Course IntroductionCourse OverviewThe number of patients with ESLD in the US is expected to continue to grow through 2020, largely due to the burden of chronic viral hepatitis which already exists in our popula-tion. As they age, a larger number of patients will develop decompensation events such as variceal bleeding, hepatic encephalopathy, hepatocellular carcinoma, hyponatremia and renal failure. This increase in ESLD patients will create an increasing demand for health care providers who are able to care for the growing population, both in and out of the hospital.

As such, this cutting edge, half-day course will teach diag-nosis and management of common complications seen in patients with ESLD. After attending this educational program, the attendee will be able to recognize the treat-able complications quickly and use the latest therapies in a reasonable fashion. Learning will concentrate on the areas which are evidence-based or literature-based; including portosystemic encephalopathy, hyponatremia, hepatocel-lular carcinoma, hepatorenal syndrome and bleeding due to portal hypertension.

Conference Highlights · Updates on the latest clinical guidelines with strong

patient-focused educational sessions.

· Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty.

· Small classroom learning environment with attendance limited to approximately 50 practitioners per city.

· Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout.

· Receive up to 4.25 AMA PRA Category 1 Credits™.

· Convenient local venues and affordable registration fee.

Scripps Conference Services & CME11025 N. Torrey Pines Rd.Suite 200, Maildrop: SCRC200La Jolla, CA 92037

AccreditationPhysicians (MD/DO)This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and Scripps Clinic Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians.

Scripps Health designates this live activity for a maximum number of 4.25 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course.

Registered NursesThe California State Board of Registered Nurses (BRN) accepts AMA PRA Category 1 Credit(s)™ as meet-ing continuing education require-ments for license renewal. Most state Boards of Registered Nurses accept AMA PRA Category 1 Credit(s)™ as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit.

Nurse Practitioners The American College of Nurse Practitioners (ACNP) accepts AMA PRA Category 1 Credit(s)™ from organiza-tions accredited by the ACCME. This activity has been approved for a max-imum of 4.25 AMA PRA Category 1 Credit(s)™.

Physician Assistants AAPA accepts Category I credit from AMA Category I CME organizations accredited by ACCME.

DisclosureCommercial SupportThis course is supported, in part, by educational grants from industry, in accordance with ACCME accredi-tation Standards for Commercial Support. At the time of printing, a complete listing of commer-cial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity.

Cultural and Linguistic CompetencyThis activity is in compliance with California Assembly Bill 1195 which requires that all CME activities com-prising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic con-cerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity.

San Diego, California New York, New York Los Angeles, California

June 11 June 25 July 9

•Gastroenterologists

•Hepatologists

•Oncologists

•Transplant Physicians

•Nurse Practitioners

•Physician Assistants

•Nurse Specialists

Target Audience:

San Diego, CA June 11

New York, NY June 25

Los Angeles, CA July 9

Training Program and Treatment Update 2011

Target Audience:Gastroenterologists

Hepatologists

Oncologists

Transplant Physicians

Nurse Practitioners

Physician Assistants

Nurse Specialists

National End Stage Liver DiseaseTraining Program and Treatment Update 2011

June–July 20113 cities across the US

Scripps Conference Services & CME858-652-5400www.scripps.org/conferenceservices

Program

Please check one:____ San Diego, CA • June 11

____ New York, NY • June 25

____ Los Angeles, CA • July 9End Stage Liver Disease ____ $45 ____ $60

End Stage Liver Disease Group Rate* ____ $35 ____ $50*Register three (3) or more from your office and each of you will receive $10 off your registration.

By completing this registration form and returning it to Scripps you are acknowledging compliance with all attendance policies.

PLEASE PRINT CLEARLY. SHOULD WE HAVE ANY CONFERENCE COMMUNICATIONS, PLEASE PROVIDE YOUR DIRECT CONTACT INFORMATION.

