%

isoflurane. 7-10MBq of [64

Cu]CuCl2 will

be injected via lateral tail vein,

followed by PET/CT imaging at 0-2 h, 5

h, 24 h and 48 h post radiotracer

injection.

After the imaging session, mice will be

sacrificed and tissues collected for in

10

vitro analysis. This opens the way to a

deeper understanding of the

molecular basis of dextran-catechin

treatment and its potential

applicability to other type of cancers

depending on copper.

Stathmin Regulation of Microrna

Expression in Neuroblastoma Cells

Maria Kavallaris, et al.

Neuroblastoma, the most common

solid tumour of young children,

frequently presents with aggressive

metastatic disease and for these

children the 5-year survival rates are

dismal.

Recently, research by the Kavallaris’

group and funded by The Kids’ Cancer

Project has shown that a protein

called stathmin mediates

neuroblastoma metastasis. Thanks to

continuation of funding by TKCP, the

project will focus on understanding

the role that specific DNA sequences

play in regulating metastasis and

potentially develop new targeted

therapies.

Disinfecting Indian Waters with

Novel Antimicrobial Polymer

Membranes

Cyrille Boyer, Edgar Wong

Cyrille Boyer & Edgar Wong will be

collaborating with IITD materials

scientist, Leena Nebhani, to develop

new and effective water purification

membranes that can kill multidrug-

resistant bacteria found in Indian

waters. Clean and safe water supply

is essential for preventing the spread

of infectious diseases caused by

bacteria. In India, clean water supply

remains inadequate and this has led

to bacteria-causing diseases such as

bloody diarrhoea or dysentery.

Furthermore, the rise of antibiotic

resistance means there is an

increased urgency in developing novel

and effective materials to combat this

global issue. By using advanced

polymer engineering, this project will

provide effective nanomaterials that

can safeguard our health from 'bad

bugs'.

Regulation of ERK Driven Cell

Proliferation by the Actin

Cytoskeleton

Dr Elizabeth Hinde, Prof Peter

Gunning, et al.

The cells in your body respond to

external signals and control their

proliferation by transmitting signals

from one part of the cell to another.

This has usually been thought to

involve the movement of signals

through a liquid medium without the

involvement of any machinery to

control the movement. The project

aims to test the role of the

architecture of the cells in physically

moving a growth signal from one

place to another. We think that the

architecture involved plays a key role

in cancer.

The Role of Nuclear Architecture in

the DNA Damage Response

Dr Elizabeth Hinde, et al.

The goal of the proposed research is

to understand how dynamic changes

to the chromatin genome packaging

network, interact with the DNA

damage response and gene

expression machinery, to repair

damaged DNA and the impact this has

on cancer biology. To do so we are

combining cutting edge molecular

biology techniques with innovative

novel microscopy methods developed

by our research team, that far exceed

the spatiotemporal resolution currently

used to study chromatin biology.

Precision Nanomedicine-Based

Diagnostics and Therapeutics for

Refractory Malignancies

Prof Maria Kavallaris, Prof Justin

Gooding, Prof Richard Lock, Prof Tom

Davis

The vast majority of cancer patients die

of their disease due to the emergence

of drug resistant cancer cells or

metastatic disease that is diagnosed at

late stages. Our program aims to

develop new types of therapy to

specifically target aggressive cancers.

To detect cancer early and evaluate the

effectiveness of cancer therapy, we will

develop sensitive diagnostic tools and

devices. This research has application

to both childhood and adult cancers.

Self-Assembled Hydrogels as a Model

for Neurodegeneration

Dr Adam Martin NHMRC-ARC

Dementia Research Development

Fellowship

Alzheimer’s disease (AD) is a

neurodegenerative disease which

currently affects over 340,000

Australians. Often, symptoms of AD are

not apparent until the disease is well

advanced, limiting chances of

successful treatment. In this project,

hydrogels made from biocompatible

peptides will be used to grow neural

cell culture models to study the

development of the disease in its early

stages. This will help to develop new

diagnostic tools for the early detection

of AD.

Scaling Manufacture of Three-

Dimensional Microstructures for the

11

http://www.thekidscancerproject.org.au/about-us/about-childhood-cancer/glossary#metastasis

https://researchdata.ands.org.au/dr-elizabeth-hinde/661680

https://researchdata.ands.org.au/prof-peter-gunning/524137

https://researchdata.ands.org.au/prof-peter-gunning/524137

https://researchdata.ands.org.au/dr-elizabeth-hinde/661680

https://researchdata.ands.org.au/prof-richard-lock/527709

https://researchdata.ands.org.au/prof-richard-lock/527709

https://researchdata.ands.org.au/prof-tom-davis/530323

https://researchdata.ands.org.au/dr-adam-martin/661966

Medical Devices Industry

ARC Linkage Projects

Pall Thordarson, et al.

This project aims to transform

microscale three-dimensional

prototyping into a cheap high volume

manufacturing process through a

novel soft embossing process.

Although three-dimensional printing

has been hailed as a disruptive

technology, because it can print

complex shapes directly from

drawings, it is too slow at microscale

for high volume manufacture. This

research will develop microdevices

for painless collection of blood, its

analysis, and drug delivery. Cost-

effective manufacture of these

microdevices is expected to tap into

the large medical devices industry,

leading to establishing new

businesses in the point-of-care and

drug delivery markets.

Precision Luminescent Solar

Concentrators from Robust Quantum

Dot Arrays


Pall Thordarson, Richard Tilley, et al.

This project aims to make

luminescent solar concentrators that

can harness solar energy from

surfaces not suited for conventional

solar cells, such as car windows. It will

design, synthesise and conduct

detailed energy transfer studies of

robust inorganic quantum dot arrays

with fit-for-purpose precise spectral

properties. Synthetic light-harvesting

dye arrays have often been proposed

to solve bottleneck challenges in the

solar energy sector but there are

issues with stability, processing and

their photophysical output matching

market needs. This project’s dyes are

expected to create market

opportunities for Australian

luminescent solar concentrator

technology.

Modulating T Cell Responses with

Novel Lck Activating Compounds


Katharina Gaus, et al.

This project aims to research T cell

receptor (TCR) signal initiation and

network plasticity and identify uses

for drugs that affect the kinase Lck.

The TCR signalling network has

considerable plasticity so that

modulation of one molecule (here the

drug target is Lck) can have non-linear

effects on T cell function. This project

intends to use novel drugs to

understand how the T cell network

can be exploited to control both the

magnitude and quality of the T cell

responses. This research is expected

to aid the design of immune-

modulating drugs.

Rapid, Ultra-Sensitive Protein

Structure Elucidation by Mass

Spectrometry

ARC Discovery Projects

William Donald

This project seeks to develop a

method for rapidly discovering classes

of molecules that bind to unique sites

on proteins. The development of new

pharmaceuticals is frequently delayed

by the time and resources required to

identify the sites that new chemical

entities bind to protein targets. A

recent discovery has resulted in the

ability to completely characterise

large protein sequences directly from

single mass spectra. This project aims

to leverage this breakthrough by

developing a rapid new approach for

revealing ligand-protein binding sites

using whole-protein mass

spectrometry. This would enable novel

sites of interactions between molecules

and protein targets to be discovered

rapidly with high sensitivity. In turn,

this would allow the efficient design of

next-generation classes of bioactive

molecules.

Equipment for Advanced Surface

Analysis

ARC LIEF Projects

Cyrille Boyer, et al.

This project aims to establish

equipment for advanced surface

analysis to provide Australian

researchers with cutting-edge

capabilities in surface science. Vital

chemical and physical reactions often

occur at surfaces. Understanding these

reactions requires analysis of the

composition and electronic structure of

the surface and near-surface regions.

Neutral impact collision ion scattering

spectroscopy and inverse

photoemission spectroscopy measure

concentration depth profiles and

electronic structure. The depth

resolution of the profiles is in the order

of the distance between two

neighbouring atoms in a solid or liquid

and is the best currently achievable.

The equipment providing these

capabilities is expected to support

research with applications in

photovoltaics, catalysis, colloid surfaces

and interfaces, coatings and

nanocomposites.

Facility for Characterisation of

BioNanomaterials

Justin Gooding, Cyrille Boyer, Pall

Thordarson, et al.

The facility for characterisation of

bionanomaterials aims to provide

researchers with access to an

integrated facility for advanced

12

characterisation of nanomaterials

from inception to application in

biomedicine. Nanotechnology has

contributed to significant advances

across a range of disciplines and is

increasingly used in biomedical

applications. The facility aims to allow

detailed examination of how

nanomaterials interact in biological

systems; from individual

nanoparticles to whole animals, and

through developing this fundamental

understanding provide the means to

produce new and highly effective

nanomaterials for biomedical

applications. The facility plans to

support programs using

nanomaterials for molecular imaging

and intelligent drug delivery, while

developing greater understanding of

how to create more effective

nanobiomaterials.

Elucidating the Mechanism by which

MutY-Homolog Knockdown Kills

Pancreatic Cancer Cells

Phoebe Phillips, et al.

Pancreatic cancer is a deadly disease

that urgently requires better

treatments. A/Prof Phillips, Dr

Sharbeen, and their team have

identified a protein that, when

inhibited, can kill pancreatic cancer

cells and decrease their resistance to

cancer drugs. This project will identify

the mechanism(s) behind these effects.

This information will help translate

their target into the clinic.

