Ohio Opiate Trends The poison center perspective Alfred Aleguas, BS Pharm, PharmD, D.ABAT Director,...
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Transcript of Ohio Opiate Trends The poison center perspective Alfred Aleguas, BS Pharm, PharmD, D.ABAT Director,...
Ohio Opiate TrendsThe poison center perspective
Alfred Aleguas, BS Pharm, PharmD, D.ABATDirector, Northern Ohio Poison Center
Cleveland, OH
Ohio Poison Center Collaborative• 3 Ohio poison centers serving 11.5 million
– Northern Ohio Poison Center (NOPC), Cleveland– Central Ohio Poison Center (COPC), Columbus– Cincinnati Drug and Poison Information Center
(DPIC)
All 3 are certified by the American Association of Poison Control Centers (AAPCC); there are 57 such centers
All data is transmitted into the National Poison Data System, in near real-time.
Stats
Analyzed all opiate exposures from 2005-2012 (extrap) for all of Ohio
• Looked at the numbers with an outcome of moderate, severe or death
• Compared the age ranges involved
Drugs
• Hydrocodone/APAP• Oxycodone(+/- APAP)• Methadone• Morphine
• Tramadol• Buprenorphine• Oxymorphone• Fentanyl
1369 1343
1,500
1599
1821
1693 16811619
0
200
400
600
800
1000
1200
1400
1600
1800
2000
2005 2006 2007 2008 2009 2010 2011 2012
Year
Ohio Exposures
303
350
393
546
445 438
533 524
0
100
200
300
400
500
600
2005 2006 2007 2008 2009 2010 2011 2012Year
HCF Severity
Exposures
361 371
343
490
548
449
160
135
0
100
200
300
400
500
600
2005 2006 2007 2008 2009 2010 2011 2012Year
Hydrocodone/APAP
Exposures
263274
302308
341328
258
300
0
50
100
150
200
250
300
350
2005 2006 2007 2008 2009 2010 2011 2012
Year
Oxycodone
Oxycodone
168 168174
145149
141
108
83
0
20
40
60
80
100
120
140
160
180
2005 2006 2007 2008 2009 2010 2011 2012Year
Methadone
126
84
128
111114
108
91
83
0
20
40
60
80
100
120
140
2005 2006 2007 2008 2009 2010 2011 2012Year
Morphine
290
332349
446
506
472
521497
0
100
200
300
400
500
600
2005 2006 2007 2008 2009 2010 2011 2012
Year
Tramadol
Tramadol
42
23
184
90
194
86
0
50
100
150
200
250
300
2010 2011 2012Year
Buprenorphine
Buprenorphine<5 yo
Buprenorphine total
2010
2011
2012
Oxymorphone
Fentanyl
12
74
45
8
46
41
0
10
20
30
40
50
60
70
80
Year
Oxymorphone and Fentanyl
Oxymorphone
Fentanyl
0
10
20
30
40
50
60
70
80
Percent
1 2Year
Ped vs Adult 2005,2010
Peds
Adults
0
5
10
15
20
25
30
35
40
Percent
<19 20-29 30-39 40-49 50-59 60-69 70-79 80-89 >90
Age group % 2005, 2010
2005
2010
12048
14378
21104
28606
25130
17140
15638
11851
0
5000
10000
15000
20000
25000
30000
2005 2006 2007 2008 2009 2010 2011 2012Year
Hydrocodone/APAP
4833
9829
15086
17634
11335
10683
8968
6525
0
2000
4000
6000
8000
10000
12000
14000
16000
18000
2005 2006 2007 2008 2009 2010 2011 2012Year
Oxycodone
Oxycodone
8831
10903
17525
20866
19970
15556
14594
10028
0
5000
10000
15000
20000
25000
2005 2006 2007 2008 2009 2010 2011 2012Year
Oxycodone/APAP
Oxycodone/APAP
1561
3178
3419
3760
2344
1824
1440 1415
0
500
1000
1500
2000
2500
3000
3500
4000
2005 2006 2007 2008 2009 2010 2011 2012Year
Methadone
Methadone
2533
3003
4014
5177
4385
2758
2209
1733
0
1000
2000
3000
4000
5000
6000
2005 2006 2007 2008 2009 2010 2011 2012Year
Morphine
Morphine
2952
4110
5328
6730
4601
3207
2935
2391
0
1000
2000
3000
4000
5000
6000
7000
2005 2006 2007 2008 2009 2010 2011 2012Year
Tramadol
Tramadol