Faculty & Location Information

June 11 – San Diego, CaliforniaSan Diego Marriott Del Mar11966 El Camino RealSan Diego, CA 92130858-523-1700

Donald Hillebrand, MDScripps Clinic

Tarek Hassanein, MDSouthern California Liver Centers

Joanie Salotti, NP UC San Diego Medical Center

June 25 – New York, New YorkRenaissance New York Times SquareTwo Times Square714 Seventh Avenue at West 48th StreetNew York, NY 10036212-765-7676

Robert S. Brown, Jr., MD, MPHColumbia University

Albert Min, MDBeth Israel Medical Center

Margie Fernandez Sloves, DNPColumbia University

July 9 – Los Angeles, CaliforniaCourtyard Pasadena Old Town180 North Fair Oaks AvenuePasadena, CA 91103626-403-7600

Sammy Saab, MDUniversity of California, Los Angeles

Fred Poordad, MDCedars-Sinai Medical Center

Sherona Ngashea Bau, ACNP, MSNUniversity of California, Los Angeles

Lucy Mathew, NPCedars-Sinai Medical Center

Conference FeesIncluded: course tuition, course materials, and breakfast.Not Included: travel costs, lodging and parking.

Pre-Registration ends Tuesday prior to

program dateOnsite Registration

Registration

N A M E ( F I R S T , M I , L A S T ) D E G R E E ( M D , D O , P H D , R N , E T C )

B A D G E N A M E ( I F D I F F E R E N T F R O M A B O V E )

A F F I L I A T I O N / H O S P I T A L / C O M P A N Y S P E C I A L T Y

D I R E C T M A I L I N G A D D R E S S

C I T Y S T A T E Z I P

D I R E C T P H O N E F A X

E - M A I L

A S S I S T A N T N A M E A S S I S T A N T D I R E C T T E L E P H O N E

A S S I S T A N T E - M A I L

Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA).

_________________________________________________________________________________________________________________________

C R E D I T C A R D N U M B E R E X P I R A T I O N D A T E

N A M E O N C A R D S I G N A T U R E

B I L L I N G A D D R E S S ( I F D I F F E R E N T F R O M A B O V E )

PAYMENT METHOD ❏ Check Please make checks payable to Scripps (in US dollars only).

❏ Visa ❏ MasterCard ❏ Amex ❏ Discover If paying by credit card, please complete information below:

Office use only:

Date rec’d ____________ Check no/approval CD _______________ Amount ______________ Confirmation Sent ______________ Initials __________

Four Easy Ways To RegisterOnline www.scripps.org/conferenceservicesFax 858-652-5565Phone 858-652-5400Mail Scripps Conference Services & CME End Stage Liver Disease Conference 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037

Questions?Contact Scripps Conference Services & CMEPhone 858-652-5400Email med.edu@scrippshealth.org

Attendance PoliciesRegistration ConfirmationA confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office.

Attendee Cancellation, Substitution, RefundThe course tuition is refundable, minus a $15 processing fee, if your cancellation is received in writing no later than one week prior to the course. Attendee substitutions are allowed, but notifica-tion must be made in writing no later than one week prior to the course. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to “no shows.”

Guest Attendance PolicyAll conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for confer-ence attendees. Non-registered guests (including children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at registration are required for entrance into all functions and will be strictly enforced.

Scripps Conference Modification or CancellationScripps reserves the right to modify the course’s schedule or pro-gram as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation.

Recording and Photography ClauseScripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing mate-rials, presentations and course content sales.

Exhibit OpportunitiesFor information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact:

Scripps Conference Services & CME858-652-5400med.edu@scrippshealth.orgwww.scripps.org/conferenceservices

Educational ObjectivesAfter attending this activity the participants should be able to:

· Summarize the causes of hepatic encephalopathy.

· Assess treatment options, including the use of non-absorbable antibiotics and lactulose therapies.

· Perform the appropriate and routine diagnostic tests required to ensure early diagnosis of HCC.

· Integrate newer treatment options for HCC including the use of tyrosine kinase inhibitors.