New Way to Target Pancreatic Cancer and Prevent Tumour Growth

015

A/Prof Phoebe Phillips is exploring a new way to target pancreatic cancer – by reducing the scar tissue around the tumour. This would improve the delivery of drugs to the cancer and prevent further growth. The research is a result of collaboration with Professor Cyrille Boyer as well as Professor Maria Kavallaris and Dr Joshua McCarroll. Published in the journal Biomacromolecules, the article generated immense media interest both in Australia and overseas.

13

High Impact Papers

The Centre continued its great research and publication record in 2016. Our team of

researchers published 113 journal articles, 14 of which have impact factors over 10.

Below is a list of Articles with Impact Factors >10

C. Boyer, N. Corrigan, K. Jung, D.

Nguyen, T. Nguyen, N. Adnan, S.

Oliver, S. Shanmugam, J. Yeow,

2016, Bioapplications of Copper

Mediated Living Radical

Polymerization Atom Transfer

Radical Polymerization & Copper

Mediated Polymerization,

Chemical Reviews, 116, 1803-1949

[IF 38.5]

J. M. Ren, T. G. McKenzie, Q. Fu, E.

H. H. Wong, J. Xu, Z. An, S.

Shanmugam, T. P. Davis, C. Boyer

and G. G. Qiao, 2016, Star Polymers,

Chemical Reviews, 116 (12), 6743-

6836. [IF 37.369]

N. Corrigan, S. Shanmugam, J. Xu,

C. Boyer, 2016, Photoredox

Catalysis in Organic and Polymer

Synthesis, Chemical Society

Reviews, 45, 6165-6212, [IF 35.4]

Hinde E; Thammasiraphop K; Duong

HTT; Yeow J; Karagoz B; Boyer C;

Gooding JJ; Gaus, 2016, Pair

correlation microscopy reveals the

role of nanoparticle shape in

intracellular transport and site of

drug release, Nature

Nanotechnology. (In Press) [IF

35.267]

S. Shanmugam, C. Boyer, 2016,

Organocatalyzed polymerization

driven by solar energy, Science,

352 (6289), 1053-1054. [IF 33.5]

K. A. Gilmore, M. W. Lampley, C.

Boyer, E. Harth, 2016, Matrices for

combined delivery of proteins and

synthetic molecules, Advanced Drug

Delivery Reviews, 98, 77-85. [IF15.0]

A. Andres-Arroyo, B. Gupta, F.

Wang, J. J. Gooding and P. J. Reece,

2016, Optical Manipulation and

Spectroscopy of Silicon

Nanoparticles Exhibiting Dielectric

Resonances, Nano Letters, 16(3),

1903-1910. [IF 13.779]

Zhang L; Vogel YB; Noble BB;

Gonçales VR; Darwish N; Brun AL;

Gooding JJ; Wallace GG; Coote ML;

Ciampi S, 2016, TEMPO Monolayers

on Si(100) Electrodes: Electrostatic

Effects by the Electrolyte and

Semiconductor Space-Charge on

the Electroactivity of a Persistent

Radical, Journal of the American

Chemical Society, 138(30), 9611–

9619. [IF 13.038]

J. Xu, S. Shanmugam, C. Fu, K. F.

Aguey-Zinsou, C. Boyer, 2016,

Selective Photo-Activation: From

Single Unit Monomer Insertion

Reaction to Controlled Polymer

Architectures, Journal of the

American Chemical Society, 138

(9), 3094–3106. [IF 13.0]

J. J. Gooding and K. Gaus, 2016,

Single-Molecule Sensors: Challenges

and Opportunities for Quantitative

Analysis, Angewandte Chemie -

International Edition, 55(38), 11354-

11366 [IF 11.709]

J. Xu, C. Fu, S. Shanmugam, C. J.

Hawker, G. Moad, C. Boyer, 2016,

Synthesis of Discrete Oligomers by

Sequential PET-RAFT Single-Unit

Monomer Insertion. Angewandte

Chemie International Edition,

December 2016. [IF 11.7]

S. Shanmugam, J. Xu, C Boyer,

2016, Light‐Regulated

Polymerization under Near‐

Infrared/Far‐Red Irradiation

Catalyzed by Bacteriochlorophyll a.

Angewandte Chemie International

Edition, 55, 3, 1036-1040 [IF 11.5]

J.J. Gooding, 2016, Single Entity

Electrochemistry progresses to cell

counting, Angew. Chem. Int. Ed. 55

(42), 12956-12958. [IF >10]

Y.H. Zheng, C. Jiang, S.H. Ng, Y. Lu, F.

Han, U. Bach, J.J. Gooding, 2016,

Unclonable plasmonic security

labels achieved by shadow-mask-

lithography assisted self-assembly,

Adv. Mater. 28 2330-2336. [IF >10]

14

Engagement

15

Media

The ACN researchers are dedicated to reaching out beyond the scientific community and have

engaged in various television, radio, newspaper, magazine and online interviews; and contributed

to newspaper articles and online blogs to promote the Centre and its research. The following list

provides a glimpse of the Centre’s extensive media engagement.

A/Prof John McGhee, “Virtual

reality explores drug delivery to

breast cancer cells”.

Related media coverage:

- SBS, Virtual reality gives patients a

room with a view, 11/10/2016

- Australian Financial Review,

Virtual reality to spread beyond

games to change the way we live,

8/9/2016

- The Age, Virtual reality trip inside

cancer cells can help design better

chemotherapy drugs, 16/8/2016

- Sydney Morning Herald, Virtual

reality trip inside cancer cells can

help design better chemotherapy

drugs, 16/8/2016

- WIRED, 'Edible' robots and

batteries you can swallow could

finally help cure cancer, 23/8/2016

- Mashable Australia, Virtual reality

allows scientists to walk into a

cancer cell,16/8/2016

- UNSW Newsroom, Virtual reality

explores drug delivery to breast

cancer cells,16/8/2016

- New Scientist, Virtual reality lets

you stroll around a breast cancer

cell, 1/7/2016

- The Australian, Nano cell project:

art meets science to make the

invisible visible, 31/8/2016

- ABC Fantastic Journey , 16/8/2016

- ABC Midday News, 16/8/2016

P.S. Khiabani, A.H. Soeriyadi, P.J.

Reece, J.J. Gooding, A Paper Based

Sensor for Monitor Sun Exposure,

ACS Sensors 1 775-780 (2016).


- ACS Sensors, Monitoring sun

exposure with a portable paper

sensor, 25/5/2016

- Science Daily, Monitoring sun


sensor, 25/5/2016

- Electronics, Portable Paper-Sensor

Device Helps Monitor Sun

Exposure, 25/5/2016

- Health Medicine Network,

Monitoring sun exposure with a

portable paper sensor, 25/5/2016

- Controlled Environments

Magazine, Portable Paper Sensor

Monitors Sunburn Risk, 25/5/2016

- Engineering and Technology

Magazine, 27/5/2016

- MD Linx, A paper-thin idea for a

sunburn sensor, 27/5/2016

- Trend Hunter, Color-Changing

Sunburn Sensors, 30/5/2016

- Innovation Toranto, Monitoring

sun exposure with a portable

paper sensor, 25/5/2016

- iPR Newswire, Paper UV Sensor

Can Monitor Sun Exposure —

Market Talk, 25/5/2016

- UPI, Paper-based sensor may help

people avoid overexposure to sun,

26/5/2016

- Science News Line, Monitoring Sun

Exposure with a Portable Paper

Sensor, 25/5/2016

- Abomas, Monitoring sun exposure

with a portable paper sensor,

26/5/2016

- New Atlas, Treated paper warns

users of impending sunburn,

25/5/2016

- Phys Org, Monitoring sun


sensor, 25/5/2016

- Check The Science, Monitoring sun


sensor, 26/5/2016

- AZO Sensors, Researchers Develop

Portable, Paper-Based Sensor for

Monitoring Sun Exposure,

26/5/2016

- JDW Insured, Monitoring sun


sensor

- The Economist, Avoiding Sunburn,

Patched Up, 4/6/2016

- Science Meets Business, Portable

paper sun sensor, 7/6/2016

- UNSW Newsroom, Sunburn sensor

among top techs at nanomedicine

conference, 21/6/2016

- ABC Radio, New waterproof patch

could alert users to excessive sun

exposure, 22/6/2016

- Channel 7, New patch provides an

'early warning' against sunburn,

22/6/2016

- KABC-TV Channel 7, Los Angeles.

16

E. Hinde, K. Thammasiraphop,

H.T.T. Duong, J. Yeow, B.

Karagoza, C. Boyer, J.J. Gooding,

K. Gaus, Pair-correlation

microscopy reveals the role of

nanoparticle shape in intracellular

transport and site of drug release,

Nature Nanotech. (In press)


- Science Daily , Journey to the

centre of the cell: Nano-rods and

worms wriggle best, 12/9/2016

- COMPAMED, Journey to the

center of the cell: Nano-rods and

worms wriggle best, 13/9/2016

- Nano Today, The long and the

short of it: Nanoparticle shape

matters to cells, 1/12/2016

- Life Biotechnology, Nano rod and

worm are the best shaped

nanoparticles in cancer drug

delivery, 16/9/2016

- Asian Scientist, Nanoparticles

Shaped Like Rods & Worms Enter

Cell Nucleus More Easily,

22/9/2016

- The Australian, ‘Hotrods’ prove the

best vehicle for nanotech delivery,

29/9/2016

Dr Declan Kuch, Medium website,

Health Data Futures: Prediction,

Platforms, Populations,

20/10/2016

Pasquier E, André N, Street J,

Chougule A, Rekhi B, Ghosh J,

Philip DS, Meurer M, MacKenzie

KL, Kavallaris M, Banavali SD.

