Onken PARDI ModSTI, 2016-05-18...10 Acknowledgements NIH*PARDI*Working*Group NETE*Solutions...
Transcript of Onken PARDI ModSTI, 2016-05-18...10 Acknowledgements NIH*PARDI*Working*Group NETE*Solutions...
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Improving the Research Portfolio Data Infrastructure at NIH
Modeling Science, Technology & InnovationWashington DCMay 17-‐18, 2016
James Onken, Ph.D., MPHDirector, Office of Data Analysis Tools and Systems
NIH Office of Extramural Research
Public accountability and leadership are key aspects of NIH’s stewardship of the biomedical enterprise…[C]urrent deficiencies in information management methods and infrastructure to collect, analyze, and report level-‐of-‐investment data in a timely fashion need to be addressed…NIH must also improve its tracking and analysis of the research accomplishments of scientists trained and supported with NIH funds.
Committee on the Organizational Structure of the National Institutes of HealthNational Research Council
http://www.nap.edu/catalog/107769.htm
National Research CouncilJuly 2003
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Need for Data Integration“NIH administrative staff have had limited tools to retrieve, analyze, and report the results of the NIH collective investment in biomedical research… A better way would be a more facile, integrated analysis and reporting tool for use across the NIH by administrative leadership and program staff. This tool (or these tools) would take advantage of recent informatics capabilities.”
August 2012NIH Advisory Committee to the Director, Data and Informatics Working Group
http://acd.od.nih.gov/Data and Informatics Working Group Report.pdf
“NIH should link its own data infrastructure with that of its many partners in the science and health ecosystems who are already tracking many outcomes of interest to NIH (e.g., CDC, U.S. Patent and Trademark Office, Food and Drug Administration).”
March 2014NIH Scientific Management Review Board
Working Group on Approaches to Assess the Value of Biomedical Research Supported by NIHhttp://smrb.od.nih.gov/documents/reports/VOBR-‐Report-‐122013.pdf
“Measures of research activities, outputs, and technology transfer are important,and both the measures and the underlying data need to be improved. [NIH Data] would be more valuable if its data had more complete coverage, were linked to other data sources, and were made more accessible to researchers.”
June 2014NRC Committee on Assessing the Value of Research in Advancing National Goals
http://nap.edu/catalog.php?record_id=18804
Use CaseMining Patents for Government Interest…
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In 1993-‐1994 alone, 1890 patents cited discoveries made by NIGMS grantees… 14 percent of all U.S. patents for drugs and medicines in 1994 cited NIGMS-‐supported papers. Further, the number of NIGMS citations is the second highest of all the Institutes at NIH, and it is the fifth highest when measured against all organizations, including all private organizations.
… Again
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Direct CitationSemantic Annotation:
• Investigator Names• Organizations• Products• Technologies• Diseases• Areas of Research• Relationships
Text Similarity
Grants Administration
Linking Data in PARDI
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PARDI v1.0 System Architecture
PaaS
RDF Server(Neo4j)
PARDIData Warehouse
(PostgreSQL & Red Hat Enterprise Linux )
Local Server
Clinical Guidelines
Clinical Trials
Web of Science/iCite
FDA Orange Book
FDA Purple Book
Patents/iTech
ETL
IRDB (Oracle)
User Interface
User Interface
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Use CaseThe Development of Gardasil
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Linked to NIH Funding
ReTRACEResearch Timeline Reporting, Analysis, and Curation Environment
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ReTRACE Network
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Cure Network Informatics
R. Sanders Williams, Samad Lotia, Alisha K. Holloway, Alexander R. Pico. From Scientific Discovery to Cures: Bright Stars within a Galaxy. Cell, 2015; 163 (1): 21 DOI: 10.1016/j.cell.2015.09.007
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Cited References
NIH Supported InstitutionsNIH
Grants
Foundational Publications
Clinical Tr ials
Repatha
Repatha Network
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NIH ExPORTERhttps://ExPORTER.nih.gov
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Federal RePORTERhttps://FederalRePORTER.nih.gov
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• NIH• NSF• EPA• USDA (USFS, ARS, NIFA)• ACF• AHRQ
• CDC• DOD (CNRM, CDMRP, DVBIC)• FDA• NIDILRR• NASA• VA
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Federal RePORTERProject Descriptions
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Federal RePORTERResults
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Federal ExPORTER
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World RePORThttps://WorldRePORT.nih.gov
Redesign Summer 2016Funding:
• NIH• MRC• BMGF• EU• CIHR
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Acknowledgements
NIH PARDI Working Group
NETE Solutions
Science and Technology Policy Institute
NIH OD Sponsors and CollaboratorsDPCPSI Office of Portfolio Analysis (George Santangelo)OER Office of Planning, Analysis, and Communication (Luci Roberts)OER Office of Research Information Systems (Rick Ikeda)OSP Office of Science Management and Reporting (Marina Volkov)
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THANK YOU
NOTES:
James Onken, Ph.D., MPH, Director, OER DATA Systems ([email protected])Brian Haugen, Ph.D. Health Science Policy Analyst ([email protected])
Cindy Danielson, Ph.D., Health Science Policy Analyst ([email protected])
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