· Identify the multiple causes for renal insufficiency in patients with ESLD including diuretic overuse, GI bleed-ing, systemic infection, hepatic decompensation, and hepatorenal syndromes type 1 and 2.

· Determine the risks for hyponatremia in the ESLD patient and the options for management including the use of vasopressin antagonists.

· Follow the guidelines for diagnosis and management of ascites in patients with ESLD including diuretics, therapeutic paracentesis, and transjugular intrahepatic portosystemic shunt (TIPS).

· Discuss the indications for MARS in the ESLD patient and when liver/kidney transplantation is considered an appropriate option for management.

· Evaluate real-life cases which exemplify many of the complications of ESLD seen in a liver transplant center.

7:30 am Registration, Continental Breakfast & View Exhibits

8 am Complications of ESLD: Hepatic Encephalopathy

8:30 am Complications of ESLD: Hyponatremia and Hepatorenal Syndrome

9 am New Treatment Options for Hepatocellular Carcinoma

9:30 am Complications of ESLD: Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Variceal Bleeding

10 am Break & View Exhibits

10:15 am Case Presentations & Discussion on Treatment Guidelines

• Managing HCC in Different Settings• Drugs for Hyponatremia

12:30 pm Adjournment from Scripps Clinic’s End Stage Liver Disease Training Program and Treatment Update

12:35 pm Complimentary Lunch CME Satellite Symposium Sponsored by University of Michigan and Supported by Salix Pharmaceuticals, Inc. Hepatic Encephalopathy Update: Emerging Trends and Clinical Advancements

About ScrippsSC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology research, linking spon-sors with our 73 sites to provide faster, higher-quality research results compared to "conventional" sponsor-site arrange-ments. SCLRC also educates clinicians throughout the US with CME training focusing on HBV and HCV. For more information visit www.scliver.com

Scripps Conference Services & CME, which offers nation-ally recognized annual conferences in various specialty areas, is committed to improving the quality of health care and advancing the practice of medicine by providing exceptional educational courses for physicians and other health care professionals. More information and conference brochure downloads are available at www.scripps.org/conferenceservices.

Program

Please check one:____ San Diego, CA • June 11

____ New York, NY • June 25

____ Los Angeles, CA • July 9End Stage Liver Disease ____ $45 ____ $60

End Stage Liver Disease Group Rate* ____ $35 ____ $50*Register three (3) or more from your office and each of you will receive $10 off your registration.

By completing this registration form and returning it to Scripps you are acknowledging compliance with all attendance policies.

PLEASE PRINT CLEARLY. SHOULD WE HAVE ANY CONFERENCE COMMUNICATIONS, PLEASE PROVIDE YOUR DIRECT CONTACT INFORMATION.

Faculty & Location Information

June 11 – San Diego, CaliforniaSan Diego Marriott Del Mar11966 El Camino RealSan Diego, CA 92130858-523-1700

Donald Hillebrand, MDScripps Clinic

Tarek Hassanein, MDSouthern California Liver Centers

Joanie Salotti, NP UC San Diego Medical Center

June 25 – New York, New YorkRenaissance New York Times SquareTwo Times Square714 Seventh Avenue at West 48th StreetNew York, NY 10036212-765-7676

Robert S. Brown, Jr., MD, MPHColumbia University

Albert Min, MDBeth Israel Medical Center

Margie Fernandez Sloves, DNPColumbia University

July 9 – Los Angeles, CaliforniaCourtyard Pasadena Old Town180 North Fair Oaks AvenuePasadena, CA 91103626-403-7600

Sammy Saab, MDUniversity of California, Los Angeles

Fred Poordad, MDCedars-Sinai Medical Center

Sherona Ngashea Bau, ACNP, MSNUniversity of California, Los Angeles

Lucy Mathew, NPCedars-Sinai Medical Center

Conference FeesIncluded: course tuition, course materials, and breakfast.Not Included: travel costs, lodging and parking.