2016, 'Effective Management of

Advanced Angiosarcoma by the

Synergistic Combination of

Propranolol and Vinblastine-based

Metronomic Chemotherapy: A

Bench to Bedside Study',

EBioMedicine, vol. 6, pp. 87 – 95.

Related Media Coverage:

- Australian Life Scientist, Blood

pressure drug boosts the effect of

chemo, 3/10/2016.

Dr Majid E Warkiani, collaborative

work with MIT on “Electric Field

Cancer Therapy”.


- MIT News, New microfluidic device

offers means for studying electric

field cancer therapy, July 5 2016.

- Digital Trends, A coin-sized device

could have big effect on treating

cancer with electric fields, July 6

2016.

- Science Daily, New microfluidic

device offers means for studying

electric field cancer therapy, July 6

2016.

Nguyen TK; Duong HT T;

Selvanayagam R; Boyer C; Barraud

N, 2015, 'Iron oxide nanoparticle-

mediated hyperthermia stimulates

dispersal in bacterial biofilms and

enhances antibiotic efficacy',

Scientific Reports, vol. 5


- Phys.org, Nanotech weapon

against chronic bacterial infections

in hospitals, 18/12/2015

- Nanotechnology Now,

Nanotechnology Now - Press

Release: Nanotech weapon against

chronic bacterial infections in

hospitals, 18/12/2015

- Health Medicinet, Australian

researchers develop new

technique to combat chronic

bacterial infections in hospitals,

18/12/2015

- Infection Control Today, Scientists

Develop Nanotech Weapon

Against Chronic Bacterial

Infections, 18/12/2015

- Scicasts, Researchers Develop New

Technique to Combat Chronic

Bacterial Infections in Hospitals

- R&D, Nanotech weapon against

chronic bacterial infections in

hospitals, 18/12/2015

- Medindia, Nanoparticles Used To

Fight Chronic Bacterial Infections

In Hospitals, 18/12/2015

- Medical News Today, Nanotech

weapon against chronic bacterial

infections in hospitals, 18/12/2015

- Gizmag Emerging Technology

Magazine, Scientists use

nanoparticles to attack chronic

bacterial infections, 18/12/2015

- KurzweilAI, Magnetic

nanoparticles combat biofilms, a

source of chronic bacterial

infections, 21/12/2015

- Mariela Cabrera, Iron oxide

nanoparticle-mediated

hyperthermia stimulates dispersal

in bacterial biofilms and enhances

antibiotic efficacy, 23/12/2015

17

Teo J, McCarroll JA, Boyer, C,

Youkhana J, Sagnella SM, Duong

HT, Liu J, Sharbeen G, Goldstein D,

Davis TP, Kavallaris M, Phillips PA.

A rationally optimized nanoparticle

system for the delivery of RNA

interference therapeutics into

pancreatic tumors in vivo.

Biomacromolecules,17,2337-51

(2016).


- Daily Telegraph, "Scientists

deserve a gold medal".

- Adelaide Advertiser, "Medical

triumph in war on cancer".

- Daily Telegraph, "Aussies unlock

secret of world's deadliest cancer",

08 Aug 2016

- UNSW Newsroom, "New cancer

nanomedicine reduces pancreatic

tumour growth".

- ABC Newcastle Radio Interview

with Paul Bevan, "Bevan says

researchers from UNSW have

made a breakthrough in the

treatment of Pancreatic Cancer".

- Radio 2UE, "Interview with Dr

Phoebe Phillips, Head, UNSW

Pancreatic Cancer Translational

Research Group, to discuss her

group's breakthrough in the battle

against pancreatic cancer".

- Invited article for the Last Post.

"New cancer nanomedicine

reduces pancreatic tumour

growth".

- Research Australia's website. "New

cancer nanomedicine overcomes

drug delivery barrier in pancreatic

cancer".

- Invited article for Inspire

Magazine.

- TV Channel 9, "Australian medical

researchers are on the verge of a

breakthrough that could

dramatically reduce deaths from

pancreatic cancer".

- Radio 2GB, Alan Jones, "Jones says

Sydney scientists have achieved a

breakthrough in the battle against

pancreatic cancer".

- Cure Cancer Australia's website,

"Unlocking the Potential to Treat

Pancreatic Cancer".

- Medical Republic magazine, "The

age of programmable cancer

drugs", 5th October 2016

- TV Channel 9, "An Australian team

has developed a new drug and a

way to getting pancreatic cancer

through to tumours"

- TV Channel 7, Mark Ferguson,

"UNSW scientists have achieved a


pancreatic cancer".

- TV Channel 9, Peter Overton,

"UNSW scientists have achieved a


pancreatic cancer".

- Radio Channel 9, Eva Milic, "UNSW

scientists have achieved a


pancreatic cancer".

- Radio 96 FM, "Scientists from

UNSW have invented a technology

which can be used to combat

pancreatic cancer".

- TV NBN Lismore, "After 16 years of

work, Dr Phoebe Phillips and her

team at UNSW has developed a

new drug for fighting pancreatic

cancer".

- Channel 9 Expert Opinion,

"Australian scientists are one step

closer to winning the fight against

pancreatic cancer which claims

five Australian lives a day".

- TV Channel 9, Today Show, Lisa

Wilkinson, "Scientists in Sydney

are claiming a breakthrough in the

battle against pancreatic cancer".

- The Western Weekender

Newspaper, 'Positive Signs for New

Cancer Drug'.

- TV NBN Godford, "Five Australians

die from pancreatic cancer every

day. Doctor Phoebe Phillips and

her team at UNSW have

developed a new drug and a way

of getting it through to the

tumours".

- The Medical Republic, The age of

programmable cancer drugs,

5/10/2016.

18

Events

7th International Nanomedicine Conference

The 7th International Nanomedicine Conference, hosted by the ACN and the CBNS, took place at the Crowne

Plaza, Coogee Beach from 27-29 June 2016. This is a key event in the nanomedicine research community and

was attended by biologists, clinicians, chemists, material chemists and engineers from around the world.

36 ACN members, post-doctoral researchers, and PhD students presented their research at the Conference,

including 11 oral presentations and 25 posters. Congratulations go to 3 of our PhD students Ms Kristel Tjandra,

Mr Manish Sriram and Mr Alistair Laos for receiving poster competition prizes. Special thanks go to our

conference Support Committee team leaders Dr Robert Utama, Mr Manish Sriram, Mr Vincent Tan and our

wonderful team of volunteers who helped make the event successful.

Professor George Whitesides from

Harvard University gave a plenary talk at

the Conference. “Simple/Low-cost

Bioanalysis for the Developing World

and Point of Care”.

Professors Justin Gooding & Maria

Kavallaris (co-chairs) welcoming

plenary speaker Professor Vincent

Rotello from University of

Massachusetts.

The 3D Imaging workshop at the

Conference attracted great interest

among cancer researchers.

Mr Vincent Tan, PhD student from the Gooding group presented his research at the conference, “Polymeric hydrogel used as an extracellular matrix mimic for 3D cell culturing”.

Mr Walter Muskovic, PhD student from the Kavallaris group discussing research with a fellow Conference delegate.

Dr David Chang, PhD student from the

Kavallaris group studying posters

during poster session.

19

Presentations

The Centre puts great value on the knowledge shared and gained at conferences both

local and international. The following is a list of selected talks, seminars and poster

presentations in 2016.

Plenary Presentations

– Conferences and

Symposia

J.J. Gooding, “Single Entity Sensors:

From Detecting Many to Detecting

One to Detecting Many” Biosensors

Symposium 2016, Melbourne, 30th

November 2016 (Financially

Supported)

J.J. Gooding, Cell based measurement

tools to explore therapeutic action ,

Emerging Therapeutics Summit

(ETS’16) Melbourne, Australia 23 – 25

Nov 2016 (Financially supported)

J.J. Gooding, S.G. Parker, Y. Yang, S.

Ciampi, K. Chuah, Y.F. Wu, Single

Entity Electrochemistry: An

Electroanalytical Perspective,

Electrochem2016, Royal Society of

Chemistry, Leicester, 17-19 Aug, 2016.

(Fully financially supported)

J.J. Gooding, L.M.H. Lai, I.Y. Goon, K.

Chuah, E. Murago, R. Tavallaie, D.B.

Hibbert, Magnetic Nanoparticles As

Dispersible Electrodes, ElecNano7,

Lille, France, 23-25 May 2016.

(Financially supported)

M. Kavallaris, “Next Big Thing:

Nanotechnology in Cancer Therapy”,

South Australian committee of the

Australian Society for Medical

Research (ASMR), State Scientific

Meeting, Adelaide, 8-Jun-16

M. Kavallaris, “Targeting Cancer-

Associated Genes Using Nanoparticle

Delivery of Gene Silencing”, Emerging

Therapeutics Summit 2016,

Melbourne, 23-25 Nov 2016

M. Kavallaris, “Gene silencing in solid

tumours: opportunities and

challenges”, Nanomedicine: Prospects

for a Brighter Future in Healthcare,

Mauritius, 01-04 Aug 2016

ME Warkiani, Microfluidic Platforms

for Cancer Diagnosis. 2nd Nastran

International Cancer Symposium,

September 28-29, 2016, Mashhad,

Iran.

