One Health in ActionDr. Ralph Richardson

Dean, College of Veterinary MedicineKansas State University

Dr. Neil OlsonDean, College of Veterinary Medicine

University of Missouri

Cooperation between human and veterinary medicine in selected endeavors, working locally, nationally and globally.

Building on common pool of knowledge in physiology, pathology, epidemiology, etc.

Simultaneous study of environmental and zoonotic diseases in people, domestic and wild animals.

What is one health?

One Health MovementThe Convergence of…

Human Health

Animal Health

Environmental Health

Ref: JAVMA One Health, July 15, 2008

60% OF THE 1,462 KNOWN INFECTIOUS ILLNESSES ARE CAUSED BY AGENTS WHICH ARE MULTI-HOST

PATHOGENS AND MOVE ACROSS SPECIES LINES.

IN THE LAST 30 YEARS, 70% OF THE NEW HUMAN INFECTIONS HAVE BEEN ZOONOTIC.

Emerging infectious disease

Spinach outbreak 200 people, 26 states, 3 dead

Food-as-foe

"I never thought you could die from E.coli. Never. I had heard of E.coli and I just thought it was food poisoning" she said."I never ever thought Mason would die from it.”

-- Family’s call for E. coli lessons01.nov.05

BBC News

Mason Jones Dec. 24, 1999 - Oct. 6,

2005

Similar appearance of fully cooked and uncooked breaded products

Product packaging of fully cooked vs. uncooked products

Cause for consumer confusion?

“Between animal and human medicine there is no dividing line – nor should there be. The object is different but the experience obtained constitutes the basis of all medicine.” - Rudolf Virchow (1821-1902)

NEW YORK TIMES, SEPTEMBER 10, 2012“Vets and Physicians Find Research Parallels”

“One reason is a growing frustration with the inefficiency of using the rodent model in lab research, which often fails to translate to human subjects…this type of research model has led to a host of collaborative research projects aimed at speeding the journey from lab to human clinical trials, and in the end, producing a result that can be applied to human and animal patients alike.”

Comparative Neurology Program

Diseases of the Nervous System

Epilepsy & movement disorders

Meningitis & encephalitis

Brain tumors

Stroke & head injury

Spinal injury & herniated disks

Muscular dystrophy & other muscle diseases

Comparative Neurology

Program

What do these two have in common?

http://en.wikipedia.org/wiki/Lou_Gehrig

From lab to clinic

Identification of new genes

Development of new therapies

Canine genome map provided the tools

Cancer in Animals

50% of animals that live beyond 10 years of age will develop cancer

Improved methods of diagnosis

Increased demand for care

Cancer Incidence by Species(Age-adjusted Incidence)

381 cases/100,000 dogs per year

264 cases/100,000 cats per year

300 cases/100,000 people each year

Why are animal cancer models useful?

Shorter life span

Why are animal cancer models useful?

Sharedenvironment

Why are animal cancer models useful?

Controllable factors

Lifestyle choices

Diet

Hormonal status

Placebo effect

Why are animal cancer models useful?

Pedigree may be known

The Quadramet Story at MU

One Health in Action

Samarium 153 developed at MU (1980s)

Osteosarcoma

Clinical trials in dogs (1990s)

Critical data for FDA to conduct human clinical trials

The Quadramet Story at MU

Springer Spaniel owned by St. Louis couple in early 2000s

Wife’s father developed metastatic tumor in spine (2005)

Treated with Quadramet

2012 couple bequested $5M ofestate to MU CVM

Ongoing clinical trials with next generation drug (cyclosam)

Cooperation between human and veterinary medicine in selected endeavors, working locally, nationally and globally

Building on common pools of knowledge in physiology, pathology, epidemiology, etc.

Simultaneous study of environmental and zoonotic diseases in people, domestic and wild animals

Assurance of scientific rigor

Identifying mutual benefit for animals and humans

How will programs be built?

The Greater Kansas City Community Foundation“A Time to Get it Right” and “Staying Competitive in the New Economy”

 “It is essential that faculty members and researchers in Kansas City’s key 4 life sciences organizations, e.g., universities, the Stowers Institute, area medical centers and life sciences businesses, be strongly encouraged to work together. Every effort should be made by organizations to remove those factors that hinder such intellectual collaboration.”