Pre-Registration ends Tuesday prior to

program dateOnsite Registration

Registration

N A M E ( F I R S T , M I , L A S T ) D E G R E E ( M D , D O , P H D , R N , E T C )

B A D G E N A M E ( I F D I F F E R E N T F R O M A B O V E )

A F F I L I A T I O N / H O S P I T A L / C O M P A N Y S P E C I A L T Y

D I R E C T M A I L I N G A D D R E S S

C I T Y S T A T E Z I P

D I R E C T P H O N E F A X

E - M A I L

A S S I S T A N T N A M E A S S I S T A N T D I R E C T T E L E P H O N E

A S S I S T A N T E - M A I L

Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA).

_________________________________________________________________________________________________________________________

C R E D I T C A R D N U M B E R E X P I R A T I O N D A T E

N A M E O N C A R D S I G N A T U R E

B I L L I N G A D D R E S S ( I F D I F F E R E N T F R O M A B O V E )

PAYMENT METHOD ❏ Check Please make checks payable to Scripps (in US dollars only).

❏ Visa ❏ MasterCard ❏ Amex ❏ Discover If paying by credit card, please complete information below:

Office use only:

Date rec’d ____________ Check no/approval CD _______________ Amount ______________ Confirmation Sent ______________ Initials __________

Four Easy Ways To RegisterOnline www.scripps.org/conferenceservicesFax 858-652-5565Phone 858-652-5400Mail Scripps Conference Services & CME End Stage Liver Disease Conference 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037

Questions?Contact Scripps Conference Services & CMEPhone 858-652-5400Email med.edu@scrippshealth.org

Attendance PoliciesRegistration ConfirmationA confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office.

Attendee Cancellation, Substitution, RefundThe course tuition is refundable, minus a $15 processing fee, if your cancellation is received in writing no later than one week prior to the course. Attendee substitutions are allowed, but notifica-tion must be made in writing no later than one week prior to the course. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to “no shows.”

Guest Attendance PolicyAll conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for confer-ence attendees. Non-registered guests (including children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at registration are required for entrance into all functions and will be strictly enforced.

Scripps Conference Modification or CancellationScripps reserves the right to modify the course’s schedule or pro-gram as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation.

Recording and Photography ClauseScripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing mate-rials, presentations and course content sales.

Exhibit OpportunitiesFor information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact:

Scripps Conference Services & CME858-652-5400med.edu@scrippshealth.orgwww.scripps.org/conferenceservices

Educational ObjectivesAfter attending this activity the participants should be able to:

· Summarize the causes of hepatic encephalopathy.

· Assess treatment options, including the use of non-absorbable antibiotics and lactulose therapies.

· Perform the appropriate and routine diagnostic tests required to ensure early diagnosis of HCC.

· Integrate newer treatment options for HCC including the use of tyrosine kinase inhibitors.

· Identify the multiple causes for renal insufficiency in patients with ESLD including diuretic overuse, GI bleed-ing, systemic infection, hepatic decompensation, and hepatorenal syndromes type 1 and 2.

· Determine the risks for hyponatremia in the ESLD patient and the options for management including the use of vasopressin antagonists.

· Follow the guidelines for diagnosis and management of ascites in patients with ESLD including diuretics, therapeutic paracentesis, and transjugular intrahepatic portosystemic shunt (TIPS).

· Discuss the indications for MARS in the ESLD patient and when liver/kidney transplantation is considered an appropriate option for management.

· Evaluate real-life cases which exemplify many of the complications of ESLD seen in a liver transplant center.