Keynote Talks –

Conferences and

Symposia

J.J. Gooding, From understanding cell-

material interactions to 3D printing of

cells, Advanced Manufacturing

Summit 2016, Sydney, Australia, 14-15

Nov 2016 (Financially supported)

R.H. Utama, L. Atapattu, C. Fife, A.

O’Mahony, J. Ribeiro, M. Kavallaris, J.J.

Gooding, The 3D Printing of Cells, 17th

International Biotechnology

Symposium and Exhibition,

Melbourne, Australia, 24-27 Oct 2016.


X. Lu, X.Y. Cheng, T. Tabarin, P.R.

Nicovich, K. Gaus, J.J. Gooding,

Towards Single Molecule Biosensors

using super-resolution microscopy,

26th Anniversary World Congress on

Biosensors, Gothenburg, Sweden, 25-

27 May 2016. (Financially supported)

M.H. Choudhury, S. Ciampi, S.G.

Parker, Y. Yang, R. Tavallaie, L. Zarei,

V.R. Goncales, J.J. Gooding, Light

Activated Electrochemistry: A strategy

for performing voltammetry on a

monolithic surface where you want,

when you want with micron scale

spatial resolution, 19th Topical

Meeting of the International Society

of Electrochemistry, Auckland, New

Zealand, 17-20 April 2016. (Financially

supported)

J.J. Gooding, Interdisciplinary

Research involving Chemistry, Physics,

Biology, Mathematics and

Engineering: Why I need your help?,

Science Teachers Association New

South Wales, Annual Conference,

University of New South Wales,

Sydney, 19-20 February 2016.


M. Kavallaris, "Leadership

effectiveness & influencing Culture",

The Women in STEM Leadership

Summit, Sydney, 23-24 Aug 2016

M. Kavallaris, "Targeting Aggressive

Cancers with Nanoparticle Delivery or

RNAi" 1st International Society for

Nanomedicine Congress, Korea

University, Seoul, Korea, 28 -30 Sep

2016

M. Kavallaris, “New Therapies for

Cancer” Nuclear Sciences &

Technologies for Health III: A New

Paradigm for Molecular Imaging,

Charles Perkins Centre, University of

Sydney, 14-Nov-16

Invited Talks –

Conferences and

Symposia

20

J.J. Gooding, Nanotechnology and

Biosensors: From Detecting Small

Molecules and Drugs to the

Monitoring of the Activity of Whole

Cells, Workshop on Advances in

Biotechnology for Food & Medical

Applications, Sydney University,

Sydney, 5-7 Oct 2016.

E. Hinde, K. Thammasiraphop, H.T.T.

Duong, J. Yeow, B. Karagoza, C. Boyer,

J.J. Gooding, K. Gaus, Pair-correlation


nanoparticle shape in intracellular

transport and site of drug release,

Warwick Polymer Conference 2016,

Warwick UK, 11-14 July 2016.


J.J. Gooding, K. Chuah, E. Murago, R.

Tavallaie, S.M. Silva, D.B. Hibbert,

Magnetic Nanoparticles As Dispersible

Electrodes, 251st American Chemical

Society National Meeting, San Diego,

13-17 March 2016.

J.J. Gooding, L.M.H. Lai, I.Y. Goon, K.

Chuah, E. Murago, R. Tavallaie, D.B.

Hibbert, Magnetic Nanoparticles As

Dispersible Electrodes, Pittcon 2016,

Atlanta, 6-10 March 2016. (Financially

supported)

M.H. Choudhury, S. Ciampi, Y. Yang, V.

Gonçales, M.B. Kashi, J.J. Gooding,

Switching electrochemistry on and off

at monolayer modified silicon

electrodes using light, Centre for

Electrochemistry, Annual Workshop

on Electrochemistry, Austin, Texas,

USA, 13-14 February 2016. (Financially

supported)

J.J. Gooding, Next Generation

Biosensors: From Detecting Many to

Detecting One to Detecting Many, ACS

on Campus, University of Hyderabad,

India, 29 Jan 2016 (Fully financially

supported)

J.J. Gooding, Next Generation

Biosensors: From Detecting Many to

Detecting One to Detecting Many, ACS

on Campus, Indian Institute of

Technology Bombay, India 25 Jan 2016

(Fully financially supported)

M. Kavallaris, “Cancer: Microtubules,

drug resistance and

nanotherapeutics”, John Curtin School

of Medical Research, Canberra, 4 Nov

2016.

M. Kavallaris, “Designing Polymer

Therapeutics for the Treatment of

Childhood Cancer” 11th International

Symposium on Polymer Therapeutics

(ISPT), Centro de Investigación

Príncipe Felipe, Valencia, Spain, 23-25

May 2016

M. Kavallaris, "Nanoparticle Delivery

to 3D Cell & Animal Models” First

Summer School of International

Society for Nanomedicine, Seoul

National University Hospital, Seoul,

Korea, 26 – 28 Sep 2016

M. Kavallaris, “Cancer, Microtubules

& Nanomedicine” Houston Methodist

Research Institute, Houston USA, 15

Apr 2016

M. Kavallaris, “Delivery Systems for

Cancer Therapy – Why do we need

them” Drug Delivery Australia

Conference 2016 – Particles to People,

Sydney, 27-28 Oct 2016

M. Kavallaris, Australasian

Pharmaceutical Science Association

(APSA) Annual Scientific Meeting,

“Precision medicine, personalising

healthcare”, Sydney, 2-5 Dec 2016

O. Vittorio, "Dextran-Catechin

conjugate: Targeting copper

metabolism in neuroblastoma”.

Chemistry, Physics and

Nanotechnology, University of

Technology Sydney, Sydney 20th May

2016.

O. Vittorio, “Dextran-Catechin


metabolism in neuroblastoma”. The

Kids Research Institute, The Children’s

Hospital at Westmead, Sydney, 25

May 2016

C Boyer, "Photoredoxcatalysts; An

efficient Tool for Modern Polymer

Synthesis", MACRO 2016, Istanbul,

Turkey, 17-21 July 2016.

C Boyer, “Functional nanomaterials”,

ACS Conference: American Chemical

Society Philadelphia, 20-25th August,

2016. (All Expenses Paid)

C Boyer, “CO and NO Releasing

Polymers as Antimicrobial Agents”,

ACS Conference: American Chemical

Society Philadelphia, 20-25th August,

2016. (All Expenses Paid)

C Boyer, “Light responsive materials

for controlled delivery”, Zing

Conference Polymer Chemistry,

Ireland, 5-9 August 2016. (Partially

Funded)

C Boyer, “Photoredox chemistry for

polymer synthesis”, World Living

Polymerization, Budapest, 29 May – 3

June 2016. (Partially Funded)

C Boyer, Selective photocatalysis: A

new tool for polymer chemists.

Emerging Polymer Technologies

Summit, Melbourne, Australia, 14 – 16

September 2016.

J McCarroll, The role of microtubule

proteins in regulating tumour growth

and chemoresistance. 8th Annual

Garvan Cell Signalling Symposium,

Oct, 2016, Sydney, Australia.

J McCarroll, Developing RNA-based

therapies for the treatment of cancer.

Drug Delivery Australia Conference,

Oct, 2016, Sydney, Australia.

ME Warkiani, The emerging role of

inertial microfluidics in high

throughput cell sorting. ACS Annual

Conference, Oct 30 – Nov 2, 2016,

Sydney, Australia

J McCarroll, Beatson Institute, “The

role of microtubules in regulating lung

21

cancer growth and chemoresistance”,

Glasgow, Scotland, 6th

July 2016

Phillips PA. Targeting the tumour stroma for the treatment of pancreatic cancer. Beatson International Cancer Conference, Glasgow, UK. July, 2016. (All travel expenses paid)

M.E. Warkiani, 1st National Microfluidic Conference, March 5-6, 2016, Tehran, Iran

Zi (Sophia) Gu, Biocompatible

layered double hydroxide

nanoparticles for targeted drug

delivery and bio-imaging, 7th

International Nanomedicine

Conference, Sydney 27-29 June

2016.

Seminars – Universities

and Societies

M. Kavallaris, “Microtubules: Multiple

Functions in Cancer Drug Resistance,

Tumourigenesis and Metastasis”,

Centro de Investigaciones Biologicas,

Madrid University, Madrid, Spain, 20

May 2016

M. Kavallaris, “Cancer, Microtubules

and Nanotherapeutics”, Centre de

Recherche en Oncologie biologique et

Oncopharmacologie, INSERM,

University of Marseille, 17 May 2016

J McCarroll, Co-Convenor for Kids

Cancer Alliance “Emerging

Technology” workshop Dec 9, 2016.

O Vittorio. “Dextran-Catechin


metabolism in neuroblastoma”.

Chemistry, Physics and

Nanotechnology, University of

Technology Sydney, Sydney 20th

May

2016.

M.E. Warkiani, Faculty of

Engineering, Edith Cowan University,

Perth, Australia 2016

Other Oral

Presentations

M. Parviz, K. Gaus, J.J. Gooding, A dual

optical and electrochemical system for

monitoring cell surface interactions

and the response of cells to

therapeutics, The 67th Annual

Meeting of the International Society of

Electrochemistry, Den Haag,

Netherlands, 21-26 Aug 2016.

