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2012/SOM2/CD/WKSP/011

Online Information in Toxicology, Environmental Health and Chemical Safety, and the World Library

of Toxicology

Submitted by: United States

Workshop on Concept of Data Exchange on Chemical Products and Chemical

Substances Hazardous Properties Kazan, Russia

21 May 2012

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Philip Wexler 

Toxicology and Environmental Health Information Program 

National Library of Medicine, Bethesda, MD, USA

wexlerp@mail.nih.gov

Доброе утро1

что вы видите, это не Россия

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U.S. Department of Health and Human Services

National Institutes of Health

National Library of Medicine (2012 Budget ‐ $338 Million; 804 FTEs)

Specialized Information Services Division

Toxicology and Environmental Health Information Program (est 1967)Information Program (est.1967)

TEHIP builds and hosts free online databases and other resources on the Web,collaborates with other governmental and non‐governmental organizations, and has an active public training and outreach program.

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• Traditionally has been the scientific community.

• Increasingly has included a spectrum of users from the technically oriented professional to the general public.

• Among these are toxicologists, physicians, lawyers and regulators, journalists, environmental advocates, information professionals, consumers,

d h l h ldand school children.

• Opportunities are ripe exploring more international collaborations.

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Broad Scopeoad Scope

● HSDB – Hazardous Substances Data Bank

● TOXLINE – TOXicology Literature onLINE

● TRI – Toxics Release Inventory (EPA) & TOXMAP

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FocusedFocused

• Cancer

CCRIS ‐ Chemical Carcinogenesis Research Information System (NCI)

CPDB – Carcinogenic Potency Data Base (link to UC Berkeley)

• Chemical Nomenclature and Locator

ChemIDplus – Synonyms, Superlist, Acute Tox Data, Phys Props, 3‐D structure

• Genetic Tox

G T (EPA)Gene‐Tox (EPA)

• Developmental and Reproductive

DART ‐ Developmental and Reproductive Toxicology (Intergovernmental)

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Focused

• Drug‐Induced Liver Injury

LiverTox {Beta Version}

• Medicinals

Drug Information PortalDietary Supplements Labels DatabaseLactMed – Drugs and LactationPillBox {Beta Version} – Pill Image Database

• Occupational Safety and Health

Haz‐Map

• Consumer Products

Household Products Database 7

Focused

• Radiation

REMM – Radiation Emergency Medical ManagementCHEMM – Chemical Hazards Emergency Management

• Emergency Response

WISER – Wireless Information System for Emergency Responders

• Kids

ToxTownT MToxMystery

• Risk Assessment

Integrated Risk Information System (IRIS) – EPAInternational Toxicity Estimates for Risk (ITER) - TERA

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HSDB

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TOXLINE

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Consider also PubMed

Consider also PubMed

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• U.S. EPA Database

N b f d f h i l l d t i• Numbers of pounds of chemicals released to air, water, soil, deep wells (via underground injection)

• Off‐site waste transfer, source reduction and recycling, waste treatment methods

• Originated with SARA (Superfund Amendments and R h i i A )Reauthorization Act)

• Outgrowth of 1984 Bhopal disaster – Union Carbide methyl isocyanate release

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• Pollution Prevention Act, 1990

T M M i C biliti t di d t• ToxMap – Mapping Capabilities, extending data beyond TRI

• PRTRs – Aarhus Convention – PRTR Protocol entered into force October, 2009

• 1987 – 2010 ‐ ‐ ‐ 24 years of TRI

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TRI

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Japan PRTR (from OECD)

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ITER

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HouseholdProductsDatabase

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LactMed

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WISER

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ToxLearn

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EPA’s ECOTOX

ATSDR (US Agency for Toxic Substances and Disease Registry) ( g y g y)Toxicological Profiles

US State of New Jersey – Right to Know Hazardous Substance Fact Sheets

EXTOXNET – For Pesticides Information

Collaborative on Health and the Environment (CHE) – Toxicant and Disease Database

PAN (Pesticide Action Network) ‐ Pesticides Database

Cambridge Information Group/ProQuest Toxicology Abstracts Cambridge Information Group/ProQuest – Toxicology Abstracts

Thomson Reuters ‐ POISINDEX

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ACToR is EPA's online warehouse of all publicly available chemical toxicity data and can be used to find all publiclyavailable data about potential chemical risks to human health and the environment. ACToR aggregates data from over1000 public sources on over 500,000 environmental chemicals searchable by chemical name, other identifiers and bychemical structure.The data warehouse:

Allows users to search and query data from other EPA chemical toxicity databases including:ToxRefDB (30 years and $2 billion worth of animal toxicity studies).ToxCastDB (data from screening 1,000 chemicals in over 500 high‐throughput assays).ExpoCastDB (consolidate and link human exposure and exposure factor data for chemical prioritization).DSSTox (provides high quality chemical structures and annotations). 