7:30 am Registration, Continental Breakfast & View Exhibits

8 am Complications of ESLD: Hepatic Encephalopathy

8:30 am Complications of ESLD: Hyponatremia and Hepatorenal Syndrome

9 am New Treatment Options for Hepatocellular Carcinoma

9:30 am Complications of ESLD: Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Variceal Bleeding

10 am Break & View Exhibits

10:15 am Case Presentations & Discussion on Treatment Guidelines

• Managing HCC in Different Settings• Drugs for Hyponatremia

12:30 pm Adjournment from Scripps Clinic’s End Stage Liver Disease Training Program and Treatment Update

12:35 pm Complimentary Lunch CME Satellite Symposium Sponsored by University of Michigan and Supported by Salix Pharmaceuticals, Inc. Hepatic Encephalopathy Update: Emerging Trends and Clinical Advancements

About ScrippsSC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology research, linking spon-sors with our 73 sites to provide faster, higher-quality research results compared to "conventional" sponsor-site arrange-ments. SCLRC also educates clinicians throughout the US with CME training focusing on HBV and HCV. For more information visit www.scliver.com

Scripps Conference Services & CME, which offers nation-ally recognized annual conferences in various specialty areas, is committed to improving the quality of health care and advancing the practice of medicine by providing exceptional educational courses for physicians and other health care professionals. More information and conference brochure downloads are available at www.scripps.org/conferenceservices.

Program

Please check one:____ San Diego, CA • June 11

____ New York, NY • June 25

____ Los Angeles, CA • July 9End Stage Liver Disease ____ $45 ____ $60

End Stage Liver Disease Group Rate* ____ $35 ____ $50*Register three (3) or more from your office and each of you will receive $10 off your registration.

By completing this registration form and returning it to Scripps you are acknowledging compliance with all attendance policies.

PLEASE PRINT CLEARLY. SHOULD WE HAVE ANY CONFERENCE COMMUNICATIONS, PLEASE PROVIDE YOUR DIRECT CONTACT INFORMATION.

Faculty & Location Information

June 11 – San Diego, CaliforniaSan Diego Marriott Del Mar11966 El Camino RealSan Diego, CA 92130858-523-1700

Donald Hillebrand, MDScripps Clinic

Tarek Hassanein, MDSouthern California Liver Centers

Joanie Salotti, NP UC San Diego Medical Center

June 25 – New York, New YorkRenaissance New York Times SquareTwo Times Square714 Seventh Avenue at West 48th StreetNew York, NY 10036212-765-7676

Robert S. Brown, Jr., MD, MPHColumbia University

Albert Min, MDBeth Israel Medical Center

Margie Fernandez Sloves, DNPColumbia University

July 9 – Los Angeles, CaliforniaCourtyard Pasadena Old Town180 North Fair Oaks AvenuePasadena, CA 91103626-403-7600

Sammy Saab, MDUniversity of California, Los Angeles

Fred Poordad, MDCedars-Sinai Medical Center

Sherona Ngashea Bau, ACNP, MSNUniversity of California, Los Angeles

Lucy Mathew, NPCedars-Sinai Medical Center

Conference FeesIncluded: course tuition, course materials, and breakfast.Not Included: travel costs, lodging and parking.

Pre-Registration ends Tuesday prior to

program dateOnsite Registration

Registration

N A M E ( F I R S T , M I , L A S T ) D E G R E E ( M D , D O , P H D , R N , E T C )

B A D G E N A M E ( I F D I F F E R E N T F R O M A B O V E )

A F F I L I A T I O N / H O S P I T A L / C O M P A N Y S P E C I A L T Y

D I R E C T M A I L I N G A D D R E S S

C I T Y S T A T E Z I P

D I R E C T P H O N E F A X

E - M A I L

A S S I S T A N T N A M E A S S I S T A N T D I R E C T T E L E P H O N E

A S S I S T A N T E - M A I L

Please indicate any special needs (including dietary restrictions). Special requests will be considered and accommodated in full compliance with the Americans with Disabilities Act (ADA).

_________________________________________________________________________________________________________________________

C R E D I T C A R D N U M B E R E X P I R A T I O N D A T E

N A M E O N C A R D S I G N A T U R E

B I L L I N G A D D R E S S ( I F D I F F E R E N T F R O M A B O V E )

PAYMENT METHOD ❏ Check Please make checks payable to Scripps (in US dollars only).

