OH CH H H H O - swgdrug.org...17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement...
5
17-beta-hydroxy-17-alpha-methylandrost-1-en-3-one The Drug Enforcement Administration's Special Testing and Research Laboratory generated this monograph using structurally confirmed reference material. Latest Revision: 11/22/2016 Page 1 of 5 SWGDRUG.org/monographs.htm Form Chemical Formula Molecular Weight Melting Point ( o C) Neutral C 20 H 30 O 2 302.45 Not Determined CH 3 CH 3 CH 3 O OH H H H H 1. GENERAL INFORMATION IUPAC Name: 17-beta-hydroxy-17-alpha-methylandrost-1-en-3-one CAS#: 65-04-3 Synonyms: 1,(5-alpha)-Androsten-17-alpha-methyl-17-beta-ol-3-one; 17- beta-hydroxy-17-alpha-methyl-5-alpha-androst-1-en-3-one; 17-alpha-methyl- -dihydrotestosterone; 1,(5-alpha-Androsten-17-alpha-methyl-17-beta-ol-3-one; Methyl-1-testosterone; 1-dehydromethandrostenolone (Steraloids) Source: DEA Reference Material Collection Appearance: White powder UV max (nm): Not determined 2. CHEMICAL AND PHYSICAL DATA 2.1 CHEMICAL DATA
Transcript of OH CH H H H O - swgdrug.org...17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement...
-
17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 11/22/2016 Page 1 of 5SWGDRUG.org/monographs.htm
Form Chemical Formula Molecular Weight Melting Point (oC)
Neutral C20H30O2 302.45 Not Determined
CH3
CH3 CH3
O
OH
H
H H
H
1. GENERAL INFORMATION
IUPAC Name: 17-beta-hydroxy-17-alpha-methylandrost-1-en-3-one
CAS#: 65-04-3
Synonyms: 1,(5-alpha)-Androsten-17-alpha-methyl-17-beta-ol-3-one;17- beta-hydroxy-17-alpha-methyl-5-alpha-androst-1-en-3-one; 17-alpha-methyl--dihydrotestosterone;1,(5-alpha-Androsten-17-alpha-methyl-17-beta-ol-3-one; Methyl-1-testosterone;1-dehydromethandrostenolone (Steraloids)
Source: DEA Reference Material Collection
Appearance: White powder
UVmax(nm): Not determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
-
17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 11/22/2016 Page 2 of 5SWGDRUG.org/monographs.htm
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~5 mg/mL in CDCl3 containing TMS for 0 ppm reference and dimethylsulfone as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds
1HNMR: 17-beta-hydroxy-17-alpha-methylandrost-1-en-3-one; Lot # B0365; CDCl3; 400MHz
7.0 6.5 6.0 5.5 5.0 4.5 4.0 3.5 3.0 2.5 2.0 1.5 1.0 0.5 0
81351111
7.150
1
5.875
1
2.4 2.3 2.2
11
CHCl3
dimethylsulfone
TMS
1.75 1.50 1.25 1.00
8135
-
17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 11/22/2016 Page 3 of 5SWGDRUG.org/monographs.htm
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~4 mg/mL in MeOH
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: HP-1 MS (or equivalent); 30m x 0.25 mm x 0.25 mCarrier Gas: Helium at 1.5 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC
MS Source: 250oC MS Quad: 150oCOven program:
1) 100oC initial temperature for 1.0 min2) Ramp to 300oC at 14 oC/min3) Hold final temperature for 25.0 min
Injection Parameters: Split Ratio = 20:1, 1 L injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 90
Tune file: stune.u Acquisition mode: scanRetention Time: 15.915 min
EI Mass Spectrum: 17-beta-hydroxy-17-alpha-methylandrost-1-en-3-one; Lot# B0365
m/z300280260240220200180160140120100806040
[x 1
05]
Inte
nsity
0
0.5
1.0
1.5
2.0
2.5
3.0
39393939393939393939393939393939393939393939
41414141414141414141414141414141414141414141
43434343434343434343434343434343434343434343
53535353535353535353535353535353535353535353
55555555555555555555555555555555555555555555
5757575757575757575757575757575757575757575758585858585858585858585858585858585858585858
67676767676767676767676767676767676767676767
71717171717171717171717171717171717171717171
79797979797979797979797979797979797979797979
81818181818181818181818181818181818181818181
91919191919191919191919191919191919191919191
93939393939393939393939393939393939393939393
105105105105105105105105105105105105105105105105105105105105105105
107107107107107107107107107107107107107107107107107107107107107107109109109109109109109109109109109109109109109109109109109109109109
121121121121121121121121121121121121121121121121121121121121121121
122122122122122122122122122122122122122122122122122122122122122122
123123123123123123123123123123123123123123123123123123123123123123134134134134134134134134134134134134134134134134134134134134134134
135135135135135135135135135135135135135135135135135135135135135135147147147147147147147147147147147147147147147147147147147147147147 160160160160160160160160160160160160160160160160160160160160160160
161161161161161161161161161161161161161161161161161161161161161161 163163163163163163163163163163163163163163163163163163163163163163
175175175175175175175175175175175175175175175175175175175175175175176176176176176176176176176176176176176176176176176176176176176176
187187187187187187187187187187187187187187187187187187187187187187199199199199199199199199199199199199199199199199199199199199199199
200200200200200200200200200200200200200200200200200200200200200200202202202202202202202202202202202202202202202202202202202202202202
213213213213213213213213213213213213213213213213213213213213213213229229229229229229229229229229229229229229229229229229229229229229
242242242242242242242242242242242242242242242242242242242242242242244244244244244244244244244244244244244244244244244244244244244244
245245245245245245245245245245245245245245245245245245245245245245
260260260260260260260260260260260260260260260260260260260260260260269269269269269269269269269269269269269269269269269269269269269269