Includes chemical structure physico chemical values in vitro assay data and in vivo toxicology dataIncludes chemical structure, physico‐chemical values, in vitro assay data and in vivo toxicology data.Includes, but not limited to, high and medium production volume industrial chemicals, pesticides (active and inertingredients), and potential ground and drinking water contaminants. 

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Books, Journals, Organizations, Education, National/Regional/Global Laws and Conventions, / g / ,History

Professional Societies such as the US Society of Toxicology, the Russian Society of Toxicology, and the International Union of Toxicology (IUTOX)

Toxicology Education Foundation (TEF) 

Toxicology History Association (THA)

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Evolution of Information/Communication TechnologyEvolution of Information/Communication Technology

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Web 1.0 – Read Only; One Way; Consume; Non‐interactive; Observe and Utilize Web 2 0 – Read/Write; Two Way; Consume and Contribute; Interactive; Web 2.0  Read/Write; Two Way; Consume and Contribute; Interactive; 

Participate/Collaborate and Utilize

Getting Information:

Pre‐Computer Age: Go somewhere; slow. Desktop Age: Be somewhere; quicker. Mobile Age: Be anywhere; potentially instantaneous.

Yesterday: Few acknowledged experts.  Unidirectional information providers.  Static.

Today: Many would‐be experts (e.g. blogs), and many more non‐expert voices,(e.g. Amazon and other customer  reviews).  Multidirectional information.  Share.

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Mobile access

E R d d P i t D d E‐ Readers and Print‐on‐Demand

Social Media and Collaborative Tools

Wikis

Blogs

Facebook

Twitter

PodCasts and WebCasts

RSS Feeds

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Information overload – an already old problem still seeking new solutionsseeking new solutions

Portals of Portals

Targeted Information?

How to decrease redundancy?

How to enhance collaboration?

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WLTWorld Library of Toxicology

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● Online, Web‐based portal containing links to global information resources, digital and other.

● Ported to Toxipedia/IUTOX with initial NLM funding: http://www.wltox.org  

● Built by Economy Correspondents (CCs), currently on a wiki platform.

● Subject scope – Toxicology, chemical safety, environmental health, and allied fields such as occupational safety and health, risk assessment, and radiation.

● Geographic Scope – National, multi‐lateral (regional and international), and multi‐lingual

● IUTOX & MLA nominated Advisory Board

● HON (Health on the Net) Certified

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● Scattered information needs organization, consolidation, and interconnectivity to be of use.

● Political, travel, economic, and communication boundaries between● Political, travel, economic, and communication boundaries between many economies are becoming porous.

● Toxicologists will benefit by learning of toxicological activities of their colleagues in other economies and at a multi‐lateral level.

● It can serve as a catalyst to stimulate collaborative projects and a resource tool to reduce duplication of effort.

● Toxicologists in developing economies will be able to contribute resources and learn about activities in the developed world.

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● Including resources of consumer interest will help educate the public.

● It provides a single source that incorporates links to toxicology sites in both the economy’s native language and English.

● It offers a portal that adheres to the principles of quality, reliability, and credibility.

● It establishes a network of economy Correspondents for building and maintaining economy sites.

● It can demonstrate the feasibility of creating similar portals in other fields such as medicine and art.

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● UN Conference on Environment and Development, Rio de Janeiro, Brazil (aka Earth Summit), 1992

● Chapter 19, Agenda 21 – “intensified information exchange”

● Global Information Network on Chemicals (GINC) proposed, 1994

● GINC placed under the framework of Inter‐Organization for the Sound Management of Chemicals (IOMC),  with pilot phase in Asia, and support of Japan Ministry of Health, 1995p , pp p y ,

● Followed by meetings through 2000

● GINC maintenance suspended, 2003

● NLM begins work on WLT, 2004

● NLM ports pilot WLT to Toxipedia and public release, 200954

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economy Specific

● Government Agencies● Non‐Government Organizations● Non Government Organizations● Universities● Professional Societies● Poison Information/Control Centers● Miscellaneous Resources● Key Publications● Databases

Legal Links● Legal Links● About (economy)● Multilateral Organization Contacts● Literature References from TOXLINE

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Continent/Regional Information

● GlobAlert (from Environmental Health News)( )

● International Links (e.g.  UNEP/SAICM, OECD Environment Directorate, IARC, ILO, etc.)

● International Laws/Conventions  (e.g. Basel, Stockholm, Rotterdam, etc.)

● Core Databases and Other Resources

T i i d C● Training and Careers

● Glossaries

● Ancillary – Currency Exchange, Web Translators, World Clock, Culture Crossing

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Note: Russia is listed underb h E d A iboth Europe and Asia.

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Благодарю вас за внимание

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