❏ Visa ❏ MasterCard ❏ Amex ❏ Discover If paying by credit card, please complete information below:

Office use only:

Date rec’d ____________ Check no/approval CD _______________ Amount ______________ Confirmation Sent ______________ Initials __________

Four Easy Ways To RegisterOnline www.scripps.org/conferenceservicesFax 858-652-5565Phone 858-652-5400Mail Scripps Conference Services & CME End Stage Liver Disease Conference 11025 North Torrey Pines Road Suite 200, Maildrop: SCRC200 La Jolla, California 92037

Questions?Contact Scripps Conference Services & CMEPhone 858-652-5400Email med.edu@scrippshealth.org

Attendance PoliciesRegistration ConfirmationA confirmation letter will be e-mailed or mailed to you upon receipt of the conference registration form and payment. If you have not received it within two weeks, please contact the Scripps Conference Services & CME office.

Attendee Cancellation, Substitution, RefundThe course tuition is refundable, minus a $15 processing fee, if your cancellation is received in writing no later than one week prior to the course. Attendee substitutions are allowed, but notifica-tion must be made in writing no later than one week prior to the course. After this date, under no circumstances will refunds, credits, or substitutions be granted. No refunds or credits will be given to “no shows.”

Guest Attendance PolicyAll conference activities (including educational sessions, meal functions, exhibit hall, etc.) are exclusively reserved for confer-ence attendees. Non-registered guests (including children, family members, colleagues, etc.) are not allowed in the conference areas. Badges provided at registration are required for entrance into all functions and will be strictly enforced.

Scripps Conference Modification or CancellationScripps reserves the right to modify the course’s schedule or pro-gram as necessary. Scripps also reserves the right to cancel this conference, in which case a full refund of the registration fee will be provided. We are unable to refund any travel costs (flight, hotel, etc.) in the case of Scripps cancellation.

Recording and Photography ClauseScripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in marketing mate-rials, presentations and course content sales.

Exhibit OpportunitiesFor information on exhibit and support opportunities during this and many other Scripps educational conferences, please contact:

Scripps Conference Services & CME858-652-5400med.edu@scrippshealth.orgwww.scripps.org/conferenceservices

Educational ObjectivesAfter attending this activity the participants should be able to:

· Summarize the causes of hepatic encephalopathy.

· Assess treatment options, including the use of non-absorbable antibiotics and lactulose therapies.

· Perform the appropriate and routine diagnostic tests required to ensure early diagnosis of HCC.

· Integrate newer treatment options for HCC including the use of tyrosine kinase inhibitors.

· Identify the multiple causes for renal insufficiency in patients with ESLD including diuretic overuse, GI bleed-ing, systemic infection, hepatic decompensation, and hepatorenal syndromes type 1 and 2.

· Determine the risks for hyponatremia in the ESLD patient and the options for management including the use of vasopressin antagonists.

· Follow the guidelines for diagnosis and management of ascites in patients with ESLD including diuretics, therapeutic paracentesis, and transjugular intrahepatic portosystemic shunt (TIPS).

· Discuss the indications for MARS in the ESLD patient and when liver/kidney transplantation is considered an appropriate option for management.

· Evaluate real-life cases which exemplify many of the complications of ESLD seen in a liver transplant center.

7:30 am Registration, Continental Breakfast & View Exhibits

8 am Complications of ESLD: Hepatic Encephalopathy

8:30 am Complications of ESLD: Hyponatremia and Hepatorenal Syndrome

9 am New Treatment Options for Hepatocellular Carcinoma

9:30 am Complications of ESLD: Transjugular Intrahepatic Portosystemic Shunt (TIPS) for Variceal Bleeding

10 am Break & View Exhibits

10:15 am Case Presentations & Discussion on Treatment Guidelines

• Managing HCC in Different Settings• Drugs for Hyponatremia

12:30 pm Adjournment from Scripps Clinic’s End Stage Liver Disease Training Program and Treatment Update

12:35 pm Complimentary Lunch CME Satellite Symposium Sponsored by University of Michigan and Supported by Salix Pharmaceuticals, Inc. Hepatic Encephalopathy Update: Emerging Trends and Clinical Advancements