284284284284284284284284284284284284284284284284284284284284284284287287287287287287287287287287287287287287287287287287287287287287
302302302302302302302302302302302302302302302302302302302302302302
303303303303303303303303303303303303303303303303303303303303303303
-
17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 11/22/2016 Page 4 of 5SWGDRUG.org/monographs.htm
3.3 INFRARED SPECTROSCOPY (FTIR)
Insrument: FTIR with diamond ATR attachment (1 bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 8Aperture: 150
FTIR ATR (Diamond 1 Bounce): 17-beta-hydroxy-17-alpha-methylandrost-1-en-3-one; Lot# B0365
Wavenumber (cm-1)4000 3500 3000 2500 2000 1500 1000
%Tr
ansm
ittan
ce
82
84
86
88
90
92
94
407407407407407407407407407407407407407407407407407407407407407407
451451451451451451451451451451451451451451451451451451451451451451
490490490490490490490490490490490490490490490490490490490490490490507
507507507507507507507507507507507507507507507507507507507507507
557557557557557557557557557557557557557557557557557557557557557557
781781781781781781781781781781781781781781781781781781781781781781
903903903903903903903903903903903903903903903903903903903903903903
935935935935935935935935935935935935935935935935935935935935935935
972972972972972972972972972972972972972972972972972972972972972972
1066106610661066106610661066106610661066106610661066106610661066106610661066106610661066
10841084108410841084108410841084108410841084108410841084108410841084108410841084108410841163116311631163116311631163116311631163116311631163116311631163116311631163116311631163
12231223122312231223122312231223122312231223122312231223122312231223122312231223122312231271
127112711271127112711271127112711271127112711271127112711271127112711271127112711271
1367136713671367136713671367136713671367136713671367136713671367136713671367136713671367
1439143914391439143914391439143914391439143914391439143914391439143914391439143914391439
1662166216621662166216621662166216621662166216621662166216621662166216621662166216621662
2856285628562856285628562856285628562856285628562856285628562856285628562856285628562856
2928292829282928292829282928292829282928292829282928292829282928292829282928292829282928
3512351235123512351235123512351235123512351235123512351235123512351235123512351235123512
Wavenumber (cm-1)1760 1680 1600 1520 1440 1360 1280 1200 1120 1040 960 880 800 720 640
%Tr
ansm
ittan
ce
82
84
86
88
90
92
94
407407407407407407407407407407407407407407407407407407407407407407
430430430430430430430430430430430430430430430430430430430430430430451
451451451451451451451451451451451451451451451451451451451451451
474474474474474474474474474474474474474474474474474474474474474474
490490490490490490490490490490490490490490490490490490490490490490507
507507507507507507507507507507507507507507507507507507507507507
557557557557557557557557557557557557557557557557557557557557557557
692692692692692692692692692692692692692692692692692692692692692692
781781781781781781781781781781781781781781781781781781781781781781
823823823823823823823823823823823823823823823823823823823823823823
862862862862862862862862862862862862862862862862862862862862862862
903903903903903903903903903903903903903903903903903903903903903903
935935935935935935935935935935935935935935935935935935935935935935
972972972972972972972972972972972972972972972972972972972972972972
10011001100110011001100110011001100110011001100110011001100110011001100110011001100110011030103010301030103010301030103010301030103010301030103010301030103010301030103010301030
1066106610661066106610661066106610661066106610661066106610661066106610661066106610661066
1084108410841084108410841084108410841084108410841084108410841084108410841084108410841084
1163116311631163116311631163116311631163116311631163116311631163116311631163116311631163
12011201120112011201120112011201120112011201120112011201120112011201120112011201120112011223122312231223122312231223122312231223122312231223122312231223122312231223122312231223
1261126112611261126112611261126112611261126112611261126112611261126112611261126112611261
1271127112711271127112711271127112711271127112711271127112711271127112711271127112711271
1296129612961296129612961296129612961296129612961296129612961296129612961296129612961296
1367136713671367136713671367136713671367136713671367136713671367136713671367136713671367
1394139413941394139413941394139413941394139413941394139413941394139413941394139413941394
1408140814081408140814081408140814081408140814081408140814081408140814081408140814081408
1439143914391439143914391439143914391439143914391439143914391439143914391439143914391439
1471147114711471147114711471147114711471147114711471147114711471147114711471147114711471
1662166216621662166216621662166216621662166216621662166216621662166216621662166216621662
-
17-beta-hydroxy-17-alpha-methylandrost-1-en-3-oneThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 11/22/2016 Page 5 of 5SWGDRUG.org/monographs.htm
https://en.wikipedia.org/wiki/Tapentadolhttps://en.wikipedia.org/wiki/Tapentadol
4. ADDITIONAL RESOURCES
No additional resources as of 03/2016
![5-EAPB - swgdrug.org · EI Mass Spectrum: 5-EAPB HCl; Lot# 0455564-11 40 60 80 100 120 140 160 180 200 m/z [x 10 5] Intensity 2 4 30 4444 51 565656 62 6363 72 77 898989 91 102102102102102](https://static.fdocuments.us/doc/165x107/5f8c61b47eb4d70c087706d0/5-eapb-ei-mass-spectrum-5-eapb-hcl-lot-0455564-11-40-60-80-100-120-140-160.jpg)