B. Gupta, D. Wakefield, N. Di

Girolamo, K. Gaus, P.J. Reece, J.J.

Gooding, In vivo detection of protease

activity using porous silicon

microsensors, World Congress on

Biosensors, Gothenburg, Sweden, 25-

27 May 2016.

V.R. Gonçales, S. Ciampi, J.J. Gooding,

Effect of different electrolytes of the

Hofmeister series on SiOx formation at

alkyne protected silicon surfaces, 19th

Topical Meeting of the International

Society of Electrochemistry, Auckland,

New Zealand, 17-20 April 2016.

P. Sowti, A.H. Soeriyadi, J.J. Gooding,

A Cheap and Simple Approach to

Monitor Sun Exposure based on

Photocatalytic Properties of Titanium

Dioxide, Pittcon 2016, Atlanta, 6-10

March 2016.

M. Kashi, Y.F. Wu, V. Goncales, M.

Choudhury, S. Ciampi, J.J. Gooding,

Electrochemical Behaviour of Highly-

and Poorly-doped p-Si-AuNP

Electrodes, Pittcon 2016, Atlanta, 6-10

March 2016.

A. Barfidokht, S. Ciampi, E. Luais, N.

Darwish, J.J. Gooding, Distance-

Dependent Electron Transfer at

Passivated Electrodes Decorated by

Gold Nanoparticles, International

Conference of Nanoscience and

Nanotechnology 2016, Canberra, 7-11

February 2016.

B. McVey, X. Liu, X. Hao, J.J. Gooding,

R. Seed-mediated synthesis and

characterization of Cu quaternary

chalcogenide nanocrystals,

International Conference of

Nanoscience and Nanotechnology

2016, Canberra, 7-11 February 2016.

R. Tilley, A. McGrath, S. Cheong,

Synthesis of Gold-Palladium

Nanoparticles for Hyperthermia

Cancer Therapy. International


Nanotechnology 2016, Canberra,

7-11 February 2016.

L. Gloag, S. Cheong, J.J Gooding, R.

Tilley, Structural characterisation and

growth study of Au-Ru core-branched

nanoparticles, International



February 2016.

R. Tavallaie, N. Darwish, D.B. Hibbert,

J.J. Gooding, Impact of Single Base pair

Mismatches on Electron-Transfer

Processes at redox labelled-DNA/RNA

Modified Gold Surfaces, International



February 2016.

Y.H. Zheng, X. Lu, A.H. Soeriyadi, X.Y.

Cheng, T. Tabarin, P. Nicovich, L. Rosa,

S.H. Ng, U. Bach, K. Gaus, J.J. Gooding,

Towards Single Molecule Sensors,




B. Gupta, D. Wakefield, N. Di

Girolamo, K. Gaus, P.J. Reece, J.J.

Gooding, Porous Silicon Microsensors

for the Detection of Protease Activity

In Vivo, International Conference of



22

R. Piya, B. Gupta, P. J. Reece, J.J.

Gooding, Micropatterned Porous

Silicon Photonic Crystal in Studying

Cellular Heterogeneity, International



February 2016.

S.G. Parker, Y. Yang, S. Ciampi, J.J.

Gooding, Single-Cell Isolation using

Electrochemically-Switchable Surfaces,




O. Vittorio, M. B. Brandl , G. Cirillo, K.

Kimpton, E. Hinde, M. Kavallaris

Dextran-Catechin conjugate targets

copper metabolism in neuroblastoma.

Advances in Neuroblastoma Research

Association Meetings, Cairns 2016.

O. Vittorio, M. B. Brandl , G. Cirillo, K.

Kimpton, E. Hinde, H. Duong, C. Boyer,

M. Kavallaris. Dextran-Catechin

conjugate: An anticancer nano-

modified natural compound targeting

copper metabolism in neuroblastoma.

AACR Annual Meeting 2016 in New

Orleans, Louisiana.

Sharbeen G, Youkhana J, Mawson A,

McCarroll J, Akerman A, Goldstein D,

and Phillips PA. MutY-homolog

modulates pancreatic cancer cell

survival and chemoresistance. The

Australasian Pancreatic Club Meeting,

2016, Sydney, NSW

Akerman A, Sharbeen G, Holst J,

Youkhana J, Naim S, Liu J, McCarroll J,

Goldstein D, Erkan M and Phillips PA.

Targeting a solute carrier to

reprogram tumour-promoting stromal

cells in pancreatic cancer. The

Australasian Pancreatic Club Meeting,

2016, Sydney, NSW.



Goldstein D, Erkan M, Phillips P.



cells in pancreatic cancer. Australian

Society for Medical Research (ASMR)

NSW State Conference, Sydney, 2016.

M.E. Warkiani, ANZNMF conference, Brisbane, Australia 2016 M.E. Warkiani, EmTech Asia conference, 26-27 January, 2016, Singapore M.E. Warkiani, ISCT 2016 conference, May 25-28, 2016, Singapore Dr Celine Heu, The use of self-

assembled hydrogel for the

development of an in vitro tissue

boundary 3D tumour model

monitored by Light Sheet

Fluorescence Microscopy. 7th


Conference, Sydney, 27-29 June 2016.

Dr Bakul Gupta, Detection of Protease

Activity using Porous Silicon Photonic

Crystals. 7th International

Nanomedicine Conference, Sydney,

27-29 June 2016.

Dr Adam Martin, Controlling self-

assembly in short peptide hydrogels.

7th International Nanomedicine


Dr Stephen Parker, Single-Cell

Isolation using Electrochemically-

Switchable Surfaces. 7th International


27-29 June 2016.

Ms Maryam Parviz, Developing a

Simultaneous Opto/Electrical

Screening System: A More

Comprehensive methodology to study

cellular responses. 7th International


27-29 June 2016.

Dr Roya Tavallaie, Amplified

electrochemical detection of

microRNA by interaction of redox

labelled RNA/RNA duplex with p19

protein. 7th International


27-29 June 2016.

Prof Richard Tilley, Solution Synthesis

and Optical Properties of Silicon

Nanocrystals for Biomedical Imaging.

7th International Nanomedicine


Mr Vincent Tan, Polymeric hydrogel

used as an extracellular matrix mimic

for 3D cell culturing. 7th International


27-29 June 2016.

Mr Jonathan Wojciechowski,

Designing Supramolecular Heat-Set

Hydrogels for 3D Cell Culture. 7th



Ms Parisa Sowti Khiabani, A Paper

Based Sensor for Monitor Sun

Exposure. 7th International


27-29 June 2016.

Poster Presentations



Phillips PA. MutY-Homolog modulates

pancreatic cancer cell survival and

chemoresistance. Sydney Cancer

Conference, 2016.



Goldstein D, Erkan M, Phillips PA.



cells in pancreatic cancer. Sydney

Cancer Conference, 2016.



Phillips PA. MutY-Homolog modulates

pancreatic cancer cell survival and

chemoresistance. European

Pancreatic Club, Liverpool, UK, 2016.

23

ACN members’ poster presentations

at the 7th International

Nanomedicine Conference held

in Sydney from 27-29 June 2016:

Mr Abbas Darestani Farahani, Effect

of Aromatic Capping Group on Packing

of Amino Acids.

Mr Eric Du, Properties of peptide

hydrogels and cardiac stem cells.

Ms Genevieve Duché, Encapsulating

self-assembled peptide hydrogels in

liposomes for drug delivery and

aesthetic therapy.

Mr Md Musfizur Hassan, Rational and

Strategic Design of Hydrogelators for

Controlled Drug Delivery.

Mr Saimon Moraes Silva,

Development of a calibration free

approach for the multiplex microRNA

detection in biological fluids based on

the ‘dispersible electrodes’ concept.

Mr Robert Healey, Tag-specific and

residue-specific fluorescent labelling

of a GPCR protein drug.

Ms Susan Ireland, The Molecular

Pharmacology of the Sweet Taste

Receptor.

Mr Cheng (Johnson) Jiang, Antifouling

featured biosensor: from surface

chemistry to sensing applications.

Ms Mohi Kahram , Electrically

switchable polymers as effective

platforms for smart biosurfaces.

Prof Naresh Kumar, Immobilization of

Quorum Sensing Inhibitors

Dihydropyrrolones as Antibacterial

Coatings.

Mr Andrew Robinson, The Effect of

Amino Acid Constituents on the

Properties of Self-assembled Peptide

Hydrogels for Medical Application.

Mr Alistair Laos, Cooperative subunit

refolding of a light-harvesting protein

through a self-chaperone mechanism.

Mr Ian Lin, Impact of Increasing

Hydrophilicity on Hydrogel

Biocompatibility.

Dr Frieda Mansfeld, An Antibody-

Doxorubicin Conjugate to Target

Neuroblastoma Cells.

Mr Alex Mason, Engineered

polymersomes with asymmetric

membranes for protein encapsulation.

Ms Manchen Zhao, Using nanoscopy

with a single-molecule pull-down

assay based on poly-L-lysine grafted

polyethylene glycol surfaces to

monitor many single protein-protein

interactions.

Mr Walter Muskovic, Identifying

microRNA Therapeutic Targets in

Glioblastoma.

Ms Raheleh Pardehkhorram,

Immuno-Gold Nanorods Composite

for Food Safety Monitoring.