About ScrippsSC Liver Research Consortium (SCLRC) is an organization of physicians specializing in hepatology research, linking spon-sors with our 73 sites to provide faster, higher-quality research results compared to "conventional" sponsor-site arrange-ments. SCLRC also educates clinicians throughout the US with CME training focusing on HBV and HCV. For more information visit www.scliver.com

Scripps Conference Services & CME, which offers nation-ally recognized annual conferences in various specialty areas, is committed to improving the quality of health care and advancing the practice of medicine by providing exceptional educational courses for physicians and other health care professionals. More information and conference brochure downloads are available at www.scripps.org/conferenceservices.

Course IntroductionCourse OverviewThe number of patients with ESLD in the US is expected to continue to grow through 2020, largely due to the burden of chronic viral hepatitis which already exists in our popula-tion. As they age, a larger number of patients will develop decompensation events such as variceal bleeding, hepatic encephalopathy, hepatocellular carcinoma, hyponatremia and renal failure. This increase in ESLD patients will create an increasing demand for health care providers who are able to care for the growing population, both in and out of the hospital.

As such, this cutting edge, half-day course will teach diag-nosis and management of common complications seen in patients with ESLD. After attending this educational program, the attendee will be able to recognize the treat-able complications quickly and use the latest therapies in a reasonable fashion. Learning will concentrate on the areas which are evidence-based or literature-based; including portosystemic encephalopathy, hyponatremia, hepatocel-lular carcinoma, hepatorenal syndrome and bleeding due to portal hypertension.

Conference Highlights · Updates on the latest clinical guidelines with strong

patient-focused educational sessions.

· Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty.

· Small classroom learning environment with attendance limited to approximately 50 practitioners per city.

· Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout.

· Receive up to 4.25 AMA PRA Category 1 Credits™.

· Convenient local venues and affordable registration fee.

Scripps Conference Services & CME11025 N. Torrey Pines Rd.Suite 200, Maildrop: SCRC200La Jolla, CA 92037

AccreditationPhysicians (MD/DO)This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and Scripps Clinic Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians.

Scripps Health designates this live activity for a maximum number of 4.25 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course.

Registered NursesThe California State Board of Registered Nurses (BRN) accepts AMA PRA Category 1 Credit(s)™ as meet-ing continuing education require-ments for license renewal. Most state Boards of Registered Nurses accept AMA PRA Category 1 Credit(s)™ as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit.

Nurse Practitioners The American College of Nurse Practitioners (ACNP) accepts AMA PRA Category 1 Credit(s)™ from organiza-tions accredited by the ACCME. This activity has been approved for a max-imum of 4.25 AMA PRA Category 1 Credit(s)™.

Physician Assistants AAPA accepts Category I credit from AMA Category I CME organizations accredited by ACCME.

DisclosureCommercial SupportThis course is supported, in part, by educational grants from industry, in accordance with ACCME accredi-tation Standards for Commercial Support. At the time of printing, a complete listing of commer-cial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity.

Cultural and Linguistic CompetencyThis activity is in compliance with California Assembly Bill 1195 which requires that all CME activities com-prising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic con-cerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity.

San Diego, California New York, New York Los Angeles, California

June 11 June 25 July 9

•Gastroenterologists

•Hepatologists

•Oncologists

•Transplant Physicians

•Nurse Practitioners

•Physician Assistants

•Nurse Specialists

Target Audience:

San Diego, CA June 11

New York, NY June 25

Los Angeles, CA July 9

Training Program and Treatment Update 2011

Target Audience:Gastroenterologists

Hepatologists

Oncologists

Transplant Physicians

Nurse Practitioners

Physician Assistants

Nurse Specialists

National End Stage Liver DiseaseTraining Program and Treatment Update 2011

June–July 20113 cities across the US

Scripps Conference Services & CME858-652-5400www.scripps.org/conferenceservices

Course IntroductionCourse OverviewThe number of patients with ESLD in the US is expected to continue to grow through 2020, largely due to the burden of chronic viral hepatitis which already exists in our popula-tion. As they age, a larger number of patients will develop decompensation events such as variceal bleeding, hepatic encephalopathy, hepatocellular carcinoma, hyponatremia and renal failure. This increase in ESLD patients will create an increasing demand for health care providers who are able to care for the growing population, both in and out of the hospital.

As such, this cutting edge, half-day course will teach diag-nosis and management of common complications seen in patients with ESLD. After attending this educational program, the attendee will be able to recognize the treat-able complications quickly and use the latest therapies in a reasonable fashion. Learning will concentrate on the areas which are evidence-based or literature-based; including portosystemic encephalopathy, hyponatremia, hepatocel-lular carcinoma, hepatorenal syndrome and bleeding due to portal hypertension.

Conference Highlights ·Updates on the latest clinical guidelines with strong

patient-focused educational sessions.

·Local experts providing an interdisciplinary team approach to treatment with physician and midlevel provider faculty.

·Small classroom learning environment with attendance limited to approximately 50 practitioners per city.

·Interactive formats including practical case studies, small group discussion, and question and answer opportunities throughout.

·Receive up to 4.25 AMA PRA Category 1 Credits™.

·Convenient local venues and affordable registration fee.

Scripps Conference Services & CME11025 N. Torrey Pines Rd.Suite 200, Maildrop: SCRC200La Jolla, CA 92037

AccreditationPhysicians (MD/DO)This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Scripps Health and Scripps Clinic Liver Research Consortium. Scripps Health is accredited by the ACCME to provide continuing medical education for physicians.

Scripps Health designates this live activity for a maximum number of 4.25 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Documentation of awarded credit is provided for registered attendees in exchange for completed activity evaluation. Certificates of attendance are available, upon request, at the end of the course.

Registered NursesThe California State Board of Registered Nurses (BRN) accepts AMA PRA Category 1 Credit(s)™ as meet-ing continuing education require-ments for license renewal. Most state Boards of Registered Nurses accept AMA PRA Category 1 Credit(s)™ as meeting continuing education requirements for license renewal. Nurses should check with their state board regarding use of CME credit.

Nurse Practitioners The American College of Nurse Practitioners (ACNP) accepts AMA PRA Category 1 Credit(s)™ from organiza-tions accredited by the ACCME. This activity has been approved for a max-imum of 4.25 AMA PRA Category 1 Credit(s)™.

Physician Assistants AAPA accepts Category I credit from AMA Category I CME organizations accredited by ACCME.

DisclosureCommercial SupportThis course is supported, in part, by educational grants from industry, in accordance with ACCME accredi-tation Standards for Commercial Support. At the time of printing, a complete listing of commer-cial supporters was not available. Appropriate acknowledgement will be given to all supporters at the time of the educational activity.

Cultural and Linguistic CompetencyThis activity is in compliance with California Assembly Bill 1195 which requires that all CME activities com-prising a patient care element include curriculum addressing the topic of cultural and linguistic competency. The intent of this bill is to ensure that health care professionals are able to meet the cultural and linguistic con-cerns of a diverse patient population through effective and appropriate professional development. Cultural and linguistic competency was incorporated into the planning of this activity.

San Diego, CaliforniaNew York, New YorkLos Angeles, California

June 11June 25July 9

• Gastroenterologists

• Hepatologists

• Oncologists

• Transplant Physicians

• Nurse Practitioners

• Physician Assistants

• Nurse Specialists

Target Audience:

San Diego, CA June 11

New York, NY June 25

Los Angeles, CA July 9

Training Program and Treatment Update 2011

Target Audience:Gastroenterologists

Hepatologists

Oncologists

Transplant Physicians

Nurse Practitioners

Physician Assistants

Nurse Specialists

National End Stage Liver Disease Training Program and Treatment Update 2011

June–July 20113 cities across the US

Scripps Conference Services & CME858-652-5400www.scripps.org/conferenceservices