Ms Maryam Parviz, Screening the

effect of a cation-independent

mannose 6-phosphate receptor

inhibitor, PXS 64, on fibrosis using a

label-free and non-invasive method.

Mr Manish Sriram, Single plasmonic

particles for digital biosensing.

Ms Kristel Tjandra, Active Targeting of

Doxorubicin through Conjugation to

Phage Display-Selected Peptide.

Dr Robert Utama, Generation of 3D

Cell Culture Models Using 3D

Bioprinting.

Dr James Webb, Ultra-Fast Energy

Transfer in Fluorescent Perylene

Arrays.

Mr Chin (Ken) Wong, Anisotropically-

Shaped Fluorescent Polymersomes:

From Ellipsoids to Tubes Through Fine-

Tuning of π-Stacking Strengths in

Diblock Terpolymers.

Ms Duyen Nguyen, Highly Modulated

Light-Activated Polymeric Hydrogels

for 3D Cell Culture.

Mr Manish Sriram receiving ACS Sensors

Poster prize from Editor-in-Chief Professor

Justin Gooding.

Poster prize winner Ms Kristel Tjandra presenting her poster at Conference.

Mr Alistair Laos receiving Bioconjugate Chemistry poster prize from Editor-in-Chief Professor Vince Rotello.

24

Collaborating Organisations

The ACN actively pursues research collaboration both within our multi -disciplinary

Centre and outside the Centre. Below is a list of our external research collaboration

partners in 2016.

ANSTO, Australia

ARC Centre of Excellence for

Electromaterials Science, Australia

ARC Centre of Excellence in

Advanced Molecular Imaging,

Australia

Australian Synchrotron, Australia

Boron Molecular, Australia

Children’s Cancer Institute ,

Australia

Clockwerk Pty Ltd, Australia

CSIRO Manufacturing, Australia

Deakin University, Australia

EnGeneic, Australia

Ettason Pty Ltd, Australia

European Molecular Biology

Laboratory (EMBL) Australia Node

in Single Molecule Science, UNSW

Flurosol Industries Pty Ltd,

Australia

Griffith University, Australia

Inventia Australia

Macquarie University, Australia

Mark Wainwright Analytical

Centre, UNSW

Monash Institute of

Pharmaceutical Sciences, Australia

Monash University, Australia

RR Medsciences Pty Ltd, Australia

Sydney Children's Hospital ,

Australia

University of Newcastle, Australia

University of South Australia,

Australia

University of Western Australia,

Australia

University of Wollongong,

Australia

Victor Chang Cardiac Research

Institute, Australia

East China University of Science

and Technology, China

Qingdao University, China

Xi’an Jiaotong University, China

German Cancer Consortium (DKTK)

Dresden and German Cancer

Research Center (DKFZ), Germany

Leibniz Institute of Solid State and

Material Research Dresden

Germany

Center for Radiation Research in

Oncology , Germany

Ruhr Universität Bochum,

Germany

University of Florence, Italy

Victoria University of Wellington,

New Zealand

Madrid University, Spain

University of Geneva, Switzerland

Delft University of Technology

The Netherlands

Radboud University Nijmegen

The Netherlands

Imperial College London, UK

University of Liverpool, UK

Beatson Institute, Glasgow

Scotland, UK

Arizona State University, USA

Center for Nanotechnology in

Society, University of California,

Santa Barbara, USA

Princeton University, USA

University of Texas at Austin, USA

University of California Davis, USA

25

Awards, Prizes and Achievements

There are a number of significant achievements by Centre researchers in 2016. Key

achievements are listed below.

On 23 May 2016, ARC Laureate Fellow and Scientia Professor Justin Gooding was elected Fellow of the Australian Academy of Science for his outstanding contributions to science and scientific research. Justin uses electrochemistry, synthetic chemistry, interfacial physical chemistry, electron transfer theory, protein biochemistry, and cytochemistry, in order to modify surfaces at the molecular level to enable them to specifically recognise biochemical molecules and to transduce that biochemical information to the end user directly within biological fluids. He combines this experience in fundamental bioelectronics with chemometrics to fabricate practical biosensors. His outstanding achievements include the molecular wiring of the enzyme glucose oxidase (a diabetes monitor), molecular wiring of the redox protein cyctochrome-c to silicon, a peptide electrode array to detect bioactive metals, ‘DNA electrodes’, and porous photonic silicon with immobilised peptides able to detect protease activity – aiming for an infection-sensing chip.

Professor Maria Kavallaris was inducted as a Fellow of the Australian Academy of Health and Medical Sciences (AAHMS) on 6 October 2016. The Fellowship acknowledges Professor Kavallaris as an outstanding research leader who has made seminal discoveries on mechanisms of clinical drug resistance and tumour aggressiveness in childhood and adult cancers. Her world leadership in cancer and microtubules, and her discoveries have led to patents and industry linkages for the development of cancer therapeutics. The honour also recognises Professor Kavallaris’s achievements as a founding Director of the Australian Centre for NanoMedicine at UNSW Australia, an innovative cross-disciplinary initiative developing nanotechnology for medical applications. More broadly, her election as a new Fellow pays tribute to her outstanding leadership in medical research advocacy, peer review, mentoring and advanced research policy.

Professor Cyrille Boyer achieved an unprecedented feat by scooping two prestigious awards: the Journal of Polymer Science Innovation Award and the Biomacromolecules/Macromolecules Young Investigator Award at the 252nd American Chemical Society National Meeting & Exposition on August 21-25, 2016, in Philadelphia, Pennsylvania, U.S. The awards were in recognition of his outstanding contributions in development of new functional polymers and new nanomaterials for biological applications. Professor Boyer has made major contributions to the field of polymer science, with a body of work focussed on creating novel, specialised polymers utilising living polymerisation. Employing his expertise in polymer chemistry, Professor Boyer has stimulated a paradigm shift in light-activated polymerisation.

26

Scientia Professor Justin Gooding

- Elected Fellow of the Australian

Academy of Science

- Elected Fellow of the

International Society of

Electrochemistry

- Faraday Medal of the Royal

Society of Chemistry

Electrochemistry Division

- Royal Society of NSW Walter

Burfitt Prize, and the Archibald

Liversidge Medal for 2016

- Appointed Co-Director of NSW

Smart Sensing Network

- Announced winner of the

Biosensors and Bioelectronics Award

for the most original contribution to

Biosensors Congress 2016 for his

keynote speech “Towards Single

Molecule Biosensors using super-

resolution microscopy”

Professor Maria Kavallaris

- Inducted as a Fellow of the

Australian Academy of Health and

Medical Sciences (AAHMS) on 6th

October, 2016

- Awarded a prestigious NHMRC

Principle Research Fellowship valued

at $763,845 for her project entitled:

Precision nanomedicine-based

cancer therapeutics. The award was

announced by Minister for Health on

27th

October, 2016

Dr Alex Soeriyadi

- Selected as one of 13 Australian

scientists to tour China as part of the

Australia-China Young Scientists

Exchange Program (YSEP).

Professor Cyrille Boyer

- 2016 Emerging Investigator by

Chemical Society Reviews

- 2016 Finalist of University of

New South Wales Eureka Prize for

Scientific Research

- 2016 LeFevre Memorial Prize

(awarded by the Australian Academy

of Science)

- 2016 ACS Biomacromolecules/

Macromolecules Award (awarded by

American Chemical Society)

- 2016 Journal of Polymer

Science Innovation (awarded by

Wiley)

- Recognised as one of 20 Rising

Stars at UNSW

Dr Elizabeth Hinde

- Awarded a Cancer Institute

NSW Early Career Fellowship

Dr Majid Ebrahimi Warkiani

- Awarded the Nanyang

Outstanding Young Alumni Award in

Sep 2016

A/Prof Phoebe Phillips

- Invited member of NHMRC

Expert Advisory Grant Committee

Dr David Chang

- Awarded Genito-Urinary

Fellowship Grant by The Royal

Australian & New Zealand College of

Radiologists (RANZCR) $25,000.

David is a PhD student in Maria’s

group.

- Convergent Bio-Nano Science &

Technology Bursary Award – Animal

imaging workshop, Brisbane 26th

August 2016

Dr William Donald

- Awarded the Royal Australian

Chemical Institute (RACI) Peter W.

Alexander Medal for early career

excellence in Analytical Chemistry on

18/10/2016 and RACI Physical

Chemistry Division Lectureship

(2016)

- Project leader of one of the five

NSW Smart Sensing Network flagship

projects.

- Named Emerging Investigator

by the Analyst on 14/10/2016.

- Named Emerging Investigator

by Journal of the American Society of

Mass Spectrometry on 9/11/2016.

Dr Joshua McCarroll

- Cancer Institute NSW Career

Development Fellowship

Mr Walter Muskovic

- Awarded a Brain Foundation

grant at the Art Gallery of NSW on 24

Oct 2016. Walter is a tumor biologist

and a PhD student in Maria’s group.

Awarded 18th

EMBL PhD Symposium

Heidelberg, Germany November

2016 Travel Grant $3,000

Dr Jason Xu

- Awarded a prestigious ARC

Future Fellowship for his 4 year

project entitled: Precisely Controlled

Macromolecular Synthesis through

Green and Sustainable

Chemistry. The award was

announced by Minister for Education

and Training on 1 November, 2016.

Jason is a postdoc in Cyrille’s group.

27

Governance, Our People & Visitors

28

Steering Committee

The Steering Committee provides support, guidance and oversight on strategy and

stakeholder engagement as well as monitoring progress towards the delivery of key

performance indicators and other objectives. The ACN Steering Committee is chaired

by Professor Mark Hoffman (Presiding Dean) and is comprised of members from the

associate Faculties of Science and Medicine. The 2016 Steering Committee meetings

are noted below.

Steering Committee Members May 2 Sep 5 Dec 1

Professor Mark Hoffman (Chairman) Dean of Engineering, UNSW

● ● ●

Professor Rodney Phillips Dean of Medicine, UNSW

●

Professor Peter Lovibond Dean of Science, UNSW

● ● ●

Scientia Professor Ian Dawes School of Biotechnology and Biomolecular Sciences, UNSW

● ● ●

Scientia Professor Justin Gooding ACN Co-Director School of Chemistry, UNSW

● ● ●

Professor Maria Kavallaris ACN Co-Director Children’s Cancer Institute Australia

● ● ●

Professor Cyrille Boyer ACN Co-Director School of Chemical Engineering, UNSW

● ●

Dr Joshua Peterson Interim Centre Manager (Till July 2016) Australian Centre for NanoMedicine

●

Kimberly Edmunds Centre Manager (From August 2016) Australian Centre for NanoMedicine

● ●

29

Organisational Chart

Centre Co-Directors

Professors Justin Gooding, Maria Kavallaris and Cyrille Boyer

Members

Research Associates and PostDocs

Research Students and Honours Students

Associate Members

Centre Manager

Kimberly Edmunds

30

ACN Members and Students

Members

Scientia Prof Katharina Gaus NHMRC Senior Research Fellow Medicine

Prof Naresh Kumar

Science

Professor Richard Tilley

Science

Prof Pall

Thordarson

Science

Conjoint Prof Ivan Greguric ANSTO Life Sciences

A/Prof Phoebe

Phillipps

UNSW Fellowship

Enhancement

Package (NHMRC

CDF) Medicine

A/Prof John

McGhee*

UNSW Art & Design

A/Prof Matthew

Kearnes

ARC Future Fellow

Arts & Social Sci

Dr Joshua

McCarroll

Cancer Institute

CDF Fellow

Medicine

Dr Majid E Warkiani

Engineering

Dr William (Alex) Donald*

Science

Dr Alex Soeriyadi*

NHMRC ECF Fellow

Science

Dr Adam Martin*

NHMRC-ARC Dementia Rsch

Dev Fellow

Science

Dr Edgar Wong*

VC PostDoc

Engineering

Dr Sophia Gu*

NHMRC ECR

Engineering

Dr Damia Mawad*

Science

Dr. Orazio Vittorio*

Cancer Institute

ECF Fellow

Medicine

Dr Jason Xu*

ARC Future Fellow

Engineering

*2016 new members

31

Associate Members

Professor Martina Stenzel

A/Pro Shelli McAlpine

Dr May Lim

Dr Renee Whan

Research Fellows

Dr Elizabeth Hinde (Cancer

Institute ECF)

Dr S R C Vivekchand (VC)

Dr Enrico Klotzsch (VC)

Dr Yuanhui Zheng (VC)

Dr Hongxu Lu (DECRA)

Dr. Padmavathy Bakthavathsalam

(Trust-India Fellow)

Dr. Yuhua Xue (VC)

Post Docs

Dr Celine Heu (till Dec 2016)

Dr Declan Kuch

Dr Frieda Mansfeld

Dr James Webb

Dr Miriam Brandl (till Sep 2016)

Dr Guillaume Longatte

Dr Stephen Parker

Dr Roya Tavallaie

Dr Robert Utama

Dr Lakmali Atapattu (from Mar 2016)

Dr Christopher Fife (till Mar 2016)

Dr James Webb(till Dec 2016)

Dr Wee Teo

Dr Amelia Parker(from Jan 2016)

Dr Sela Po’uha

PhD Students

Mr Nik Nik Mohd Adnan

Ms Laura Jeffress

Ms Anouschka Akerman

Ms Fida’a Alshawawreh*

Ms Sri Augustina

Mr Ali Bagheri

Mr Kumar Bishwajit

Mr Zhenbang Cao

Mr Lachlan Carter

Dr David Chang

Mr Nat Corrigan

Mr Eric Du

Ms Genevieve Duche

Mr Morphy Dumlao

Mr Sanjun Fan*

Mr Abbas Farahani

Ms Helen Forgham

Mr Fei Han

Mr Md Musfizur Hassan

Mr Robert Healey**

Ms Susan Ireland

Mr Cheng (Johnson) Jiang **

Mr Kenward Jung

Ms Mohaddeseh Kahram

Ms Felicity Kao*

Mr Alexander Kross

Ms Joanna Kwiatek

Mr Alistair Laos**

Mr Xun Lu **

Mr Yong (Jerry) Lu (till Nov 2016)

Mr Alex (Yuanqing) Ma

Mr Alex Mason**

Ms Mahdie Mollazade**

Mr Saimon Moraes Silva

Mr Walter Muskovic

Ms Khanh Nguyen

Ms Duyen Nguyen*

Ms Susan Oliver

Ms Amelia Parker**

Ms Rahelleh Pardekhorram

Ms Maryam Parviz **

Ms Ranjana Piya

Mr Bijan Pouryousefi Markhali*

Mr Mehdi Rafeie

Mr Abu Sadat Md. Sayem Rahman

Mr Siva Shanmugam

Mr Saimon Silva*

Ms Parisa Sowti

Mr Manish Sriram

Mr Vincent Tan

Ms Safura Taufik*

Ms Kristel Tjandra

Mr Jason Tran

Mr Jonathan Wojciechowski

Mr Chin (Ken) Wong

Mr Yanfang Wu

Mr Ming Han Eugene Yee

Mr Jonathan Yeow

Ms Leila Zarei

Ms Manchen Zhao

Ms Kelly Zong

Mr. Kumar Sutradhar*

Ms. Zahara Sadrehani*

Ms Rashin Zangeneh*

Thi Diep Nguyen*

Honours Students

Mr Peter O’Mara*

Mr Ian Lin

Mr Michael Lawler

Ms Joy Zhang

Ms Aria Ahmed Cox

Gervase Ng*

Henry Xu*

Peter Judzewitsch*

Centre Administration Kimberly Edmunds

Centre Manager (From Aug 2016)

Dr Joshua Peterson

Research Officer

Mr Eh Hau Pan

Lab Manager

Ms Kathleen Kimpton

Research Assistant

Ms Tara McGilligan

EA to Prof Kavallaris (till Dec 2016)

Mrs Jesu Schlogl

EA to Prof Kavallaris (from Dec 2016)

Ms Rose-Marie Olsson

Senior Research Assistant

Mrs Sona Samuels

Research Assistant

Ms Efremova Varvara

Research Assistant

*joined in 2016

** graduated in 2016

32

Visitors to the ACN

The ACN has hosted a diverse range of visitors from academia and industry within

Australia and around the world during 2016. Our visitors have presented seminars

and met with research staff and students to investigate potential collaboration

opportunities.

A/Professor Ross Dickins Laboratory Head Aust Ctr for Blood Diseases Monash University Australia Dr Belinda Parker ARC Future Fellow Latrobe University Australia Professor David Huang Laboratory Head Cancer and Haematology Walter and Eliza Hall Institute of Medical Research Australia Dr Charles Farnsworth Senior Proteomics Applications Scientist Cell Signalling Technology Australia Dr Paul Timpson Lab Head - Invasion and Metastasis Garvan Institute of Medical Research Australia Dr Samir Taoudi Lab Head – Molecular Medicine Walter and Eliza Hall Institute of Medical Research Australia

Prof Michelle Coote Fellow of Aust Academy of Science Australian National University Prof Gail Risbridger NHMRC Senior Principal Research Fellow Peter MacCallum Cancer Centre Australia Prof James Camakaris The University of Melbourne Prof Phillip Robinson Head, Cell Signalling Unit Children's Medical Research Institute NSW

Professor Brandon Wainwright Director, Inst for Molecular Bioscience The University of Queensland Professor Swaminathan Iyer ARC Future Fellow University of Western Australia Dr Toby Bell Monash University Australia Dr Annette Kunkele Charité Universitätsmedizin Berlin Germany Dr Markus Elsner Senior Editor Nature Biotechnology Germany Dr Peter Gölitz Editor-in-Chief of Angewandte Chemie Wiley-VCH Germany Professor Angelika Eggert Berlin School of Integrative Oncology Germany Prof Addy Pross Ben-Gurion University of the Negev Israel Dr Giuseppe Cirillo The University of Calabria Italy Prof Keji Maruoka Kyoto University Japan Prof Bronwyn Parry King's College London Prof Eric Bakker University of Geenva Switzerland Prof Jan H van Esch Delft University of Technology The Netherlands

Professor Volga Bulmis Izmir Institute of Technology Turkey Prof James Wilsdon Sheffield University UK Dr Jane Calvert University of Edinburgh UK Prof Véronique Gouverneur Oxford University UK Prof Arieh Warshel University of Southern California USA A/Prof Diana M Bowman Arizona State University USA Dr Tito Fojo Columbia University Medical Centre USA Prof Felix Castellano North Carolina State University USA Prof George Whitesides Harvard University USA Dr Jack London Thomas Jefferson University USA Prof Vince Rotello University of Massachusetts Amherst USA Dr Curtis Harris National Cancer Institute USA

33

http://www.wehi.edu.au/about-structure/scientific-divisions/cancer-and-haematology

Publications

Books/Book

Chapters

Chilvers J; Kearnes MB, (eds.),

2016, Remaking Participation:

Science, Environment and

Emergent Publics, Routledge,

Abingdon, Oxon OX14 4RN

Chilvers J;Kearnes M, 2016,

'Science, democracy and

emergent publics', in

Remaking Participation:


Emergent Publics, pp. 1 – 27.


'Remaking participation:

Towards reflexive

engagement', in Remaking

Participation: Science,

Environment and Emergent

Publics, pp. 261 – 288.


'Participation in the making:

Rethinking public engagement

in co-productionist terms', in

Remaking Participation:


Emergent Publics, pp. 31 - 63,

Sharbeen G; McAlpine S;

Phillips P, 2016, 'HSP47: The

new heat shock protein

therapeutic target', in Topics

in Medicinal Chemistry, pp.

197 – 220.

Mawad D; Lauto A; Wallace

GG, 2016, 'Conductive

Polymer Hydrogels', in Kalia S

(ed.), Polymeric Hydrogels As

Smart Biomaterials, edn.

Springer Series on Polymer

and Composite Materials,

Springer Int Publishing Ag, pp.

19 – 44.

Silva SM; Justin Gooding J,

2016, 'Chapter 8: Dispersible

electrodes: An approach to

developing sensing devices

that can quickly detect

ultralow concentrations of

analyte', in RSC Detection

Science, edn. 6, pp. 279 – 295.

Byrne, F. L., McCarroll, J. A.,

and Kavallaris, M. (2016)

Analyses of tumor burden in

vivo and metastasis ex vivo

using luciferase-expressing

cancer cells in an orthotopic

mouse model of

neuroblastoma, In Methods in

Molecular Biology, pp 61-77.

Mansfeld F M, Davis TP,

Kavallaris M (2016),

“Nanotechnology in Medical

Research”. Micro and

nanotechnologies for vaccine

development, pp. 21 – 45.

Journal Articles

Abu-Siniyeh A; Owen DM;

Benzing C; Rinkwitz S; Becker

TS; Majumdar A; Gaus K, 2016,

'The aPKC/Par3/Par6 Polarity

Complex and Membrane

Order Are Functionally

Interdependent in Epithelia

During Vertebrate

Organogenesis', Traffic, vol.

17, pp. 66 – 79.

Adnan NNM; Cheng YY; Ong

NMN; Kamaruddin TT; Rozlan

E; Schmidt TW; Duong HTT;

Boyer C, 2016, 'Effect of gold

nanoparticle shapes for

phototherapy and drug

delivery', Polymer Chemistry,

vol. 7, pp. 2888 – 2903.

Akerman A; Vennin C; Sharbeen

G; Warren SC; Timpson P;

Phillips PA, 2016, 'Novel

therapeutics and preclinical

imaging for pancreatic cancer -

View from the lab', Cancer

Forum, vol. 40, pp. 16 – 22.

Al-Eisawi Z; Stefani C; Jansson

PJ; Arvind A; Sharpe PC; Basha

MT; Iskander GM; Kumar N;

Kovacevic Z; Lane DJR, 2016,

'Novel Mechanism of

Cytotoxicity for the Selective

Selenosemi-carbazone, 2-

Acetylpyridine 4, 4-Dimethyl-3-

selenosemicarbazone

(Ap44mSe): Lysosomal

Membrane Permeabilization',

Journal of Medicinal Chemistry,

vol. 59, pp. 294 – 312.

Andres-Arroyo A; Gupta B;

Wang F; Gooding JJ; Reece PJ,

2016, 'Optical Manipulation and

Spectroscopy of Silicon

Nanoparticles Exhibiting

Dielectric Resonances', Nano

Letters, vol. 16, pp. 1903 – 1910.

Asadnia M; Kottapalli AGP;

Karavitaki KD; Warkiani ME;

Miao J; Corey DP; Triantafyllou

M, 2016, 'From Biological Cilia

to Artificial Flow Sensors:

Biomimetic Soft Polymer

Nanosensors with High Sensing

Performance', Scientific Reports,

vol. 6.

34

Bagheri A; Arandiyan H; Boyer C;

Lim M, 2016, 'Lanthanide-doped

upconversion nanoparticles:

Emerging intelligent light-

activated drug delivery systems',

Advanced Science, vol. 3.

Bagheri A; Yeow J; Arandiyan H;

Xu J; Boyer C; Lim M, 2016,

'Macromol. Rapid Commun.

11/2016.', Macromol Rapid

Commun, vol. 37, pp. 940.

Bagheri A; Yeow J; Arandiyan H;

Xu J; Boyer C; Lim M, 2016,

'Polymerization of a

Photocleavable Monomer Using

Visible Light', Macromolecular

Rapid Communications. vol. 37,

pp. 905 – 910.

Banik R; Roy S; Dlháň Ľ; Titiš J;

Boča R; Kirillov AM; Martin AD;

Bauza A; Frontera A; Rodríguez-

Diéguez A, 2016, 'Self-assembly

synthesis, structure, topology,

and magnetic properties of a

mononuclear Fe( iii )-violurate

derivative: a combined

experimental and theoretical

study', Dalton Trans., vol. 45,

pp. 16166 – 16172.

Bingul M; Kumar N; Black DS,

2016, 'Synthesis and reactions

of new 2-hydroxymethyldime-

thoxyindoles', Tetrahedron, vol.

72, pp. 234 – 239.

Bingul M; Tan O; Gardner CR;

Sutton SK; Arndt GM; Marshall

GM; Cheung BB; Kumar N; Black

DSC, 2016, 'Synthesis,

characterization and anti-cancer

activity of hydrazide derivatives

incorporating a quinoline

moiety', Molecules, vol. 21.

Biswas NN; Kutty SK; Iskander

GM; Mielczarek M; Bhadbhade

MM; Gardner CR; Black DS;

Kumar N, 2016, 'Synthesis of

brominated novel N-

heterocycles: New scaffolds for

antimicrobial discovery',

Tetrahedron, vol. 72, pp. 539 –

546.

Boyer C; Corrigan NA; Jung K;

Nguyen D; Nguyen T-K; Adnan

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ACS Macro Letters, vol. 5, pp.

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41

Cover Gallery

(From Left to Right, Top to Bottom)

Drug Delivery: Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems (Adv. Sci. 7/2016), Ali Bagheri, Hamidreza Arandiyan, Cyrille Boyer and May Lim

(Front Cover) Controlled Polymerization: Beyond Traditional RAFT: Alternative Activation of Thiocarbonylthio Compounds for Controlled Polymerization (Adv. Sci. 9/2016), T. G. McKenzie, Q. Fu, M. Uchiyama, K. Satoh, J. Xu, C. Boyer, Masami

Kamigaito, Greg Qiao (Frontispiece Inside Cover) A Polymerization-Induced Self-Assembly Approach To Nanoparticles Loaded With Singlet Oxygen Generators (Macromolecules,

9/2016), J. Yeow, S. Shanmugam, N. Corrigan, R. Kuchel, J. Xu, C.

Boyer (Front Cover)

Targeted Drug Delivery: Carbon-Quantum-Dots-Loaded Mesoporous Silica Nanocarriers with pH-Switchable Zwitterionic Surface and Enzyme-Responsive Pore-Cap for Targeted Imaging and Drug Delivery to Tumor (Adv. Health. Mater. 12/2016), X. Chen, Z.N. Liu, J.J.

Gooding, Y.S. Zhou (Inside Front Cover) Star Polymers (Chemical Reviews, 12/2016), J. M. Ren, T. G. McKenzie, Q. Fu, E. H. H. Wong, J. Xu, Z. An, S. Shanmugam, T. P. Davis, C. Boyer,

and G. G. Qiao (Front Cover Centre Image)

Polymerization of a Photocleavable Monomer Using Visible Light (Macromol. Rapid Commun. 11/2016), Ali Bagheri, Jonathan Yeow, Hamidreza Arandiyan, Jiangtao Xu, Cyrille Boyer and May Lim

(Back Cover) The Interaction of CORM-2 with Block Copolymers Containing Poly(4-vinylpyridine): Macromolecular Scaffolds for Carbon Monoxide Delivery in Biological Systems (Macromol. Rapid Commun. 9/2016), Diep Nguyen, Nik Nik M. Adnan,

Susan Oliver and Cyrille Boyer (Front Cover) A Logic Gate for External Regulation of Photopolymerization(Polymer Chemistry, 42/2016), S. Shanmugam, J. Xu and C.

Boyer (Inside Front Cover)

42

http://onlinelibrary.wiley.com/doi/10.1002/marc.201670047/full

http://onlinelibrary.wiley.com/doi/10.1002/marc.201670047/full

Financial Report

43

Above: The mitochondria (orange) and endosomes (blue) inside a virtual breast cancer cell. Image: John McGhee

Australian Centre for NanoMedicine

Chemical Sciences Building (F10) UNSW SYDNEY UNSW SYDNEY NSW 2052 AUSTRALIA T: +61 (2) 9385 6031 E: [email protected]

www.acn.unsw.edu.au www.oznanomed.org

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